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Fusion gene ID: 21567 |
FusionGeneSummary for MED26_SLC1A6 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MED26_SLC1A6 | Fusion gene ID: 21567 | Hgene | Tgene | Gene symbol | MED26 | SLC1A6 | Gene ID | 9441 | 6511 |
Gene name | mediator complex subunit 26 | solute carrier family 1 member 6 | |
Synonyms | CRSP7|CRSP70 | EAAT4 | |
Cytomap | 19p13.11 | 19p13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | mediator of RNA polymerase II transcription subunit 26ARC70CRSP complex subunit 7activator-recruited cofactor 70 kDa componentcofactor required for Sp1 transcriptional activation subunit 7cofactor required for Sp1 transcriptional activation, subunit | excitatory amino acid transporter 4sodium-dependent glutamate/aspartate transportersolute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O95402 | P48664 | |
Ensembl transtripts involved in fusion gene | ENST00000263390, | ENST00000430939, ENST00000221742, ENST00000600144, ENST00000598504, ENST00000544886, | |
Fusion gene scores | * DoF score | 15 X 6 X 10=900 | 7 X 3 X 7=147 |
# samples | 15 | 8 | |
** MAII score | log2(15/900*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MED26 [Title/Abstract] AND SLC1A6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MED26 | GO:0006357 | regulation of transcription by RNA polymerase II | 15989967 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-61-1728-01A | MED26 | chr19 | 16738683 | - | SLC1A6 | chr19 | 15083729 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000263390 | ENST00000430939 | MED26 | chr19 | 16738683 | - | SLC1A6 | chr19 | 15083729 | - |
In-frame | ENST00000263390 | ENST00000221742 | MED26 | chr19 | 16738683 | - | SLC1A6 | chr19 | 15083729 | - |
5CDS-5UTR | ENST00000263390 | ENST00000600144 | MED26 | chr19 | 16738683 | - | SLC1A6 | chr19 | 15083729 | - |
5CDS-5UTR | ENST00000263390 | ENST00000598504 | MED26 | chr19 | 16738683 | - | SLC1A6 | chr19 | 15083729 | - |
5CDS-5UTR | ENST00000263390 | ENST00000544886 | MED26 | chr19 | 16738683 | - | SLC1A6 | chr19 | 15083729 | - |
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FusionProtFeatures for MED26_SLC1A6 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MED26 | SLC1A6 |
Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpre-initiation complex with RNA polymerase II and the generaltranscription factors. | Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7791878). Functions as a symporter thattransports one amino acid molecule together with two or threeNa(+) ions and one proton, in parallel with the counter-transportof one K(+) ion. Mediates Cl(-) flux that is not coupled to aminoacid transport; this avoids the accumulation of negative chargesdue to aspartate and Na(+) symport (By similarity). Plays aredundant role in the rapid removal of released glutamate from thesynaptic cleft, which is essential for terminating thepostsynaptic action of glutamate (Probable).