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Fusion gene ID: 2165 |
FusionGeneSummary for APLN_APLN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APLN_APLN | Fusion gene ID: 2165 | Hgene | Tgene | Gene symbol | APLN | APLN | Gene ID | 8862 | 8862 |
| Gene name | apelin | apelin | |
| Synonyms | APEL|XNPEP2 | APEL|XNPEP2 | |
| Cytomap | Xq26.1 | Xq26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | apelinAGTRL1 ligandAPJ endogenous ligand | apelinAGTRL1 ligandAPJ endogenous ligand | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9ULZ1 | Q9ULZ1 | |
| Ensembl transtripts involved in fusion gene | ENST00000307484, ENST00000429967, ENST00000427399, | ENST00000307484, ENST00000429967, ENST00000427399, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: APLN [Title/Abstract] AND APLN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | APLN | GO:0060183 | apelin receptor signaling pathway | 11359874 |
| Hgene | APLN | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 23263626 |
| Hgene | APLN | GO:1904022 | positive regulation of G-protein coupled receptor internalization | 11359874 |
| Hgene | APLN | GO:1905564 | positive regulation of vascular endothelial cell proliferation | 23263626 |
| Tgene | APLN | GO:0060183 | apelin receptor signaling pathway | 11359874 |
| Tgene | APLN | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 23263626 |
| Tgene | APLN | GO:1904022 | positive regulation of G-protein coupled receptor internalization | 11359874 |
| Tgene | APLN | GO:1905564 | positive regulation of vascular endothelial cell proliferation | 23263626 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG009509 | APLN | chrX | 128781395 | - | APLN | chrX | 128781865 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000307484 | ENST00000307484 | APLN | chrX | 128781395 | - | APLN | chrX | 128781865 | - |
| intron-3UTR | ENST00000307484 | ENST00000429967 | APLN | chrX | 128781395 | - | APLN | chrX | 128781865 | - |
| intron-3UTR | ENST00000307484 | ENST00000427399 | APLN | chrX | 128781395 | - | APLN | chrX | 128781865 | - |
| intron-3UTR | ENST00000429967 | ENST00000307484 | APLN | chrX | 128781395 | - | APLN | chrX | 128781865 | - |
| intron-3UTR | ENST00000429967 | ENST00000429967 | APLN | chrX | 128781395 | - | APLN | chrX | 128781865 | - |
| intron-3UTR | ENST00000429967 | ENST00000427399 | APLN | chrX | 128781395 | - | APLN | chrX | 128781865 | - |
| intron-3UTR | ENST00000427399 | ENST00000307484 | APLN | chrX | 128781395 | - | APLN | chrX | 128781865 | - |
| intron-3UTR | ENST00000427399 | ENST00000429967 | APLN | chrX | 128781395 | - | APLN | chrX | 128781865 | - |
| intron-3UTR | ENST00000427399 | ENST00000427399 | APLN | chrX | 128781395 | - | APLN | chrX | 128781865 | - |
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FusionProtFeatures for APLN_APLN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APLN | APLN |
| Endogenous ligand for the apelin receptor (APLNR)(PubMed:10525157). Drives internalization of the apelin receptor(By similarity). Apelin-36 dissociates more hardly than(pyroglu)apelin-13 from APLNR (By similarity). Hormone involved inthe regulation of cardiac precursor cell movements duringgastrulation and heart morphogenesis (By similarity). Has aninhibitory effect on cytokine production in response to T-cellreceptor/CD3 cross-linking; the oral intake of apelin in thecolostrum and the milk might therefore modulate immune responsesin neonates (By similarity). Plays a role in early coronary bloodvessels formation (By similarity). Mediates myocardialcontractility in an ERK1/2-dependent manner (By similarity). Mayalso have a role in the central control of body fluid homeostasisby influencing vasopressin release and drinking behavior (Bysimilarity). {ECO:0000250|UniProtKB:Q4TTN8,ECO:0000250|UniProtKB:Q9R0R3, ECO:0000250|UniProtKB:Q9R0R4,ECO:0000269|PubMed:10525157}. (Microbial infection) Endogenous ligand for the apelinreceptor (APLNR), an alternative coreceptor with CD4 for HIV-1infection (PubMed:11090199). Inhibits HIV-1 entry in cellscoexpressing CD4 and APLNR (PubMed:11090199). Apelin-36 has agreater inhibitory activity on HIV infection than other syntheticapelin derivatives (PubMed:11090199).{ECO:0000269|PubMed:11090199}. | Endogenous ligand for the apelin receptor (APLNR)(PubMed:10525157). Drives internalization of the apelin receptor(By similarity). Apelin-36 dissociates more hardly than(pyroglu)apelin-13 from APLNR (By similarity). Hormone involved inthe regulation of cardiac precursor cell movements duringgastrulation and heart morphogenesis (By similarity). Has aninhibitory effect on cytokine production in response to T-cellreceptor/CD3 cross-linking; the oral intake of apelin in thecolostrum and the milk might therefore modulate immune responsesin neonates (By similarity). Plays a role in early coronary bloodvessels formation (By similarity). Mediates myocardialcontractility in an ERK1/2-dependent manner (By similarity). Mayalso have a role in the central control of body fluid homeostasisby influencing vasopressin release and drinking behavior (Bysimilarity). {ECO:0000250|UniProtKB:Q4TTN8,ECO:0000250|UniProtKB:Q9R0R3, ECO:0000250|UniProtKB:Q9R0R4,ECO:0000269|PubMed:10525157}. (Microbial infection) Endogenous ligand for the apelinreceptor (APLNR), an alternative coreceptor with CD4 for HIV-1infection (PubMed:11090199). Inhibits HIV-1 entry in cellscoexpressing CD4 and APLNR (PubMed:11090199). Apelin-36 has agreater inhibitory activity on HIV infection than other syntheticapelin derivatives (PubMed:11090199).{ECO:0000269|PubMed:11090199}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for APLN_APLN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for APLN_APLN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for APLN_APLN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for APLN_APLN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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