	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 21702

FusionGeneSummary for METTL23_METTL23

Fusion gene summary

Fusion gene information	Fusion gene name: METTL23_METTL23
	Fusion gene ID: 21702
		Hgene	Tgene
	Gene symbol	METTL23	METTL23
	Gene ID	124512	124512
	Gene name	methyltransferase like 23	methyltransferase like 23
	Synonyms	C17orf95\|MRT44	C17orf95\|MRT44
	Cytomap	17q25.1	17q25.1
	Type of gene	protein-coding	protein-coding
	Description	methyltransferase-like protein 23spike binding protein 1	methyltransferase-like protein 23spike binding protein 1
	Modification date	20180519	20180519
	UniProtAcc	Q86XA0	Q86XA0
	Ensembl transtripts involved in fusion gene	ENST00000589977, ENST00000591571, ENST00000586738, ENST00000588783, ENST00000586752, ENST00000588302, ENST00000590964, ENST00000341249, ENST00000588822, ENST00000586200,	ENST00000589977, ENST00000591571, ENST00000586738, ENST00000588783, ENST00000586752, ENST00000588302, ENST00000590964, ENST00000341249, ENST00000588822, ENST00000586200,
Fusion gene scores	* DoF score	3 X 4 X 3=36	3 X 4 X 2=24
	# samples	4	4
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: METTL23 [Title/Abstract] AND METTL23 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BU689941	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
ChiTaRS3.1			BF825543	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000589977	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586752	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586752	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000590964	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000341249	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000341249	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000588822	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586200	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-intron	ENST00000589977	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+

Top

FusionProtFeatures for METTL23_METTL23

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
METTL23 Q86XA0	METTL23 Q86XA0
Probable methyltransferase. {ECO:0000250}.	Probable methyltransferase. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for METTL23_METTL23

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for METTL23_METTL23

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for METTL23_METTL23

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for METTL23_METTL23

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	METTL23	C3714756	Intellectual Disability	1	CTD_human
Tgene	METTL23	C3714756	Intellectual Disability	1	CTD_human

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 21702

FusionGeneSummary for METTL23_METTL23

FusionProtFeatures for METTL23_METTL23

FusionGeneSequence for METTL23_METTL23

FusionGenePPI for METTL23_METTL23

RelatedDrugs for METTL23_METTL23

RelatedDiseases for METTL23_METTL23