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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21682

FusionGeneSummary for METTL17_STOML1

check button Fusion gene summary
Fusion gene informationFusion gene name: METTL17_STOML1
Fusion gene ID: 21682
HgeneTgene
Gene symbol

METTL17

STOML1

Gene ID

64745

9399

Gene namemethyltransferase like 17stomatin like 1
SynonymsMETT11D1SLP-1|STORP|hUNC-24
Cytomap

14q11.2

15q24.1

Type of geneprotein-codingprotein-coding
Descriptionmethyltransferase-like protein 17, mitochondrialfalse p73 target gene proteinmethyltransferase 11 domain containing 1methyltransferase 11 domain-containing protein 1protein RSM22 homolog, mitochondrialstomatin-like protein 1EPB72-like 1EPB72-like protein 1protein unc-24 homologstomatin (EBP72)-like 1stomatin (EPB72)-like 1stomatin-related protein
Modification date2018051920180519
UniProtAcc

Q9H7H0

Q9UBI4

Ensembl transtripts involved in fusion geneENST00000339374, ENST00000555177, 
ENST00000382985, ENST00000556670, 
ENST00000564777, ENST00000316900, 
ENST00000316911, ENST00000561656, 
ENST00000541638, ENST00000359750, 
Fusion gene scores* DoF score3 X 3 X 1=91 X 1 X 1=1
# samples 31
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: METTL17 [Title/Abstract] AND STOML1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF922030METTL17chr14

21464209

+STOML1chr15

74279529

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000339374ENST00000564777METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000339374ENST00000316900METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000339374ENST00000316911METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000339374ENST00000561656METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000339374ENST00000541638METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000339374ENST00000359750METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000555177ENST00000564777METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000555177ENST00000316900METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000555177ENST00000316911METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000555177ENST00000561656METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000555177ENST00000541638METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000555177ENST00000359750METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000382985ENST00000564777METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000382985ENST00000316900METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000382985ENST00000316911METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000382985ENST00000561656METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000382985ENST00000541638METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000382985ENST00000359750METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000556670ENST00000564777METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000556670ENST00000316900METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000556670ENST00000316911METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000556670ENST00000561656METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000556670ENST00000541638METTL17chr14

21464209

+STOML1chr15

74279529

-
intron-intronENST00000556670ENST00000359750METTL17chr14

21464209

+STOML1chr15

74279529

-

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FusionProtFeatures for METTL17_STOML1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
METTL17

Q9H7H0

STOML1

Q9UBI4

May be a component of the mitochondrial small ribosomalsubunit. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for METTL17_STOML1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for METTL17_STOML1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for METTL17_STOML1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for METTL17_STOML1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource