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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21586

FusionGeneSummary for MED9_NT5M

check button Fusion gene summary
Fusion gene informationFusion gene name: MED9_NT5M
Fusion gene ID: 21586
HgeneTgene
Gene symbol

MED9

NT5M

Gene ID

55090

56953

Gene namemediator complex subunit 95',3'-nucleotidase, mitochondrial
SynonymsMED25dNT-2|dNT2|mdN
Cytomap

17p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 9mediator of RNA polymerase II transcription, subunit 9 homologmediator subunit 255'(3')-deoxyribonucleotidase, mitochondrial5' nucleotidase, mitochondrial5(3)-deoxyribonucleotidasedeoxy-5'-nucleotidase 2mitochondrial 5' nucleotidase
Modification date2018052320180519
UniProtAcc

Q9NWA0

Q9NPB1

Ensembl transtripts involved in fusion geneENST00000268711, ENST00000580462, 
ENST00000585041, 
ENST00000389022, 
ENST00000582909, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: MED9 [Title/Abstract] AND NT5M [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-DD-AAE4-01AMED9chr17

17380579

+NT5Mchr17

17248108

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000268711ENST00000389022MED9chr17

17380579

+NT5Mchr17

17248108

+
5CDS-3UTRENST00000268711ENST00000582909MED9chr17

17380579

+NT5Mchr17

17248108

+
Frame-shiftENST00000580462ENST00000389022MED9chr17

17380579

+NT5Mchr17

17248108

+
5CDS-3UTRENST00000580462ENST00000582909MED9chr17

17380579

+NT5Mchr17

17248108

+
3UTR-3CDSENST00000585041ENST00000389022MED9chr17

17380579

+NT5Mchr17

17248108

+
3UTR-3UTRENST00000585041ENST00000582909MED9chr17

17380579

+NT5Mchr17

17248108

+

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FusionProtFeatures for MED9_NT5M


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED9

Q9NWA0

NT5M

Q9NPB1

Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and soprotects mitochondrial DNA replication from excess dTTP. Has onlymarginal activity towards dIMP and dGMP.{ECO:0000269|PubMed:10899995}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MED9_NT5M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MED9_NT5M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MED9MED10, MED13L, MED13, MED12, MED14, MED23, MED15, MED24, MED16, MED25, MED17, MED26, CDK8, CDK19, MED27, MED4, MED19, MED6, MED7, MED8, MED18, MED20, MED29, MED30, MED28, MED21, MED22, MED11, MED31, MED1, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2J, ZC3H13, OBFC1, APP, FBXW7, ESR1, CCNC, NRGN, TCL1B, SPAG9, CARM1NT5MPTTG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MED9_NT5M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MED9_NT5M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource