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Fusion gene ID: 21548 |
FusionGeneSummary for MED24_STAC2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MED24_STAC2 | Fusion gene ID: 21548 | Hgene | Tgene | Gene symbol | MED24 | STAC2 | Gene ID | 9862 | 342667 |
Gene name | mediator complex subunit 24 | SH3 and cysteine rich domain 2 | |
Synonyms | ARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP100 | 24b2|24b2/STAC2 | |
Cytomap | 17q21.1 | 17q12 | |
Type of gene | protein-coding | protein-coding | |
Description | mediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10 | SH3 and cysteine-rich domain-containing protein 2SRC homology 3 and cysteine-rich domain-containing protein 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O75448 | Q6ZMT1 | |
Ensembl transtripts involved in fusion gene | ENST00000394126, ENST00000356271, ENST00000394128, ENST00000394127, ENST00000501516, ENST00000479829, | ENST00000333461, | |
Fusion gene scores | * DoF score | 14 X 9 X 8=1008 | 8 X 5 X 6=240 |
# samples | 15 | 8 | |
** MAII score | log2(15/1008*10)=-2.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MED24 [Title/Abstract] AND STAC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MED24 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 12218053 |
Hgene | MED24 | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 11867769 |
Hgene | MED24 | GO:0030521 | androgen receptor signaling pathway | 12218053 |
Hgene | MED24 | GO:0045893 | positive regulation of transcription, DNA-templated | 10198638 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-VQ-AA6G-01A | MED24 | chr17 | 38209551 | - | STAC2 | chr17 | 37369385 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000394126 | ENST00000333461 | MED24 | chr17 | 38209551 | - | STAC2 | chr17 | 37369385 | - |
Frame-shift | ENST00000356271 | ENST00000333461 | MED24 | chr17 | 38209551 | - | STAC2 | chr17 | 37369385 | - |
Frame-shift | ENST00000394128 | ENST00000333461 | MED24 | chr17 | 38209551 | - | STAC2 | chr17 | 37369385 | - |
Frame-shift | ENST00000394127 | ENST00000333461 | MED24 | chr17 | 38209551 | - | STAC2 | chr17 | 37369385 | - |
In-frame | ENST00000501516 | ENST00000333461 | MED24 | chr17 | 38209551 | - | STAC2 | chr17 | 37369385 | - |
5UTR-3CDS | ENST00000479829 | ENST00000333461 | MED24 | chr17 | 38209551 | - | STAC2 | chr17 | 37369385 | - |
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FusionProtFeatures for MED24_STAC2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MED24 | STAC2 |
Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:12218053,ECO:0000269|PubMed:16595664}. | Plays a redundant role in promoting the expression ofcalcium channel CACNA1S at the cell membrane, and therebycontributes to increased channel activity. Slows down theinactivation rate of the calcium channel CACNA1C.{ECO:0000250|UniProtKB:Q8R1B0}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >STAC2 | chr17:38209551 | chr17:37369385 | ENST00000333461 | - | 8 | 11 | 354_411 | 331 | 412 | Domain | SH3 2 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000356271 | - | 3 | 25 | 128_132 | 71 | 977 | Motif | Note=LXXLL motif 1 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000356271 | - | 3 | 25 | 344_348 | 71 | 977 | Motif | Note=LXXLL motif 2 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000356271 | - | 3 | 25 | 448_452 | 71 | 977 | Motif | Note=LXXLL motif 3 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000356271 | - | 3 | 25 | 557_561 | 71 | 977 | Motif | Note=LXXLL motif 4 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000356271 | - | 3 | 25 | 788_792 | 71 | 977 | Motif | Note=LXXLL motif 5 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000356271 | - | 3 | 25 | 857_861 | 71 | 977 | Motif | Note=LXXLL motif 6 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394127 | - | 3 | 25 | 128_132 | 71 | 977 | Motif | Note=LXXLL motif 1 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394127 | - | 3 | 25 | 344_348 | 71 | 977 | Motif | Note=LXXLL motif 2 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394127 | - | 3 | 25 | 448_452 | 71 | 977 | Motif | Note=LXXLL motif 3 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394127 | - | 3 | 25 | 557_561 | 71 | 977 | Motif | Note=LXXLL motif 4 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394127 | - | 3 | 25 | 788_792 | 71 | 977 | Motif | Note=LXXLL motif 5 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394127 | - | 3 | 25 | 857_861 | 71 | 977 | Motif | Note=LXXLL motif 6 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394128 | - | 3 | 26 | 128_132 | 71 | 990 | Motif | Note=LXXLL motif 1 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394128 | - | 3 | 26 | 344_348 | 71 | 990 | Motif | Note=LXXLL motif 2 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394128 | - | 3 | 26 | 448_452 | 71 | 990 | Motif | Note=LXXLL motif 3 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394128 | - | 3 | 26 | 557_561 | 71 | 990 | Motif | Note=LXXLL motif 4 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394128 | - | 3 | 26 | 788_792 | 71 | 990 | Motif | Note=LXXLL motif 5 |
Hgene | >MED24 | chr17:38209551 | chr17:37369385 | ENST00000394128 | - | 3 | 26 | 857_861 | 71 | 990 | Motif | Note=LXXLL motif 6 |
Tgene | STAC2 | chr17:38209551 | chr17:37369385 | ENST00000333461 | - | 8 | 11 | 70_101 | 331 | 412 | Compositional bias | Note=Pro-rich |
Tgene | STAC2 | chr17:38209551 | chr17:37369385 | ENST00000333461 | - | 8 | 11 | 292_351 | 331 | 412 | Domain | SH3 1 |
Tgene | STAC2 | chr17:38209551 | chr17:37369385 | ENST00000333461 | - | 8 | 11 | 110_161 | 331 | 412 | Zinc finger | Phorbol-ester/DAG-type |
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FusionGeneSequence for MED24_STAC2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MED24_ENST00000394126_chr17_38209551_-_STAC2_ENST00000333461_chr17_37369385_-_177aa MSFSLAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLK >In-frame_MED24_ENST00000501516_chr17_38209551_-_STAC2_ENST00000333461_chr17_37369385_-_152aa MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAISSQGKIGDRVGFFPANFVQRVR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MED24_ENST00000394126_chr17_38209551_-_STAC2_ENST00000333461_chr17_37369385_-_531nt ATGTCCTTTTCTTTAGCTCCATTTCTTTCACCTCAAAGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGTGGTCAAC CTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAAAGGAGCC ACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTACCTGAAG TATGCCATTAGTTCCCAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCAACGGGTGAGGCCAGGCGAGAATGTT TGGCGCTGCTGCCAACCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCAGATCTGCGTGGGCGTGGGCAGAAGC >In-frame_MED24_ENST00000501516_chr17_38209551_-_STAC2_ENST00000333461_chr17_37369385_-_456nt ATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTC TTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATC TTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCAACGGGTGAGG CCAGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCAGATCTGCGTG GGCGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCAGTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGCCCTGACTGAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MED24_ENST00000394126_chr17_38209551_-_STAC2_ENST00000333461_chr17_37369385_-_2706nt GGTGCGATCTCGGCTCACCCCAACAACCTCCGCCTCCCGGGTTCAAGCGATTCTACTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGC ATGCACCACCAAGCCCGGCTAATTTTGTATTTTTAGTGGAGACGAGGTTTCTCCATGTTGGTCAGGCTAGTCTCGAACTCCTGACCTCCG GTGATTCGCCCGCCTCTGCCTCCCGAAGTGCTGGGATTACAGGTGCGAGCCACTGCGCTCGGCCGATACTTTCTTAGTGCCCCAGTTTAA GGAAGGGCGGTTCAGGAGGAGAGAGTCTGACAGGATCTTACTTTATCCCTTTAGCTCTTTTTCTTTCAAATTCCTCTGTCTCGCTTAAAT CTTCCCGCATCTTCTCCTTTCTATTTAATTCTGCCTTCCCCGGTTCTCCTTAGAACCTCATGTCCTTTTCTTTAGCTCCATTTCTTTCAC CTCAAAGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGG AGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGT TACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGCAAGATCGGCG ACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCAACGGGTGAGGCCAGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACA AGGAACAGGGTTACATGAGCCTCAAGGAGAACCAGATCTGCGTGGGCGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCA GTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGCCCTGACTGAGATCTGAGAGGAGCCAAGGGAACCCAGATGACACCCTTGCCCATGCC TGGACCTTGCTTCTGGCCAGGGAGGGGATCAGGCCCCCTTGTCCACTCCATACCCTTCCTCCCTCTGTCCCTCTCCTAGGTGCCACTTAC CGTGGCTTAGGAGCCTTTTGTACTGGGGAAGATTTTATTTCTTGGGTGGGGTGCCCTGAGTGGGTTGATCCTCTGGGACTTGGCGGGGAT GGGGTGGGGTGGGAGGGAATGAGGAAGCTACAGGTAGGTCCACCCAACGCCCAGGCACCCCAGTCTACTTGCTGGGCTGAGTCCAGCCCT GGGGAAGATTCCTGGGGAATTTATTTGCTGCTTCTCCCAGCCTTCCCCTGCCCACACCACCTGCGCATGCCTGGCACACCCCTCTCCCCA CAGAGCCTCTGCTTGGGTCTATGTGTGTGTGACCGTGCATCTGCTCCTTTGCAAGTGGGGTCTTGGGAGCAGGCCTTTTTGTGTCCTCGG CCCTCCACCCTTGGTGGGGAGGGGACCCAGGACCATAGGAAGGTCCTGAGTCCACCTCCTGGTCTCCACCTCTGTCATTCCGTCAATTCT CAGGAAAGTTTTGCAGGAATCTCTCCCGTTACTTGAAACCTGGGCGGACAGATGAGGGGAAGGCTGAGGTCCCTGGAAGGTGTAACAAAT CAGAGACTATCTGTTCAAGTAGAAAACCCAAGAGCTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTG GGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAGTACGAAACTTAGCCAGGCA TGATGGGGGTCTGCCTGTAATGCCAGCTACTCCAGAGGCTGAGGCAAGAGAATCACTTGAACCCGGGAGGCGGAGGTTTCAGTGAGCCGA GATTGCACCATTGCACCCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGAAAGAAAAGGAAACCCAAGAGCT GCCTGGACACACGGAAACCCAACTGAGAACAAAATCCTGGCCCGTGCTTGGTCAAAGCAAACCCATTTCACTGTCAGGACCCCCGGTCAC ACAGGAACCACCCGCCAGGGGAGCCTGTGACTGTCAGTTCCTGTCCCAGGCTTTGCCCGGCCGCCCCAGGAACCCAACCCTCTGGGCTGA CCTTTCTCCTGCTTCTCTCCAGGCTCTGCAGGGGACAGGGCAGGTGCTGCAGGAGCCCCTTTGCTGGCTTTATCTGCTCCCTTGTTCTGG ACACAGAGCCCTGGGAAAAAGAGGGGGTGGAAGACAGACAAGGAAGGTGGAATGTTCTGTTTTGGCCACCAGGAAATGGGGTGGGGTGGG CATACACAGAGAGGACCCCTCTCTTAATACAGCTGCTTTTCTCGGTGCCAACCTCCCTCCCCCAAGCTCAGATCCTCCTCTTATGCCCTT GATTGTGCCAGCCCATGCCACCCCCATCCTGGGCACAGTTACACCCTCCCATGCAGTGGGAGAAACACAGACCCTCGTACCCAAAGGCCC CTGCCCCACTTCTCCCCCACAAAGCGGGGTCTCAAGCCACACTGCCCTGTTTGCTGCCATGAGGCCCCCCCCCCCAGCAATATCCCAGGG GCGGGCCCAATGCCCACTGTACATGAGGCTGCATGATGGGTCTGGGGCCTTGCTGATTCCCCAGACCCCTAATTAAATGTTTCTTGTCCC >In-frame_MED24_ENST00000501516_chr17_38209551_-_STAC2_ENST00000333461_chr17_37369385_-_2222nt GAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACAT GAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAA TCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCA ACGGGTGAGGCCAGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCA GATCTGCGTGGGCGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCAGTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGC CCTGACTGAGATCTGAGAGGAGCCAAGGGAACCCAGATGACACCCTTGCCCATGCCTGGACCTTGCTTCTGGCCAGGGAGGGGATCAGGC CCCCTTGTCCACTCCATACCCTTCCTCCCTCTGTCCCTCTCCTAGGTGCCACTTACCGTGGCTTAGGAGCCTTTTGTACTGGGGAAGATT TTATTTCTTGGGTGGGGTGCCCTGAGTGGGTTGATCCTCTGGGACTTGGCGGGGATGGGGTGGGGTGGGAGGGAATGAGGAAGCTACAGG TAGGTCCACCCAACGCCCAGGCACCCCAGTCTACTTGCTGGGCTGAGTCCAGCCCTGGGGAAGATTCCTGGGGAATTTATTTGCTGCTTC TCCCAGCCTTCCCCTGCCCACACCACCTGCGCATGCCTGGCACACCCCTCTCCCCACAGAGCCTCTGCTTGGGTCTATGTGTGTGTGACC GTGCATCTGCTCCTTTGCAAGTGGGGTCTTGGGAGCAGGCCTTTTTGTGTCCTCGGCCCTCCACCCTTGGTGGGGAGGGGACCCAGGACC ATAGGAAGGTCCTGAGTCCACCTCCTGGTCTCCACCTCTGTCATTCCGTCAATTCTCAGGAAAGTTTTGCAGGAATCTCTCCCGTTACTT GAAACCTGGGCGGACAGATGAGGGGAAGGCTGAGGTCCCTGGAAGGTGTAACAAATCAGAGACTATCTGTTCAAGTAGAAAACCCAAGAG CTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAG CCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAGTACGAAACTTAGCCAGGCATGATGGGGGTCTGCCTGTAATGCCAGCTACTCCA GAGGCTGAGGCAAGAGAATCACTTGAACCCGGGAGGCGGAGGTTTCAGTGAGCCGAGATTGCACCATTGCACCCCAGCCTGGGCAACAGA GCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGAAAGAAAAGGAAACCCAAGAGCTGCCTGGACACACGGAAACCCAACTGAGAACAAAA TCCTGGCCCGTGCTTGGTCAAAGCAAACCCATTTCACTGTCAGGACCCCCGGTCACACAGGAACCACCCGCCAGGGGAGCCTGTGACTGT CAGTTCCTGTCCCAGGCTTTGCCCGGCCGCCCCAGGAACCCAACCCTCTGGGCTGACCTTTCTCCTGCTTCTCTCCAGGCTCTGCAGGGG ACAGGGCAGGTGCTGCAGGAGCCCCTTTGCTGGCTTTATCTGCTCCCTTGTTCTGGACACAGAGCCCTGGGAAAAAGAGGGGGTGGAAGA CAGACAAGGAAGGTGGAATGTTCTGTTTTGGCCACCAGGAAATGGGGTGGGGTGGGCATACACAGAGAGGACCCCTCTCTTAATACAGCT GCTTTTCTCGGTGCCAACCTCCCTCCCCCAAGCTCAGATCCTCCTCTTATGCCCTTGATTGTGCCAGCCCATGCCACCCCCATCCTGGGC ACAGTTACACCCTCCCATGCAGTGGGAGAAACACAGACCCTCGTACCCAAAGGCCCCTGCCCCACTTCTCCCCCACAAAGCGGGGTCTCA AGCCACACTGCCCTGTTTGCTGCCATGAGGCCCCCCCCCCCAGCAATATCCCAGGGGCGGGCCCAATGCCCACTGTACATGAGGCTGCAT |
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FusionGenePPI for MED24_STAC2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MED24 | MED10, MED9, MED29, MED19, MED28, MED26, CDK8, THRA, VDR, PPARA, PPARG, RXRA, MED1, HNF4A, ESR1, ESR2, MED30, BRD4, RPAP2, AR, PARP1, SMAD1, SMAD2, SMAD3, TRRAP, SREBF1, MED12, MED18, ZC3H13, TRIP4, OBFC1, QKI, TRA, MED14, GSK3B, TNFSF11, RPS6KA6, CTDP1, APP, MED13, MED8, MED16, MED17, MED4, MED11, MED21, MED22, PPP6R1, TFIP11, FBXW7, EPAS1, CDK19, MED7, CCNC, NR1I3, TCL1B, MED15, MED20, MED23, MED6, MED25, MED27, KPNB1, XRCC3, EMC2, PPP4R1, ZWINT, KIFAP3, MMGT1, SUCO, LMO2 | STAC2 | ATXN1, ATXN1L, LNX1, BRCA1, LMNA |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MED24_STAC2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MED24_STAC2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |