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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21834

FusionGeneSummary for MGMT_SNORA31

check button Fusion gene summary
Fusion gene informationFusion gene name: MGMT_SNORA31
Fusion gene ID: 21834
HgeneTgene
Gene symbol

MGMT

SNORA31

Gene ID

4255

677814

Gene nameO-6-methylguanine-DNA methyltransferasesmall nucleolar RNA, H/ACA box 31
Synonyms-ACA31|SNORA31A
Cytomap

10q26.3

13q14.13

Type of geneprotein-codingsnoRNA
Descriptionmethylated-DNA--protein-cysteine methyltransferase6-O-methylguanine-DNA methyltransferaseO-6-methylguanine-DNA-alkyltransferaseO6-methylguanine-DNA methyltransferasemethylguanine-DNA methyltransferaseACA31 snoRNA
Modification date2018052720180329
UniProtAcc

P16455

Ensembl transtripts involved in fusion geneENST00000306010, ENST00000462672, 
ENST00000516624, ENST00000517111, 
ENST00000516429, ENST00000517180, 
ENST00000516953, ENST00000516327, 
ENST00000517204, ENST00000516019, 
ENST00000516528, ENST00000516190, 
ENST00000515993, ENST00000517219, 
ENST00000517043, ENST00000516771, 
ENST00000517232, ENST00000516773, 
ENST00000516482, ENST00000516241, 
ENST00000516728, ENST00000517079, 
ENST00000516029, ENST00000517242, 
ENST00000362607, ENST00000517250, 
ENST00000516049, ENST00000516540, 
ENST00000516287, 
Fusion gene scores* DoF score5 X 4 X 3=602 X 1 X 2=4
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: MGMT [Title/Abstract] AND SNORA31 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMGMT

GO:0043066

negative regulation of apoptotic process

24147153

HgeneMGMT

GO:2000781

positive regulation of double-strand break repair

24147153


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-XR-A8TF-01AMGMTchr10

131265560

+SNORA31chr14

42063681

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306010ENST00000516624MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000517111MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516429MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000517180MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516953MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516327MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000517204MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516019MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516528MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516190MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000515993MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000517219MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000517043MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516771MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000517232MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516773MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516482MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516241MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516728MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000517079MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516029MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000517242MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000362607MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000517250MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-3UTRENST00000306010ENST00000516049MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516540MGMTchr10

131265560

+SNORA31chr14

42063681

+
5CDS-intronENST00000306010ENST00000516287MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516624MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000517111MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516429MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000517180MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516953MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516327MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000517204MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516019MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516528MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516190MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000515993MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000517219MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000517043MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516771MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000517232MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516773MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516482MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516241MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516728MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000517079MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516029MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000517242MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000362607MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000517250MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-3UTRENST00000462672ENST00000516049MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516540MGMTchr10

131265560

+SNORA31chr14

42063681

+
intron-intronENST00000462672ENST00000516287MGMTchr10

131265560

+SNORA31chr14

42063681

+

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FusionProtFeatures for MGMT_SNORA31


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGMT

P16455

SNORA31

Involved in the cellular defense against the biologicaleffects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT)in DNA. Repairs the methylated nucleobase in DNA bystoichiometrically transferring the methyl group to a cysteineresidue in the enzyme. This is a suicide reaction: the enzyme isirreversibly inactivated. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MGMT_SNORA31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MGMT_SNORA31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MGMTCSNK2A1, CSNK2A2, PRKACA, PRKCA, ESR1, CREBBP, EP300, SMC1A, HIST1H4A, HIST1H2AM, H2BFM, HIST3H3, MCM3, MSH2, TOP1, PRKDC, XRCC6, DDX5, DDX24, USP19, RNF8, PSME2, UBB, PSMD9, FBXO2, FBXO27, HSP90AA1, HSP90AB1, CDK12, CDK10, PRKCH, PRPF4, CDKL5, SET, PTPN4, YWHAZ, KPNB1, WNT9B, PABPC3, ANP32E, NCL, HNRNPA2B1, HNRNPC, RPS15A, RPLP1, EIF3H, EEF1A1, EEF1A2, EEF1B2, SLC25A4, SLC25A6, PKM, TTPA, IL25, FBL, TUBB4B, TUBA1C, ANXA1, ANXA2, ACTB, MYO7A, VIM, PHB, SRP9, SSRP1, PCNA, CDK2, CDK1, CCNB1, CDKN1A, MCM2, ORC1, POLD1, BRCA2, FANCASNORA31


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MGMT_SNORA31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMGMTP16455DB01593ZincMethylated-DNA--protein-cysteine methyltransferasesmall moleculeapproved|investigational

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RelatedDiseases for MGMT_SNORA31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMGMTC0017638Glioma3CTD_human
HgeneMGMTC0017636Glioblastoma2CTD_human
HgeneMGMTC0006118Brain Neoplasms1CTD_human
HgeneMGMTC0023418leukemia1CTD_human
HgeneMGMTC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneMGMTC0026640Mouth Neoplasms1CTD_human
HgeneMGMTC0027540Necrosis1CTD_human
HgeneMGMTC0032927Precancerous Conditions1CTD_human
HgeneMGMTC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneMGMTC1168401Squamous cell carcinoma of the head and neck1CTD_human
HgeneMGMTC1449861Micronuclei, Chromosome-Defective1CTD_human