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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21794

FusionGeneSummary for MGAT4B_RNF130

check button Fusion gene summary
Fusion gene informationFusion gene name: MGAT4B_RNF130
Fusion gene ID: 21794
HgeneTgene
Gene symbol

MGAT4B

RNF130

Gene ID

11282

55819

Gene namemannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme Bring finger protein 130
SynonymsGNT-IV|GNT-IVBG1RZFP|GOLIATH|GP
Cytomap

5q35.3

5q35.3

Type of geneprotein-codingprotein-coding
Descriptionalpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase BN-acetylglucosaminyltransferase IVbN-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVbUDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosE3 ubiquitin-protein ligase RNF130RING-type E3 ubiquitin transferase RNF130g1-related zinc finger proteingoliath homolog
Modification date2018052220180523
UniProtAcc

Q9UQ53

Q86XS8

Ensembl transtripts involved in fusion geneENST00000337755, ENST00000292591, 
ENST00000521305, 
ENST00000522208, 
ENST00000521389, ENST00000261947, 
ENST00000520564, 
Fusion gene scores* DoF score3 X 3 X 3=2710 X 7 X 6=420
# samples 310
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MGAT4B [Title/Abstract] AND RNF130 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-N1-A6IA-01AMGAT4Bchr5

179225165

-RNF130chr5

179347426

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000337755ENST00000522208MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
5CDS-intronENST00000337755ENST00000521389MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
5CDS-intronENST00000337755ENST00000261947MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
5CDS-intronENST00000337755ENST00000520564MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
Frame-shiftENST00000292591ENST00000522208MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
5CDS-intronENST00000292591ENST00000521389MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
5CDS-intronENST00000292591ENST00000261947MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
5CDS-intronENST00000292591ENST00000520564MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
intron-3CDSENST00000521305ENST00000522208MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
intron-intronENST00000521305ENST00000521389MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
intron-intronENST00000521305ENST00000261947MGAT4Bchr5

179225165

-RNF130chr5

179347426

-
intron-intronENST00000521305ENST00000520564MGAT4Bchr5

179225165

-RNF130chr5

179347426

-

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FusionProtFeatures for MGAT4B_RNF130


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGAT4B

Q9UQ53

RNF130

Q86XS8

Glycosyltransferase that participates in the transfer ofN-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structureof N-linked glycans. Essential for the production of tri- andtetra-antennary N-linked sugar chains. Has lower affinities fordonors or acceptors than MGAT4A, suggesting that, underphysiological conditions, it is not the main contributor in N-glycan biosynthesis. May have a role during the programmed cell death ofhematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. {ECO:0000250, ECO:0000269|PubMed:16549277}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MGAT4B_RNF130


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MGAT4B_RNF130


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MGAT4BSYNJ2BP, UQCRFS1, SLC26A2, SFXN2, VDAC1, HBB, PLAUR, YIPF3, DKKL1RNF130FGFR3, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2N, UBE2Z, MYC, UBC, CD1B, TSPAN18, NRG1, TMEM231, MCOLN3, TSPAN17, BTNL8, PTCH1, ZACN, HTR3C, PON2, CDC5L, SCGB1D4, GGT7, MANSC1, HTR3A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MGAT4B_RNF130


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MGAT4B_RNF130


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRNF130C0033578Prostatic Neoplasms1CTD_human