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Fusion gene ID: 21644 |
FusionGeneSummary for MEMO1_MCU |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MEMO1_MCU | Fusion gene ID: 21644 | Hgene | Tgene | Gene symbol | MEMO1 | MCU | Gene ID | 51072 | 90550 |
| Gene name | mediator of cell motility 1 | mitochondrial calcium uniporter | |
| Synonyms | C2orf4|CGI-27|MEMO|NS5ATP7 | C10orf42|CCDC109A|HsMCU | |
| Cytomap | 2p22.3 | 10q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein MEMO1C21orf19-like proteinHCV NS5A-transactivated protein 7hepatitis C virus NS5A-transactivated protein 7mediator of ErbB2-driven cell motility 1 | calcium uniporter protein, mitochondrialcoiled-coil domain-containing protein 109A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y316 | Q8NE86 | |
| Ensembl transtripts involved in fusion gene | ENST00000295065, ENST00000379383, ENST00000404530, ENST00000490459, ENST00000426310, ENST00000407893, | ENST00000373053, ENST00000357157, ENST00000536019, ENST00000605416, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 5 X 1 X 4=20 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/20*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MEMO1 [Title/Abstract] AND MCU [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MCU | GO:0006851 | mitochondrial calcium ion transmembrane transport | 21685888|24560927 |
| Tgene | MCU | GO:0019722 | calcium-mediated signaling | 21685886|21685888 |
| Tgene | MCU | GO:0036444 | calcium import into the mitochondrion | 22925203 |
| Tgene | MCU | GO:0051259 | protein complex oligomerization | 21685886 |
| Tgene | MCU | GO:0051561 | positive regulation of mitochondrial calcium ion concentration | 21685888|24560927 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ACC | TCGA-OR-A5K5-01A | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000295065 | ENST00000373053 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| Frame-shift | ENST00000295065 | ENST00000357157 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| Frame-shift | ENST00000295065 | ENST00000536019 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| 5CDS-intron | ENST00000295065 | ENST00000605416 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| Frame-shift | ENST00000379383 | ENST00000373053 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| Frame-shift | ENST00000379383 | ENST00000357157 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| Frame-shift | ENST00000379383 | ENST00000536019 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| 5CDS-intron | ENST00000379383 | ENST00000605416 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| In-frame | ENST00000404530 | ENST00000373053 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| In-frame | ENST00000404530 | ENST00000357157 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| In-frame | ENST00000404530 | ENST00000536019 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| 5CDS-intron | ENST00000404530 | ENST00000605416 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| 5UTR-3CDS | ENST00000490459 | ENST00000373053 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| 5UTR-3CDS | ENST00000490459 | ENST00000357157 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| 5UTR-3CDS | ENST00000490459 | ENST00000536019 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| 5UTR-intron | ENST00000490459 | ENST00000605416 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| Frame-shift | ENST00000426310 | ENST00000373053 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| Frame-shift | ENST00000426310 | ENST00000357157 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| Frame-shift | ENST00000426310 | ENST00000536019 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| 5CDS-intron | ENST00000426310 | ENST00000605416 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| intron-3CDS | ENST00000407893 | ENST00000373053 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| intron-3CDS | ENST00000407893 | ENST00000357157 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| intron-3CDS | ENST00000407893 | ENST00000536019 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
| intron-intron | ENST00000407893 | ENST00000605416 | MEMO1 | chr2 | 32142995 | - | MCU | chr10 | 74594117 | + |
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FusionProtFeatures for MEMO1_MCU |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MEMO1 | MCU |
| May control cell migration by relaying extracellularchemotactic signals to the microtubule cytoskeleton. Mediator ofERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays animportant role in ERBB2-dependent stabilization of microtubules atthe cell cortex. It controls the localization of APC and CLASP2 tothe cell membrane, via the regulation of GSK3B activity. In turn,membrane-bound APC allows the localization of the MACF1 to thecell membrane, which is required for microtubule capture andstabilization. Is required for breast carcinoma cell migration.{ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}. | Mitochondrial inner membrane calcium uniporter thatmediates calcium uptake into mitochondria (PubMed:21685888,PubMed:21685886, PubMed:23101630, PubMed:22904319,PubMed:23178883, PubMed:22829870, PubMed:22822213,PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutesthe pore-forming and calcium-conducting subunit of the uniportercomplex (uniplex) (PubMed:23755363). Activity is regulated byMICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1increases MCU activity (PubMed:24560927, PubMed:26903221).Mitochondrial calcium homeostasis plays key roles in cellularphysiology and regulates cell bioenergetics, cytoplasmic calciumsignals and activation of cell death pathways. Involved inbuffering the amplitude of systolic calcium rises incardiomyocytes (PubMed:22822213). While dispensable for baselinehomeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight'response during acute stress: acts by mediating a rapid increaseof mitochondrial calcium in pacemaker cells (PubMed:25603276).participates in mitochondrial permeability transition duringischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulatingmitochondrial calcium uptake (PubMed:22904319, PubMed:22829870).Mitochondrial calcium uptake in skeletal muscle cells is involvedin muscle size in adults (By similarity). Regulates synapticvesicle endocytosis kinetics in central nerve terminal (Bysimilarity). Involved in antigen processing and presentation (Bysimilarity). {ECO:0000250|UniProtKB:Q3UMR5,ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888,ECO:0000269|PubMed:22822213, ECO:0000269|PubMed:22829870,ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630,ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:23755363,ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24560927,ECO:0000269|PubMed:25603276, ECO:0000269|PubMed:26341627,ECO:0000269|PubMed:26903221}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MEMO1_MCU |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MEMO1_ENST00000404530_chr2_32142995_-_MCU_ENST00000373053_chr10_74594117_+_447aa MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCAL SSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMERYTRGSLPGRIWELFIAALLCPLMMLQWFIKMGYL XYLXGYHPGVNAVSSHSSLSLTLLVYFYDNCKKRIGELTELLSIHQMVFALLLQQEXTSSSLMTLSWSLMTXHTTYDHQKETSXVMKMQQ RXMMXRHWSSNYTPHCALSSTSXTRKGSLLKDXRISKSSWLPWKRYELRLAEKLRRGPLWCYGVALPTWPHSLAFWPGLPGGNIPGTSWS >In-frame_MEMO1_ENST00000404530_chr2_32142995_-_MCU_ENST00000357157_chr10_74594117_+_426aa MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCAL SSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMERYTRGSLPGRIWELFIAALLCPLMMLQWFIKMGYL XYLXGYHPGVNAVSSHSSLSLTLLVYFYDNCKKRIGELTELLSIHQMVFALLLQQEXTSSSLMTLSWSLMTXHTTYDHQKEXRWGFAMLA RMVLNSXPQVIYLPQPPKVPRLXPYELRLAEKLRRGPLWCYGVALPTWPHSLAFWPGLPGGNIPGTSWSQXHTSSLMEVPWQCMHILXXH >In-frame_MEMO1_ENST00000404530_chr2_32142995_-_MCU_ENST00000536019_chr10_74594117_+_447aa MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCAL SSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMERYTRGSLPGRIWELFIAALLCPLMMLQWFIKMGYL XYLXGYHPGVNAVSSHSSLSLTLLVYFYDNCKKRIGELTELLSIHQMVFALLLQQEXTSSSLMTLSWSLMTXHTTYDHQKETSXVMKMQQ RXMMXRHWSSNYTPHCALSSTSXTRKGSLLKDXRISKSSWLPWKRYELRLAEKLRRGPLWCYGVALPTWPHSLAFWPGLPGGNIPGTSWS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MEMO1_ENST00000404530_chr2_32142995_-_MCU_ENST00000373053_chr10_74594117_+_1343nt ATGTCCAACCGAGTGGTCTGCCGAGAAGCCAGTCACGCCGGGAGCTGGTACACAGCCTCAGGACCGCAGCTGAATGCACAGCTAGAAGGT TGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCC CATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTT TCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAA CGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGGTACACCAGAGGA TCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAATGGGTTACCTG TGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTTTTACGACAAC TGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATAGACCTCCTCC TCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGACCTCTTAAGTCATGAAAATGCAGCAA CGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACACCACACTGTGCATTGAGCAGCACCAGTTAAACAAGGAAAGGGAGCTTATTG AAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGAAAAGGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGG TGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGACATCATGGAGC CAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACACGCCAGGAATATGTTTATCCAGAAGCCA GAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAGGATGCAATTG >In-frame_MEMO1_ENST00000404530_chr2_32142995_-_MCU_ENST00000357157_chr10_74594117_+_1280nt ATGTCCAACCGAGTGGTCTGCCGAGAAGCCAGTCACGCCGGGAGCTGGTACACAGCCTCAGGACCGCAGCTGAATGCACAGCTAGAAGGT TGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCC CATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTT TCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAA CGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGGTACACCAGAGGA TCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAATGGGTTACCTG TGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTTTTACGACAAC TGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATAGACCTCCTCC TCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGTAGAGATGGGGTTTTGCCATGTTGGCC AGAATGGTTTTGAACTCCTGACCTCAAGTTATCTACCTGCCTCAGCCTCCCAAAGTGCCGAGATTATAGCCGTACGAATTGAGATTAGCA GAAAAGCTGAGAAGAGGACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGT GGGAATATTCCTGGGACATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACAC GCCAGGAATATGTTTATCCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGA AATACAATCAACTCAAGGATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTGCCTCTCCGAC >In-frame_MEMO1_ENST00000404530_chr2_32142995_-_MCU_ENST00000536019_chr10_74594117_+_1343nt ATGTCCAACCGAGTGGTCTGCCGAGAAGCCAGTCACGCCGGGAGCTGGTACACAGCCTCAGGACCGCAGCTGAATGCACAGCTAGAAGGT TGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCC CATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTT TCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAA CGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGGTACACCAGAGGA TCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAATGGGTTACCTG TGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTTTTACGACAAC TGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATAGACCTCCTCC TCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGACCTCTTAAGTCATGAAAATGCAGCAA CGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACACCACACTGTGCATTGAGCAGCACCAGTTAAACAAGGAAAGGGAGCTTATTG AAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGAAAAGGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGG TGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGACATCATGGAGC CAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACACGCCAGGAATATGTTTATCCAGAAGCCA GAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAGGATGCAATTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MEMO1_ENST00000404530_chr2_32142995_-_MCU_ENST00000373053_chr10_74594117_+_3265nt ATGCTCAGTGGGCAGGACCCGTTAGAGTGGCGAGCGGCACAGGCACCAAGATGTCCAACCGAGTGGTCTGCCGAGAAGCCAGTCACGCCG GGAGCTGGTACACAGCCTCAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAG CCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAA TTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTC GTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTG AAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGGTACACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCAC TGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAATGGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCA GTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTTTTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTA TTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATAGACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATA CCACGTACGACCACCAAAAAGAGACCTCTTAAGTCATGAAAATGCAGCAACGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACAC CACACTGTGCATTGAGCAGCACCAGTTAAACAAGGAAAGGGAGCTTATTGAAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGA AAAGGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGG CATTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGACATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAAT GTATGCATATTTTGTAATGACACGCCAGGAATATGTTTATCCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAA AAAGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAGGATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATT ACAAGTACATCTGCCTCTCCGACAAATTGGTGAAAAAGATTGATCTGCAAAAAGCCTCTGAATCCTGGCAGAAGGAACACCTGTTTGCCT TTTTAATTAAAGCATTGCAGGTGGAAGCTGGGAGCCATGTGGGGGGTAGAGCGTTTTTACCTTTAATTATAAAACAAAAACAGAAAGGAT CTGAGGGAAGAAGGGAATGTTAAAACCTGAGGATCAGGCATTGTGGAATATAAGCTCAAAGGGCTTAGTGAATATTGTCTTAACCAAGTA TCTCAGTTTCTGGATGAAAATGATGCAGTTATATAGTTGAGAGATTCATAAAGAGAAAACAATGCTGGGGGTGTTCGTTTCTTGCATCTT CTTTGCAGAGTCAGCAAAAGAGTAACACACCAGCACCCCACTCGACTCTATTTGTTTTTAATTTAACTGTCCCTATTTTTGACATAGGAG TAAATAAATATACTAGAAAAGCAAATTCTCATGATATGCTAAAATATCATTAGCATTTATTTTAAATTGGACCCAGTCTCTGCAGAGTTA CCAGGAATCTTTCCTTCCAGCATCCCTTTACTGACCACCTACCTGTACCTCTTGGTTACACTCATTTTTTCCATTTGATAATTGGAACCA ACTTATAACTGTTTAATAATTGACACTTTAGATTATCTCTTAATACCTTCTTAAATGTCTATATATCCCAGTGCTCTGGATCAGTGTCTA AAAATCACTGGCAACACTGCATGAGGTTGTTGGTTTTGTTTTGTTTTATTAATTAGTCTTTCACAGGAGGAATAATTGCCCTCCTTTATA TACTTATCTATTGATAATCCCCTCTCCCTCCAGAACACAAATCAGAGGGAAAGGGGGTGTTCAGCTGTACTACCAAATCAGGAAGATGTA AGGTTTACAAATTGGCTAAGAATCATGGCTCTGTAGCCATTTCAACCAGAATAATTTTATTGCTAATCTGCTTTGTGTGACAGCATTCCA GGCCAGCCAGATGGGACTGCCTTGTCTGGAGGCTTTGTTCATCTCGAAGGACACACACTTCCACACTGTTTGTGAGCCCTCCCACCTCCA CAACTTCAGTTGTAAATCAAGTGTGTGGATCTCAAAGGGTGCAATTTATCTTTATATAGGAATACATTTCTAGGGCTTCCTTCAAGCCCA CTCTCTTCACCCTATTTTTTCTTATCTTAAATTGAGAGAAAGAGAATTAATCTTATACTTTGTCAAAACATTTTCTACCATATTTCCAGA TGACATCTGCGCTTGAAGAGTCAAAGGAATCTGTGTCTAATATCCTGTTTTTAACTGCTGTAGGGGCAGGATGGAAAGGATGATGGGGGC TGCCACACCACTGATTGGCCTTTTCTTTCACGTGATTCATCCTTCCTCATTGTGGCAAGGAGTTTCTTTCTCTTTTTCTTCCTCCTTTGG GATCATTGTGTATGAAAAGAAAAACTTTAAATGACAAACCCAGACTCCAGGTGCCTTGCAAAGGTTGAAGGCCAGCCAGGATTGCTGCTG CTGCTGCTACTCCTGCCAACACCCCTTTCATTGGCATGACGGAATGAAAGGATGCATGTCTCCACTTCCTGACCCTCCGCCCACTTCCTT CTCCCTCCACCACCCCCAGTCGTCAGCTCCTTCCCTCATTTATTTTTGTTAAGTTGTGTGAATTATTTTTAACCCATTTATCCTGTTTGT GCATAGGGTTTTTAAGAAGAAACAGCACAGTGCAACGAGCAAATCTTTTTGGGGTGTGTGGGAAGCAAGGGAGGGAGGACATGGAGAAAA GTTCTTTAAACAAATAGCAAACTATTGAACATGTGTAAAATCCTGTATCATTTATGAAATATGTATAAAAAGCAATGTACCTTCTGGAAC >In-frame_MEMO1_ENST00000404530_chr2_32142995_-_MCU_ENST00000357157_chr10_74594117_+_3202nt ATGCTCAGTGGGCAGGACCCGTTAGAGTGGCGAGCGGCACAGGCACCAAGATGTCCAACCGAGTGGTCTGCCGAGAAGCCAGTCACGCCG GGAGCTGGTACACAGCCTCAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAG CCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAA TTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTC GTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTG AAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGGTACACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCAC TGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAATGGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCA GTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTTTTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTA TTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATAGACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATA CCACGTACGACCACCAAAAAGAGTAGAGATGGGGTTTTGCCATGTTGGCCAGAATGGTTTTGAACTCCTGACCTCAAGTTATCTACCTGC CTCAGCCTCCCAAAGTGCCGAGATTATAGCCGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGGTGCTATGGGGTGG CCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGACATCATGGAGCCAGTAACATACTT CATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACACGCCAGGAATATGTTTATCCAGAAGCCAGAGACAGACAATA CTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAGGATGCAATTGCTCAGGCAGAAAT GGACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTGCCTCTCCGACAAATTGGTGAAAAAGATTGATCTGCAAAAAGCCTCTGAAT CCTGGCAGAAGGAACACCTGTTTGCCTTTTTAATTAAAGCATTGCAGGTGGAAGCTGGGAGCCATGTGGGGGGTAGAGCGTTTTTACCTT TAATTATAAAACAAAAACAGAAAGGATCTGAGGGAAGAAGGGAATGTTAAAACCTGAGGATCAGGCATTGTGGAATATAAGCTCAAAGGG CTTAGTGAATATTGTCTTAACCAAGTATCTCAGTTTCTGGATGAAAATGATGCAGTTATATAGTTGAGAGATTCATAAAGAGAAAACAAT GCTGGGGGTGTTCGTTTCTTGCATCTTCTTTGCAGAGTCAGCAAAAGAGTAACACACCAGCACCCCACTCGACTCTATTTGTTTTTAATT TAACTGTCCCTATTTTTGACATAGGAGTAAATAAATATACTAGAAAAGCAAATTCTCATGATATGCTAAAATATCATTAGCATTTATTTT AAATTGGACCCAGTCTCTGCAGAGTTACCAGGAATCTTTCCTTCCAGCATCCCTTTACTGACCACCTACCTGTACCTCTTGGTTACACTC ATTTTTTCCATTTGATAATTGGAACCAACTTATAACTGTTTAATAATTGACACTTTAGATTATCTCTTAATACCTTCTTAAATGTCTATA TATCCCAGTGCTCTGGATCAGTGTCTAAAAATCACTGGCAACACTGCATGAGGTTGTTGGTTTTGTTTTGTTTTATTAATTAGTCTTTCA CAGGAGGAATAATTGCCCTCCTTTATATACTTATCTATTGATAATCCCCTCTCCCTCCAGAACACAAATCAGAGGGAAAGGGGGTGTTCA GCTGTACTACCAAATCAGGAAGATGTAAGGTTTACAAATTGGCTAAGAATCATGGCTCTGTAGCCATTTCAACCAGAATAATTTTATTGC TAATCTGCTTTGTGTGACAGCATTCCAGGCCAGCCAGATGGGACTGCCTTGTCTGGAGGCTTTGTTCATCTCGAAGGACACACACTTCCA CACTGTTTGTGAGCCCTCCCACCTCCACAACTTCAGTTGTAAATCAAGTGTGTGGATCTCAAAGGGTGCAATTTATCTTTATATAGGAAT ACATTTCTAGGGCTTCCTTCAAGCCCACTCTCTTCACCCTATTTTTTCTTATCTTAAATTGAGAGAAAGAGAATTAATCTTATACTTTGT CAAAACATTTTCTACCATATTTCCAGATGACATCTGCGCTTGAAGAGTCAAAGGAATCTGTGTCTAATATCCTGTTTTTAACTGCTGTAG GGGCAGGATGGAAAGGATGATGGGGGCTGCCACACCACTGATTGGCCTTTTCTTTCACGTGATTCATCCTTCCTCATTGTGGCAAGGAGT TTCTTTCTCTTTTTCTTCCTCCTTTGGGATCATTGTGTATGAAAAGAAAAACTTTAAATGACAAACCCAGACTCCAGGTGCCTTGCAAAG GTTGAAGGCCAGCCAGGATTGCTGCTGCTGCTGCTACTCCTGCCAACACCCCTTTCATTGGCATGACGGAATGAAAGGATGCATGTCTCC ACTTCCTGACCCTCCGCCCACTTCCTTCTCCCTCCACCACCCCCAGTCGTCAGCTCCTTCCCTCATTTATTTTTGTTAAGTTGTGTGAAT TATTTTTAACCCATTTATCCTGTTTGTGCATAGGGTTTTTAAGAAGAAACAGCACAGTGCAACGAGCAAATCTTTTTGGGGTGTGTGGGA AGCAAGGGAGGGAGGACATGGAGAAAAGTTCTTTAAACAAATAGCAAACTATTGAACATGTGTAAAATCCTGTATCATTTATGAAATATG >In-frame_MEMO1_ENST00000404530_chr2_32142995_-_MCU_ENST00000536019_chr10_74594117_+_3263nt ATGCTCAGTGGGCAGGACCCGTTAGAGTGGCGAGCGGCACAGGCACCAAGATGTCCAACCGAGTGGTCTGCCGAGAAGCCAGTCACGCCG GGAGCTGGTACACAGCCTCAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAG CCATTATTGCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAA TTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTC GTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTG AAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAGGTACACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCAC TGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAATGGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCA GTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTTTTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTA TTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATAGACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATA CCACGTACGACCACCAAAAAGAGACCTCTTAAGTCATGAAAATGCAGCAACGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACAC CACACTGTGCATTGAGCAGCACCAGTTAAACAAGGAAAGGGAGCTTATTGAAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGA AAAGGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGG CATTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGACATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAAT GTATGCATATTTTGTAATGACACGCCAGGAATATGTTTATCCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAA AAAGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAGGATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATT ACAAGTACATCTGCCTCTCCGACAAATTGGTGAAAAAGATTGATCTGCAAAAAGCCTCTGAATCCTGGCAGAAGGAACACCTGTTTGCCT TTTTAATTAAAGCATTGCAGGTGGAAGCTGGGAGCCATGTGGGGGGTAGAGCGTTTTTACCTTTAATTATAAAACAAAAACAGAAAGGAT CTGAGGGAAGAAGGGAATGTTAAAACCTGAGGATCAGGCATTGTGGAATATAAGCTCAAAGGGCTTAGTGAATATTGTCTTAACCAAGTA TCTCAGTTTCTGGATGAAAATGATGCAGTTATATAGTTGAGAGATTCATAAAGAGAAAACAATGCTGGGGGTGTTCGTTTCTTGCATCTT CTTTGCAGAGTCAGCAAAAGAGTAACACACCAGCACCCCACTCGACTCTATTTGTTTTTAATTTAACTGTCCCTATTTTTGACATAGGAG TAAATAAATATACTAGAAAAGCAAATTCTCATGATATGCTAAAATATCATTAGCATTTATTTTAAATTGGACCCAGTCTCTGCAGAGTTA CCAGGAATCTTTCCTTCCAGCATCCCTTTACTGACCACCTACCTGTACCTCTTGGTTACACTCATTTTTTCCATTTGATAATTGGAACCA ACTTATAACTGTTTAATAATTGACACTTTAGATTATCTCTTAATACCTTCTTAAATGTCTATATATCCCAGTGCTCTGGATCAGTGTCTA AAAATCACTGGCAACACTGCATGAGGTTGTTGGTTTTGTTTTGTTTTATTAATTAGTCTTTCACAGGAGGAATAATTGCCCTCCTTTATA TACTTATCTATTGATAATCCCCTCTCCCTCCAGAACACAAATCAGAGGGAAAGGGGGTGTTCAGCTGTACTACCAAATCAGGAAGATGTA AGGTTTACAAATTGGCTAAGAATCATGGCTCTGTAGCCATTTCAACCAGAATAATTTTATTGCTAATCTGCTTTGTGTGACAGCATTCCA GGCCAGCCAGATGGGACTGCCTTGTCTGGAGGCTTTGTTCATCTCGAAGGACACACACTTCCACACTGTTTGTGAGCCCTCCCACCTCCA CAACTTCAGTTGTAAATCAAGTGTGTGGATCTCAAAGGGTGCAATTTATCTTTATATAGGAATACATTTCTAGGGCTTCCTTCAAGCCCA CTCTCTTCACCCTATTTTTTCTTATCTTAAATTGAGAGAAAGAGAATTAATCTTATACTTTGTCAAAACATTTTCTACCATATTTCCAGA TGACATCTGCGCTTGAAGAGTCAAAGGAATCTGTGTCTAATATCCTGTTTTTAACTGCTGTAGGGGCAGGATGGAAAGGATGATGGGGGC TGCCACACCACTGATTGGCCTTTTCTTTCACGTGATTCATCCTTCCTCATTGTGGCAAGGAGTTTCTTTCTCTTTTTCTTCCTCCTTTGG GATCATTGTGTATGAAAAGAAAAACTTTAAATGACAAACCCAGACTCCAGGTGCCTTGCAAAGGTTGAAGGCCAGCCAGGATTGCTGCTG CTGCTGCTACTCCTGCCAACACCCCTTTCATTGGCATGACGGAATGAAAGGATGCATGTCTCCACTTCCTGACCCTCCGCCCACTTCCTT CTCCCTCCACCACCCCCAGTCGTCAGCTCCTTCCCTCATTTATTTTTGTTAAGTTGTGTGAATTATTTTTAACCCATTTATCCTGTTTGT GCATAGGGTTTTTAAGAAGAAACAGCACAGTGCAACGAGCAAATCTTTTTGGGGTGTGTGGGAAGCAAGGGAGGGAGGACATGGAGAAAA GTTCTTTAAACAAATAGCAAACTATTGAACATGTGTAAAATCCTGTATCATTTATGAAATATGTATAAAAAGCAATGTACCTTCTGGAAC |
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FusionGenePPI for MEMO1_MCU |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MEMO1 | DISC1, ITGA4, REL, TRIM27, TACC1, TCF4, TRIP6, LZTS2, LNX1, RBM45, UBE3D, UPF1, ANKFY1, DICER1, DNAAF2, HMBOX1, WDR54, TARBP2, CFL2, AKR1A1, AKR1B1, APOA1BP, BPNT1, DSTN, GALK2, KYNU, NEDD8, RFK, SELENBP1, YKT6, CUL3, COPRS, CD93 | MCU | ICT1, ELAVL1, ABCC1, SLC38A2, SLC1A5, ERLIN2, COLEC10, GNAI2, NYX, NDUFA9, MYC, RAB7A, VAPA, GOLT1B, ZNF526, NDUFA4, ASPH, TOR1AIP2, EDEM2, SLC5A8, APLNR, SLC22A6, IRGC, PDCD1, SLC15A1, ARMC6, IL13RA2, SMDT1, EIF2B1, EIF2B2, EIF2B4, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MEMO1_MCU |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MEMO1_MCU |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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