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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 21673

FusionGeneSummary for METTL15_SLC1A3

check button Fusion gene summary
Fusion gene informationFusion gene name: METTL15_SLC1A3
Fusion gene ID: 21673
HgeneTgene
Gene symbol

METTL15

SLC1A3

Gene ID

196074

6507

Gene namemethyltransferase like 15solute carrier family 1 member 3
SynonymsMETT5D1EA6|EAAT1|GLAST|GLAST1
Cytomap

11p14.1

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionprobable methyltransferase-like protein 15methyltransferase 5 domain containing 1methyltransferase 5 domain-containing protein 1probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1putative S-adenosyl-L-methionine-dependent methyltransfexcitatory amino acid transporter 1GLAST-1sodium-dependent glutamate/aspartate transporter 1solute carrier family 1 (glial high affinity glutamate transporter), member 3
Modification date2018052320180519
UniProtAcc

A6NJ78

P43003

Ensembl transtripts involved in fusion geneENST00000406787, ENST00000342303, 
ENST00000407364, ENST00000303459, 
ENST00000403099, ENST00000379199, 
ENST00000265113, ENST00000506725, 
ENST00000381918, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 9 X 6=540
# samples 112
** MAII scorelog2(1/1*10)=3.32192809488736log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: METTL15 [Title/Abstract] AND SLC1A3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC1A3

GO:0015813

L-glutamate transmembrane transport

26690923

TgeneSLC1A3

GO:0051938

L-glutamate import

7521911

TgeneSLC1A3

GO:0070779

D-aspartate import across plasma membrane

7521911

TgeneSLC1A3

GO:0071805

potassium ion transmembrane transport

20477940

TgeneSLC1A3

GO:0098712

L-glutamate import across plasma membrane

26690923

TgeneSLC1A3

GO:0140009

L-aspartate import across plasma membrane

20477940

TgeneSLC1A3

GO:1902476

chloride transmembrane transport

20477940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1Y0-01AMETTL15chr11

28232745

+SLC1A3chr5

36674151

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000406787ENST00000265113METTL15chr11

28232745

+SLC1A3chr5

36674151

+
5CDS-intronENST00000406787ENST00000506725METTL15chr11

28232745

+SLC1A3chr5

36674151

+
5CDS-intronENST00000406787ENST00000381918METTL15chr11

28232745

+SLC1A3chr5

36674151

+
In-frameENST00000342303ENST00000265113METTL15chr11

28232745

+SLC1A3chr5

36674151

+
5CDS-intronENST00000342303ENST00000506725METTL15chr11

28232745

+SLC1A3chr5

36674151

+
5CDS-intronENST00000342303ENST00000381918METTL15chr11

28232745

+SLC1A3chr5

36674151

+
In-frameENST00000407364ENST00000265113METTL15chr11

28232745

+SLC1A3chr5

36674151

+
5CDS-intronENST00000407364ENST00000506725METTL15chr11

28232745

+SLC1A3chr5

36674151

+
5CDS-intronENST00000407364ENST00000381918METTL15chr11

28232745

+SLC1A3chr5

36674151

+
In-frameENST00000303459ENST00000265113METTL15chr11

28232745

+SLC1A3chr5

36674151

+
5CDS-intronENST00000303459ENST00000506725METTL15chr11

28232745

+SLC1A3chr5

36674151

+
5CDS-intronENST00000303459ENST00000381918METTL15chr11

28232745

+SLC1A3chr5

36674151

+
intron-3CDSENST00000403099ENST00000265113METTL15chr11

28232745

+SLC1A3chr5

36674151

+
intron-intronENST00000403099ENST00000506725METTL15chr11

28232745

+SLC1A3chr5

36674151

+
intron-intronENST00000403099ENST00000381918METTL15chr11

28232745

+SLC1A3chr5

36674151

+
intron-3CDSENST00000379199ENST00000265113METTL15chr11

28232745

+SLC1A3chr5

36674151

+
intron-intronENST00000379199ENST00000506725METTL15chr11

28232745

+SLC1A3chr5

36674151

+
intron-intronENST00000379199ENST00000381918METTL15chr11

28232745

+SLC1A3chr5

36674151

+

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FusionProtFeatures for METTL15_SLC1A3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
METTL15

A6NJ78

SLC1A3

P43003

Probable S-adenosyl-L-methionine-dependentmethyltransferase. {ECO:0000250}. Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940,PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as asymporter that transports one amino acid molecule together withtwo or three Na(+) ions and one proton, in parallel with thecounter-transport of one K(+) ion (PubMed:20477940). MediatesCl(-) flux that is not coupled to amino acid transport; thisavoids the accumulation of negative charges due to aspartate andNa(+) symport (PubMed:20477940). Plays a redundant role in therapid removal of released glutamate from the synaptic cleft, whichis essential for terminating the postsynaptic action of glutamate(By similarity). {ECO:0000250|UniProtKB:P56564,ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923,ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515,ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMETTL15chr11:28232745chr5:36674151ENST00000303459+37100_1021351281RegionS-adenosyl-L-methionine binding
HgeneMETTL15chr11:28232745chr5:36674151ENST00000342303+48100_1021351244RegionS-adenosyl-L-methionine binding
HgeneMETTL15chr11:28232745chr5:36674151ENST00000406787+47100_102135280RegionS-adenosyl-L-methionine binding
HgeneMETTL15chr11:28232745chr5:36674151ENST00000407364+47100_102135408RegionS-adenosyl-L-methionine binding
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310346_376174543IntramembraneDiscontinuously helical
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310426_459174543IntramembraneDiscontinuously helical
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28346_376174498IntramembraneDiscontinuously helical
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28426_459174498IntramembraneDiscontinuously helical
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310363_365174543RegionAspartate binding
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310443_447174543RegionAspartate binding
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28363_365174498RegionAspartate binding
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28443_447174498RegionAspartate binding
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310261_269174543Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310298_318174543Topological domainExtracellular
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310341_345174543Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310377_385174543Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310413_425174543Topological domainExtracellular
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310460_472174543Topological domainExtracellular
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310495_542174543Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28261_269174498Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28298_318174498Topological domainExtracellular
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28341_345174498Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28377_385174498Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28413_425174498Topological domainExtracellular
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28460_472174498Topological domainExtracellular
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28495_542174498Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310237_260174543TransmembraneHelical%3B Name%3D4
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310270_297174543TransmembraneHelical%3B Name%3D5
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310319_340174543TransmembraneHelical%3B Name%3D6
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310386_412174543TransmembraneHelical%3B Name%3D7
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310473_494174543TransmembraneHelical%3B Name%3D8
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28237_260174498TransmembraneHelical%3B Name%3D4
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28270_297174498TransmembraneHelical%3B Name%3D5
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28319_340174498TransmembraneHelical%3B Name%3D6
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28386_412174498TransmembraneHelical%3B Name%3D7
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28473_494174498TransmembraneHelical%3B Name%3D8

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMETTL15chr11:28232745chr5:36674151ENST00000379199+13100_102-43100RegionS-adenosyl-L-methionine binding
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310109_122174543Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310146_236174543Topological domainExtracellular
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+3101_47174543Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+31069_86174543Topological domainExtracellular
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28109_122174498Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28146_236174498Topological domainExtracellular
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+281_47174498Topological domainCytoplasmic
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+2869_86174498Topological domainExtracellular
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+310123_145174543TransmembraneHelical%3B Name%3D3
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+31048_68174543TransmembraneHelical%3B Name%3D1
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000265113+31087_108174543TransmembraneHelical%3B Name%3D2
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+28123_145174498TransmembraneHelical%3B Name%3D3
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+2848_68174498TransmembraneHelical%3B Name%3D1
TgeneSLC1A3chr11:28232745chr5:36674151ENST00000381918+2887_108174498TransmembraneHelical%3B Name%3D2


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FusionGeneSequence for METTL15_SLC1A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_METTL15_ENST00000406787_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_504aa
MLRYPYFCRMYKECLSCWLESGIPNLGVWPNRIHTTAEKYREYEAREQTDQTQAQELHRSQDRDFETMAKLHIPVMVDEVVHCLSPQKGQ
IFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSE
AMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGV
IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINM
DGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSL

>In-frame_METTL15_ENST00000342303_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_504aa
MLRYPYFCRMYKECLSCWLESGIPNLGVWPNRIHTTAEKYREYEAREQTDQTQAQELHRSQDRDFETMAKLHIPVMVDEVVHCLSPQKGQ
IFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSE
AMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGV
IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINM
DGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSL

>In-frame_METTL15_ENST00000407364_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_504aa
MLRYPYFCRMYKECLSCWLESGIPNLGVWPNRIHTTAEKYREYEAREQTDQTQAQELHRSQDRDFETMAKLHIPVMVDEVVHCLSPQKGQ
IFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSE
AMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGV
IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINM
DGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSL

>In-frame_METTL15_ENST00000303459_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_504aa
MLRYPYFCRMYKECLSCWLESGIPNLGVWPNRIHTTAEKYREYEAREQTDQTQAQELHRSQDRDFETMAKLHIPVMVDEVVHCLSPQKGQ
IFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSE
AMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGV
IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINM
DGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_METTL15_ENST00000406787_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_1512nt
ATGCTTCGGTATCCATATTTTTGTAGAATGTATAAAGAATGCCTTTCATGTTGGTTGGAATCTGGCATACCTAATTTAGGTGTCTGGCCA
AACAGAATACATACTACAGCAGAAAAATATAGAGAATATGAAGCCCGGGAGCAAACAGATCAAACTCAAGCCCAGGAGTTACACAGATCT
CAAGATAGAGATTTTGAAACTATGGCTAAATTACATATTCCAGTAATGGTGGATGAAGTTGTTCATTGTTTGTCACCACAAAAAGGACAG
ATTTTTCTAGATATGACATTTGGTTCGGGAGGGCACACAAAAGCCATTCTGCAGAAGGAGTCAGATATTGTTCTCTATGCCTTGGACAGA
GACCCAACAGCTTATGCATTAGCTGAACATCTTTCAGAGTTGTATCCGAACATGTTCCCTCCAAATCTGGTAGAAGCCTGCTTTAAACAG
TTTAAAACCAACTATGAGAAGAGAAGCTTTAAAGTGCCCATCCAGGCCAACGAAACGCTTGTGGGTGCTGTGATAAACAATGTGTCTGAG
GCCATGGAGACTCTTACCCGAATCACAGAGGAGCTGGTCCCAGTTCCAGGATCTGTGAATGGAGTCAATGCCCTGGGTCTAGTTGTCTTC
TCCATGTGCTTCGGTTTTGTGATTGGAAACATGAAGGAACAGGGGCAGGCCCTGAGAGAGTTCTTTGATTCTCTTAACGAAGCCATCATG
AGACTGGTAGCAGTAATAATGTGGTATGCCCCCGTGGGTATTCTCTTCCTGATTGCTGGGAAGATTGTGGAGATGGAAGACATGGGTGTG
ATTGGGGGGCAGCTTGCCATGTACACCGTGACTGTCATTGTTGGCTTACTCATTCACGCAGTCATCGTCTTGCCACTCCTCTACTTCTTG
GTAACACGGAAAAACCCTTGGGTTTTTATTGGAGGGTTGCTGCAAGCACTCATCACCGCTCTGGGGACCTCTTCAAGTTCTGCCACCCTA
CCCATCACCTTCAAGTGCCTGGAAGAGAACAATGGCGTGGACAAGCGCGTCACCAGATTCGTGCTCCCCGTAGGAGCCACCATTAACATG
GATGGGACTGCCCTCTATGAGGCTTTGGCTGCCATTTTCATTGCTCAAGTTAACAACTTTGAACTGAACTTCGGACAAATTATTACAATC
AGCATCACAGCCACAGCTGCCAGTATTGGGGCAGCTGGAATTCCTCAGGCGGGCCTGGTCACTATGGTCATTGTGCTGACATCTGTCGGC
CTGCCCACTGACGACATCACGCTCATCATCGCGGTGGACTGGTTCCTGGATCGCCTCCGGACCACCACCAACGTACTGGGAGACTCCCTG
GGAGCTGGGATTGTGGAGCACTTGTCACGACATGAACTGAAGAACAGAGATGTTGAAATGGGTAACTCAGTGATTGAAGAGAATGAAATG

>In-frame_METTL15_ENST00000342303_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_1512nt
ATGCTTCGGTATCCATATTTTTGTAGAATGTATAAAGAATGCCTTTCATGTTGGTTGGAATCTGGCATACCTAATTTAGGTGTCTGGCCA
AACAGAATACATACTACAGCAGAAAAATATAGAGAATATGAAGCCCGGGAGCAAACAGATCAAACTCAAGCCCAGGAGTTACACAGATCT
CAAGATAGAGATTTTGAAACTATGGCTAAATTACATATTCCAGTAATGGTGGATGAAGTTGTTCATTGTTTGTCACCACAAAAAGGACAG
ATTTTTCTAGATATGACATTTGGTTCGGGAGGGCACACAAAAGCCATTCTGCAGAAGGAGTCAGATATTGTTCTCTATGCCTTGGACAGA
GACCCAACAGCTTATGCATTAGCTGAACATCTTTCAGAGTTGTATCCGAACATGTTCCCTCCAAATCTGGTAGAAGCCTGCTTTAAACAG
TTTAAAACCAACTATGAGAAGAGAAGCTTTAAAGTGCCCATCCAGGCCAACGAAACGCTTGTGGGTGCTGTGATAAACAATGTGTCTGAG
GCCATGGAGACTCTTACCCGAATCACAGAGGAGCTGGTCCCAGTTCCAGGATCTGTGAATGGAGTCAATGCCCTGGGTCTAGTTGTCTTC
TCCATGTGCTTCGGTTTTGTGATTGGAAACATGAAGGAACAGGGGCAGGCCCTGAGAGAGTTCTTTGATTCTCTTAACGAAGCCATCATG
AGACTGGTAGCAGTAATAATGTGGTATGCCCCCGTGGGTATTCTCTTCCTGATTGCTGGGAAGATTGTGGAGATGGAAGACATGGGTGTG
ATTGGGGGGCAGCTTGCCATGTACACCGTGACTGTCATTGTTGGCTTACTCATTCACGCAGTCATCGTCTTGCCACTCCTCTACTTCTTG
GTAACACGGAAAAACCCTTGGGTTTTTATTGGAGGGTTGCTGCAAGCACTCATCACCGCTCTGGGGACCTCTTCAAGTTCTGCCACCCTA
CCCATCACCTTCAAGTGCCTGGAAGAGAACAATGGCGTGGACAAGCGCGTCACCAGATTCGTGCTCCCCGTAGGAGCCACCATTAACATG
GATGGGACTGCCCTCTATGAGGCTTTGGCTGCCATTTTCATTGCTCAAGTTAACAACTTTGAACTGAACTTCGGACAAATTATTACAATC
AGCATCACAGCCACAGCTGCCAGTATTGGGGCAGCTGGAATTCCTCAGGCGGGCCTGGTCACTATGGTCATTGTGCTGACATCTGTCGGC
CTGCCCACTGACGACATCACGCTCATCATCGCGGTGGACTGGTTCCTGGATCGCCTCCGGACCACCACCAACGTACTGGGAGACTCCCTG
GGAGCTGGGATTGTGGAGCACTTGTCACGACATGAACTGAAGAACAGAGATGTTGAAATGGGTAACTCAGTGATTGAAGAGAATGAAATG

