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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21666

FusionGeneSummary for METRNL_UBC

check button Fusion gene summary
Fusion gene informationFusion gene name: METRNL_UBC
Fusion gene ID: 21666
HgeneTgene
Gene symbol

METRNL

UBC

Gene ID

284207

7316

Gene namemeteorin like, glial cell differentiation regulatorubiquitin C
Synonyms-HMG20
Cytomap

17q25.3

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionmeteorin-like proteinmeteorin, glial cell differentiation regulator-likesubfatinpolyubiquitin-C
Modification date2018051920180523
UniProtAcc

Q641Q3

P0CG48

Ensembl transtripts involved in fusion geneENST00000320095, ENST00000570778, 
ENST00000571814, ENST00000571940, 
ENST00000536769, ENST00000538617, 
ENST00000546120, ENST00000339647, 
ENST00000536661, 
Fusion gene scores* DoF score3 X 2 X 3=1814 X 14 X 3=588
# samples 315
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/588*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: METRNL [Title/Abstract] AND UBC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA310301METRNLchr17

81052121

-UBCchr12

125396659

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000320095ENST00000536769METRNLchr17

81052121

-UBCchr12

125396659

+
In-frameENST00000320095ENST00000538617METRNLchr17

81052121

-UBCchr12

125396659

+
Frame-shiftENST00000320095ENST00000546120METRNLchr17

81052121

-UBCchr12

125396659

+
In-frameENST00000320095ENST00000339647METRNLchr17

81052121

-UBCchr12

125396659

+
5CDS-intronENST00000320095ENST00000536661METRNLchr17

81052121

-UBCchr12

125396659

+
Frame-shiftENST00000570778ENST00000536769METRNLchr17

81052121

-UBCchr12

125396659

+
Frame-shiftENST00000570778ENST00000538617METRNLchr17

81052121

-UBCchr12

125396659

+
Frame-shiftENST00000570778ENST00000546120METRNLchr17

81052121

-UBCchr12

125396659

+
Frame-shiftENST00000570778ENST00000339647METRNLchr17

81052121

-UBCchr12

125396659

+
5CDS-intronENST00000570778ENST00000536661METRNLchr17

81052121

-UBCchr12

125396659

+
Frame-shiftENST00000571814ENST00000536769METRNLchr17

81052121

-UBCchr12

125396659

+
Frame-shiftENST00000571814ENST00000538617METRNLchr17

81052121

-UBCchr12

125396659

+
Frame-shiftENST00000571814ENST00000546120METRNLchr17

81052121

-UBCchr12

125396659

+
Frame-shiftENST00000571814ENST00000339647METRNLchr17

81052121

-UBCchr12

125396659

+
5CDS-intronENST00000571814ENST00000536661METRNLchr17

81052121

-UBCchr12

125396659

+
3UTR-3CDSENST00000571940ENST00000536769METRNLchr17

81052121

-UBCchr12

125396659

+
3UTR-3CDSENST00000571940ENST00000538617METRNLchr17

81052121

-UBCchr12

125396659

+
3UTR-3CDSENST00000571940ENST00000546120METRNLchr17

81052121

-UBCchr12

125396659

+
3UTR-3CDSENST00000571940ENST00000339647METRNLchr17

81052121

-UBCchr12

125396659

+
3UTR-intronENST00000571940ENST00000536661METRNLchr17

81052121

-UBCchr12

125396659

+

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FusionProtFeatures for METRNL_UBC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
METRNL

Q641Q3

UBC

P0CG48

Hormone induced following exercise or cold exposure thatpromotes energy expenditure. Induced either in the skeletal muscleafter exercise or in adipose tissue following cold exposure and ispresent in the circulation. Able to stimulate energy expenditureassociated with the browning of the white fat depots and improvesglucose tolerance. Does not promote an increase in a thermogenicgene program via direct action on adipocytes, but acts bystimulating several immune cell subtypes to enter the adiposetissue and activate their prothermogenic actions. Stimulates aneosinophil-dependent increase in IL4 expression and promotesalternative activation of adipose tissue macrophages, which arerequired for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-inducedthermogenic responses, suggesting a role in metabolic adaptationsto cold temperatures (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for METRNL_UBC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_METRNL_ENST00000320095_chr17_81052121_-_UBC_ENST00000536769_chr12_125396659_+_0aa

>In-frame_METRNL_ENST00000320095_chr17_81052121_-_UBC_ENST00000538617_chr12_125396659_+_0aa

>In-frame_METRNL_ENST00000320095_chr17_81052121_-_UBC_ENST00000339647_chr12_125396659_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_METRNL_ENST00000320095_chr17_81052121_-_UBC_ENST00000536769_chr12_125396659_+_0nt

>In-frame_METRNL_ENST00000320095_chr17_81052121_-_UBC_ENST00000538617_chr12_125396659_+_0nt

>In-frame_METRNL_ENST00000320095_chr17_81052121_-_UBC_ENST00000339647_chr12_125396659_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_METRNL_ENST00000320095_chr17_81052121_-_UBC_ENST00000536769_chr12_125396659_+_0nt

>In-frame_METRNL_ENST00000320095_chr17_81052121_-_UBC_ENST00000538617_chr12_125396659_+_0nt

>In-frame_METRNL_ENST00000320095_chr17_81052121_-_UBC_ENST00000339647_chr12_125396659_+_0nt


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FusionGenePPI for METRNL_UBC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for METRNL_UBC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for METRNL_UBC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMETRNLC0023893Liver Cirrhosis, Experimental1CTD_human