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Fusion gene ID: 21596

FusionGeneSummary for MEF2D_CD55

Fusion gene summary

Fusion gene information	Fusion gene name: MEF2D_CD55
	Fusion gene ID: 21596
		Hgene	Tgene
	Gene symbol	MEF2D	CD55
	Gene ID	4209	1604
	Gene name	myocyte enhancer factor 2D	CD55 molecule (Cromer blood group)
	Synonyms	-	CHAPLE\|CR\|CROM\|DAF\|TC
	Cytomap	1q22	1q32.2
	Type of gene	protein-coding	protein-coding
	Description	myocyte-specific enhancer factor 2DMADS box transcription enhancer factor 2, polypeptide D	complement decay-accelerating factorCD55 antigenCD55 molecule, decay accelerating factor for complement (Cromer blood group)Cromer blood group antigen
	Modification date	20180523	20180519
	UniProtAcc	Q14814	P08174
	Ensembl transtripts involved in fusion gene	ENST00000464356, ENST00000348159, ENST00000353795, ENST00000340875, ENST00000368240, ENST00000360595,	ENST00000367064, ENST00000367063, ENST00000391921, ENST00000367067, ENST00000314754, ENST00000391920, ENST00000367062, ENST00000367065, ENST00000465534,
Fusion gene scores	* DoF score	9 X 5 X 6=270	4 X 4 X 2=32
	# samples	8	4
	** MAII score	log2(8/270*10)=-1.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: MEF2D [Title/Abstract] AND CD55 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MEF2D	GO:0045944	positive regulation of transcription by RNA polymerase II	20590529
Tgene	CD55	GO:0007204	positive regulation of cytosolic calcium ion concentration	8223854
Tgene	CD55	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	12731067
Tgene	CD55	GO:0035743	CD4-positive, alpha-beta T cell cytokine production	16818763
Tgene	CD55	GO:0045916	negative regulation of complement activation	6211481
Tgene	CD55	GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation	16818763
Tgene	CD55	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	16818763

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-DX-A7EI-01A	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000464356	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-intron	ENST00000464356	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-intron	ENST00000464356	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3CDS	ENST00000348159	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000348159	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000348159	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3CDS	ENST00000353795	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000353795	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000353795	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3CDS	ENST00000340875	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000340875	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000340875	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3CDS	ENST00000368240	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000368240	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000368240	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3CDS	ENST00000360595	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-intron	ENST00000360595	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-intron	ENST00000360595	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+

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FusionProtFeatures for MEF2D_CD55

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MEF2D Q14814	CD55 P08174
Transcriptional activator which binds specifically tothe MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediatescellular functions not only in skeletal and cardiac muscledevelopment, but also in neuronal differentiation and survival.Plays diverse roles in the control of cell growth, survival andapoptosis via p38 MAPK signaling in muscle-specific and/or growthfactor-related transcription. Plays a critical role in theregulation of neuronal apoptosis (By similarity). {ECO:0000250,ECO:0000269\|PubMed:10849446, ECO:0000269\|PubMed:11904443,ECO:0000269\|PubMed:12691662, ECO:0000269\|PubMed:15743823,ECO:0000269\|PubMed:15834131}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for MEF2D_CD55

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MEF2D_CD55

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
MEF2D	YWHAQ, HDAC5, HDAC4, EP300, CABIN1, NFATC2, SP1, MAPK7, MEF2A, SNCA, CARM1, PRMT5, MAPK14, COPS5, HDAC3, KAT2B, SENP3, PRKACA, ASH2L, MEN1, RBBP5, KMT2D, HIRA, HDAC1, ASCL1, APP, CDK6, SHMT2, MOV10, NXF1, SKP2, FUS, XPO1, JUN, DNMT3L, MEF2B	CD55	CD55, NDUFB7, MPV17, MAN2A1, RAB31, PTCD3, SLC2A1, MRPL4, GNAI3, INF2, ZMPSTE24, PTRH2, S100A10, SYNJ2BP, TIMM50, SLC12A4, NDUFS7, ATP6V1E1, SLC25A24, PICALM, CHI3L1, C6orf120, LCK, C2, TRIM25

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MEF2D_CD55

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	CD55	P08174	DB00446	Chloramphenicol	Complement decay-accelerating factor	small molecule	approved\|vet_approved

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RelatedDiseases for MEF2D_CD55

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MEF2D	C0338480	Common Migraine	1	CTD_human
Tgene	CD55	C0014175	Endometriosis	1	CTD_human
Tgene	CD55	C0236733	Amphetamine-Related Disorders	1	CTD_human

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Fusion gene ID: 21596

FusionGeneSummary for MEF2D_CD55

FusionProtFeatures for MEF2D_CD55

FusionGeneSequence for MEF2D_CD55

FusionGenePPI for MEF2D_CD55

RelatedDrugs for MEF2D_CD55

RelatedDiseases for MEF2D_CD55