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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 21531

FusionGeneSummary for MED21_PIP5K1C

check button Fusion gene summary
Fusion gene informationFusion gene name: MED21_PIP5K1C
Fusion gene ID: 21531
HgeneTgene
Gene symbol

MED21

PIP5K1C

Gene ID

9412

23396

Gene namemediator complex subunit 21phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
SynonymsSRB7|SURB7|hSrb7LCCS3|PIP5K-GAMMA|PIP5K1-gamma|PIP5Kgamma
Cytomap

12p11.23

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 21RNA polymerase II holoenzyme component SRB7RNAPII complex component SRB7SRB7 suppressor of RNA polymerase B homologphosphatidylinositol 4-phosphate 5-kinase type-1 gammadiphosphoinositide kinasephosphatidylinositol-4-phosphate 5-kinase, type I, gammaptdIns(4)P-5-kinase 1 gammatype I PIP kinase
Modification date2018052320180520
UniProtAcc

Q13503

O60331

Ensembl transtripts involved in fusion geneENST00000546323, ENST00000536503, 
ENST00000282892, 
ENST00000335312, 
ENST00000539785, ENST00000589578, 
ENST00000537021, ENST00000587482, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 5 X 3=75
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED21 [Title/Abstract] AND PIP5K1C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED21

GO:0045944

positive regulation of transcription by RNA polymerase II

12037571


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1KZ-01AMED21chr12

27175554

+PIP5K1Cchr19

3661999

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000546323ENST00000335312MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
In-frameENST00000546323ENST00000539785MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
In-frameENST00000546323ENST00000589578MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
In-frameENST00000546323ENST00000537021MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
5CDS-5UTRENST00000546323ENST00000587482MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
3UTR-3CDSENST00000536503ENST00000335312MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
3UTR-3CDSENST00000536503ENST00000539785MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
3UTR-3CDSENST00000536503ENST00000589578MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
3UTR-3CDSENST00000536503ENST00000537021MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
3UTR-5UTRENST00000536503ENST00000587482MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
In-frameENST00000282892ENST00000335312MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
In-frameENST00000282892ENST00000539785MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
In-frameENST00000282892ENST00000589578MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
In-frameENST00000282892ENST00000537021MED21chr12

27175554

+PIP5K1Cchr19

3661999

-
5CDS-5UTRENST00000282892ENST00000587482MED21chr12

27175554

+PIP5K1Cchr19

3661999

-

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FusionProtFeatures for MED21_PIP5K1C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED21

Q13503

PIP5K1C

O60331

Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:15249124,ECO:0000269|PubMed:9660976}. Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate(PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety ofcellular processes and is the substrate to formphosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3),another second messenger. The majority of PtdIns(4,5)P2 is thoughtto occur via type I phosphatidylinositol 4-phosphate 5-kinasesgiven the abundance of PtdIns4P. Participates in a variety ofcellular processes such as vesicle mediated transport, celladhesion, cell polarization and cell migration. Together withPIP5K1A is required for phagocytosis, but they regulate differenttypes of actin remodeling at sequential steps. Promotes particleattachment by generating the pool of PtdIns(4,5)P2 that inducescontrolled actin depolymerization to facilitate Fc-gamma-Rclustering. Mediates RAC1-dependent reorganization of actinfilaments. Required for synaptic vesicle transport. Controls theplasma membrane pool of PtdIns(4,5)P2 implicated in synapticvesicle endocytosis and exocytosis. Plays a role in endocytosismediated by clathrin and AP-2 (adaptor protein complex 2).Required for clathrin-coated pits assembly at the synapse.Participates in cell junction assembly. Modulates adherensjunctions formation by facilitating CDH1 trafficking. Required forfocal adhesion dynamics. Modulates the targeting of talins (TLN1and TLN2) to the plasma membrane and their efficient assembly intofocal adhesions. Regulates the interaction between talins (TLN1and TLN2) and beta-integrins. Required for uropodium formation andretraction of the cell rear during directed migration. Has a rolein growth factor- stimulated directional cell migration andadhesion. Required for talin assembly into nascent adhesionsforming at the leading edge toward the direction of the growthfactor. Negative regulator of T-cell activation and adhesion.Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarizationand adhesion induced by T-cell receptor. Together with PIP5K1A hasa role during embryogenesis and together with PIP5K1B may have arole immediately after birth. {ECO:0000269|PubMed:12422219,ECO:0000269|PubMed:12847086, ECO:0000269|PubMed:17261850,ECO:0000269|PubMed:17635937}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePIP5K1Cchr12:27175554chr19:3661999ENST00000335312-21875_44373669DomainPIPK
TgenePIP5K1Cchr12:27175554chr19:3661999ENST00000537021-21775_44373701DomainPIPK
TgenePIP5K1Cchr12:27175554chr19:3661999ENST00000539785-21775_44373641DomainPIPK
TgenePIP5K1Cchr12:27175554chr19:3661999ENST00000589578-21775_44373708DomainPIPK

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MED21_PIP5K1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000335312_chr19_3661999_-_610aa
MADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFG
IRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMN
NILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQH
ERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD
GDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL
PCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEA

>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000539785_chr19_3661999_-_582aa
MADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFG
IRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMN
NILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQH
ERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD
GDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL
PCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEA

>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000589578_chr19_3661999_-_649aa
MADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFG
IRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMN
NILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQH
ERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD
GDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL
PCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEA
SPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFFTDGRYWIYSPRHRRLRAVTLSASGTVSDRSRPPWGEGAVPLGQQGAAG

>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000537021_chr19_3661999_-_642aa
MADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFG
IRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMN
NILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQH
ERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD
GDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL
PCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEA
SPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFWRLWGPHAPTWPWRREGRAACLCPYPPHVVTPFPGTGLCASWSPDGTGG

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000335312_chr19_3661999_-_610aa
MADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFG
IRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMN
NILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQH
ERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD
GDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL
PCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEA

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000539785_chr19_3661999_-_582aa
MADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFG
IRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMN
NILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQH
ERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD
GDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL
PCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEA

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000589578_chr19_3661999_-_649aa
MADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFG
IRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMN
NILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQH
ERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD
GDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL
PCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEA
SPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFFTDGRYWIYSPRHRRLRAVTLSASGTVSDRSRPPWGEGAVPLGQQGAAG

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000537021_chr19_3661999_-_642aa
MADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFG
IRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMN
NILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQH
ERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHD
GDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLL
PCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEA
SPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFWRLWGPHAPTWPWRREGRAACLCPYPPHVVTPFPGTGLCASWSPDGTGG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000335312_chr19_3661999_-_1830nt
ATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTGAAGGGTGCCATCCAGCTGGGCATCGGCTAC
ACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGC
AGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGG
ATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTC
ACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAGAAGCTGCTCCCTGGCTACTACATGAACCTC
AACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGGGGCAAGAACATCCGCGTCGTGGTCATGAAC
AACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAG
AAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTGCTGGACGCCGACACCTTCAGCGCCCTGGTC
AAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTGCTGCTGGGCGTGCACAACATCGACCAGCAC
GAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGCCAGAAGGCGCTCTACTCCACGGCCATGGAG
TCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGG
CTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTGGAGCACACCTGGAAGGCCCTCGTCCACGAT
GGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATGAGCAACACGGTCTTTCGGAAGAACTCCTCC
CTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAG
ATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACGCTGGAGGACGAAGGCCGGCCCGACCTCCTG
CCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCATCCACATCCCTCTCCATTCCTGAGCGGTCC
CCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAA
GAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCT
TCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGAC
GAGGAGGACGCGCCCGCCACCGACATCTACTTTCCCACCGATGAGAGGAGCTGGGTGTACTCCCCGCTCCACTATAGCGCCCAGGCCCCC

>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000539785_chr19_3661999_-_1746nt
ATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTGAAGGGTGCCATCCAGCTGGGCATCGGCTAC
ACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGC
AGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGG
ATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTC
ACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAGAAGCTGCTCCCTGGCTACTACATGAACCTC
AACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGGGGCAAGAACATCCGCGTCGTGGTCATGAAC
AACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAG
AAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTGCTGGACGCCGACACCTTCAGCGCCCTGGTC
AAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTGCTGCTGGGCGTGCACAACATCGACCAGCAC
GAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGCCAGAAGGCGCTCTACTCCACGGCCATGGAG
TCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGG
CTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTGGAGCACACCTGGAAGGCCCTCGTCCACGAT
GGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATGAGCAACACGGTCTTTCGGAAGAACTCCTCC
CTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAG
ATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACGCTGGAGGACGAAGGCCGGCCCGACCTCCTG
CCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCATCCACATCCCTCTCCATTCCTGAGCGGTCC
CCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAA
GAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCT
TCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGAC

>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000589578_chr19_3661999_-_1947nt
ATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTGAAGGGTGCCATCCAGCTGGGCATCGGCTAC
ACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGC
AGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGG
ATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTC
ACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAGAAGCTGCTCCCTGGCTACTACATGAACCTC
AACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGGGGCAAGAACATCCGCGTCGTGGTCATGAAC
AACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAG
AAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTGCTGGACGCCGACACCTTCAGCGCCCTGGTC
AAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTGCTGCTGGGCGTGCACAACATCGACCAGCAC
GAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGCCAGAAGGCGCTCTACTCCACGGCCATGGAG
TCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGG
CTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTGGAGCACACCTGGAAGGCCCTCGTCCACGAT
GGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATGAGCAACACGGTCTTTCGGAAGAACTCCTCC
CTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAG
ATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACGCTGGAGGACGAAGGCCGGCCCGACCTCCTG
CCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCATCCACATCCCTCTCCATTCCTGAGCGGTCC
CCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAA
GAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCT
TCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGAC
GAGGAGGACGCGCCCGCCACCGACATCTACTTTTTCACGGATGGGAGGTACTGGATTTACTCTCCCCGCCATCGCCGACTGCGGGCCGTG
ACGCTGAGCGCCTCGGGGACTGTAAGTGACCGCAGCCGGCCACCCTGGGGAGAAGGGGCAGTGCCCCTCGGGCAGCAGGGAGCCGCAGGT

>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000537021_chr19_3661999_-_1926nt
ATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTGAAGGGTGCCATCCAGCTGGGCATCGGCTAC
ACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGC
AGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGG
ATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTC
ACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAGAAGCTGCTCCCTGGCTACTACATGAACCTC
AACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGGGGCAAGAACATCCGCGTCGTGGTCATGAAC
AACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAG
AAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTGCTGGACGCCGACACCTTCAGCGCCCTGGTC
AAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTGCTGCTGGGCGTGCACAACATCGACCAGCAC
GAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGCCAGAAGGCGCTCTACTCCACGGCCATGGAG
TCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGG
CTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTGGAGCACACCTGGAAGGCCCTCGTCCACGAT
GGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATGAGCAACACGGTCTTTCGGAAGAACTCCTCC
CTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAG
ATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACGCTGGAGGACGAAGGCCGGCCCGACCTCCTG
CCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCATCCACATCCCTCTCCATTCCTGAGCGGTCC
CCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAA
GAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCT
TCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGAC
GAGGAGGACGCGCCCGCCACCGACATCTACTTTTGGCGCCTCTGGGGTCCCCATGCACCCACCTGGCCCTGGAGAAGGGAGGGACGGGCC
GCGTGCCTGTGCCCCTACCCACCGCACGTCGTCACCCCTTTTCCTGGGACTGGTTTGTGCGCGTCCTGGTCTCCGGATGGTACGGGGGGC

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000335312_chr19_3661999_-_1830nt
ATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTGAAGGGTGCCATCCAGCTGGGCATCGGCTAC
ACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGC
AGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGG
ATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTC
ACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAGAAGCTGCTCCCTGGCTACTACATGAACCTC
AACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGGGGCAAGAACATCCGCGTCGTGGTCATGAAC
AACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAG
AAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTGCTGGACGCCGACACCTTCAGCGCCCTGGTC
AAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTGCTGCTGGGCGTGCACAACATCGACCAGCAC
GAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGCCAGAAGGCGCTCTACTCCACGGCCATGGAG
TCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGG
CTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTGGAGCACACCTGGAAGGCCCTCGTCCACGAT
GGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATGAGCAACACGGTCTTTCGGAAGAACTCCTCC
CTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAG
ATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACGCTGGAGGACGAAGGCCGGCCCGACCTCCTG
CCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCATCCACATCCCTCTCCATTCCTGAGCGGTCC
CCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAA
GAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCT
TCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGAC
GAGGAGGACGCGCCCGCCACCGACATCTACTTTCCCACCGATGAGAGGAGCTGGGTGTACTCCCCGCTCCACTATAGCGCCCAGGCCCCC

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000539785_chr19_3661999_-_1746nt
ATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTGAAGGGTGCCATCCAGCTGGGCATCGGCTAC
ACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGC
AGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGG
ATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTC
ACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAGAAGCTGCTCCCTGGCTACTACATGAACCTC
AACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGGGGCAAGAACATCCGCGTCGTGGTCATGAAC
AACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAG
AAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTGCTGGACGCCGACACCTTCAGCGCCCTGGTC
AAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTGCTGCTGGGCGTGCACAACATCGACCAGCAC
GAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGCCAGAAGGCGCTCTACTCCACGGCCATGGAG
TCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGG
CTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTGGAGCACACCTGGAAGGCCCTCGTCCACGAT
GGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATGAGCAACACGGTCTTTCGGAAGAACTCCTCC
CTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAG
ATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACGCTGGAGGACGAAGGCCGGCCCGACCTCCTG
CCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCATCCACATCCCTCTCCATTCCTGAGCGGTCC
CCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAA
GAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCT
TCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGAC

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000589578_chr19_3661999_-_1947nt
ATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTGAAGGGTGCCATCCAGCTGGGCATCGGCTAC
ACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGC
AGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGG
ATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTC
ACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAGAAGCTGCTCCCTGGCTACTACATGAACCTC
AACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGGGGCAAGAACATCCGCGTCGTGGTCATGAAC
AACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAG
AAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTGCTGGACGCCGACACCTTCAGCGCCCTGGTC
AAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTGCTGCTGGGCGTGCACAACATCGACCAGCAC
GAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGCCAGAAGGCGCTCTACTCCACGGCCATGGAG
TCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGG
CTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTGGAGCACACCTGGAAGGCCCTCGTCCACGAT
GGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATGAGCAACACGGTCTTTCGGAAGAACTCCTCC
CTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAG
ATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACGCTGGAGGACGAAGGCCGGCCCGACCTCCTG
CCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCATCCACATCCCTCTCCATTCCTGAGCGGTCC
CCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAA
GAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCT
TCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGAC
GAGGAGGACGCGCCCGCCACCGACATCTACTTTTTCACGGATGGGAGGTACTGGATTTACTCTCCCCGCCATCGCCGACTGCGGGCCGTG
ACGCTGAGCGCCTCGGGGACTGTAAGTGACCGCAGCCGGCCACCCTGGGGAGAAGGGGCAGTGCCCCTCGGGCAGCAGGGAGCCGCAGGT

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000537021_chr19_3661999_-_1926nt
ATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTGAAGGGTGCCATCCAGCTGGGCATCGGCTAC
ACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGC
AGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGG
ATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTC
ACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAGAAGCTGCTCCCTGGCTACTACATGAACCTC
AACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGGGGCAAGAACATCCGCGTCGTGGTCATGAAC
AACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAG
AAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTGCTGGACGCCGACACCTTCAGCGCCCTGGTC
AAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTGCTGCTGGGCGTGCACAACATCGACCAGCAC
GAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGCCAGAAGGCGCTCTACTCCACGGCCATGGAG
TCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGG
CTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTGGAGCACACCTGGAAGGCCCTCGTCCACGAT
GGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATGAGCAACACGGTCTTTCGGAAGAACTCCTCC
CTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAG
ATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACGCTGGAGGACGAAGGCCGGCCCGACCTCCTG
CCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCATCCACATCCCTCTCCATTCCTGAGCGGTCC
CCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAA
GAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCT
TCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGAC
GAGGAGGACGCGCCCGCCACCGACATCTACTTTTGGCGCCTCTGGGGTCCCCATGCACCCACCTGGCCCTGGAGAAGGGAGGGACGGGCC
GCGTGCCTGTGCCCCTACCCACCGCACGTCGTCACCCCTTTTCCTGGGACTGGTTTGTGCGCGTCCTGGTCTCCGGATGGTACGGGGGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000335312_chr19_3661999_-_4848nt
AGCTGTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCAC
CCTGAAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTA
CGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACC
TGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTC
CAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCT
GCAGAAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTC
GGGGGGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCAC
CTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCT
CCTGCTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAG
CCTGCTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGT
GGGCCAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGG
CGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAA
ACTGGAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTT
CATGAGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACC
GCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCC
CACGCTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCT
GTCATCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACA
GGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGT
GGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGA
CGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTCCCACCGATGAGAGGAGCTGGGT
GTACTCCCCGCTCCACTATAGCGCCCAGGCCCCCCCGGCCTCCGACGGCGAGAGCGACACATAATTTCTATGCAGCCCCCGACCCAGAGC
CGAGCTCCACTTCTGCTCCGGCTGCCCCCGAAGGCGCTGCCCACCCCGCTGAGGCCCAGAGCTCGGGAGATGCCCGCCTCGCCGCCCCAC
CGGACCTCGTCCTCCCCCTGCACGGATGCCGACGGCCGGGCCCCTCCCCGACAAGCCTCCCAGGGCCCCGGCACCCCGGTCGGCAGCCTG
CCCCTGTGAGACCCACCCTCCCGAGCGGCCAATCGCATTTGAGTCCTTATTTGGCACAGAGACGGAAGCACGTGTGTGCCGTTTTAGGAA
AAGAACAAAAAAGACACAAACAAACCAACCAGAGGGAGAAGAGCCCCTGCCCACTGCACTCTTTGGTTCTCTGCTGTGCCTGCCTGTGTC
CTGAGGAAGAAGCCAGGCTGTTCGCGGTGGCCTCTGGGGACCTGAGCCCCGGGGGCCCCATCGGCCTGCAGAGGGGACGGCTGGGGTCCC
GAGCAACTCTGCCTCCATCCACGTGGGAAGCGGACCCTCCTGCCCTCAGCTTGGGTTTGGGGGCCTCAGTGCAGGACATCTGGCCTGAAC
ATCGACTGTGGGGACAGCCCTCGCCCTGCCAAGCACTGCGGCCACTCAGCAGCTATGTTCCCGCCGCAGTGGGGCCCTGACGCCCACCTC
CCAGGTGCCCCTCGAGCAAAAACCTCTGGCGCCTCCAATCCAGACCCACCACAGCTGGAGGGCCAGGCCTCCTCTTCCCCAGGCTGCCAC
CCACGCTGGCGGAGCTCAGGGCTGGGGACTTGTCCTTCTCTTCCAACGTAGGCCACTCAGCAACTGGCATGGAGGGCCCAGGCAACGGAG
ACGTTTTCTCCATGGCAGGACAGAGCGGGAGGCCGGGCCTTGGGCCACAGGAGACCAGCTCAGGGCGGAAGGTCAGGCTCCCCGCCCCCT
CCACGTGGAGACATGGCCTAGGGGGCCAGGCCCGGCTCCACAGGAGTCTCCTTCAGGACTGGTGTGGATGTCCGCCGCCTCTTTCTTGTT
TAAGTGATGTGATGTCTCCGAGGAGGGGAGAGAAGACTTTGTTTCCGACTCATCACCCTCCAAGAGGGCAGCGCTCCCAGTGGTGGGACT
CAGCCCAGACTGCCCTGGGGCAGCTTCCTGGGCCCGCTGCGCTCAGAGGGTGCTGGTTGGAGGCCAGAGCTCGGCAGAGTCACCCACCCT
GCCCTTCCCCAGGACCCCTGAGAGGGGCTTATTGGTGATGGCTGTGGGAATCCCCCACTTCCAAGATGTGCCCAGGATGTGAGGAGCTGG
AGTGGAAGCTGCACCTTTGGGAAGAATTCCTCTCCAGACCTGGCAGAGCCTGGTGTGGGGTCTGAGACGGCCGGAGAACCTCCCAGGCAG
GGCTCTGTGTTTTGTCTGTTACAACCTCCGTATGACGCCACGCCACCCGCTGTTCACGTCCCGTCGGCCTCCTGCACAGCCCACACGCTG
CGCCCGGAAGGCCCCTGCTGTGGAGAAGCCGGACCCATCCCCGAGGTCCCCAGCGAGGACACACACTCCACGAGAGCAGCCCCTCCACTC
TGCCCAGGAGAGGGGCCGACCCTCCTCGGGAACCGGCCAGCCGCGTGGCTCCCAGCATCCATCAGGACAAGCCCACGTGGGGTCCTCCCT
GCGTGCTCAGAGGGTCTGTCCAGCCCTGGGAAGCGACCTTGGCCTCAGTTCACAGCCTGGTGCTCATCTGCTGGCACCGGGCATCCACCC
ATCAGCCCCCGCCCTGTCCCTCCGAAGGACACCCAGCAGGCACCCCCCGGGGAGGCAGGGGCAGAGGTCAGAAGGGGTGTCTGGGACCTG
GATGGCCAGCAGGGACAGGGGCATTGTCATCTCAAAGGCCCAACCCCCAGAGGCCACACCAGTCCTCCCAGGGAGTCCTCGAGTCGCCCT
GCCCAGAGCCCTGGCACCAGAGACGCCAAGAGCCTGTGGGGTGACTCGGAGCAGCAGGTGTGGCCCCGGGCGGGCGGCACCGCGTCCAGG
GCAGCCTCCCTCCGCTGAGTGACACGGGACACCAGTGCCCGGCCGACGCGCCTTTGCAGGAGAAATGTGCAAACCTCTGTGGATACCATT
TCATTTCCATTCTTGTGTTGTCTCCAAGGCCCTTTTGGAGATATACTTGGTGTTGGTTGTGTTTTTTGGTTCCTTTTCAGAGAACTGTAA
ACCGAGGCTGACGTGCTCCACTGACTGTGCCGAGGGGCGGGGGCAGGAGGACGGCAAGACCTATTTATAATATTTAGCGAACTCGGTCTC
CCTCAGATCCCCCGCGAGGGAGGCTGCTGGACCCACCCCGCTGTCCCCCATGATAGAAGTCTGTAAATACCTTGGTGACCAATGCCCACT
TCCCCTCCTGGGTCACCTCTGATGGCTGCTGTCCACTGAGAACGTGGGCAGTGTCCAAATTCCTGTACTGTAAAGACTAAAAGGCGTTTG
CTCTGAGACTGACAAGGCGGAAACTTCCATGTGTCTCCTGCCAGGCTCTGTCCCCCTACGCCATCCCGACACGTCCCCGTTCCCCCGAAA
CCTGGCTCAGTGCAATACTCCCATTGCCATGGGGTCCTTCACCATGGTACTGTCTCCACAGCCCTCAGTCCCCACCCCAGGAGAGGCGCC
TGCCACCTCCTCCTCATCTCCGGTGGTTCAATCGCTCCGCCTGTCCCCAACCCAGTCCCATTTTTATGGCCAAACTGATTCTGAAACAAA
ATGAAACTGCAAACCTCGTGTGTCTTAACTCCCCCCAGGGATGCCACTCCATTCCTCCGCCCCGTGGTCTGGTGCGTGACAATCCAAAGC
GCCGAGACGAGGGTGCTGTGTCCCTCAAACCCAGAGTGGTGGGCGCCTCTGAAACCATACAGCCACTCCTGGCCCCAAACACTGGTTTGC

>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000539785_chr19_3661999_-_2071nt
AGCTGTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCAC
CCTGAAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTA
CGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACC
TGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTC
CAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCT
GCAGAAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTC
GGGGGGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCAC
CTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCT
CCTGCTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAG
CCTGCTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGT
GGGCCAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGG
CGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAA
ACTGGAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTT
CATGAGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACC
GCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCC
CACGCTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCT
GTCATCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACA
GGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGT
GGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGA
CGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTAATTTCTATGCAGCCCCCGACC
CAGAGCCGAGCTCCACTTCTGCTCCGGCTGCCCCCGAAGGCGCTGCCCACCCCGCTGAGGCCCAGAGCTCGGGAGATGCCCGCCTCGCCG
CCCCACCGGACCTCGTCCTCCCCCTGCACGGATGCCGACGGCCGGGCCCCTCCCCGACAAGCCTCCCAGGGCCCCGGCACCCCGGTCGGC
AGCCTGCCCCTGTGAGACCCACCCTCCCGAGCGGCCAATCGCATTTGAGTCCTTATTTGGCACAGAGACGGAAGCACGTGTGTGCCGTTT

>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000589578_chr19_3661999_-_2790nt
AGCTGTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCAC
CCTGAAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTA
CGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACC
TGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTC
CAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCT
GCAGAAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTC
GGGGGGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCAC
CTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCT
CCTGCTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAG
CCTGCTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGT
GGGCCAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGG
CGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAA
ACTGGAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTT
CATGAGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACC
GCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCC
CACGCTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCT
GTCATCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACA
GGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGT
GGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGA
CGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTTCACGGATGGGAGGTACTGGAT
TTACTCTCCCCGCCATCGCCGACTGCGGGCCGTGACGCTGAGCGCCTCGGGGACTGTAAGTGACCGCAGCCGGCCACCCTGGGGAGAAGG
GGCAGTGCCCCTCGGGCAGCAGGGAGCCGCAGGTCCCCGGCCGGAAGCTCAGTGTCTGACGTCAGTTGTTTTCCAGAAGGGCTTTGGGTA
AATCACGGCTGCAATTGAGGTCAGCCACGCTGGCCCCGGACCAGGCGCTGGGCTGCATGCGTCACTGGGAATGTCATTCGGTCCCACGTC
GAACCGGGCGCTCCATAGGGCAGCACCATCACCAGGTGCACAGCTGAGGCCCAGGGTCTGCTTCGGACCCCGGCCAGACCCCAGCGAGCC
CCTCTCTGCCCCTGGACCCAGCCCTCTCGTGTCAGGGTGTCTTGGGTGGACGCTTCTCACTCGTGCAGACCTGGCTGCCCGTGGCCCCGC
TGGCTGCACAGGGGAGGTTGCACAGGTCAGCAGAGTGGCTGCAGGGCCGGGCTCTGAACCGCAGGGCCATGGAGACGGGGAGGAGATGGT
CTCTCCACACCCACCTCACAGATGGAGGCGCTGAGGCCTCGGCTCCCCTGGGAGCCTGGGAGACCACACGGTTTAGTCAAAATCCAGATC
CCCAAGCTCTCAAGGAGGTCCCCCTGGGACGCCACATGGGCCCCACGTAGCTGTGAGATCCTCAGGGCCTGCTGTTGTCATTATGACCAA
TAAGCAAGGGGCCCAGAGAGCCTAAGAGACCTGCCCAGCACCGCACAGCCAGAACGGGGCGCAGACCCAAAGCAGGAGTGTCCCCTCGAG
ACAAAGCCTCCGCCGAGGCCGCCGTGACTCCCCGCCCATCAGCAAACCTCTCCGAGCACCTCTGTGTGCCAGGCACTGTGGAGTGACCCC
AAGAGGTGGAGACCACTTCCCCGGCTGCTCTAGGCAGCTCCGTCCCACGGAGCCAGCGGGAAGCCAGCCACCGCGAAGCCGTGCCCCGGA

>In-frame_MED21_ENST00000546323_chr12_27175554_+_PIP5K1C_ENST00000537021_chr19_3661999_-_3183nt
AGCTGTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCAC
CCTGAAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTA
CGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACC
TGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTC
CAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCT
GCAGAAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTC
GGGGGGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCAC
CTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCT
CCTGCTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAG
CCTGCTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGT
GGGCCAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGG
CGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAA
ACTGGAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTT
CATGAGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACC
GCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCC
CACGCTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCT
GTCATCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACA
GGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGT
GGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGA
CGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTGGCGCCTCTGGGGTCCCCATGC
ACCCACCTGGCCCTGGAGAAGGGAGGGACGGGCCGCGTGCCTGTGCCCCTACCCACCGCACGTCGTCACCCCTTTTCCTGGGACTGGTTT
GTGCGCGTCCTGGTCTCCGGATGGTACGGGGGGCCTGGGGGCCATGTCGTGCTGTGTGTCTGTGTCCTGATGCCCTGCCAGGTGGGCAGC
AGAGAAGGGAGAAGGGTCCTCGGTCCTGCCCCTGCCCCGGCACCCCCCACCTTCTGCTTGGCAGTCAGCTGTCCCCACCTGCTCCCCGCC
ACCTCCCTCCGCCTCTCCCACCCGACCACGGGGGTGGCCGCCTCATCCGCTGTCCTCTGTTTTCCTTCCTCCTCCGGCCCACCCGGCCCG
CCCCGTCCAGTTCACGGATGGGAGGTACTGGATTTACTCTCCCCGCCATCGCCGACTGCGGGCCGTGACGCTGAGCGCCTCGGGGACTGT
AAGTGACCGCAGCCGGCCACCCTGGGGAGAAGGGGCAGTGCCCCTCGGGCAGCAGGGAGCCGCAGGTCCCCGGCCGGAAGCTCAGTGTCT
GACGTCAGTTGTTTTCCAGAAGGGCTTTGGGTAAATCACGGCTGCAATTGAGGTCAGCCACGCTGGCCCCGGACCAGGCGCTGGGCTGCA
TGCGTCACTGGGAATGTCATTCGGTCCCACGTCGAACCGGGCGCTCCATAGGGCAGCACCATCACCAGGTGCACAGCTGAGGCCCAGGGT
CTGCTTCGGACCCCGGCCAGACCCCAGCGAGCCCCTCTCTGCCCCTGGACCCAGCCCTCTCGTGTCAGGGTGTCTTGGGTGGACGCTTCT
CACTCGTGCAGACCTGGCTGCCCGTGGCCCCGCTGGCTGCACAGGGGAGGTTGCACAGGTCAGCAGAGTGGCTGCAGGGCCGGGCTCTGA
ACCGCAGGGCCATGGAGACGGGGAGGAGATGGTCTCTCCACACCCACCTCACAGATGGAGGCGCTGAGGCCTCGGCTCCCCTGGGAGCCT
GGGAGACCACACGGTTTAGTCAAAATCCAGATCCCCAAGCTCTCAAGGAGGTCCCCCTGGGACGCCACATGGGCCCCACGTAGCTGTGAG
ATCCTCAGGGCCTGCTGTTGTCATTATGACCAATAAGCAAGGGGCCCAGAGAGCCTAAGAGACCTGCCCAGCACCGCACAGCCAGAACGG
GGCGCAGACCCAAAGCAGGAGTGTCCCCTCGAGACAAAGCCTCCGCCGAGGCCGCCGTGACTCCCCGCCCATCAGCAAACCTCTCCGAGC
ACCTCTGTGTGCCAGGCACTGTGGAGTGACCCCAAGAGGTGGAGACCACTTCCCCGGCTGCTCTAGGCAGCTCCGTCCCACGGAGCCAGC

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000335312_chr19_3661999_-_4844nt
GTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTG
AAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTG
GTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTC
GCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAAC
CCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAG
AAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGG
GGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTAC
AAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTG
CTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTG
CTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGC
CAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGG
ATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTG
GAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATG
AGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTG
GGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACG
CTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCA
TCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGAT
GGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTC
CCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAG
GAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTCCCACCGATGAGAGGAGCTGGGTGTAC
TCCCCGCTCCACTATAGCGCCCAGGCCCCCCCGGCCTCCGACGGCGAGAGCGACACATAATTTCTATGCAGCCCCCGACCCAGAGCCGAG
CTCCACTTCTGCTCCGGCTGCCCCCGAAGGCGCTGCCCACCCCGCTGAGGCCCAGAGCTCGGGAGATGCCCGCCTCGCCGCCCCACCGGA
CCTCGTCCTCCCCCTGCACGGATGCCGACGGCCGGGCCCCTCCCCGACAAGCCTCCCAGGGCCCCGGCACCCCGGTCGGCAGCCTGCCCC
TGTGAGACCCACCCTCCCGAGCGGCCAATCGCATTTGAGTCCTTATTTGGCACAGAGACGGAAGCACGTGTGTGCCGTTTTAGGAAAAGA
ACAAAAAAGACACAAACAAACCAACCAGAGGGAGAAGAGCCCCTGCCCACTGCACTCTTTGGTTCTCTGCTGTGCCTGCCTGTGTCCTGA
GGAAGAAGCCAGGCTGTTCGCGGTGGCCTCTGGGGACCTGAGCCCCGGGGGCCCCATCGGCCTGCAGAGGGGACGGCTGGGGTCCCGAGC
AACTCTGCCTCCATCCACGTGGGAAGCGGACCCTCCTGCCCTCAGCTTGGGTTTGGGGGCCTCAGTGCAGGACATCTGGCCTGAACATCG
ACTGTGGGGACAGCCCTCGCCCTGCCAAGCACTGCGGCCACTCAGCAGCTATGTTCCCGCCGCAGTGGGGCCCTGACGCCCACCTCCCAG
GTGCCCCTCGAGCAAAAACCTCTGGCGCCTCCAATCCAGACCCACCACAGCTGGAGGGCCAGGCCTCCTCTTCCCCAGGCTGCCACCCAC
GCTGGCGGAGCTCAGGGCTGGGGACTTGTCCTTCTCTTCCAACGTAGGCCACTCAGCAACTGGCATGGAGGGCCCAGGCAACGGAGACGT
TTTCTCCATGGCAGGACAGAGCGGGAGGCCGGGCCTTGGGCCACAGGAGACCAGCTCAGGGCGGAAGGTCAGGCTCCCCGCCCCCTCCAC
GTGGAGACATGGCCTAGGGGGCCAGGCCCGGCTCCACAGGAGTCTCCTTCAGGACTGGTGTGGATGTCCGCCGCCTCTTTCTTGTTTAAG
TGATGTGATGTCTCCGAGGAGGGGAGAGAAGACTTTGTTTCCGACTCATCACCCTCCAAGAGGGCAGCGCTCCCAGTGGTGGGACTCAGC
CCAGACTGCCCTGGGGCAGCTTCCTGGGCCCGCTGCGCTCAGAGGGTGCTGGTTGGAGGCCAGAGCTCGGCAGAGTCACCCACCCTGCCC
TTCCCCAGGACCCCTGAGAGGGGCTTATTGGTGATGGCTGTGGGAATCCCCCACTTCCAAGATGTGCCCAGGATGTGAGGAGCTGGAGTG
GAAGCTGCACCTTTGGGAAGAATTCCTCTCCAGACCTGGCAGAGCCTGGTGTGGGGTCTGAGACGGCCGGAGAACCTCCCAGGCAGGGCT
CTGTGTTTTGTCTGTTACAACCTCCGTATGACGCCACGCCACCCGCTGTTCACGTCCCGTCGGCCTCCTGCACAGCCCACACGCTGCGCC
CGGAAGGCCCCTGCTGTGGAGAAGCCGGACCCATCCCCGAGGTCCCCAGCGAGGACACACACTCCACGAGAGCAGCCCCTCCACTCTGCC
CAGGAGAGGGGCCGACCCTCCTCGGGAACCGGCCAGCCGCGTGGCTCCCAGCATCCATCAGGACAAGCCCACGTGGGGTCCTCCCTGCGT
GCTCAGAGGGTCTGTCCAGCCCTGGGAAGCGACCTTGGCCTCAGTTCACAGCCTGGTGCTCATCTGCTGGCACCGGGCATCCACCCATCA
GCCCCCGCCCTGTCCCTCCGAAGGACACCCAGCAGGCACCCCCCGGGGAGGCAGGGGCAGAGGTCAGAAGGGGTGTCTGGGACCTGGATG
GCCAGCAGGGACAGGGGCATTGTCATCTCAAAGGCCCAACCCCCAGAGGCCACACCAGTCCTCCCAGGGAGTCCTCGAGTCGCCCTGCCC
AGAGCCCTGGCACCAGAGACGCCAAGAGCCTGTGGGGTGACTCGGAGCAGCAGGTGTGGCCCCGGGCGGGCGGCACCGCGTCCAGGGCAG
CCTCCCTCCGCTGAGTGACACGGGACACCAGTGCCCGGCCGACGCGCCTTTGCAGGAGAAATGTGCAAACCTCTGTGGATACCATTTCAT
TTCCATTCTTGTGTTGTCTCCAAGGCCCTTTTGGAGATATACTTGGTGTTGGTTGTGTTTTTTGGTTCCTTTTCAGAGAACTGTAAACCG
AGGCTGACGTGCTCCACTGACTGTGCCGAGGGGCGGGGGCAGGAGGACGGCAAGACCTATTTATAATATTTAGCGAACTCGGTCTCCCTC
AGATCCCCCGCGAGGGAGGCTGCTGGACCCACCCCGCTGTCCCCCATGATAGAAGTCTGTAAATACCTTGGTGACCAATGCCCACTTCCC
CTCCTGGGTCACCTCTGATGGCTGCTGTCCACTGAGAACGTGGGCAGTGTCCAAATTCCTGTACTGTAAAGACTAAAAGGCGTTTGCTCT
GAGACTGACAAGGCGGAAACTTCCATGTGTCTCCTGCCAGGCTCTGTCCCCCTACGCCATCCCGACACGTCCCCGTTCCCCCGAAACCTG
GCTCAGTGCAATACTCCCATTGCCATGGGGTCCTTCACCATGGTACTGTCTCCACAGCCCTCAGTCCCCACCCCAGGAGAGGCGCCTGCC
ACCTCCTCCTCATCTCCGGTGGTTCAATCGCTCCGCCTGTCCCCAACCCAGTCCCATTTTTATGGCCAAACTGATTCTGAAACAAAATGA
AACTGCAAACCTCGTGTGTCTTAACTCCCCCCAGGGATGCCACTCCATTCCTCCGCCCCGTGGTCTGGTGCGTGACAATCCAAAGCGCCG
AGACGAGGGTGCTGTGTCCCTCAAACCCAGAGTGGTGGGCGCCTCTGAAACCATACAGCCACTCCTGGCCCCAAACACTGGTTTGCATCC

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000539785_chr19_3661999_-_2067nt
GTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTG
AAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTG
GTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTC
GCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAAC
CCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAG
AAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGG
GGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTAC
AAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTG
CTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTG
CTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGC
CAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGG
ATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTG
GAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATG
AGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTG
GGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACG
CTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCA
TCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGAT
GGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTC
CCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAG
GAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTAATTTCTATGCAGCCCCCGACCCAGA
GCCGAGCTCCACTTCTGCTCCGGCTGCCCCCGAAGGCGCTGCCCACCCCGCTGAGGCCCAGAGCTCGGGAGATGCCCGCCTCGCCGCCCC
ACCGGACCTCGTCCTCCCCCTGCACGGATGCCGACGGCCGGGCCCCTCCCCGACAAGCCTCCCAGGGCCCCGGCACCCCGGTCGGCAGCC

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000589578_chr19_3661999_-_2786nt
GTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTG
AAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTG
GTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTC
GCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAAC
CCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAG
AAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGG
GGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTAC
AAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTG
CTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTG
CTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGC
CAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGG
ATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTG
GAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATG
AGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTG
GGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACG
CTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCA
TCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGAT
GGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTC
CCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAG
GAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTTCACGGATGGGAGGTACTGGATTTAC
TCTCCCCGCCATCGCCGACTGCGGGCCGTGACGCTGAGCGCCTCGGGGACTGTAAGTGACCGCAGCCGGCCACCCTGGGGAGAAGGGGCA
GTGCCCCTCGGGCAGCAGGGAGCCGCAGGTCCCCGGCCGGAAGCTCAGTGTCTGACGTCAGTTGTTTTCCAGAAGGGCTTTGGGTAAATC
ACGGCTGCAATTGAGGTCAGCCACGCTGGCCCCGGACCAGGCGCTGGGCTGCATGCGTCACTGGGAATGTCATTCGGTCCCACGTCGAAC
CGGGCGCTCCATAGGGCAGCACCATCACCAGGTGCACAGCTGAGGCCCAGGGTCTGCTTCGGACCCCGGCCAGACCCCAGCGAGCCCCTC
TCTGCCCCTGGACCCAGCCCTCTCGTGTCAGGGTGTCTTGGGTGGACGCTTCTCACTCGTGCAGACCTGGCTGCCCGTGGCCCCGCTGGC
TGCACAGGGGAGGTTGCACAGGTCAGCAGAGTGGCTGCAGGGCCGGGCTCTGAACCGCAGGGCCATGGAGACGGGGAGGAGATGGTCTCT
CCACACCCACCTCACAGATGGAGGCGCTGAGGCCTCGGCTCCCCTGGGAGCCTGGGAGACCACACGGTTTAGTCAAAATCCAGATCCCCA
AGCTCTCAAGGAGGTCCCCCTGGGACGCCACATGGGCCCCACGTAGCTGTGAGATCCTCAGGGCCTGCTGTTGTCATTATGACCAATAAG
CAAGGGGCCCAGAGAGCCTAAGAGACCTGCCCAGCACCGCACAGCCAGAACGGGGCGCAGACCCAAAGCAGGAGTGTCCCCTCGAGACAA
AGCCTCCGCCGAGGCCGCCGTGACTCCCCGCCCATCAGCAAACCTCTCCGAGCACCTCTGTGTGCCAGGCACTGTGGAGTGACCCCAAGA

>In-frame_MED21_ENST00000282892_chr12_27175554_+_PIP5K1C_ENST00000537021_chr19_3661999_-_3179nt
GTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTG
AAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTG
GTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTC
GCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAAC
CCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAG
AAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGG
GGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTAC
AAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTG
CTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTG
CTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGC
CAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGG
ATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTG
GAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATG
AGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTG
GGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACG
CTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCA
TCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGAT
GGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTC
CCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAG
GAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTGGCGCCTCTGGGGTCCCCATGCACCC
ACCTGGCCCTGGAGAAGGGAGGGACGGGCCGCGTGCCTGTGCCCCTACCCACCGCACGTCGTCACCCCTTTTCCTGGGACTGGTTTGTGC
GCGTCCTGGTCTCCGGATGGTACGGGGGGCCTGGGGGCCATGTCGTGCTGTGTGTCTGTGTCCTGATGCCCTGCCAGGTGGGCAGCAGAG
AAGGGAGAAGGGTCCTCGGTCCTGCCCCTGCCCCGGCACCCCCCACCTTCTGCTTGGCAGTCAGCTGTCCCCACCTGCTCCCCGCCACCT
CCCTCCGCCTCTCCCACCCGACCACGGGGGTGGCCGCCTCATCCGCTGTCCTCTGTTTTCCTTCCTCCTCCGGCCCACCCGGCCCGCCCC
GTCCAGTTCACGGATGGGAGGTACTGGATTTACTCTCCCCGCCATCGCCGACTGCGGGCCGTGACGCTGAGCGCCTCGGGGACTGTAAGT
GACCGCAGCCGGCCACCCTGGGGAGAAGGGGCAGTGCCCCTCGGGCAGCAGGGAGCCGCAGGTCCCCGGCCGGAAGCTCAGTGTCTGACG
TCAGTTGTTTTCCAGAAGGGCTTTGGGTAAATCACGGCTGCAATTGAGGTCAGCCACGCTGGCCCCGGACCAGGCGCTGGGCTGCATGCG
TCACTGGGAATGTCATTCGGTCCCACGTCGAACCGGGCGCTCCATAGGGCAGCACCATCACCAGGTGCACAGCTGAGGCCCAGGGTCTGC
TTCGGACCCCGGCCAGACCCCAGCGAGCCCCTCTCTGCCCCTGGACCCAGCCCTCTCGTGTCAGGGTGTCTTGGGTGGACGCTTCTCACT
CGTGCAGACCTGGCTGCCCGTGGCCCCGCTGGCTGCACAGGGGAGGTTGCACAGGTCAGCAGAGTGGCTGCAGGGCCGGGCTCTGAACCG
CAGGGCCATGGAGACGGGGAGGAGATGGTCTCTCCACACCCACCTCACAGATGGAGGCGCTGAGGCCTCGGCTCCCCTGGGAGCCTGGGA
GACCACACGGTTTAGTCAAAATCCAGATCCCCAAGCTCTCAAGGAGGTCCCCCTGGGACGCCACATGGGCCCCACGTAGCTGTGAGATCC
TCAGGGCCTGCTGTTGTCATTATGACCAATAAGCAAGGGGCCCAGAGAGCCTAAGAGACCTGCCCAGCACCGCACAGCCAGAACGGGGCG
CAGACCCAAAGCAGGAGTGTCCCCTCGAGACAAAGCCTCCGCCGAGGCCGCCGTGACTCCCCGCCCATCAGCAAACCTCTCCGAGCACCT
CTGTGTGCCAGGCACTGTGGAGTGACCCCAAGAGGTGGAGACCACTTCCCCGGCTGCTCTAGGCAGCTCCGTCCCACGGAGCCAGCGGGA


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FusionGenePPI for MED21_PIP5K1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MED21POLR2A, BRCA1, GTF2E1, GTF2F1, GTF2H4, MED10, MED9, MED29, MED19, MED28, MED26, PPARGC1A, CREBBP, KAT2B, SMARCB1, CDK8, MED30, MED6, MED14, GTF2B, CDK7, TCERG1, THRA, VDR, HNF4A, ESR2, ESR1, MED18, MED1, TRIM27, TARBP2, PCBD2, ZSCAN1, MED12, ZC3H13, SREBF1, TP53, THRB, SKP1, VAV2, ELAVL1, MED11, MED22, MED16, MED8, MED24, MED4, MED17, MED13, FBXW7, HTT, MAGEB4, MED21, BLOC1S6, ZNF655, SSC5D, MED7, CCNC, MED23, MED20, CSNK2A2, POLR2G, RACGAP1, MED27, DHRS3, MED13L, MED12L, FBXL19, CDK19, MED25, MED31, MED15, VAMP8, VTI1B, RNF20, SRC, ULBP2, SPAG5, EEPD1, PTPRG, KIF2C, POLR2J, ZMPSTE24, CKAP4, FYN, YES1, RNF40, HPCAL1, GNAZ, BIRC5, ABLIM1, PALM, HRAS, GAP43, VAMP3, CSNK1G3, STX8, ERICH5, MPZL1, SMPDL3B, POLR2I, EFNA5, SGPL1, PAG1, SCCPDH, GNAQ, PTPN11, INPP5A, POLR2D, RPAP2, POLR2M, PTRH2, CNTN1PIP5K1CPIP5KL1, ARF6, TLN2, SNX5, TLN1, CDH1, AP2A2, AP2B1, MOV10, LAPTM4B, RABGGTB, PIP5K1A, ITGB1, NEDD4, COQ2, SOAT1, VDAC1, UBC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MED21_PIP5K1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MED21_PIP5K1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePIP5K1CC1969655LETHAL CONGENITAL CONTRACTURAL SYNDROME 31CTD_human;ORPHANET;UNIPROT