{ECO:0000250|UniProtKB:O35921, ECO:0000269|PubMed:7791878,ECO:0000305}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 371_401 | 68 | 565 | Intramembrane | Discontinuously helical |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 451_484 | 68 | 565 | Intramembrane | Discontinuously helical |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 388_390 | 68 | 565 | Region | Aspartate binding |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 468_472 | 68 | 565 | Region | Aspartate binding |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 133_153 | 68 | 565 | Transmembrane | Helical |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 262_285 | 68 | 565 | Transmembrane | Helical%3B Name%3D4 |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 295_322 | 68 | 565 | Transmembrane | Helical%3B Name%3D5 |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 344_365 | 68 | 565 | Transmembrane | Helical%3B Name%3D6 |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 411_437 | 68 | 565 | Transmembrane | Helical%3B Name%3D7 |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 498_519 | 68 | 565 | Transmembrane | Helical%3B Name%3D8 |
Tgene | >SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 99_119 | 68 | 565 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >MED26 | chr19:16738683 | chr19:15083729 | ENST00000263390 | - | 1 | 3 | 228_325 | 24 | 601 | Compositional bias | Note=Pro-rich |
Hgene | >MED26 | chr19:16738683 | chr19:15083729 | ENST00000263390 | - | 1 | 3 | 10_87 | 24 | 601 | Domain | TFIIS N-terminal |
Tgene | SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 1_55 | 68 | 565 | Topological domain | Cytoplasmic |
Tgene | SLC1A6 | chr19:16738683 | chr19:15083729 | ENST00000221742 | - | -1 | 9 | 56_76 | 68 | 565 | Transmembrane | Helical |
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FusionGeneSequence for MED26_SLC1A6 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MED26_ENST00000263390_chr19_16738683_-_SLC1A6_ENST00000430939_chr19_15083729_-_523aa MTAAPASPQQIRDRLLQAIDPQSNIDHEQPWQQPVPAGERPAAGPGGLAAAAAGKPAAESTAHAPAPADHDPRARAALPAPKRLHSADGQ RRGHWGQPGLCPAPISAHLPPDQVLLFSWRASDEDAADAGVTSHCLQPGHRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGA SMPPPFSVENGTSFLENVTRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIW YAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLE EGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITL >In-frame_MED26_ENST00000263390_chr19_16738683_-_SLC1A6_ENST00000221742_chr19_15083729_-_24aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MED26_ENST00000263390_chr19_16738683_-_SLC1A6_ENST00000430939_chr19_15083729_-_1569nt ATGACAGCGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACATAGACCATGAGCAGCCA TGGCAACAGCCTGTTCCTGCGGGAGAGCGGCCAGCGGCTGGGCCGGGTGGGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGC ACTGCGCACGCGCCTGCGCCTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTGCTGACGGTCAG CGCCGTGGTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAGCTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGA GCTTCTGATGAGGATGCTGCAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGAAATATGTTTCCACCAAACCTTGTGGAG GCCTGCTTCAAACAGTTCAAGACGCAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAACGGGTCTGAGCCGGGTGCC TCCATGCCTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTCACTCGGGCCTTGGGTACCCTGCAGGAGATGCTGAGC TTTGAGGAGACTGTACCCGTGCCTGGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGTGGCCTTTGGGCTGGTCATT GGTGGCATGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAATGAGGCTATTATGAGGCTGGTGGGCATCATTATCTGG TATGCACCTGTGGGCATCCTGTTCCTGATTGCTGGGAAGATTCTGGAGATGGAAGACATGGCCGTCCTGGGGGGTCAGCTGGGCATGTAC ACCCTGACCGTCATCGTGGGCCTGTTCCTCCATGCCGGCATTGTCCTTCCCCTCATCTACTTCCTCGTCACTCACCGGAACCCCTTCCCC TTCATTGGGGGCATGCTACAAGCCCTCATCACCGCTATGGGCACGTCTTCCAGCTCGGCAACGCTGCCCATCACCTTCCGCTGCCTGGAG GAGGGCCTGGGTGTGGACCGCCGCATCACCAGGTTCGTCCTGCCCGTGGGCGCCACGGTCAACATGGATGGCACTGCCCTCTACGAGGCC CTGGCTGCCATCTTCATTGCTCAAGTTAACAACTACGAGCTCAACCTGGGTCAGATCACAACCATCAGCATCACGGCCACAGCAGCCAGT GTTGGGGCTGCTGGCATCCCCCAGGCGGGTCTGGTCACCATGGTCATTGTGCTTACGTCGGTCGGCTTGCCCACGGAAGACATCACGCTC ATCATTGCCGTGGACTGGTTCCTTGACCGGCTTCGCACAATGACCAACGTACTGGGGGACTCAATTGGAGCGGCCGTCATCGAGCACTTG TCTCAGCGGGAGCTGGAGCTTCAGGAAGCTGAGCTTACCCTCCCCAGCCTGGGGAAACCCTACAAGTCCCTCATGGCACAGGAGAAGGGG >In-frame_MED26_ENST00000263390_chr19_16738683_-_SLC1A6_ENST00000221742_chr19_15083729_-_72nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MED26_ENST00000263390_chr19_16738683_-_SLC1A6_ENST00000430939_chr19_15083729_-_1993nt TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACATAGACCATGAGCAGCCATGGCAAC AGCCTGTTCCTGCGGGAGAGCGGCCAGCGGCTGGGCCGGGTGGGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGCACTGCGC ACGCGCCTGCGCCTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTGCTGACGGTCAGCGCCGTG GTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAGCTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGAGCTTCTG ATGAGGATGCTGCAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGAAATATGTTTCCACCAAACCTTGTGGAGGCCTGCT TCAAACAGTTCAAGACGCAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAACGGGTCTGAGCCGGGTGCCTCCATGC CTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTCACTCGGGCCTTGGGTACCCTGCAGGAGATGCTGAGCTTTGAGG AGACTGTACCCGTGCCTGGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGTGGCCTTTGGGCTGGTCATTGGTGGCA TGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAATGAGGCTATTATGAGGCTGGTGGGCATCATTATCTGGTATGCAC CTGTGGGCATCCTGTTCCTGATTGCTGGGAAGATTCTGGAGATGGAAGACATGGCCGTCCTGGGGGGTCAGCTGGGCATGTACACCCTGA CCGTCATCGTGGGCCTGTTCCTCCATGCCGGCATTGTCCTTCCCCTCATCTACTTCCTCGTCACTCACCGGAACCCCTTCCCCTTCATTG GGGGCATGCTACAAGCCCTCATCACCGCTATGGGCACGTCTTCCAGCTCGGCAACGCTGCCCATCACCTTCCGCTGCCTGGAGGAGGGCC TGGGTGTGGACCGCCGCATCACCAGGTTCGTCCTGCCCGTGGGCGCCACGGTCAACATGGATGGCACTGCCCTCTACGAGGCCCTGGCTG CCATCTTCATTGCTCAAGTTAACAACTACGAGCTCAACCTGGGTCAGATCACAACCATCAGCATCACGGCCACAGCAGCCAGTGTTGGGG CTGCTGGCATCCCCCAGGCGGGTCTGGTCACCATGGTCATTGTGCTTACGTCGGTCGGCTTGCCCACGGAAGACATCACGCTCATCATTG CCGTGGACTGGTTCCTTGACCGGCTTCGCACAATGACCAACGTACTGGGGGACTCAATTGGAGCGGCCGTCATCGAGCACTTGTCTCAGC GGGAGCTGGAGCTTCAGGAAGCTGAGCTTACCCTCCCCAGCCTGGGGAAACCCTACAAGTCCCTCATGGCACAGGAGAAGGGGGCATCCC GGGGACGGGGAGGCAACGAGAGTGCTATGTGAGGGGCCTCCAGCTCTGCCCCCCCAGAGAGGAGGGAAGGGGGCTGGGGAGGGGAGTCCT GGTGACACATCTGTTGCCCAACTGACCGTGGGCTGAACACACGTTCTGCTTGACTCATTTAGGGGGGAGGGAAAAGTGAAATAAAGGAGC >In-frame_MED26_ENST00000263390_chr19_16738683_-_SLC1A6_ENST00000221742_chr19_15083729_-_2054nt TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACGATAGACCATGAGCAGCCATGGCAA CAGCCTGTTCCTGCGGGAGAGCGGCCAGCGGCTGGGCCGGGTGGGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGCACTGCG CACGCGCCTGCGCCTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTGCTGACGGTCAGCGCCGT GGTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAGCTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGAGCTTCT GATGAGGATGCTGCAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGGTATGGCATCCCTGGACAACAAGGCCACGGGGCG GATGGGGATGCGGGCAGCTGTGTACTACATGGTGACCACCATCATCGCGGTCTTCATCGGCATCCTCATGGTCACCATCATCCATCCCGG GAAGGGCTCCAAGGAGGGGCTGCACCGGGAGGGCCGGATCGAGACCATCCCCACAGCTGATGCCTTCATGGACCTGATCAGAAATATGTT TCCACCAAACCTTGTGGAGGCCTGCTTCAAACAGTTCAAGACGCAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAA CGGGTCTGAGCCGGGTGCCTCCATGCCTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTCACTCGGGCCTTGGGTAC CCTGCAGGAGATGCTGAGCTTTGAGGAGACTGTACCCGTGCCTGGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGT GGCCTTTGGGCTGGTCATTGGTGGCATGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAATGAGGCTATTATGAGGCT GGTGGGCATCATTATCTGGTATGCACCTGTGGGCATCCTGTTCCTGATTGCTGGGAAGATTCTGGAGATGGAAGACATGGCCGTCCTGGG GGGTCAGCTGGGCATGTACACCCTGACCGTCATCGTGGGCCTGTTCCTCCATGCCGGCATTGTCCTTCCCCTCATCTACTTCCTCGTCAC TCACCGGAACCCCTTCCCCTTCATTGGGGGCATGCTACAAGCCCTCATCACCGCTATGGGCACGTCTTCCAGCTCGGCAACGCTGCCCAT CACCTTCCGCTGCCTGGAGGAGGGCCTGGGTGTGGACCGCCGCATCACCAGGTTCGTCCTGCCCGTGGGCGCCACGGTCAACATGGATGG CACTGCCCTCTACGAGGCCCTGGCTGCCATCTTCATTGCTCAAGTTAACAACTACGAGCTCAACCTGGGTCAGATCACAACCATCAGCAT CACGGCCACAGCAGCCAGTGTTGGGGCTGCTGGCATCCCCCAGGCGGGTCTGGTCACCATGGTCATTGTGCTTACGTCGGTCGGCTTGCC CACGGAAGACATCACGCTCATCATTGCCGTGGACTGGTTCCTTGACCGGCTTCGCACAATGACCAACGTACTGGGGGACTCAATTGGAGC GGCCGTCATCGAGCACTTGTCTCAGCGGGAGCTGGAGCTTCAGGAAGCTGAGCTTACCCTCCCCAGCCTGGGGAAACCCTACAAGTCCCT |
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FusionGenePPI for MED26_SLC1A6 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MED26 | MED10, MED9, MED29, MED19, MED28, MED13L, MED13, MED12, MED1, MED14, MED23, MED15, MED24, MED16, MED25, MED17, CDK8, CDK19, MED27, MED4, MED6, MED7, MED8, MED18, MED20, MED30, MED21, MED22, MED11, MED31, POLR2J, POLR2D, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2L, CEBPB, TRRAP, SREBF1, ZC3H13, QKI, TADA2A, CTDP1, EPAS1, EAF1, ELL, CDK9, TAF1, TAF4, TAF6, CCNT1, CCNT2, TCEA1, TCEB3, AFF4, MLLT3, TBP, CCNC, POLR2K, TAF2, TAF3, TAF4B, TAF5, TAF7, TAF8, TAF9, TAF10, TAF11, TAF13, TAF15, ELL2, EAF2, AFF1, MLLT1, ICE1, ICE2, EWSR1, MASTL, AURKA, TRIM25 | SLC1A6 | ARIH2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED26_SLC1A6 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SLC1A6 | P48664 | DB00142 | Glutamic Acid | Excitatory amino acid transporter 4 | small molecule | approved|nutraceutical |
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RelatedDiseases for MED26_SLC1A6 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SLC1A6 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | SLC1A6 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | SLC1A6 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | SLC1A6 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |