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Fusion gene ID: 21836 |
FusionGeneSummary for MGRN1_C16orf96 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MGRN1_C16orf96 | Fusion gene ID: 21836 | Hgene | Tgene | Gene symbol | MGRN1 | C16orf96 | Gene ID | 23295 | 342346 |
| Gene name | mahogunin ring finger 1 | chromosome 16 open reading frame 96 | |
| Synonyms | RNF156 | - | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase MGRN1RING finger protein 156RING-type E3 ubiquitin transferase MGRN1mahogunin RING finger protein 1mahogunin ring finger 1, E3 ubiquitin protein ligaseprobable E3 ubiquitin-protein ligase MGRN1 | uncharacterized protein C16orf96 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O60291 | A6NNT2 | |
| Ensembl transtripts involved in fusion gene | ENST00000262370, ENST00000415496, ENST00000399577, ENST00000588994, ENST00000586183, ENST00000588015, | ENST00000444310, | |
| Fusion gene scores | * DoF score | 7 X 8 X 8=448 | 2 X 3 X 6=36 |
| # samples | 13 | 7 | |
| ** MAII score | log2(13/448*10)=-1.78498710902915 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/36*10)=0.959358015502654 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MGRN1 [Title/Abstract] AND C16orf96 [Title/Abstract] AND fusion [Title/Abstract] Common Fusion Transcripts Identified in Colorectal Cancer Cell Lines by High-Throughput RNA Sequencing (pmid: 24151535) | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MGRN1 | GO:0043951 | negative regulation of cAMP-mediated signaling | 19737927 |
| Hgene | MGRN1 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway | 19737927 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-2Y-A9H6-01A | MGRN1 | chr16 | 4718313 | + | C16orf96 | chr16 | 4621562 | + |
| TCGA | LD | LIHC | TCGA-BD-A2L6-01A | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4621562 | + |
| TCGA | LD | LUSC | TCGA-77-8140-01A | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4621562 | + |
| TCGA | LD | OV | TCGA-13-1498-01A | MGRN1 | chr16 | 4702825 | + | C16orf96 | chr16 | 4643225 | + |
| TCGA | LD | SKCM | TCGA-EE-A20F-06A | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4621562 | + |
| TCGA | LD | STAD | TCGA-CD-8527-01A | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4644352 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262370 | ENST00000444310 | MGRN1 | chr16 | 4718313 | + | C16orf96 | chr16 | 4621562 | + |
| In-frame | ENST00000415496 | ENST00000444310 | MGRN1 | chr16 | 4718313 | + | C16orf96 | chr16 | 4621562 | + |
| In-frame | ENST00000399577 | ENST00000444310 | MGRN1 | chr16 | 4718313 | + | C16orf96 | chr16 | 4621562 | + |
| In-frame | ENST00000588994 | ENST00000444310 | MGRN1 | chr16 | 4718313 | + | C16orf96 | chr16 | 4621562 | + |
| In-frame | ENST00000586183 | ENST00000444310 | MGRN1 | chr16 | 4718313 | + | C16orf96 | chr16 | 4621562 | + |
| 3UTR-3CDS | ENST00000588015 | ENST00000444310 | MGRN1 | chr16 | 4718313 | + | C16orf96 | chr16 | 4621562 | + |
| Frame-shift | ENST00000262370 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4621562 | + |
| Frame-shift | ENST00000415496 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4621562 | + |
| Frame-shift | ENST00000399577 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4621562 | + |
| Frame-shift | ENST00000588994 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4621562 | + |
| Frame-shift | ENST00000586183 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4621562 | + |
| intron-3CDS | ENST00000588015 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4621562 | + |
| In-frame | ENST00000262370 | ENST00000444310 | MGRN1 | chr16 | 4702825 | + | C16orf96 | chr16 | 4643225 | + |
| In-frame | ENST00000415496 | ENST00000444310 | MGRN1 | chr16 | 4702825 | + | C16orf96 | chr16 | 4643225 | + |
| In-frame | ENST00000399577 | ENST00000444310 | MGRN1 | chr16 | 4702825 | + | C16orf96 | chr16 | 4643225 | + |
| In-frame | ENST00000588994 | ENST00000444310 | MGRN1 | chr16 | 4702825 | + | C16orf96 | chr16 | 4643225 | + |
| In-frame | ENST00000586183 | ENST00000444310 | MGRN1 | chr16 | 4702825 | + | C16orf96 | chr16 | 4643225 | + |
| intron-3CDS | ENST00000588015 | ENST00000444310 | MGRN1 | chr16 | 4702825 | + | C16orf96 | chr16 | 4643225 | + |
| Frame-shift | ENST00000262370 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4644352 | + |
| Frame-shift | ENST00000415496 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4644352 | + |
| Frame-shift | ENST00000399577 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4644352 | + |
| Frame-shift | ENST00000588994 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4644352 | + |
| Frame-shift | ENST00000586183 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4644352 | + |
| intron-3CDS | ENST00000588015 | ENST00000444310 | MGRN1 | chr16 | 4675049 | + | C16orf96 | chr16 | 4644352 | + |
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FusionProtFeatures for MGRN1_C16orf96 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MGRN1 | C16orf96 |
| E3 ubiquitin-protein ligase. Mediates monoubiquitinationat multiple sites of TSG101 in the presence of UBE2D1, but not ofUBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling bycompeting with GNAS-binding to MCRs and inhibiting agonist-inducedcAMP production. Does not inhibit ADRB2-signaling. Does notpromote MC1R ubiquitination. Acts also as a negative regulator ofhedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074,ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557,ECO:0000269|PubMed:19737927}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >C16orf96 | chr16:4718313 | chr16:4621562 | ENST00000444310 | + | 0 | 16 | 145_176 | 140 | 1142 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >C16orf96 | chr16:4718313 | chr16:4621562 | ENST00000444310 | + | 0 | 16 | 757_810 | 140 | 1142 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >C16orf96 | chr16:4718313 | chr16:4621562 | ENST00000444310 | + | 0 | 16 | 306_440 | 140 | 1142 | Compositional bias | Note=Pro-rich |
| Tgene | >C16orf96 | chr16:4718313 | chr16:4621562 | ENST00000444310 | + | 0 | 16 | 568_614 | 140 | 1142 | Compositional bias | Note=Ala-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MGRN1 | chr16:4702825 | chr16:4643225 | ENST00000262370 | + | 4 | 17 | 278_317 | 147 | 577 | Zinc finger | RING-type |
| Hgene | >MGRN1 | chr16:4702825 | chr16:4643225 | ENST00000399577 | + | 4 | 17 | 278_317 | 147 | 553 | Zinc finger | RING-type |
| Hgene | >MGRN1 | chr16:4702825 | chr16:4643225 | ENST00000586183 | + | 4 | 17 | 278_317 | 147 | 583 | Zinc finger | RING-type |
| Hgene | >MGRN1 | chr16:4702825 | chr16:4643225 | ENST00000588994 | + | 4 | 16 | 278_317 | 147 | 555 | Zinc finger | RING-type |
| Hgene | >MGRN1 | chr16:4718313 | chr16:4621562 | ENST00000262370 | + | 8 | 17 | 278_317 | 242 | 577 | Zinc finger | RING-type |
| Hgene | >MGRN1 | chr16:4718313 | chr16:4621562 | ENST00000399577 | + | 8 | 17 | 278_317 | 242 | 553 | Zinc finger | RING-type |
| Hgene | >MGRN1 | chr16:4718313 | chr16:4621562 | ENST00000586183 | + | 8 | 17 | 278_317 | 242 | 583 | Zinc finger | RING-type |
| Hgene | >MGRN1 | chr16:4718313 | chr16:4621562 | ENST00000588994 | + | 8 | 16 | 278_317 | 242 | 555 | Zinc finger | RING-type |
| Tgene | C16orf96 | chr16:4702825 | chr16:4643225 | ENST00000444310 | + | 10 | 16 | 145_176 | 924 | 1142 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | C16orf96 | chr16:4702825 | chr16:4643225 | ENST00000444310 | + | 10 | 16 | 74_101 | 924 | 1142 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | C16orf96 | chr16:4702825 | chr16:4643225 | ENST00000444310 | + | 10 | 16 | 757_810 | 924 | 1142 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | C16orf96 | chr16:4718313 | chr16:4621562 | ENST00000444310 | + | 0 | 16 | 74_101 | 140 | 1142 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | C16orf96 | chr16:4702825 | chr16:4643225 | ENST00000444310 | + | 10 | 16 | 306_440 | 924 | 1142 | Compositional bias | Note=Pro-rich |
| Tgene | C16orf96 | chr16:4702825 | chr16:4643225 | ENST00000444310 | + | 10 | 16 | 568_614 | 924 | 1142 | Compositional bias | Note=Ala-rich |
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FusionGeneSequence for MGRN1_C16orf96 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MGRN1_C16orf96 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MGRN1 | UBE2G2, TSG101, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2I, UBE2J2, UBE2W, UBE2T, MC1R, MC4R, MC2R, MRAP, ELAVL1, FBXO6, ITCH, NEDD4, HSPA4, TRIM74, TUBA4A, ATXN3, HTT, APBB1, TAZ, ATP1B4, BTNL8, PTPRK, AMFR, DUSP6, PSG8, ANKRD46, ATRN, C9orf40, PDCD2, INTS7, C19orf52, HSDL1, MEGF8, FAM19A4, MFN1 | C16orf96 | ABCE1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MGRN1_C16orf96 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MGRN1_C16orf96 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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