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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21589

FusionGeneSummary for MEF2A_LRRC28

check button Fusion gene summary
Fusion gene informationFusion gene name: MEF2A_LRRC28
Fusion gene ID: 21589
HgeneTgene
Gene symbol

MEF2A

LRRC28

Gene ID

4205

123355

Gene namemyocyte enhancer factor 2Aleucine rich repeat containing 28
SynonymsADCAD1|RSRFC4|RSRFC9|mef2-
Cytomap

15q26.3

15q26.3

Type of geneprotein-codingprotein-coding
Descriptionmyocyte-specific enhancer factor 2AMADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)serum response factor-like protein 1leucine-rich repeat-containing protein 28
Modification date2018052320180519
UniProtAcc

Q02078

Q86X40

Ensembl transtripts involved in fusion geneENST00000453228, ENST00000354410, 
ENST00000558856, ENST00000558812, 
ENST00000338042, ENST00000557785, 
ENST00000449277, ENST00000557942, 
ENST00000558879, ENST00000301981, 
ENST00000422500, ENST00000442993, 
ENST00000447360, ENST00000331450, 
ENST00000559399, 
Fusion gene scores* DoF score5 X 6 X 4=1205 X 5 X 5=125
# samples 66
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MEF2A [Title/Abstract] AND LRRC28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMEF2A

GO:0000122

negative regulation of transcription by RNA polymerase II

16484498

HgeneMEF2A

GO:0000165

MAPK cascade

9858528

HgeneMEF2A

GO:0006351

transcription, DNA-templated

16043483

HgeneMEF2A

GO:0010613

positive regulation of cardiac muscle hypertrophy

24161931

HgeneMEF2A

GO:0045944

positive regulation of transcription by RNA polymerase II

7760790|9858528|10748098|15466416|20590529|21468593

HgeneMEF2A

GO:0071277

cellular response to calcium ion

16484498


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-X6-A7WC-01AMEF2Achr15

100138716

+LRRC28chr15

99926235

+
TCGARVUCECTCGA-PG-A5BC-01AMEF2Achr15

100215663

+LRRC28chr15

99892574

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000453228ENST00000558879MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000453228ENST00000301981MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000453228ENST00000422500MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000453228ENST00000442993MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000453228ENST00000447360MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000453228ENST00000331450MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000453228ENST00000559399MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-3CDSENST00000354410ENST00000558879MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-3CDSENST00000354410ENST00000301981MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-3CDSENST00000354410ENST00000422500MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000354410ENST00000442993MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000354410ENST00000447360MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000354410ENST00000331450MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000354410ENST00000559399MEF2Achr15

100138716

+LRRC28chr15

99926235

+
3UTR-3CDSENST00000558856ENST00000558879MEF2Achr15

100138716

+LRRC28chr15

99926235

+
3UTR-3CDSENST00000558856ENST00000301981MEF2Achr15

100138716

+LRRC28chr15

99926235

+
3UTR-3CDSENST00000558856ENST00000422500MEF2Achr15

100138716

+LRRC28chr15

99926235

+
3UTR-intronENST00000558856ENST00000442993MEF2Achr15

100138716

+LRRC28chr15

99926235

+
3UTR-intronENST00000558856ENST00000447360MEF2Achr15

100138716

+LRRC28chr15

99926235

+
3UTR-intronENST00000558856ENST00000331450MEF2Achr15

100138716

+LRRC28chr15

99926235

+
3UTR-intronENST00000558856ENST00000559399MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000558812ENST00000558879MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000558812ENST00000301981MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000558812ENST00000422500MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000558812ENST00000442993MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000558812ENST00000447360MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000558812ENST00000331450MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000558812ENST00000559399MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000338042ENST00000558879MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000338042ENST00000301981MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000338042ENST00000422500MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000338042ENST00000442993MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000338042ENST00000447360MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000338042ENST00000331450MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000338042ENST00000559399MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-3CDSENST00000557785ENST00000558879MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-3CDSENST00000557785ENST00000301981MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-3CDSENST00000557785ENST00000422500MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000557785ENST00000442993MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000557785ENST00000447360MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000557785ENST00000331450MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000557785ENST00000559399MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000449277ENST00000558879MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000449277ENST00000301981MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-3CDSENST00000449277ENST00000422500MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000449277ENST00000442993MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000449277ENST00000447360MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000449277ENST00000331450MEF2Achr15

100138716

+LRRC28chr15

99926235

+
intron-intronENST00000449277ENST00000559399MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-3CDSENST00000557942ENST00000558879MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-3CDSENST00000557942ENST00000301981MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-3CDSENST00000557942ENST00000422500MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000557942ENST00000442993MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000557942ENST00000447360MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000557942ENST00000331450MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5UTR-intronENST00000557942ENST00000559399MEF2Achr15

100138716

+LRRC28chr15

99926235

+
5CDS-intronENST00000453228ENST00000558879MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000453228ENST00000301981MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000453228ENST00000422500MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000453228ENST00000442993MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000453228ENST00000447360MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000453228ENST00000331450MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000453228ENST00000559399MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000354410ENST00000558879MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000354410ENST00000301981MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000354410ENST00000422500MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000354410ENST00000442993MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000354410ENST00000447360MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000354410ENST00000331450MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000354410ENST00000559399MEF2Achr15

100215663

+LRRC28chr15

99892574

+
intron-intronENST00000558856ENST00000558879MEF2Achr15

100215663

+LRRC28chr15

99892574

+
intron-intronENST00000558856ENST00000301981MEF2Achr15

100215663

+LRRC28chr15

99892574

+
intron-intronENST00000558856ENST00000422500MEF2Achr15

100215663

+LRRC28chr15

99892574

+
intron-3UTRENST00000558856ENST00000442993MEF2Achr15

100215663

+LRRC28chr15

99892574

+
intron-3UTRENST00000558856ENST00000447360MEF2Achr15

100215663

+LRRC28chr15

99892574

+
intron-intronENST00000558856ENST00000331450MEF2Achr15

100215663

+LRRC28chr15

99892574

+
intron-intronENST00000558856ENST00000559399MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000558812ENST00000558879MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000558812ENST00000301981MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000558812ENST00000422500MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000558812ENST00000442993MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000558812ENST00000447360MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000558812ENST00000331450MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000558812ENST00000559399MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000338042ENST00000558879MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000338042ENST00000301981MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000338042ENST00000422500MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000338042ENST00000442993MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000338042ENST00000447360MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000338042ENST00000331450MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000338042ENST00000559399MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000557785ENST00000558879MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000557785ENST00000301981MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000557785ENST00000422500MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000557785ENST00000442993MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000557785ENST00000447360MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000557785ENST00000331450MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000557785ENST00000559399MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000449277ENST00000558879MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000449277ENST00000301981MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000449277ENST00000422500MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000449277ENST00000442993MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000449277ENST00000447360MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000449277ENST00000331450MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000449277ENST00000559399MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000557942ENST00000558879MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000557942ENST00000301981MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000557942ENST00000422500MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000557942ENST00000442993MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-3UTRENST00000557942ENST00000447360MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000557942ENST00000331450MEF2Achr15

100215663

+LRRC28chr15

99892574

+
5CDS-intronENST00000557942ENST00000559399MEF2Achr15

100215663

+LRRC28chr15

99892574

+

Top

FusionProtFeatures for MEF2A_LRRC28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEF2A

Q02078

LRRC28

Q86X40


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MEF2A_LRRC28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MEF2A_LRRC28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MEF2AVGLL4, HDAC4, HDAC9, THRA, EP300, HDAC5, SMAD2, MAPK14, ASCL1, MYOG, MAPK7, MEF2D, ACTN4, HDAC7, HDAC1, HNRNPA1, UBE2I, PHB2, ERBB2IP, DDB1, NDUFB9, GNB2, GNG12, TBP, TAF8, HDAC3, HAND1, XPO1, KLC4, JUN, ATF3, ATF7, CABIN1, HIST1H2BA, MEF2C, HIRA, REV3L, SH2B1, HIST1H2BC, HIST3H3, JUND, CCDC15, MAPKAPK3, SETX, TTLL7, ZCWPW1, ITGB1, MEF2B, XYLT1, DNMT3L, TSR3LRRC28HSPD1, HSP90AB4P, HSPA1B, HSPA8, HSPA6, HSPA1L, CCT7, CUL5, NFATC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MEF2A_LRRC28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MEF2A_LRRC28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMEF2AC0033975Psychotic Disorders1PSYGENET
HgeneMEF2AC0349204Nonorganic psychosis1PSYGENET
TgeneLRRC28C0023893Liver Cirrhosis, Experimental1CTD_human