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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21786

FusionGeneSummary for MGAT1_FLT4

check button Fusion gene summary
Fusion gene informationFusion gene name: MGAT1_FLT4
Fusion gene ID: 21786
HgeneTgene
Gene symbol

MGAT1

FLT4

Gene ID

116255

2324

Gene namemonoacylglycerol O-acyltransferase 1fms related tyrosine kinase 4
SynonymsDGAT2L|DGAT2L1|MGAT1FLT-4|FLT41|LMPH1A|PCL|VEGFR-3|VEGFR3
Cytomap

2q36.1

5q35.3

Type of geneprotein-codingprotein-coding
Description2-acylglycerol O-acyltransferase 1acyl-CoA:monoacylglycerol acyltransferase 1diacylglycerol O-acyltransferase 2 like 1diacylglycerol O-acyltransferase candidate 2diacylglycerol acyltransferase 2-like protein 1hDC2vascular endothelial growth factor receptor 3fms-like tyrosine kinase 4tyrosine-protein kinase receptor FLT4
Modification date2018032920180523
UniProtAcc

P26572

P35916

Ensembl transtripts involved in fusion geneENST00000333055, ENST00000307826, 
ENST00000446023, ENST00000393340, 
ENST00000427865, ENST00000506708, 
ENST00000261937, ENST00000393347, 
ENST00000502649, ENST00000424276, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 4 X 3=60
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MGAT1 [Title/Abstract] AND FLT4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFLT4

GO:0018108

peptidyl-tyrosine phosphorylation

7898938

TgeneFLT4

GO:0035924

cellular response to vascular endothelial growth factor stimulus

9435229

TgeneFLT4

GO:0038084

vascular endothelial growth factor signaling pathway

23878260

TgeneFLT4

GO:0046777

protein autophosphorylation

7675451|9435229|23878260

TgeneFLT4

GO:0048010

vascular endothelial growth factor receptor signaling pathway

9012504


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-06-1804-01AMGAT1chr5

180235648

-FLT4chr5

180058778

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000333055ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000333055ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000333055ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-5UTRENST00000333055ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000307826ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000307826ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000307826ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-5UTRENST00000307826ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000446023ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000446023ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000446023ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-5UTRENST00000446023ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000393340ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000393340ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000393340ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-5UTRENST00000393340ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-5UTRENST00000427865ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-5UTRENST00000506708ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-

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FusionProtFeatures for MGAT1_FLT4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGAT1

P26572

FLT4

P35916

Initiates complex N-linked carbohydrate formation.Essential for the conversion of high-mannose to hybrid and complexN-glycans. Tyrosine-protein kinase that acts as a cell-surfacereceptor for VEGFC and VEGFD, and plays an essential role in adultlymphangiogenesis and in the development of the vascular networkand the cardiovascular system during embryonic development.Promotes proliferation, survival and migration of endothelialcells, and regulates angiogenic sprouting. Signaling by activatedFLT4 leads to enhanced production of VEGFC, and to a lesser degreeVEGFA, thereby creating a positive feedback loop that enhancesFLT4 signaling. Modulates KDR signaling by forming heterodimers.The secreted isoform 3 may function as a decoy receptor for VEGFCand/or VEGFD and play an important role as a negative regulator ofVEGFC-mediated lymphangiogenesis and angiogenesis. Binding ofvascular growth factors to isoform 1 or isoform 2 leads to theactivation of several signaling cascades; isoform 2 seems to beless efficient in signal transduction, because it has a truncatedC-terminus and therefore lacks several phosphorylation sites.Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signalingpathway, of MAPK8 and the JUN signaling pathway, and of the AKT1signaling pathway. Phosphorylates SHC1. Mediates phosphorylationof PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940,ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514,ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200,ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651,ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550,ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537,ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451,ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MGAT1_FLT4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MGAT1_FLT4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MGAT1MAPK6, SMAD9, NRG1, GINM1, SLC39A4, PTCH1, HTR3C, ADPGK, RELL1, FUT8, TCTN2FLT4VEGFC, SHC1, GRB2, ITGB1, IKBKG, NEDD4, FIGF, HSP90AA1, EPN1, LGALS3, LGALS8, VSIG4, PTGER3, TNF, LIPH, PLVAP, TMEM52B, MAS1, PCDHGB1, NPY2R, CHRM3, EEF1A2, DUSP19


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MGAT1_FLT4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFLT4P35916DB06589PazopanibVascular endothelial growth factor receptor 3small moleculeapproved
TgeneFLT4P35916DB08896RegorafenibVascular endothelial growth factor receptor 3small moleculeapproved
TgeneFLT4P35916DB09079NintedanibVascular endothelial growth factor receptor 3small moleculeapproved
TgeneFLT4P35916DB00398SorafenibVascular endothelial growth factor receptor 3small moleculeapproved|investigational
TgeneFLT4P35916DB01268SunitinibVascular endothelial growth factor receptor 3small moleculeapproved|investigational
TgeneFLT4P35916DB06626AxitinibVascular endothelial growth factor receptor 3small moleculeapproved|investigational
TgeneFLT4P35916DB09078LenvatinibVascular endothelial growth factor receptor 3small moleculeapproved|investigational

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RelatedDiseases for MGAT1_FLT4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFLT4C1704423Milroy Disease10ORPHANET;UNIPROT
TgeneFLT4C0032460Polycystic Ovary Syndrome1CTD_human
TgeneFLT4C1865871HEMANGIOMA, CAPILLARY INFANTILE1CTD_human;UNIPROT
TgeneFLT4C2931852Clear-cell metastatic renal cell carcinoma1CTD_human