>In-frame_METTL15_ENST00000407364_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_1512nt
ATGCTTCGGTATCCATATTTTTGTAGAATGTATAAAGAATGCCTTTCATGTTGGTTGGAATCTGGCATACCTAATTTAGGTGTCTGGCCA
AACAGAATACATACTACAGCAGAAAAATATAGAGAATATGAAGCCCGGGAGCAAACAGATCAAACTCAAGCCCAGGAGTTACACAGATCT
CAAGATAGAGATTTTGAAACTATGGCTAAATTACATATTCCAGTAATGGTGGATGAAGTTGTTCATTGTTTGTCACCACAAAAAGGACAG
ATTTTTCTAGATATGACATTTGGTTCGGGAGGGCACACAAAAGCCATTCTGCAGAAGGAGTCAGATATTGTTCTCTATGCCTTGGACAGA
GACCCAACAGCTTATGCATTAGCTGAACATCTTTCAGAGTTGTATCCGAACATGTTCCCTCCAAATCTGGTAGAAGCCTGCTTTAAACAG
TTTAAAACCAACTATGAGAAGAGAAGCTTTAAAGTGCCCATCCAGGCCAACGAAACGCTTGTGGGTGCTGTGATAAACAATGTGTCTGAG
GCCATGGAGACTCTTACCCGAATCACAGAGGAGCTGGTCCCAGTTCCAGGATCTGTGAATGGAGTCAATGCCCTGGGTCTAGTTGTCTTC
TCCATGTGCTTCGGTTTTGTGATTGGAAACATGAAGGAACAGGGGCAGGCCCTGAGAGAGTTCTTTGATTCTCTTAACGAAGCCATCATG
AGACTGGTAGCAGTAATAATGTGGTATGCCCCCGTGGGTATTCTCTTCCTGATTGCTGGGAAGATTGTGGAGATGGAAGACATGGGTGTG
ATTGGGGGGCAGCTTGCCATGTACACCGTGACTGTCATTGTTGGCTTACTCATTCACGCAGTCATCGTCTTGCCACTCCTCTACTTCTTG
GTAACACGGAAAAACCCTTGGGTTTTTATTGGAGGGTTGCTGCAAGCACTCATCACCGCTCTGGGGACCTCTTCAAGTTCTGCCACCCTA
CCCATCACCTTCAAGTGCCTGGAAGAGAACAATGGCGTGGACAAGCGCGTCACCAGATTCGTGCTCCCCGTAGGAGCCACCATTAACATG
GATGGGACTGCCCTCTATGAGGCTTTGGCTGCCATTTTCATTGCTCAAGTTAACAACTTTGAACTGAACTTCGGACAAATTATTACAATC
AGCATCACAGCCACAGCTGCCAGTATTGGGGCAGCTGGAATTCCTCAGGCGGGCCTGGTCACTATGGTCATTGTGCTGACATCTGTCGGC
CTGCCCACTGACGACATCACGCTCATCATCGCGGTGGACTGGTTCCTGGATCGCCTCCGGACCACCACCAACGTACTGGGAGACTCCCTG
GGAGCTGGGATTGTGGAGCACTTGTCACGACATGAACTGAAGAACAGAGATGTTGAAATGGGTAACTCAGTGATTGAAGAGAATGAAATG

>In-frame_METTL15_ENST00000303459_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_1512nt
ATGCTTCGGTATCCATATTTTTGTAGAATGTATAAAGAATGCCTTTCATGTTGGTTGGAATCTGGCATACCTAATTTAGGTGTCTGGCCA
AACAGAATACATACTACAGCAGAAAAATATAGAGAATATGAAGCCCGGGAGCAAACAGATCAAACTCAAGCCCAGGAGTTACACAGATCT
CAAGATAGAGATTTTGAAACTATGGCTAAATTACATATTCCAGTAATGGTGGATGAAGTTGTTCATTGTTTGTCACCACAAAAAGGACAG
ATTTTTCTAGATATGACATTTGGTTCGGGAGGGCACACAAAAGCCATTCTGCAGAAGGAGTCAGATATTGTTCTCTATGCCTTGGACAGA
GACCCAACAGCTTATGCATTAGCTGAACATCTTTCAGAGTTGTATCCGAACATGTTCCCTCCAAATCTGGTAGAAGCCTGCTTTAAACAG
TTTAAAACCAACTATGAGAAGAGAAGCTTTAAAGTGCCCATCCAGGCCAACGAAACGCTTGTGGGTGCTGTGATAAACAATGTGTCTGAG
GCCATGGAGACTCTTACCCGAATCACAGAGGAGCTGGTCCCAGTTCCAGGATCTGTGAATGGAGTCAATGCCCTGGGTCTAGTTGTCTTC
TCCATGTGCTTCGGTTTTGTGATTGGAAACATGAAGGAACAGGGGCAGGCCCTGAGAGAGTTCTTTGATTCTCTTAACGAAGCCATCATG
AGACTGGTAGCAGTAATAATGTGGTATGCCCCCGTGGGTATTCTCTTCCTGATTGCTGGGAAGATTGTGGAGATGGAAGACATGGGTGTG
ATTGGGGGGCAGCTTGCCATGTACACCGTGACTGTCATTGTTGGCTTACTCATTCACGCAGTCATCGTCTTGCCACTCCTCTACTTCTTG
GTAACACGGAAAAACCCTTGGGTTTTTATTGGAGGGTTGCTGCAAGCACTCATCACCGCTCTGGGGACCTCTTCAAGTTCTGCCACCCTA
CCCATCACCTTCAAGTGCCTGGAAGAGAACAATGGCGTGGACAAGCGCGTCACCAGATTCGTGCTCCCCGTAGGAGCCACCATTAACATG
GATGGGACTGCCCTCTATGAGGCTTTGGCTGCCATTTTCATTGCTCAAGTTAACAACTTTGAACTGAACTTCGGACAAATTATTACAATC
AGCATCACAGCCACAGCTGCCAGTATTGGGGCAGCTGGAATTCCTCAGGCGGGCCTGGTCACTATGGTCATTGTGCTGACATCTGTCGGC
CTGCCCACTGACGACATCACGCTCATCATCGCGGTGGACTGGTTCCTGGATCGCCTCCGGACCACCACCAACGTACTGGGAGACTCCCTG
GGAGCTGGGATTGTGGAGCACTTGTCACGACATGAACTGAAGAACAGAGATGTTGAAATGGGTAACTCAGTGATTGAAGAGAATGAAATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_METTL15_ENST00000406787_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_4035nt
GGCAGCTTGGCGCCAAGAAGCTCAGCCTGGCTGCGCAGGGGAAGCTCTTTGCTTGCTCGTCACCGTGGCAACGCGCGCGGCCGTTTCCGG
AGGCGGTGGCCAAAGTGGGCGGGGCTAGGCCGGAGCTGCTGGTGGGAGGCAGCCACTTGAGATCACCAGGCCTCCTGTAGACCGGCGGGT
GCAGGGCCCGGTCCCAGAGTTAAGGGAAAGTCGTTTGGAAACCCCAGGCCAACAGGACCCTTTGGCAGCTGAGGCTGGAAACAGCGGAAC
CAAAGGCAGACGGTCCTCAGTTGCTTGGGCGGACGTGGACCCAATCTGTCCGTCCTTACAAGTTTCCCCCAGGGGCAGGACCTAGACGCG
CGGCGCATTCAGGTTCTCCTGGACCGTAGTGGTAGTCGCTGGCCCGAGTTAGAGGCCAGCTGAGAAGTCTTCGTGCTTCAGATTTGTTTA
CCTACAAAATGCTTCGGTATCCATATTTTTGTAGAATGTATAAAGAATGCCTTTCATGTTGGTTGGAATCTGGCATACCTAATTTAGGTG
TCTGGCCAAACAGAATACATACTACAGCAGAAAAATATAGAGAATATGAAGCCCGGGAGCAAACAGATCAAACTCAAGCCCAGGAGTTAC
ACAGATCTCAAGATAGAGATTTTGAAACTATGGCTAAATTACATATTCCAGTAATGGTGGATGAAGTTGTTCATTGTTTGTCACCACAAA
AAGGACAGATTTTTCTAGATATGACATTTGGTTCGGGAGGGCACACAAAAGCCATTCTGCAGAAGGAGTCAGATATTGTTCTCTATGCCT
TGGACAGAGACCCAACAGCTTATGCATTAGCTGAACATCTTTCAGAGTTGTATCCGAACATGTTCCCTCCAAATCTGGTAGAAGCCTGCT
TTAAACAGTTTAAAACCAACTATGAGAAGAGAAGCTTTAAAGTGCCCATCCAGGCCAACGAAACGCTTGTGGGTGCTGTGATAAACAATG
TGTCTGAGGCCATGGAGACTCTTACCCGAATCACAGAGGAGCTGGTCCCAGTTCCAGGATCTGTGAATGGAGTCAATGCCCTGGGTCTAG
TTGTCTTCTCCATGTGCTTCGGTTTTGTGATTGGAAACATGAAGGAACAGGGGCAGGCCCTGAGAGAGTTCTTTGATTCTCTTAACGAAG
CCATCATGAGACTGGTAGCAGTAATAATGTGGTATGCCCCCGTGGGTATTCTCTTCCTGATTGCTGGGAAGATTGTGGAGATGGAAGACA
TGGGTGTGATTGGGGGGCAGCTTGCCATGTACACCGTGACTGTCATTGTTGGCTTACTCATTCACGCAGTCATCGTCTTGCCACTCCTCT
ACTTCTTGGTAACACGGAAAAACCCTTGGGTTTTTATTGGAGGGTTGCTGCAAGCACTCATCACCGCTCTGGGGACCTCTTCAAGTTCTG
CCACCCTACCCATCACCTTCAAGTGCCTGGAAGAGAACAATGGCGTGGACAAGCGCGTCACCAGATTCGTGCTCCCCGTAGGAGCCACCA
TTAACATGGATGGGACTGCCCTCTATGAGGCTTTGGCTGCCATTTTCATTGCTCAAGTTAACAACTTTGAACTGAACTTCGGACAAATTA
TTACAATCAGCATCACAGCCACAGCTGCCAGTATTGGGGCAGCTGGAATTCCTCAGGCGGGCCTGGTCACTATGGTCATTGTGCTGACAT
CTGTCGGCCTGCCCACTGACGACATCACGCTCATCATCGCGGTGGACTGGTTCCTGGATCGCCTCCGGACCACCACCAACGTACTGGGAG
ACTCCCTGGGAGCTGGGATTGTGGAGCACTTGTCACGACATGAACTGAAGAACAGAGATGTTGAAATGGGTAACTCAGTGATTGAAGAGA
ATGAAATGAAGAAACCATATCAACTGATTGCACAGGACAATGAAACTGAGAAACCCATCGACAGTGAAACCAAGATGTAGACTAACATAA
AGAAACACTTTCTTGAGCACCAGGTGTTAAAAACCATTATAAAATCTTTCCATCTCATTACAGCTCATTCGCTCCAGCAAGCCCGTCATC
TTCCCTTTCCTCCCTTCTGATAAGACTGGAAAATAGTCCTCCAAAACACAAGGGAGGATTTTGGGTGGCCAAAGTGTACAATTTTCATCC
CACAATTGAAATTTTTAAATCATTTCATGTTAGTCTTACCGAATAAGGTACCAAGATCACAAATAGTGTTGATCAGATCTTACAAGTTTA
TGTGGCACACAATCCTATAAATGTGATTTTTTTATATAAGTTAAAGAGACAAATAGTAGGCTAAAAACATTTTAAAATCAACTTTTGAAA
TTTAAAAATCTTTCAGAATACAATTCAGTTTTAGTTTCAAAATGTTAACAACTTGAATTACAACCGGTTATCAGTTGGACAGTAAGATTT
TATCCCTTTCTCTTCTGACTGGTATACCTATTTCATTAGTAGCTAGGTGCACATATACATCTAGCACAGCTGTGAGGACAGACAGAAGGC
AAAGTTTCCATGTGGCCTTGAGCAAGTCCCATCTCACCTCTAGGCCTCAGTGTCCTCATCTATAAAATGAGGGACTTCCCTAGAAGTCTT
CATGGTCTCTTCCAGCCCAGACATCCTGTGATGTCATGAAAGCACCTGCCCTCTGTTTCCCCTCAGAACACCCTGTACCATCCATGGAGC
ACGAGGCCTTCAGAAAAGACACTTCAATGGGAGTGAACATTTCTAACTAAGGACAGGATGGCTGTGTGTGGTGGTCACCAGGTCCTGTGA
GCAAAGTGCAGGTTATGCAAGTCGCCAGGCAGGAGGCCATTCCAGGAGTGGGATTATTCATCAAACTCTTTGCCCAGTTCATCCCAATGG
GGGAAGTATTCCCTTCTTTCCTACTCTGGGAAGAATGTCTCCTGCCACTCCTCAACTGATGATAGACTTCGAAAACAGATGAGAAGACTA
GCAGCTAGCAAGGGTGCTTGTGGTCACACTGTGGAACACTAAAGAGCTAGGAAAGAGTTGAGCACAGGCAACATTACAAACAAAGGATTT
GAAAACACCAAGAGTACAGGTCTTCTTTAAGGAAGAATAAAAAAGAAGAGGTTCATTTTTCTGGCTTTTTTTTTCACCTGAAACACTTTT
TCTCGAGTCCAAAATCATTCCCCCCGTGAAGTCTGCTTACCAAAACATAAGACGACTTATATATTTGAAAGAAGTCAAATGAATGAGCTC
TCTAATAGAAGTCCATGAGTTGAGTGGGTATTTCTTATTTGAAAGTGTTTTTCTTTAATCAAAAGTCCTTAGAATGAGGGAAACAAAATA
TTTATTTGTTTTGGAATCCCACTTATCAAATCATTCAAAACTTTCAGCTGGAGTGGGGTTTGCTTTTGTTTTGTTTGTGTCCATAAGAGA
AATGGTAGAAGATGAATCAGTATGAAGACACTGTCAATGAGGTTATGAGAAAAAAACAGCAGGGGCATTAGTTTCAGGCAAGGCAGCTCC
CAGGTTTAGAGATTAATTTTTACCCCCTAAGGAATATCCAGTCAAAGACGCTGAGTGGGAGCTGTCAGGCAGTAGCAGCTGTGTTTGAGT
TTCTGGCTGAAAATGGTGAAGAATGGACTTAATTATGCTAACAAACTGAAAAATCTAGACATAGATCCTCTGATATACAATTAGAGATAT
TTTTATATAGACCCCAAGCATTCTGTGCATAAAAGTTAACATTAGGCTGTGGTGCAGTAACCATTTAATGTCGAGGCTCTATTTCGGAAA
TACACTACAAATGTTAAAGTACGTGGCTGTCCTCTTAAGACACTAGTAGAGCAAAGACTTAATCATATCAACTTAATTCTGTTACACAAT
ATGTGTTTTTTAATATACTAACCATTTCTTATGGAAAGGTCCTGTGGGGAGCCCATCCTCTCGCCAAGCCATCACAGGCTCTGCATACAC

>In-frame_METTL15_ENST00000342303_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_4032nt
AGCTTGGCGCCAAGAAGCTCAGCCTGGCTGCGCAGGGGAAGCTCTTTGCTTGCTCGTCACCGTGGCAACGCGCGCGGCCGTTTCCGGAGG
CGGTGGCCAAAGTGGGCGGGGCTAGGCCGGAGCTGCTGGTGGGAGGCAGCCACTTGAGATCACCAGGCCTCCTGTAGACCGGCGGGTGCA
GGGCCCGGTCCCAGAGTTAAGGGAAAGTCGTTTGGAAACCCCAGGCCAACAGGACCCTTTGGCAGCTGAGGCTGGAAACAGCGGAACCAA
AGGCAGACGGTCCTCAGTTGCTTGGGCGGACGTGGACCCAATCTGTCCGTCCTTACAAGTTTCCCCCAGGGGCAGGACCTAGACGCGCGG
CGCATTCAGGTTCTCCTGGACCGTAGTGGTAGTCGCTGGCCCGAGTTAGAGGCCAGCTGAGAAGTCTTCGTGCTTCAGATTTGTTTACCT
ACAAAATGCTTCGGTATCCATATTTTTGTAGAATGTATAAAGAATGCCTTTCATGTTGGTTGGAATCTGGCATACCTAATTTAGGTGTCT
GGCCAAACAGAATACATACTACAGCAGAAAAATATAGAGAATATGAAGCCCGGGAGCAAACAGATCAAACTCAAGCCCAGGAGTTACACA
GATCTCAAGATAGAGATTTTGAAACTATGGCTAAATTACATATTCCAGTAATGGTGGATGAAGTTGTTCATTGTTTGTCACCACAAAAAG
GACAGATTTTTCTAGATATGACATTTGGTTCGGGAGGGCACACAAAAGCCATTCTGCAGAAGGAGTCAGATATTGTTCTCTATGCCTTGG
ACAGAGACCCAACAGCTTATGCATTAGCTGAACATCTTTCAGAGTTGTATCCGAACATGTTCCCTCCAAATCTGGTAGAAGCCTGCTTTA
AACAGTTTAAAACCAACTATGAGAAGAGAAGCTTTAAAGTGCCCATCCAGGCCAACGAAACGCTTGTGGGTGCTGTGATAAACAATGTGT
CTGAGGCCATGGAGACTCTTACCCGAATCACAGAGGAGCTGGTCCCAGTTCCAGGATCTGTGAATGGAGTCAATGCCCTGGGTCTAGTTG
TCTTCTCCATGTGCTTCGGTTTTGTGATTGGAAACATGAAGGAACAGGGGCAGGCCCTGAGAGAGTTCTTTGATTCTCTTAACGAAGCCA
TCATGAGACTGGTAGCAGTAATAATGTGGTATGCCCCCGTGGGTATTCTCTTCCTGATTGCTGGGAAGATTGTGGAGATGGAAGACATGG
GTGTGATTGGGGGGCAGCTTGCCATGTACACCGTGACTGTCATTGTTGGCTTACTCATTCACGCAGTCATCGTCTTGCCACTCCTCTACT
TCTTGGTAACACGGAAAAACCCTTGGGTTTTTATTGGAGGGTTGCTGCAAGCACTCATCACCGCTCTGGGGACCTCTTCAAGTTCTGCCA
CCCTACCCATCACCTTCAAGTGCCTGGAAGAGAACAATGGCGTGGACAAGCGCGTCACCAGATTCGTGCTCCCCGTAGGAGCCACCATTA
ACATGGATGGGACTGCCCTCTATGAGGCTTTGGCTGCCATTTTCATTGCTCAAGTTAACAACTTTGAACTGAACTTCGGACAAATTATTA
CAATCAGCATCACAGCCACAGCTGCCAGTATTGGGGCAGCTGGAATTCCTCAGGCGGGCCTGGTCACTATGGTCATTGTGCTGACATCTG
TCGGCCTGCCCACTGACGACATCACGCTCATCATCGCGGTGGACTGGTTCCTGGATCGCCTCCGGACCACCACCAACGTACTGGGAGACT
CCCTGGGAGCTGGGATTGTGGAGCACTTGTCACGACATGAACTGAAGAACAGAGATGTTGAAATGGGTAACTCAGTGATTGAAGAGAATG
AAATGAAGAAACCATATCAACTGATTGCACAGGACAATGAAACTGAGAAACCCATCGACAGTGAAACCAAGATGTAGACTAACATAAAGA
AACACTTTCTTGAGCACCAGGTGTTAAAAACCATTATAAAATCTTTCCATCTCATTACAGCTCATTCGCTCCAGCAAGCCCGTCATCTTC
CCTTTCCTCCCTTCTGATAAGACTGGAAAATAGTCCTCCAAAACACAAGGGAGGATTTTGGGTGGCCAAAGTGTACAATTTTCATCCCAC
AATTGAAATTTTTAAATCATTTCATGTTAGTCTTACCGAATAAGGTACCAAGATCACAAATAGTGTTGATCAGATCTTACAAGTTTATGT
GGCACACAATCCTATAAATGTGATTTTTTTATATAAGTTAAAGAGACAAATAGTAGGCTAAAAACATTTTAAAATCAACTTTTGAAATTT
AAAAATCTTTCAGAATACAATTCAGTTTTAGTTTCAAAATGTTAACAACTTGAATTACAACCGGTTATCAGTTGGACAGTAAGATTTTAT
CCCTTTCTCTTCTGACTGGTATACCTATTTCATTAGTAGCTAGGTGCACATATACATCTAGCACAGCTGTGAGGACAGACAGAAGGCAAA
GTTTCCATGTGGCCTTGAGCAAGTCCCATCTCACCTCTAGGCCTCAGTGTCCTCATCTATAAAATGAGGGACTTCCCTAGAAGTCTTCAT
GGTCTCTTCCAGCCCAGACATCCTGTGATGTCATGAAAGCACCTGCCCTCTGTTTCCCCTCAGAACACCCTGTACCATCCATGGAGCACG
AGGCCTTCAGAAAAGACACTTCAATGGGAGTGAACATTTCTAACTAAGGACAGGATGGCTGTGTGTGGTGGTCACCAGGTCCTGTGAGCA
AAGTGCAGGTTATGCAAGTCGCCAGGCAGGAGGCCATTCCAGGAGTGGGATTATTCATCAAACTCTTTGCCCAGTTCATCCCAATGGGGG
AAGTATTCCCTTCTTTCCTACTCTGGGAAGAATGTCTCCTGCCACTCCTCAACTGATGATAGACTTCGAAAACAGATGAGAAGACTAGCA
GCTAGCAAGGGTGCTTGTGGTCACACTGTGGAACACTAAAGAGCTAGGAAAGAGTTGAGCACAGGCAACATTACAAACAAAGGATTTGAA
AACACCAAGAGTACAGGTCTTCTTTAAGGAAGAATAAAAAAGAAGAGGTTCATTTTTCTGGCTTTTTTTTTCACCTGAAACACTTTTTCT
CGAGTCCAAAATCATTCCCCCCGTGAAGTCTGCTTACCAAAACATAAGACGACTTATATATTTGAAAGAAGTCAAATGAATGAGCTCTCT
AATAGAAGTCCATGAGTTGAGTGGGTATTTCTTATTTGAAAGTGTTTTTCTTTAATCAAAAGTCCTTAGAATGAGGGAAACAAAATATTT
ATTTGTTTTGGAATCCCACTTATCAAATCATTCAAAACTTTCAGCTGGAGTGGGGTTTGCTTTTGTTTTGTTTGTGTCCATAAGAGAAAT
GGTAGAAGATGAATCAGTATGAAGACACTGTCAATGAGGTTATGAGAAAAAAACAGCAGGGGCATTAGTTTCAGGCAAGGCAGCTCCCAG
GTTTAGAGATTAATTTTTACCCCCTAAGGAATATCCAGTCAAAGACGCTGAGTGGGAGCTGTCAGGCAGTAGCAGCTGTGTTTGAGTTTC
TGGCTGAAAATGGTGAAGAATGGACTTAATTATGCTAACAAACTGAAAAATCTAGACATAGATCCTCTGATATACAATTAGAGATATTTT
TATATAGACCCCAAGCATTCTGTGCATAAAAGTTAACATTAGGCTGTGGTGCAGTAACCATTTAATGTCGAGGCTCTATTTCGGAAATAC
ACTACAAATGTTAAAGTACGTGGCTGTCCTCTTAAGACACTAGTAGAGCAAAGACTTAATCATATCAACTTAATTCTGTTACACAATATG
TGTTTTTTAATATACTAACCATTTCTTATGGAAAGGTCCTGTGGGGAGCCCATCCTCTCGCCAAGCCATCACAGGCTCTGCATACACATG

>In-frame_METTL15_ENST00000407364_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_3929nt
GGGCGGGGCTAGGCCGGAGCTGCTGGTGGGAGGCAGCCACTTGAGATCACCAGGCCTCCTGTAGACCGGCGGGTGCAGGGCCCGGTCCCA
GAGTTAAGGGAAAGTCGTTTGGAAACCCCAGGCCAACAGGACCCTTTGGCAGCTGAGGCTGGAAACAGCGGAACCAAAGGCAGACGGTCC
TCAGTTGCTTGGGCGGACGTGGACCCAATCTGTCCGTCCTTACAAGTTTCCCCCAGGGGCAGGACCTAGACGCGCGGCGCATTCAGGTTC
TCCTGGACCGTAGTGGTAGTCGCTGGCCCGAGTTAGAGGCCAGCTGAGAAGTCTTCGTGCTTCAGATTTGTTTACCTACAAAATGCTTCG
GTATCCATATTTTTGTAGAATGTATAAAGAATGCCTTTCATGTTGGTTGGAATCTGGCATACCTAATTTAGGTGTCTGGCCAAACAGAAT
ACATACTACAGCAGAAAAATATAGAGAATATGAAGCCCGGGAGCAAACAGATCAAACTCAAGCCCAGGAGTTACACAGATCTCAAGATAG
AGATTTTGAAACTATGGCTAAATTACATATTCCAGTAATGGTGGATGAAGTTGTTCATTGTTTGTCACCACAAAAAGGACAGATTTTTCT
AGATATGACATTTGGTTCGGGAGGGCACACAAAAGCCATTCTGCAGAAGGAGTCAGATATTGTTCTCTATGCCTTGGACAGAGACCCAAC
AGCTTATGCATTAGCTGAACATCTTTCAGAGTTGTATCCGAACATGTTCCCTCCAAATCTGGTAGAAGCCTGCTTTAAACAGTTTAAAAC
CAACTATGAGAAGAGAAGCTTTAAAGTGCCCATCCAGGCCAACGAAACGCTTGTGGGTGCTGTGATAAACAATGTGTCTGAGGCCATGGA
GACTCTTACCCGAATCACAGAGGAGCTGGTCCCAGTTCCAGGATCTGTGAATGGAGTCAATGCCCTGGGTCTAGTTGTCTTCTCCATGTG
CTTCGGTTTTGTGATTGGAAACATGAAGGAACAGGGGCAGGCCCTGAGAGAGTTCTTTGATTCTCTTAACGAAGCCATCATGAGACTGGT
AGCAGTAATAATGTGGTATGCCCCCGTGGGTATTCTCTTCCTGATTGCTGGGAAGATTGTGGAGATGGAAGACATGGGTGTGATTGGGGG
GCAGCTTGCCATGTACACCGTGACTGTCATTGTTGGCTTACTCATTCACGCAGTCATCGTCTTGCCACTCCTCTACTTCTTGGTAACACG
GAAAAACCCTTGGGTTTTTATTGGAGGGTTGCTGCAAGCACTCATCACCGCTCTGGGGACCTCTTCAAGTTCTGCCACCCTACCCATCAC
CTTCAAGTGCCTGGAAGAGAACAATGGCGTGGACAAGCGCGTCACCAGATTCGTGCTCCCCGTAGGAGCCACCATTAACATGGATGGGAC
TGCCCTCTATGAGGCTTTGGCTGCCATTTTCATTGCTCAAGTTAACAACTTTGAACTGAACTTCGGACAAATTATTACAATCAGCATCAC
AGCCACAGCTGCCAGTATTGGGGCAGCTGGAATTCCTCAGGCGGGCCTGGTCACTATGGTCATTGTGCTGACATCTGTCGGCCTGCCCAC
TGACGACATCACGCTCATCATCGCGGTGGACTGGTTCCTGGATCGCCTCCGGACCACCACCAACGTACTGGGAGACTCCCTGGGAGCTGG
GATTGTGGAGCACTTGTCACGACATGAACTGAAGAACAGAGATGTTGAAATGGGTAACTCAGTGATTGAAGAGAATGAAATGAAGAAACC
ATATCAACTGATTGCACAGGACAATGAAACTGAGAAACCCATCGACAGTGAAACCAAGATGTAGACTAACATAAAGAAACACTTTCTTGA
GCACCAGGTGTTAAAAACCATTATAAAATCTTTCCATCTCATTACAGCTCATTCGCTCCAGCAAGCCCGTCATCTTCCCTTTCCTCCCTT
CTGATAAGACTGGAAAATAGTCCTCCAAAACACAAGGGAGGATTTTGGGTGGCCAAAGTGTACAATTTTCATCCCACAATTGAAATTTTT
AAATCATTTCATGTTAGTCTTACCGAATAAGGTACCAAGATCACAAATAGTGTTGATCAGATCTTACAAGTTTATGTGGCACACAATCCT
ATAAATGTGATTTTTTTATATAAGTTAAAGAGACAAATAGTAGGCTAAAAACATTTTAAAATCAACTTTTGAAATTTAAAAATCTTTCAG
AATACAATTCAGTTTTAGTTTCAAAATGTTAACAACTTGAATTACAACCGGTTATCAGTTGGACAGTAAGATTTTATCCCTTTCTCTTCT
GACTGGTATACCTATTTCATTAGTAGCTAGGTGCACATATACATCTAGCACAGCTGTGAGGACAGACAGAAGGCAAAGTTTCCATGTGGC
CTTGAGCAAGTCCCATCTCACCTCTAGGCCTCAGTGTCCTCATCTATAAAATGAGGGACTTCCCTAGAAGTCTTCATGGTCTCTTCCAGC
CCAGACATCCTGTGATGTCATGAAAGCACCTGCCCTCTGTTTCCCCTCAGAACACCCTGTACCATCCATGGAGCACGAGGCCTTCAGAAA
AGACACTTCAATGGGAGTGAACATTTCTAACTAAGGACAGGATGGCTGTGTGTGGTGGTCACCAGGTCCTGTGAGCAAAGTGCAGGTTAT
GCAAGTCGCCAGGCAGGAGGCCATTCCAGGAGTGGGATTATTCATCAAACTCTTTGCCCAGTTCATCCCAATGGGGGAAGTATTCCCTTC
TTTCCTACTCTGGGAAGAATGTCTCCTGCCACTCCTCAACTGATGATAGACTTCGAAAACAGATGAGAAGACTAGCAGCTAGCAAGGGTG
CTTGTGGTCACACTGTGGAACACTAAAGAGCTAGGAAAGAGTTGAGCACAGGCAACATTACAAACAAAGGATTTGAAAACACCAAGAGTA
CAGGTCTTCTTTAAGGAAGAATAAAAAAGAAGAGGTTCATTTTTCTGGCTTTTTTTTTCACCTGAAACACTTTTTCTCGAGTCCAAAATC
ATTCCCCCCGTGAAGTCTGCTTACCAAAACATAAGACGACTTATATATTTGAAAGAAGTCAAATGAATGAGCTCTCTAATAGAAGTCCAT
GAGTTGAGTGGGTATTTCTTATTTGAAAGTGTTTTTCTTTAATCAAAAGTCCTTAGAATGAGGGAAACAAAATATTTATTTGTTTTGGAA
TCCCACTTATCAAATCATTCAAAACTTTCAGCTGGAGTGGGGTTTGCTTTTGTTTTGTTTGTGTCCATAAGAGAAATGGTAGAAGATGAA
TCAGTATGAAGACACTGTCAATGAGGTTATGAGAAAAAAACAGCAGGGGCATTAGTTTCAGGCAAGGCAGCTCCCAGGTTTAGAGATTAA
TTTTTACCCCCTAAGGAATATCCAGTCAAAGACGCTGAGTGGGAGCTGTCAGGCAGTAGCAGCTGTGTTTGAGTTTCTGGCTGAAAATGG
TGAAGAATGGACTTAATTATGCTAACAAACTGAAAAATCTAGACATAGATCCTCTGATATACAATTAGAGATATTTTTATATAGACCCCA
AGCATTCTGTGCATAAAAGTTAACATTAGGCTGTGGTGCAGTAACCATTTAATGTCGAGGCTCTATTTCGGAAATACACTACAAATGTTA
AAGTACGTGGCTGTCCTCTTAAGACACTAGTAGAGCAAAGACTTAATCATATCAACTTAATTCTGTTACACAATATGTGTTTTTTAATAT
ACTAACCATTTCTTATGGAAAGGTCCTGTGGGGAGCCCATCCTCTCGCCAAGCCATCACAGGCTCTGCATACACATGCACTCAGTGTGGA

>In-frame_METTL15_ENST00000303459_chr11_28232745_+_SLC1A3_ENST00000265113_chr5_36674151_+_3684nt
CTAGACGCGCGGCGCATTCAGGTTCTCCTGGACCGTAGTGGTAGTCGCTGGCCCGAGTTAGAGGCCAGCTGAGAAGTCTTCGTGCTTCAG
ATTTGTTTACCTACAAAATGCTTCGGTATCCATATTTTTGTAGAATGTATAAAGAATGCCTTTCATGTTGGTTGGAATCTGGCATACCTA
ATTTAGGTGTCTGGCCAAACAGAATACATACTACAGCAGAAAAATATAGAGAATATGAAGCCCGGGAGCAAACAGATCAAACTCAAGCCC
AGGAGTTACACAGATCTCAAGATAGAGATTTTGAAACTATGGCTAAATTACATATTCCAGTAATGGTGGATGAAGTTGTTCATTGTTTGT
CACCACAAAAAGGACAGATTTTTCTAGATATGACATTTGGTTCGGGAGGGCACACAAAAGCCATTCTGCAGAAGGAGTCAGATATTGTTC
TCTATGCCTTGGACAGAGACCCAACAGCTTATGCATTAGCTGAACATCTTTCAGAGTTGTATCCGAACATGTTCCCTCCAAATCTGGTAG
AAGCCTGCTTTAAACAGTTTAAAACCAACTATGAGAAGAGAAGCTTTAAAGTGCCCATCCAGGCCAACGAAACGCTTGTGGGTGCTGTGA
TAAACAATGTGTCTGAGGCCATGGAGACTCTTACCCGAATCACAGAGGAGCTGGTCCCAGTTCCAGGATCTGTGAATGGAGTCAATGCCC
TGGGTCTAGTTGTCTTCTCCATGTGCTTCGGTTTTGTGATTGGAAACATGAAGGAACAGGGGCAGGCCCTGAGAGAGTTCTTTGATTCTC
TTAACGAAGCCATCATGAGACTGGTAGCAGTAATAATGTGGTATGCCCCCGTGGGTATTCTCTTCCTGATTGCTGGGAAGATTGTGGAGA
TGGAAGACATGGGTGTGATTGGGGGGCAGCTTGCCATGTACACCGTGACTGTCATTGTTGGCTTACTCATTCACGCAGTCATCGTCTTGC
CACTCCTCTACTTCTTGGTAACACGGAAAAACCCTTGGGTTTTTATTGGAGGGTTGCTGCAAGCACTCATCACCGCTCTGGGGACCTCTT
CAAGTTCTGCCACCCTACCCATCACCTTCAAGTGCCTGGAAGAGAACAATGGCGTGGACAAGCGCGTCACCAGATTCGTGCTCCCCGTAG
GAGCCACCATTAACATGGATGGGACTGCCCTCTATGAGGCTTTGGCTGCCATTTTCATTGCTCAAGTTAACAACTTTGAACTGAACTTCG
GACAAATTATTACAATCAGCATCACAGCCACAGCTGCCAGTATTGGGGCAGCTGGAATTCCTCAGGCGGGCCTGGTCACTATGGTCATTG
TGCTGACATCTGTCGGCCTGCCCACTGACGACATCACGCTCATCATCGCGGTGGACTGGTTCCTGGATCGCCTCCGGACCACCACCAACG
TACTGGGAGACTCCCTGGGAGCTGGGATTGTGGAGCACTTGTCACGACATGAACTGAAGAACAGAGATGTTGAAATGGGTAACTCAGTGA
TTGAAGAGAATGAAATGAAGAAACCATATCAACTGATTGCACAGGACAATGAAACTGAGAAACCCATCGACAGTGAAACCAAGATGTAGA
CTAACATAAAGAAACACTTTCTTGAGCACCAGGTGTTAAAAACCATTATAAAATCTTTCCATCTCATTACAGCTCATTCGCTCCAGCAAG
CCCGTCATCTTCCCTTTCCTCCCTTCTGATAAGACTGGAAAATAGTCCTCCAAAACACAAGGGAGGATTTTGGGTGGCCAAAGTGTACAA
TTTTCATCCCACAATTGAAATTTTTAAATCATTTCATGTTAGTCTTACCGAATAAGGTACCAAGATCACAAATAGTGTTGATCAGATCTT
ACAAGTTTATGTGGCACACAATCCTATAAATGTGATTTTTTTATATAAGTTAAAGAGACAAATAGTAGGCTAAAAACATTTTAAAATCAA
CTTTTGAAATTTAAAAATCTTTCAGAATACAATTCAGTTTTAGTTTCAAAATGTTAACAACTTGAATTACAACCGGTTATCAGTTGGACA
GTAAGATTTTATCCCTTTCTCTTCTGACTGGTATACCTATTTCATTAGTAGCTAGGTGCACATATACATCTAGCACAGCTGTGAGGACAG
ACAGAAGGCAAAGTTTCCATGTGGCCTTGAGCAAGTCCCATCTCACCTCTAGGCCTCAGTGTCCTCATCTATAAAATGAGGGACTTCCCT
AGAAGTCTTCATGGTCTCTTCCAGCCCAGACATCCTGTGATGTCATGAAAGCACCTGCCCTCTGTTTCCCCTCAGAACACCCTGTACCAT
CCATGGAGCACGAGGCCTTCAGAAAAGACACTTCAATGGGAGTGAACATTTCTAACTAAGGACAGGATGGCTGTGTGTGGTGGTCACCAG
GTCCTGTGAGCAAAGTGCAGGTTATGCAAGTCGCCAGGCAGGAGGCCATTCCAGGAGTGGGATTATTCATCAAACTCTTTGCCCAGTTCA
TCCCAATGGGGGAAGTATTCCCTTCTTTCCTACTCTGGGAAGAATGTCTCCTGCCACTCCTCAACTGATGATAGACTTCGAAAACAGATG
AGAAGACTAGCAGCTAGCAAGGGTGCTTGTGGTCACACTGTGGAACACTAAAGAGCTAGGAAAGAGTTGAGCACAGGCAACATTACAAAC
AAAGGATTTGAAAACACCAAGAGTACAGGTCTTCTTTAAGGAAGAATAAAAAAGAAGAGGTTCATTTTTCTGGCTTTTTTTTTCACCTGA
AACACTTTTTCTCGAGTCCAAAATCATTCCCCCCGTGAAGTCTGCTTACCAAAACATAAGACGACTTATATATTTGAAAGAAGTCAAATG
AATGAGCTCTCTAATAGAAGTCCATGAGTTGAGTGGGTATTTCTTATTTGAAAGTGTTTTTCTTTAATCAAAAGTCCTTAGAATGAGGGA
AACAAAATATTTATTTGTTTTGGAATCCCACTTATCAAATCATTCAAAACTTTCAGCTGGAGTGGGGTTTGCTTTTGTTTTGTTTGTGTC
CATAAGAGAAATGGTAGAAGATGAATCAGTATGAAGACACTGTCAATGAGGTTATGAGAAAAAAACAGCAGGGGCATTAGTTTCAGGCAA
GGCAGCTCCCAGGTTTAGAGATTAATTTTTACCCCCTAAGGAATATCCAGTCAAAGACGCTGAGTGGGAGCTGTCAGGCAGTAGCAGCTG
TGTTTGAGTTTCTGGCTGAAAATGGTGAAGAATGGACTTAATTATGCTAACAAACTGAAAAATCTAGACATAGATCCTCTGATATACAAT
TAGAGATATTTTTATATAGACCCCAAGCATTCTGTGCATAAAAGTTAACATTAGGCTGTGGTGCAGTAACCATTTAATGTCGAGGCTCTA
TTTCGGAAATACACTACAAATGTTAAAGTACGTGGCTGTCCTCTTAAGACACTAGTAGAGCAAAGACTTAATCATATCAACTTAATTCTG
TTACACAATATGTGTTTTTTAATATACTAACCATTTCTTATGGAAAGGTCCTGTGGGGAGCCCATCCTCTCGCCAAGCCATCACAGGCTC


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FusionGenePPI for METTL15_SLC1A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
METTL15CUL3, TRIP13, MVB12B, BSG, LIPT1, UBR2, KLHL22, RBFA, EMILIN1, CD70, IL13RA2, LAMP3, KBTBD7, GYPB, CD79A, SLC2A12, MAS1, SLC15A1, KIR3DL2, APLNRSLC1A3CUL3, ZDHHC17, LGALS3, TCTN3, TMEM17, PDZK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for METTL15_SLC1A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC1A3P43003DB00142Glutamic AcidExcitatory amino acid transporter 1 {ECO:0000303|PubMed:16042756, ECO:0000303|PubMed:8647279}small moleculeapproved|nutraceutical

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RelatedDiseases for METTL15_SLC1A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC1A3C0036341Schizophrenia4PSYGENET
TgeneSLC1A3C0004352Autistic Disorder1CTD_human
TgeneSLC1A3C0005586Bipolar Disorder1PSYGENET
TgeneSLC1A3C0014544Epilepsy1CTD_human;HPO
TgeneSLC1A3C0178417Anhedonia1PSYGENET
TgeneSLC1A3C2675211EPISODIC ATAXIA, TYPE 6 (disorder)1CTD_human;ORPHANET;UNIPROT