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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21840

FusionGeneSummary for MGRN1_PXN

check button Fusion gene summary
Fusion gene informationFusion gene name: MGRN1_PXN
Fusion gene ID: 21840
HgeneTgene
Gene symbol

MGRN1

PXN

Gene ID

23295

7837

Gene namemahogunin ring finger 1peroxidasin
SynonymsRNF156ASGD7|COPOA|D2S448|D2S448E|MG50|PRG2|PXN|VPO
Cytomap

16p13.3

2p25.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MGRN1RING finger protein 156RING-type E3 ubiquitin transferase MGRN1mahogunin RING finger protein 1mahogunin ring finger 1, E3 ubiquitin protein ligaseprobable E3 ubiquitin-protein ligase MGRN1peroxidasin homologmelanoma-associated antigen MG50p53-responsive gene 2 proteinvascular peroxidase 1
Modification date2018051920180523
UniProtAcc

O60291

P49023

Ensembl transtripts involved in fusion geneENST00000262370, ENST00000415496, 
ENST00000399577, ENST00000588994, 
ENST00000586183, ENST00000588015, 
ENST00000458477, ENST00000228307, 
ENST00000424649, ENST00000397506, 
ENST00000536957, ENST00000267257, 
ENST00000538144, 
Fusion gene scores* DoF score7 X 8 X 8=4488 X 8 X 2=128
# samples 138
** MAII scorelog2(13/448*10)=-1.78498710902915
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/128*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MGRN1 [Title/Abstract] AND PXN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMGRN1

GO:0043951

negative regulation of cAMP-mediated signaling

19737927

HgeneMGRN1

GO:0045744

negative regulation of G-protein coupled receptor protein signaling pathway

19737927

TgenePXN

GO:0030198

extracellular matrix organization

19590037

TgenePXN

GO:0042744

hydrogen peroxide catabolic process

18929642

TgenePXN

GO:0055114

oxidation-reduction process

18929642


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF762439MGRN1chr16

4740612

-PXNchr12

120654005

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000262370ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+

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FusionProtFeatures for MGRN1_PXN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGRN1

O60291

PXN

P49023

E3 ubiquitin-protein ligase. Mediates monoubiquitinationat multiple sites of TSG101 in the presence of UBE2D1, but not ofUBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling bycompeting with GNAS-binding to MCRs and inhibiting agonist-inducedcAMP production. Does not inhibit ADRB2-signaling. Does notpromote MC1R ubiquitination. Acts also as a negative regulator ofhedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074,ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557,ECO:0000269|PubMed:19737927}. Cytoskeletal protein involved in actin-membraneattachment at sites of cell adhesion to the extracellular matrix(focal adhesion).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MGRN1_PXN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MGRN1_PXN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MGRN1_PXN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MGRN1_PXN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePXNC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgenePXNC0025205Melanoma, Experimental1CTD_human
TgenePXNC0027627Neoplasm Metastasis1CTD_human