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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21606

FusionGeneSummary for MEG3_MADD

check button Fusion gene summary
Fusion gene informationFusion gene name: MEG3_MADD
Fusion gene ID: 21606
HgeneTgene
Gene symbol

MEG3

MADD

Gene ID

55384

8567

Gene namematernally expressed 3MAP kinase activating death domain
SynonymsFP504|GTL2|LINC00023|NCRNA00023|PRO0518|PRO2160|onco-lncRNA-83|prebp1DENN|IG20|RAB3GEP
Cytomap

14q32.2

11p11.2

Type of genencRNAprotein-coding
DescriptionVery putative protein from MEG3 locuslong intergenic non-protein coding RNA 23maternally expressed 3 (non-protein coding)MAP kinase-activating death domain proteinRab3 GDP/GTP exchange factordifferentially expressed in normal and neoplastic cellsinsulinoma glucagonoma clone 20
Modification date2018051720180523
UniProtAcc

Q8WXG6

Ensembl transtripts involved in fusion geneENST00000516892, ENST00000342922, 
ENST00000402799, ENST00000311027, 
ENST00000406482, ENST00000407859, 
ENST00000349238, ENST00000395344, 
ENST00000395336, ENST00000402192, 
ENST00000405573, ENST00000489415, 
Fusion gene scores* DoF score9 X 15 X 3=4054 X 5 X 3=60
# samples 185
** MAII scorelog2(18/405*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MEG3 [Title/Abstract] AND MADD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMADD

GO:0032483

regulation of Rab protein signal transduction

20937701

TgeneMADD

GO:2001236

regulation of extrinsic apoptotic signaling pathway

11577081


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV707488MEG3chr14

101295418

+MADDchr11

47351092

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000516892ENST00000342922MEG3chr14

101295418

+MADDchr11

47351092

+
intron-3UTRENST00000516892ENST00000402799MEG3chr14

101295418

+MADDchr11

47351092

+
intron-3UTRENST00000516892ENST00000311027MEG3chr14

101295418

+MADDchr11

47351092

+
intron-3UTRENST00000516892ENST00000406482MEG3chr14

101295418

+MADDchr11

47351092

+
intron-3UTRENST00000516892ENST00000407859MEG3chr14

101295418

+MADDchr11

47351092

+
intron-3UTRENST00000516892ENST00000349238MEG3chr14

101295418

+MADDchr11

47351092

+
intron-intronENST00000516892ENST00000395344MEG3chr14

101295418

+MADDchr11

47351092

+
intron-3UTRENST00000516892ENST00000395336MEG3chr14

101295418

+MADDchr11

47351092

+
intron-3UTRENST00000516892ENST00000402192MEG3chr14

101295418

+MADDchr11

47351092

+
intron-intronENST00000516892ENST00000405573MEG3chr14

101295418

+MADDchr11

47351092

+
intron-intronENST00000516892ENST00000489415MEG3chr14

101295418

+MADDchr11

47351092

+

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FusionProtFeatures for MEG3_MADD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEG3

MADD

Q8WXG6

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MEG3_MADD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MEG3_MADD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MEG3_MADD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MEG3_MADD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource