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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21631

FusionGeneSummary for MEIS2_TRPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: MEIS2_TRPM1
Fusion gene ID: 21631
HgeneTgene
Gene symbol

MEIS2

TRPM1

Gene ID

4212

4308

Gene nameMeis homeobox 2transient receptor potential cation channel subfamily M member 1
SynonymsCPCMR|HsT18361|MRG1CSNB1C|LTRPC1|MLSN1
Cytomap

15q14

15q13.3

Type of geneprotein-codingprotein-coding
Descriptionhomeobox protein Meis2Meis homolog 2Meis1, myeloid ecotropic viral integration site 1 homolog 2Meis1-related gene 1TALE homeobox protein Meis2meis1-related protein 1transient receptor potential cation channel subfamily M member 1long transient receptor potential channel 1melastatin-1transient receptor potential melastatin family
Modification date2018052320180519
UniProtAcc

O14770

Q7Z4N2

Ensembl transtripts involved in fusion geneENST00000338564, ENST00000561208, 
ENST00000397624, ENST00000382766, 
ENST00000444725, ENST00000340545, 
ENST00000559085, ENST00000219869, 
ENST00000557796, ENST00000397620, 
ENST00000424352, ENST00000559561, 
ENST00000559408, 
ENST00000397795, 
ENST00000256552, ENST00000542188, 
ENST00000559179, 
Fusion gene scores* DoF score5 X 3 X 5=755 X 4 X 4=80
# samples 55
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MEIS2 [Title/Abstract] AND TRPM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMEIS2

GO:0045931

positive regulation of mitotic cell cycle

26512644

HgeneMEIS2

GO:0045944

positive regulation of transcription by RNA polymerase II

10764806

HgeneMEIS2

GO:0110024

positive regulation of cardiac muscle myoblast proliferation

26512644

TgeneTRPM1

GO:0060402

calcium ion transport into cytosol

23452348


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-4280-01AMEIS2chr15

37329015

-TRPM1chr15

31369187

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000338564ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000338564ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000338564ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000338564ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000561208ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000561208ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000561208ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000561208ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000397624ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000397624ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000397624ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000397624ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000382766ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000382766ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000382766ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000382766ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000444725ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000444725ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000444725ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000444725ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000340545ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000340545ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000340545ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000340545ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000559085ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000559085ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000559085ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000559085ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000219869ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000219869ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000219869ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000219869ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000557796ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000557796ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000557796ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000557796ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000397620ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000397620ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000397620ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000397620ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000424352ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000424352ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000424352ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000424352ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000559561ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000559561ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000559561ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
5CDS-5UTRENST00000559561ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-
intron-5UTRENST00000559408ENST00000397795MEIS2chr15

37329015

-TRPM1chr15

31369187

-
intron-5UTRENST00000559408ENST00000256552MEIS2chr15

37329015

-TRPM1chr15

31369187

-
intron-5UTRENST00000559408ENST00000542188MEIS2chr15

37329015

-TRPM1chr15

31369187

-
intron-5UTRENST00000559408ENST00000559179MEIS2chr15

37329015

-TRPM1chr15

31369187

-

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FusionProtFeatures for MEIS2_TRPM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEIS2

O14770

TRPM1

Q7Z4N2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MEIS2_TRPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MEIS2_TRPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MEIS2PBX1, TRIM25, ZNHIT3, SP1, APP, SOX2, SQSTM1, ARNT2, DGCR6, CRBN, ANXA1, MEIS2, OSGIN1, C1orf94, LINC00238, LMX1B, MAB21L1, MEIS3, MEIS1, PBX2, PBX4, PBX3, GNB4, PIGL, MAB21L2, FAM222A, CCDC120, C16orf71, TMOD3, ACTBTRPM1TRPM1, BCOR, NANOG, POU5F1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MEIS2_TRPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MEIS2_TRPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTRPM1C2750747NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1C3UNIPROT
TgeneTRPM1C0036341Schizophrenia1PSYGENET