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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21675

FusionGeneSummary for METTL16_FXR2

check button Fusion gene summary
Fusion gene informationFusion gene name: METTL16_FXR2
Fusion gene ID: 21675
HgeneTgene
Gene symbol

METTL16

FXR2

Gene ID

79066

9513

Gene namemethyltransferase like 16FMR1 autosomal homolog 2
SynonymsMETT10DFMR1L2|FXR2P
Cytomap

17p13.3

17p13.1

Type of geneprotein-codingprotein-coding
DescriptionU6 small nuclear RNA (adenine-(43)-N(6))-methyltransferaseN6-adenosine-methyltransferase METTL16U6 snRNA methyltransferasemethyltransferase 10 domain containingmethyltransferase 10 domain-containing proteinmethyltransferase-like protein 16putative mfragile X mental retardation syndrome-related protein 2fragile X mental retardation, autosomal homolog 2fragile X-mental retardation 1-like 2
Modification date2018052320180523
UniProtAcc

Q86W50

P51116

Ensembl transtripts involved in fusion geneENST00000571669, ENST00000263092, 
ENST00000538844, 
ENST00000250113, 
ENST00000573057, 
Fusion gene scores* DoF score6 X 6 X 6=2166 X 6 X 4=144
# samples 67
** MAII scorelog2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: METTL16 [Title/Abstract] AND FXR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMETTL16

GO:0010608

posttranscriptional regulation of gene expression

28525753

HgeneMETTL16

GO:0048024

regulation of mRNA splicing, via spliceosome

28525753

HgeneMETTL16

GO:0120049

snRNA (adenine-N6)-methylation

28525753|29051200


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-IE-A6BZ-01AMETTL16chr17

2405498

-FXR2chr17

7507398

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000571669ENST00000250113METTL16chr17

2405498

-FXR2chr17

7507398

-
intron-intronENST00000571669ENST00000573057METTL16chr17

2405498

-FXR2chr17

7507398

-
Frame-shiftENST00000263092ENST00000250113METTL16chr17

2405498

-FXR2chr17

7507398

-
5CDS-intronENST00000263092ENST00000573057METTL16chr17

2405498

-FXR2chr17

7507398

-
5UTR-3CDSENST00000538844ENST00000250113METTL16chr17

2405498

-FXR2chr17

7507398

-
5UTR-intronENST00000538844ENST00000573057METTL16chr17

2405498

-FXR2chr17

7507398

-

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FusionProtFeatures for METTL16_FXR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
METTL16

Q86W50

FXR2

P51116

RNA N6-methyltransferase that methylates adenosineresidues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2Atranscripts (PubMed:28525753). Able to N6-methylate a subset ofmRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). Incontrast to the METTL3-METTL14 heterodimer, only able to methylatea limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamersequence and a specific RNA structure (PubMed:28525753). Inpresence of S-adenosyl-L-methionine, binds the 3'-UTR region ofMAT2A mRNA and specifically N6-methylates the first hairpin ofMAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR regionof MAT2A mRNA but stalls due to the lack of a methyl donor,preventing N6-methylation and promoting expression of MAT2A(PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753,PubMed:29051200). Also able to bind various lncRNAs(PubMed:29051200). Specifically binds the 3'-end of the MALAT1long non-coding RNA (PubMed:27872311).{ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753,ECO:0000269|PubMed:29051200}. RNA-binding protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for METTL16_FXR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for METTL16_FXR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
METTL16MEPCE, APP, YARS, FAM50A, HCCS, NHP2L1, TCEA1, NTRK1, METTL16, KPNA6, SLC39A9FXR2RTN3, KCTD4, RBPMS, AP1M1, TRIM37, PSME3, TRAF2, RALYL, PCBD1, AP2M1, THAP1, MEAF6, CCDC85B, C10orf62, GKAP1, CBS, RABAC1, PAICS, FBP1, LCMT1, FTH1, KCNRG, CALCOCO2, HNRNPC, TSC22D4, KXD1, ZNF451, LDOC1, RBBP8, RBMX, MCRS1, TRIM29, CCDC33, RTN4, AMOTL2, ARL6IP1, SNAP23, MBIP, RPIA, NONO, NT5C2, KIAA1217, DPPA2, KRT20, TNNT1, NECAB2, SSSCA1, NCK2, FXR2, ZBTB8A, MED7, FMR1, FXR1, CYFIP1, OTUD4, PRKAA1, EWSR1, ZSCAN1, TERF2, TBKBP1, TBK1, SIRT7, TDRD3, CUL3, CAND1, COIL, NME1, PTS, TRIM23, MPG, CAPRIN1, CPSF6, CPSF7, G3BP1, G3BP2, NUDT21, KIF1A, NDN, BYSL, CAMK2D, LASP1, LCP2, MFAP1, PIM1, SRPK2, YES1, SCEL, ZBTB22, POM121, MORF4L1, BAZ2B, CDKL3, PAF1, FAM90A1, CEP55, TBC1D22B, NIF3L1, C1orf35, HMBOX1, CEP44, PRAM1, MRPL43, SYTL4, SYT6, ZMAT2, MIA3, BRCA1, SUZ12, RNF2, BMI1, NTRK1, IFI16, SNCA, TSNAX, YWHAH, SLAIN2, P4HA3, CSNK2A2, SNX1, LGALS3BP, BTBD1, CSNK2A1, NUP214, RRP8, THUMPD3, MECP2, RNF157


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for METTL16_FXR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for METTL16_FXR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource