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Fusion gene ID: 21708 |
FusionGeneSummary for METTL24_SLC22A16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: METTL24_SLC22A16 | Fusion gene ID: 21708 | Hgene | Tgene | Gene symbol | METTL24 | SLC22A16 | Gene ID | 728464 | 85413 |
| Gene name | methyltransferase like 24 | solute carrier family 22 member 16 | |
| Synonyms | C6orf186 | CT2|FLIPT2|HEL-S-18|OAT6|OCT6|OKB1|dJ261K5.1 | |
| Cytomap | 6q21 | 6q21|6q21-q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methyltransferase-like protein 24UPF0624 protein C6orf186 | solute carrier family 22 member 16WUGSC:RG331P03.1carnitine transporter 2epididymis secretory protein Li 18flipt 2fly-like putative organic ion transporter 2fly-like putative transporter 2organic cation transporter 6organic cation transporter OKB1 | |
| Modification date | 20180329 | 20180522 | |
| UniProtAcc | Q5JXM2 | Q86VW1 | |
| Ensembl transtripts involved in fusion gene | ENST00000338882, ENST00000490043, | ENST00000368919, ENST00000330550, ENST00000439654, ENST00000456137, ENST00000461487, | |
| Fusion gene scores | * DoF score | 4 X 5 X 5=100 | 5 X 3 X 5=75 |
| # samples | 5 | 6 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: METTL24 [Title/Abstract] AND SLC22A16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SLC22A16 | GO:0015695 | organic cation transport | 12089149|15963465 |
| Tgene | SLC22A16 | GO:0015879 | carnitine transport | 12089149 |
| Tgene | SLC22A16 | GO:0046717 | acid secretion | 12089149 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-38-4630-01A | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| TCGA | LD | UCEC | TCGA-A5-A7WK-01A | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000338882 | ENST00000368919 | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| Frame-shift | ENST00000338882 | ENST00000330550 | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| Frame-shift | ENST00000338882 | ENST00000439654 | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| In-frame | ENST00000338882 | ENST00000456137 | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| 5CDS-5UTR | ENST00000338882 | ENST00000461487 | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000490043 | ENST00000368919 | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000490043 | ENST00000330550 | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000490043 | ENST00000439654 | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000490043 | ENST00000456137 | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-5UTR | ENST00000490043 | ENST00000461487 | METTL24 | chr6 | 110620125 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000338882 | ENST00000368919 | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000338882 | ENST00000330550 | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000338882 | ENST00000439654 | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000338882 | ENST00000456137 | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-5UTR | ENST00000338882 | ENST00000461487 | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000490043 | ENST00000368919 | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000490043 | ENST00000330550 | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000490043 | ENST00000439654 | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-3CDS | ENST00000490043 | ENST00000456137 | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
| intron-5UTR | ENST00000490043 | ENST00000461487 | METTL24 | chr6 | 110567335 | - | SLC22A16 | chr6 | 110778220 | - |
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FusionProtFeatures for METTL24_SLC22A16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| METTL24 | SLC22A16 |
| High affinity carnitine transporter; the uptake ispartially sodium-ion dependent. Thought to mediate the L-carnitinesecretion mechanism from testis epididymal epithelium into thelumen which is involved in the maturation of spermatozoa. Alsotransports organic cations such as tetraethylammonium (TEA) anddoxorubicin. The uptake of TEA is inhibited by various organiccations. The uptake of doxorubicin is sodium-independent.{ECO:0000269|PubMed:12089149, ECO:0000269|PubMed:15963465}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for METTL24_SLC22A16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_METTL24_ENST00000338882_chr6_110620125_-_SLC22A16_ENST00000456137_chr6_110778220_-_262aa MARERPPGRGCGVLRRCLLGAVLLFGLRLCAELRRAGPGSPTRSAPPGPAWRPPGPHLPPAPGQPRGASRRQVTYVRSGRRAPPGGGGSG TPEPGCCAPRGRPRRKGPRWHIDLQPWAGSAQSLDEEAWRFLRYISTTQIACNHMNTDSLATDSSPTHKPWSVCLDDRFNLAHQIRNKQC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_METTL24_ENST00000338882_chr6_110620125_-_SLC22A16_ENST00000456137_chr6_110778220_-_786nt ATGGCCCGGGAGAGGCCGCCCGGGAGGGGCTGCGGCGTCCTGCGCCGGTGTCTACTCGGGGCTGTGCTGTTGTTCGGCCTGCGGCTCTGC GCAGAGCTGCGGCGCGCCGGGCCCGGGTCCCCCACCCGCAGCGCCCCGCCGGGCCCGGCCTGGCGGCCACCTGGGCCGCACCTGCCGCCC GCGCCGGGCCAGCCGCGCGGCGCCAGCAGGAGGCAGGTGACCTACGTGCGCAGCGGTCGCCGGGCGCCGCCGGGGGGCGGCGGGAGCGGG ACGCCGGAGCCTGGCTGCTGTGCCCCGCGCGGGCGCCCCCGCCGGAAGGGTCCCCGGTGGCATATAGATCTCCAGCCTTGGGCAGGCTCT GCTCAGTCCCTGGATGAAGAAGCCTGGAGGTTCCTGAGATATATCAGCACCACCCAGATTGCATGCAATCACATGAATACAGACAGCCTG GCTACTGACTCTAGTCCTACACACAAGCCCTGGTCAGTGTGTCTTGACGACAGGTTCAATTTAGCTCATCAAATCCGCAACAAGCAGTGC CGCCTCTACTCCTTAGGGCTAGGAAGTGATGATACCCATTTTGAGGTTAGCATGGCCAACAACGGATGTGAAGTGCATCGTTTTGATCCT AGTGTCAAGTCAGCTCACATTCTGGAGAGTCAGCACCTTTGGTATCACCGCTTGTCCATTGACTGGCGGGATCCCCATCCAGCTGTTGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_METTL24_ENST00000338882_chr6_110620125_-_SLC22A16_ENST00000456137_chr6_110778220_-_1927nt ATGGCCCGGGAGAGGCCGCCCGGGAGGGGCTGCGGCGTCCTGCGCCGGTGTCTACTCGGGGCTGTGCTGTTGTTCGGCCTGCGGCTCTGC GCAGAGCTGCGGCGCGCCGGGCCCGGGTCCCCCACCCGCAGCGCCCCGCCGGGCCCGGCCTGGCGGCCACCTGGGCCGCACCTGCCGCCC GCGCCGGGCCAGCCGCGCGGCGCCAGCAGGAGGCAGGTGACCTACGTGCGCAGCGGTCGCCGGGCGCCGCCGGGGGGCGGCGGGAGCGGG ACGCCGGAGCCTGGCTGCTGTGCCCCGCGCGGGCGCCCCCGCCGGAAGGGTCCCCGGTGGCATATAGATCTCCAGCCTTGGGCAGGCTCT GCTCAGTCCCTGGATGAAGAAGCCTGGAGGTTCCTGAGATATATCAGCACCACCCAGATTGCATGCAATCACATGAATACAGACAGCCTG GCTACTGACTCTAGTCCTACACACAAGCCCTGGTCAGTGTGTCTTGACGACAGGTTCAATTTAGCTCATCAAATCCGCAACAAGCAGTGC CGCCTCTACTCCTTAGGGCTAGGAAGTGATGATACCCATTTTGAGGTTAGCATGGCCAACAACGGATGTGAAGTGCATCGTTTTGATCCT AGTGTCAAGTCAGCTCACATTCTGGAGAGTCAGCACCTTTGGTATCACCGCTTGTCCATTGACTGGCGGGATCCCCATCCAGCTGTTGCT GCCCAAAAACCACATAGCAACACCAGAAAACTGGGAAGCATTTTGAATGAATTTGGACATCACAAGATTCCAGAGAGTCCTCTATTTCAT ATGTGCCTTCCAGAACATCTCTTGTGGTATTCACTACTTGGCTTCTGTGTTCATGGGAGTCACCCCTCATCATGTCTGCAGGCCCCCAGG CAATGTGAGTCAGGTTGTTTTCCATAATCACTCTAATTGGAGTTTGGAGGACACCGGGGCCCTGTTGTCTTCAGGCCAGAAAGATTATGT TACGGTGCAGTTGCAGAATGGTGAGATCTGGGAGCTCTCAAGGTGTAGCAGGAATAAGAGGGAGAACACATCGAGTTTGGGCTATGAATA CACTGGCAGTAAGAAAGAGTTTCCTTGTGTGGATGGCTACATATATGACCAGAACACATGGAAAAGCACTGCGGTGACCCAGTGGAACCT GGTCTGTGACCGAAAATGGCTTGCAATGCTGATCCAGCCCCTATTTATGTTTGGAGTCCTACTGGGATCGGTGACTTTTGGCTACTTTTC TGACAGAGTAGGCTTCCTAACTGCTTGGTACAAAACCAGTGGATTCCCCACATCCAGTGCTCCTCCTCTCTAATTCAACCCACTATCTGT GAAGTGTCATCTGGACTCATTGTGGGACTTGGGGATTAGAGGACCTGAGACAAAGATGCTGCTGCCCTACTGCTTGCTAACGAAGCTAGG ACGCCGGGTGGTCTTGTGGGCCACAAGCAGTAGCATGTTTTTGTTTGGAATAGCAGCGGCGTTTGCAGTTGATTATTACACCTTCATGGC TGCTCGCTTTTTTCTTGCCATGGTTGCAAGTGGCTATCTTGTGGTGGGGTTTGTCTATGTGATGGAATTCATTGGCATGAAGTCTCGGAC ATGGGCGTCTGTCCATTTGCATTCCTTTTTTGCAGTTGGAACCCTGCTGGTGGCTTTGACAGGATACTTGGTCAGGACCTGGTGGCTTTA CCAGATGATCCTCTCCACAGTGACTGTCCCCTTTATCCTGTGCTGTTGGGTGCTCCCAGAGACACCTTTTTGGCTTCTCTCAGAGGGACG ATATGAAGAAGCACAAAAAATAGTTGACATCATGGCCAAGTGGAACAGGGCAAGCTCCTGTAAACTGTCAGAACTTTTATCACTGGACCT |
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FusionGenePPI for METTL24_SLC22A16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| METTL24 | SLC22A16 | LYN, GBP5, ACSM1, TMEM104, APBA3, RAB21, SLC25A46, GJC1, LPCAT3, PXMP2, MTX3, ATP2B2, TMEM56, SLC29A1, ATL3, SLC26A2, MFSD8, SPPL3, SERINC1, TMEM164, SYNGR2, SLC25A30, FNDC3A, FLVCR1, TSPAN15, ADIPOR1, CHCHD6, CCRN4L, AGPAT2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for METTL24_SLC22A16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for METTL24_SLC22A16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SLC22A16 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | SLC22A16 | C0853193 | Bipolar I disorder | 1 | PSYGENET |
| Tgene | SLC22A16 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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