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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21831

FusionGeneSummary for MGMT_LGI4

check button Fusion gene summary
Fusion gene informationFusion gene name: MGMT_LGI4
Fusion gene ID: 21831
HgeneTgene
Gene symbol

MGMT

LGI4

Gene ID

4255

163175

Gene nameO-6-methylguanine-DNA methyltransferaseleucine rich repeat LGI family member 4
Synonyms-AMCNMY|LGIL3
Cytomap

10q26.3

19q13.12|19q13.11

Type of geneprotein-codingprotein-coding
Descriptionmethylated-DNA--protein-cysteine methyltransferase6-O-methylguanine-DNA methyltransferaseO-6-methylguanine-DNA-alkyltransferaseO6-methylguanine-DNA methyltransferasemethylguanine-DNA methyltransferaseleucine-rich repeat LGI family member 4LGI1-like protein 3leucine-rich glioma-inactivated gene 4leucine-rich glioma-inactivated protein 4
Modification date2018052720180519
UniProtAcc

P16455

Q8N135

Ensembl transtripts involved in fusion geneENST00000306010, ENST00000462672, 
ENST00000392225, ENST00000310123, 
ENST00000493050, ENST00000591633, 
Fusion gene scores* DoF score5 X 4 X 3=601 X 1 X 1=1
# samples 51
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: MGMT [Title/Abstract] AND LGI4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMGMT

GO:0043066

negative regulation of apoptotic process

24147153

HgeneMGMT

GO:2000781

positive regulation of double-strand break repair

24147153


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A03V-01AMGMTchr10

131334641

+LGI4chr19

35622764

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000306010ENST00000392225MGMTchr10

131334641

+LGI4chr19

35622764

-
In-frameENST00000306010ENST00000310123MGMTchr10

131334641

+LGI4chr19

35622764

-
5CDS-5UTRENST00000306010ENST00000493050MGMTchr10

131334641

+LGI4chr19

35622764

-
5CDS-5UTRENST00000306010ENST00000591633MGMTchr10

131334641

+LGI4chr19

35622764

-
intron-3CDSENST00000462672ENST00000392225MGMTchr10

131334641

+LGI4chr19

35622764

-
intron-3CDSENST00000462672ENST00000310123MGMTchr10

131334641

+LGI4chr19

35622764

-
intron-5UTRENST00000462672ENST00000493050MGMTchr10

131334641

+LGI4chr19

35622764

-
intron-5UTRENST00000462672ENST00000591633MGMTchr10

131334641

+LGI4chr19

35622764

-

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FusionProtFeatures for MGMT_LGI4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGMT

P16455

LGI4

Q8N135

Involved in the cellular defense against the biologicaleffects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT)in DNA. Repairs the methylated nucleobase in DNA bystoichiometrically transferring the methyl group to a cysteineresidue in the enzyme. This is a suicide reaction: the enzyme isirreversibly inactivated. Component of Schwann cell signaling pathway(s) thatcontrols axon segregation and myelin formation (By similarity).{ECO:0000250|UniProtKB:Q8K1S1}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-39158_208128538DomainNote=LRRCT
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-36158_208128262DomainNote=LRRCT
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-39125_146128538RepeatNote=LRR 4
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-39210_252128538RepeatEAR 1
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-39256_298128538RepeatEAR 2
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-39302_349128538RepeatEAR 3
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-39351_394128538RepeatEAR 4
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-39396_439128538RepeatEAR 5
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-39441_483128538RepeatEAR 6
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-39487_532128538RepeatEAR 7
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-36125_146128262RepeatNote=LRR 4
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-36210_252128262RepeatEAR 1
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-36256_298128262RepeatEAR 2
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-36302_349128262RepeatEAR 3
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-36351_394128262RepeatEAR 4
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-36396_439128262RepeatEAR 5
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-36441_483128262RepeatEAR 6
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-36487_532128262RepeatEAR 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-39101_122128538RepeatNote=LRR 3
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-3953_74128538RepeatNote=LRR 1
TgeneLGI4chr10:131334641chr19:35622764ENST00000310123-3977_98128538RepeatNote=LRR 2
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-36101_122128262RepeatNote=LRR 3
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-3653_74128262RepeatNote=LRR 1
TgeneLGI4chr10:131334641chr19:35622764ENST00000591633-3677_98128262RepeatNote=LRR 2


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FusionGeneSequence for MGMT_LGI4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MGMT_ENST00000306010_chr10_131334641_+_LGI4_ENST00000392225_chr19_35622764_-_439aa
MLGQPAPLERFASRRPQVLAVRTVCDLVLGKMDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAAESLANNHLETLPRFLFRG
LDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHIV
LAQPFAGRCLILSWDYSLQRFRPEEELPGEPPPRPSACPAACLAGLTCLPTSPQRPPWCPASHWCWARASSCWLPACGGAHSCGPGPVPA
CAWPQRRPWPRGGCCGPMTPSSCGWKGNPASWWPMPPRRAAPRCCAATGPAFTRTRACTPGTGTRTLRPWSWTAGPTCCWPRLPSGPCSS

>In-frame_MGMT_ENST00000306010_chr10_131334641_+_LGI4_ENST00000310123_chr19_35622764_-_482aa
MLGQPAPLERFASRRPQVLAVRTVCDLVLGKMDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAAESLANNHLETLPRFLFRG
LDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHIV
LAQPFAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLE
GQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHWTGGRFERRTDIPEAEDVYATRHFQ
AGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRAFA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MGMT_ENST00000306010_chr10_131334641_+_LGI4_ENST00000392225_chr19_35622764_-_1317nt
ATGCTGGGACAGCCCGCGCCCCTAGAACGCTTTGCGTCCCGACGCCCGCAGGTCCTCGCGGTGCGCACCGTTTGCGACTTGGTACTTGGA
AAAATGGACAAGGATTGTGAAATGAAACGCACCACACTGGACAGCCCTTTGGGGAAGCTGGAGCTGTCTGGTTGTGAGCAGGGTCTGCAC
GAAATAAAGCTCCTGGGCAAGGGGACGTCTGCAGCTGAAAGCCTGGCCAATAACCATCTGGAGACCCTCCCCAGATTCCTGTTCCGAGGC
CTGGACACCCTTACTCATGTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCGTCCTCTGGCTCCTGCAGTGGATGCCCACCGTG
AATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGCTCCACCACCTCGACCCCAAGACTTTCAAGTGC
AGAGCCATAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTCGGCACTGAGCGTAGAGCCCTTCTCCTACCAAGGGGAGCCTCACATTGTG
CTGGCACAGCCCTTCGCCGGCCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGCGCTTCCGGCCCGAGGAAGAGCTGCCCGGTGAG
CCCCCTCCCCGTCCTTCTGCCTGTCCAGCAGCCTGCCTGGCTGGCCTGACCTGCCTCCCCACCTCCCCACAGCGGCCTCCGTGGTGTCCT
GCAAGCCACTGGTGCTGGGCCCGAGCCTCTTCGTGCTGGCTGCCCGCCTGTGGGGGGGCTCACAGCTGTGGGCCCGGCCCAGTCCCGGCC
TGCGCCTGGCCCCAACGCAGACCCTGGCCCCGCGGCGGCTGCTGCGGCCCAATGACGCCGAGCTCCTGTGGCTGGAAGGGCAACCCTGCT
TCGTGGTGGCCGATGCCTCCAAGGCGGGCAGCACCACGCTGCTGTGCCGCGACGGGCCCGGCTTTTACCCGCACCAGAGCCTGCACGCCT
GGCACCGGGACACGGACGCTGAGGCCCTGGAGCTGGACGGCCGGCCCCACCTGCTGCTGGCCTCGGCTTCCCAGCGGCCCGTGCTCTTCC
ACTGGACCGGTGGCCGCTTCGAGAGACGCACAGACATCCCCGAGGCCGAGGATGTCTATGCCACACGCCACTTCCAGGCTGGTGGGGACG
TGTTCCTGTGCCTCACACGCTACATTGGGGACTCCATGGTCATGCGCTGGGACGGCTCCATGTTTCGTCTGCTGCAGCAACTTCCCTCGC

>In-frame_MGMT_ENST00000306010_chr10_131334641_+_LGI4_ENST00000310123_chr19_35622764_-_1446nt
ATGCTGGGACAGCCCGCGCCCCTAGAACGCTTTGCGTCCCGACGCCCGCAGGTCCTCGCGGTGCGCACCGTTTGCGACTTGGTACTTGGA
AAAATGGACAAGGATTGTGAAATGAAACGCACCACACTGGACAGCCCTTTGGGGAAGCTGGAGCTGTCTGGTTGTGAGCAGGGTCTGCAC
GAAATAAAGCTCCTGGGCAAGGGGACGTCTGCAGCTGAAAGCCTGGCCAATAACCATCTGGAGACCCTCCCCAGATTCCTGTTCCGAGGC
CTGGACACCCTTACTCATGTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCGTCCTCTGGCTCCTGCAGTGGATGCCCACCGTG
AATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGCTCCACCACCTCGACCCCAAGACTTTCAAGTGC
AGAGCCATAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTCGGCACTGAGCGTAGAGCCCTTCTCCTACCAAGGGGAGCCTCACATTGTG
CTGGCACAGCCCTTCGCCGGCCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGCGCTTCCGGCCCGAGGAAGAGCTGCCCGCGGCC
TCCGTGGTGTCCTGCAAGCCACTGGTGCTGGGCCCGAGCCTCTTCGTGCTGGCTGCCCGCCTGTGGGGGGGCTCACAGCTGTGGGCCCGG
CCCAGTCCCGGCCTGCGCCTGGCCCCAACGCAGACCCTGGCCCCGCGGCGGCTGCTGCGGCCCAATGACGCCGAGCTCCTGTGGCTGGAA
GGGCAACCCTGCTTCGTGGTGGCCGATGCCTCCAAGGCGGGCAGCACCACGCTGCTGTGCCGCGACGGGCCCGGCTTTTACCCGCACCAG
AGCCTGCACGCCTGGCACCGGGACACGGACGCTGAGGCCCTGGAGCTGGACGGCCGGCCCCACCTGCTGCTGGCCTCGGCTTCCCAGCGG
CCCGTGCTCTTCCACTGGACCGGTGGCCGCTTCGAGAGACGCACAGACATCCCCGAGGCCGAGGATGTCTATGCCACACGCCACTTCCAG
GCTGGTGGGGACGTGTTCCTGTGCCTCACACGCTACATTGGGGACTCCATGGTCATGCGCTGGGACGGCTCCATGTTTCGTCTGCTGCAG
CAACTTCCCTCGCGCGGTGCCCACGTCTTCCAGCCACTGCTCATCGCCAGGGACCAGCTGGCCATCCTAGGCAGCGACTTCGCCTTCAGC
CAGGTCCTCCGCCTTGAGCCTGACAAGGGGCTCCTGGAGCCACTGCAGGAGCTGGGGCCTCCGGCCCTGGTGGCCCCCCGTGCCTTTGCC
CACATCACTATGGCCGGCAGACGCTTCCTCTTTGCTGCTTGCTTTAAGGGCCCCACACAGATCTACCAGCATCACGAGATCGACCTCAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MGMT_ENST00000306010_chr10_131334641_+_LGI4_ENST00000392225_chr19_35622764_-_2235nt
GTGCCCCTCGGCCCCGCCCCCGCGCCCCGGATATGCTGGGACAGCCCGCGCCCCTAGAACGCTTTGCGTCCCGACGCCCGCAGGTCCTCG
CGGTGCGCACCGTTTGCGACTTGGTACTTGGAAAAATGGACAAGGATTGTGAAATGAAACGCACCACACTGGACAGCCCTTTGGGGAAGC
TGGAGCTGTCTGGTTGTGAGCAGGGTCTGCACGAAATAAAGCTCCTGGGCAAGGGGACGTCTGCAGCTGAAAGCCTGGCCAATAACCATC
TGGAGACCCTCCCCAGATTCCTGTTCCGAGGCCTGGACACCCTTACTCATGTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCG
TCCTCTGGCTCCTGCAGTGGATGCCCACCGTGAATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGC
TCCACCACCTCGACCCCAAGACTTTCAAGTGCAGAGCCATAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTCGGCACTGAGCGTAGAGC
CCTTCTCCTACCAAGGGGAGCCTCACATTGTGCTGGCACAGCCCTTCGCCGGCCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGC
GCTTCCGGCCCGAGGAAGAGCTGCCCGGTGAGCCCCCTCCCCGTCCTTCTGCCTGTCCAGCAGCCTGCCTGGCTGGCCTGACCTGCCTCC
CCACCTCCCCACAGCGGCCTCCGTGGTGTCCTGCAAGCCACTGGTGCTGGGCCCGAGCCTCTTCGTGCTGGCTGCCCGCCTGTGGGGGGG
CTCACAGCTGTGGGCCCGGCCCAGTCCCGGCCTGCGCCTGGCCCCAACGCAGACCCTGGCCCCGCGGCGGCTGCTGCGGCCCAATGACGC
CGAGCTCCTGTGGCTGGAAGGGCAACCCTGCTTCGTGGTGGCCGATGCCTCCAAGGCGGGCAGCACCACGCTGCTGTGCCGCGACGGGCC
CGGCTTTTACCCGCACCAGAGCCTGCACGCCTGGCACCGGGACACGGACGCTGAGGCCCTGGAGCTGGACGGCCGGCCCCACCTGCTGCT
GGCCTCGGCTTCCCAGCGGCCCGTGCTCTTCCACTGGACCGGTGGCCGCTTCGAGAGACGCACAGACATCCCCGAGGCCGAGGATGTCTA
TGCCACACGCCACTTCCAGGCTGGTGGGGACGTGTTCCTGTGCCTCACACGCTACATTGGGGACTCCATGGTCATGCGCTGGGACGGCTC
CATGTTTCGTCTGCTGCAGCAACTTCCCTCGCGCGGTGCCCACGTCTTCCAGCCACTGCTCATCGCCAGGGACCAGCTGGCCATCCTAGG
CAGCGACTTCGCCTTCAGCCAGGTCCTCCGCCTTGAGCCTGACAAGGGGCTCCTGGAGCCACTGCAGGAGCTGGGGCCTCCGGCCCTGGT
GGCCCCCCGTGCCTTTGCCCACATCACTATGGCCGGCAGACGCTTCCTCTTTGCTGCTTGCTTTAAGGGCCCCACACAGATCTACCAGCA
TCACGAGATCGACCTCAGTGCCTGAGACCACCAACGGGACTCTGGGCATGGCTGGGGCCCCTGGACGGCCCCTTGGCTGGCTCCTGGCCC
TACTTGGGGTGATGGCCCGCCTGTGAGCTGCTGACCGTGGGCCACGTTCATCAGCCACACGTCTAGGCCTTAAGCCCACTTCTTAAAGGA
TCTGCACCCATGGGGGGACATAGAGGGTCCCAGCCTACTGGACCTCCCGAGCTGCCCTTCAGGTCTAAAGCAACATCTGGACATCTCGGC
TGGGGCAGATTCCCCATCAAAGGCAACCTGGGGGGTGCAGGCTGGTGCACTGCATGGAGTCGAGGTGGAGGTCACGTGCAGAGCTCCATG
AGGTCCCGGAGCCCCCCTCTCAACCCGCTCCTACCCCGCTGGTCCCTCTGAAAGCACCGAGGGGTTGATGGCATTCCTTTCCCATTCTAA
ACTCCACGCAGCCAATCGCTTTCCTGGAGGAGCGCCAACCTCGAAGACAACTCAGCACTGGGCGGGTTCCCCTCTGCTGCTTGTGCGCAT
GCGTGCGGCCGCCCAGCAAGCTGTGCCTTTTGCGCCTCTTGCGCGTGCGCCGGGGCACAGGGAGGGACAGCGGGAGGTGTCGCGGGGAGC

>In-frame_MGMT_ENST00000306010_chr10_131334641_+_LGI4_ENST00000310123_chr19_35622764_-_2158nt
GTGCCCCTCGGCCCCGCCCCCGCGCCCCGGATATGCTGGGACAGCCCGCGCCCCTAGAACGCTTTGCGTCCCGACGCCCGCAGGTCCTCG
CGGTGCGCACCGTTTGCGACTTGGTACTTGGAAAAATGGACAAGGATTGTGAAATGAAACGCACCACACTGGACAGCCCTTTGGGGAAGC
TGGAGCTGTCTGGTTGTGAGCAGGGTCTGCACGAAATAAAGCTCCTGGGCAAGGGGACGTCTGCAGCTGAAAGCCTGGCCAATAACCATC
TGGAGACCCTCCCCAGATTCCTGTTCCGAGGCCTGGACACCCTTACTCATGTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCG
TCCTCTGGCTCCTGCAGTGGATGCCCACCGTGAATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGC
TCCACCACCTCGACCCCAAGACTTTCAAGTGCAGAGCCATAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTCGGCACTGAGCGTAGAGC
CCTTCTCCTACCAAGGGGAGCCTCACATTGTGCTGGCACAGCCCTTCGCCGGCCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGC
GCTTCCGGCCCGAGGAAGAGCTGCCCGCGGCCTCCGTGGTGTCCTGCAAGCCACTGGTGCTGGGCCCGAGCCTCTTCGTGCTGGCTGCCC
GCCTGTGGGGGGGCTCACAGCTGTGGGCCCGGCCCAGTCCCGGCCTGCGCCTGGCCCCAACGCAGACCCTGGCCCCGCGGCGGCTGCTGC
GGCCCAATGACGCCGAGCTCCTGTGGCTGGAAGGGCAACCCTGCTTCGTGGTGGCCGATGCCTCCAAGGCGGGCAGCACCACGCTGCTGT
GCCGCGACGGGCCCGGCTTTTACCCGCACCAGAGCCTGCACGCCTGGCACCGGGACACGGACGCTGAGGCCCTGGAGCTGGACGGCCGGC
CCCACCTGCTGCTGGCCTCGGCTTCCCAGCGGCCCGTGCTCTTCCACTGGACCGGTGGCCGCTTCGAGAGACGCACAGACATCCCCGAGG
CCGAGGATGTCTATGCCACACGCCACTTCCAGGCTGGTGGGGACGTGTTCCTGTGCCTCACACGCTACATTGGGGACTCCATGGTCATGC
GCTGGGACGGCTCCATGTTTCGTCTGCTGCAGCAACTTCCCTCGCGCGGTGCCCACGTCTTCCAGCCACTGCTCATCGCCAGGGACCAGC
TGGCCATCCTAGGCAGCGACTTCGCCTTCAGCCAGGTCCTCCGCCTTGAGCCTGACAAGGGGCTCCTGGAGCCACTGCAGGAGCTGGGGC
CTCCGGCCCTGGTGGCCCCCCGTGCCTTTGCCCACATCACTATGGCCGGCAGACGCTTCCTCTTTGCTGCTTGCTTTAAGGGCCCCACAC
AGATCTACCAGCATCACGAGATCGACCTCAGTGCCTGAGACCACCAACGGGACTCTGGGCATGGCTGGGGCCCCTGGACGGCCCCTTGGC
TGGCTCCTGGCCCTACTTGGGGTGATGGCCCGCCTGTGAGCTGCTGACCGTGGGCCACGTTCATCAGCCACACGTCTAGGCCTTAAGCCC
ACTTCTTAAAGGATCTGCACCCATGGGGGGACATAGAGGGTCCCAGCCTACTGGACCTCCCGAGCTGCCCTTCAGGTCTAAAGCAACATC
TGGACATCTCGGCTGGGGCAGATTCCCCATCAAAGGCAACCTGGGGGGTGCAGGCTGGTGCACTGCATGGAGTCGAGGTGGAGGTCACGT
GCAGAGCTCCATGAGGTCCCGGAGCCCCCCTCTCAACCCGCTCCTACCCCGCTGGTCCCTCTGAAAGCACCGAGGGGTTGATGGCATTCC
TTTCCCATTCTAAACTCCACGCAGCCAATCGCTTTCCTGGAGGAGCGCCAACCTCGAAGACAACTCAGCACTGGGCGGGTTCCCCTCTGC
TGCTTGTGCGCATGCGTGCGGCCGCCCAGCAAGCTGTGCCTTTTGCGCCTCTTGCGCGTGCGCCGGGGCACAGGGAGGGACAGCGGGAGG


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FusionGenePPI for MGMT_LGI4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MGMTCSNK2A1, CSNK2A2, PRKACA, PRKCA, ESR1, CREBBP, EP300, SMC1A, HIST1H4A, HIST1H2AM, H2BFM, HIST3H3, MCM3, MSH2, TOP1, PRKDC, XRCC6, DDX5, DDX24, USP19, RNF8, PSME2, UBB, PSMD9, FBXO2, FBXO27, HSP90AA1, HSP90AB1, CDK12, CDK10, PRKCH, PRPF4, CDKL5, SET, PTPN4, YWHAZ, KPNB1, WNT9B, PABPC3, ANP32E, NCL, HNRNPA2B1, HNRNPC, RPS15A, RPLP1, EIF3H, EEF1A1, EEF1A2, EEF1B2, SLC25A4, SLC25A6, PKM, TTPA, IL25, FBL, TUBB4B, TUBA1C, ANXA1, ANXA2, ACTB, MYO7A, VIM, PHB, SRP9, SSRP1, PCNA, CDK2, CDK1, CCNB1, CDKN1A, MCM2, ORC1, POLD1, BRCA2, FANCALGI4TP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MGMT_LGI4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMGMTP16455DB01593ZincMethylated-DNA--protein-cysteine methyltransferasesmall moleculeapproved|investigational

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RelatedDiseases for MGMT_LGI4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMGMTC0017638Glioma3CTD_human
HgeneMGMTC0017636Glioblastoma2CTD_human
HgeneMGMTC0006118Brain Neoplasms1CTD_human
HgeneMGMTC0023418leukemia1CTD_human
HgeneMGMTC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneMGMTC0026640Mouth Neoplasms1CTD_human
HgeneMGMTC0027540Necrosis1CTD_human
HgeneMGMTC0032927Precancerous Conditions1CTD_human
HgeneMGMTC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneMGMTC1168401Squamous cell carcinoma of the head and neck1CTD_human
HgeneMGMTC1449861Micronuclei, Chromosome-Defective1CTD_human