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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21731

FusionGeneSummary for MET_ST7-AS2

check button Fusion gene summary
Fusion gene informationFusion gene name: MET_ST7-AS2
Fusion gene ID: 21731
HgeneTgene
Gene symbol

MET

ST7-AS2

Gene ID

8731

93654

Gene nameRNA guanine-7 methyltransferaseST7 antisense RNA 2
SynonymsCMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMetST7AS2|ST7OT2
Cytomap

18p11.21

7q31.2

Type of geneprotein-codingncRNA
DescriptionmRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferaseST7 antisense RNA 2 (non-protein coding)ST7 overlapping transcript 2 (antisense non-coding RNA)ST7 overlapping transcript 2 (non-protein coding)
Modification date2018052320180329
UniProtAcc

P08581

Ensembl transtripts involved in fusion geneENST00000397752, ENST00000318493, 
ENST00000436117, ENST00000495962, 
ENST00000539704, 
ENST00000432541, 
ENST00000434993, ENST00000442719, 
ENST00000446784, ENST00000456577, 
ENST00000433969, 
Fusion gene scores* DoF score8 X 7 X 8=4481 X 1 X 1=1
# samples 101
** MAII scorelog2(10/448*10)=-2.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: MET [Title/Abstract] AND ST7-AS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-HT-A61C-01AMETchr7

116371913

+ST7-AS2chr7

116752721

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000397752ENST00000432541METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-5UTRENST00000397752ENST00000434993METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-5UTRENST00000397752ENST00000442719METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000397752ENST00000446784METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000397752ENST00000456577METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000397752ENST00000433969METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000318493ENST00000432541METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-5UTRENST00000318493ENST00000434993METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-5UTRENST00000318493ENST00000442719METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000318493ENST00000446784METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000318493ENST00000456577METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000318493ENST00000433969METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000436117ENST00000432541METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-5UTRENST00000436117ENST00000434993METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-5UTRENST00000436117ENST00000442719METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000436117ENST00000446784METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000436117ENST00000456577METchr7

116371913

+ST7-AS2chr7

116752721

-
5CDS-intronENST00000436117ENST00000433969METchr7

116371913

+ST7-AS2chr7

116752721

-
3UTR-intronENST00000495962ENST00000432541METchr7

116371913

+ST7-AS2chr7

116752721

-
3UTR-5UTRENST00000495962ENST00000434993METchr7

116371913

+ST7-AS2chr7

116752721

-
3UTR-5UTRENST00000495962ENST00000442719METchr7

116371913

+ST7-AS2chr7

116752721

-
3UTR-intronENST00000495962ENST00000446784METchr7

116371913

+ST7-AS2chr7

116752721

-
3UTR-intronENST00000495962ENST00000456577METchr7

116371913

+ST7-AS2chr7

116752721

-
3UTR-intronENST00000495962ENST00000433969METchr7

116371913

+ST7-AS2chr7

116752721

-
intron-intronENST00000539704ENST00000432541METchr7

116371913

+ST7-AS2chr7

116752721

-
intron-5UTRENST00000539704ENST00000434993METchr7

116371913

+ST7-AS2chr7

116752721

-
intron-5UTRENST00000539704ENST00000442719METchr7

116371913

+ST7-AS2chr7

116752721

-
intron-intronENST00000539704ENST00000446784METchr7

116371913

+ST7-AS2chr7

116752721

-
intron-intronENST00000539704ENST00000456577METchr7

116371913

+ST7-AS2chr7

116752721

-
intron-intronENST00000539704ENST00000433969METchr7

116371913

+ST7-AS2chr7

116752721

-

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FusionProtFeatures for MET_ST7-AS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MET

P08581

ST7-AS2

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding tohepatocyte growth factor/HGF ligand. Regulates many physiologicalprocesses including proliferation, scattering, morphogenesis andsurvival. Ligand binding at the cell surface inducesautophosphorylation of MET on its intracellular domain thatprovides docking sites for downstream signaling molecules.Following activation by ligand, interacts with the PI3-kinasesubunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.Recruitment of these downstream effectors by MET leads to theactivation of several signaling cascades including the RAS-ERK,PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation isassociated with the morphogenetic effects while PI3K/AKTcoordinates prosurvival effects. During embryonic development, METsignaling plays a role in gastrulation, development and migrationof muscles and neuronal precursors, angiogenesis and kidneyformation. In adults, participates in wound healing as well asorgan regeneration and tissue remodeling. Promotes alsodifferentiation and proliferation of hematopoietic cells. Mayregulate cortical bone osteogenesis (By similarity).{ECO:0000250|UniProtKB:P16056}. Acts as a receptor for Listeria internalin inlB,mediating entry of the pathogen into cells. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MET_ST7-AS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MET_ST7-AS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
METGLMN, CDH1, CTNNB1, HGF, RANBP9, GRB2, CBL, SH3KBP1, RANBP10, SRC, SHC1, SOS1, STAT3, GAB1, GAB2, LRIG1, INPPL1, DCN, SPSB1, SPSB2, SPSB3, SPSB4, CBLC, STUB1, HSPA4, HSP90AA1, GGA3, GNG12, FBXO6, HGS, CRK, CEACAM21, LGALS9, PCBP1, CASP3, SOCS1, HSP90AB1, EGFR, ERBB3, MET, CHEK1, PTEN, SCGB1D1ST7-AS2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MET_ST7-AS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMETP08581DB08865CrizotinibHepatocyte growth factor receptorsmall moleculeapproved
HgeneMETP08581DB08875CabozantinibHepatocyte growth factor receptorsmall moleculeapproved|investigational

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RelatedDiseases for MET_ST7-AS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMETC1336839Type 1 Papillary Renal Cell Carcinoma5UNIPROT
HgeneMETC0007131Non-Small Cell Lung Carcinoma4CTD_human
HgeneMETC0001418Adenocarcinoma2CTD_human
HgeneMETC0004352Autistic Disorder2CTD_human
HgeneMETC0027627Neoplasm Metastasis2CTD_human
HgeneMETC0038356Stomach Neoplasms2CTD_human
HgeneMETC0004114Astrocytoma1CTD_human
HgeneMETC0007134Renal Cell Carcinoma1CTD_human
HgeneMETC0007137Squamous cell carcinoma1CTD_human
HgeneMETC0009241Cognition Disorders1CTD_human
HgeneMETC0014859Esophageal Neoplasms1CTD_human
HgeneMETC0017636Glioblastoma1CTD_human
HgeneMETC0019189Hepatitis, Chronic1CTD_human
HgeneMETC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneMETC0023904Liver Neoplasms, Experimental1CTD_human
HgeneMETC0024121Lung Neoplasms1CTD_human
HgeneMETC0027626Neoplasm Invasiveness1CTD_human
HgeneMETC0027819Neuroblastoma1CTD_human
HgeneMETC0029463Osteosarcoma1CTD_human
HgeneMETC0036341Schizophrenia1CTD_human
HgeneMETC0037199Sinusitis1CTD_human
HgeneMETC0345967Malignant mesothelioma1CTD_human
HgeneMETC0919267ovarian neoplasm1CTD_human
HgeneMETC1876165Copper-Overload Cirrhosis1CTD_human
HgeneMETC2239176Liver carcinoma1CTD_human;HPO;UNIPROT
HgeneMETC4084709DEAFNESS, AUTOSOMAL RECESSIVE 971UNIPROT