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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 215

FusionGeneSummary for ABHD17A_TCF3

check button Fusion gene summary
Fusion gene informationFusion gene name: ABHD17A_TCF3
Fusion gene ID: 215
HgeneTgene
Gene symbol

ABHD17A

TCF3

Gene ID

81926

83439

Gene nameabhydrolase domain containing 17Atranscription factor 7 like 1
SynonymsC19orf27|FAM108A1TCF-3|TCF3
Cytomap

19p13.3

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionalpha/beta hydrolase domain-containing protein 17Aabhydrolase domain-containing protein 17Aabhydrolase domain-containing protein FAM108A1family with sequence similarity 108, member A1protein ABHD17Atranscription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)
Modification date2018051920180523
UniProtAcc

Q96GS6

P15923

Ensembl transtripts involved in fusion geneENST00000292577, ENST00000250974, 
ENST00000590661, 
ENST00000344749, 
ENST00000262965, ENST00000453954, 
ENST00000395423, ENST00000588136, 
Fusion gene scores* DoF score4 X 3 X 4=487 X 9 X 3=189
# samples 410
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/189*10)=-0.918386234446348
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABHD17A [Title/Abstract] AND TCF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-2A-A8VT-01AABHD17Achr19

1881234

-TCF3chr19

1646426

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000292577ENST00000344749ABHD17Achr19

1881234

-TCF3chr19

1646426

-
Frame-shitENST00000292577ENST00000262965ABHD17Achr19

1881234

-TCF3chr19

1646426

-
5CDS-intronENST00000292577ENST00000453954ABHD17Achr19

1881234

-TCF3chr19

1646426

-
5CDS-intronENST00000292577ENST00000395423ABHD17Achr19

1881234

-TCF3chr19

1646426

-
5CDS-intronENST00000292577ENST00000588136ABHD17Achr19

1881234

-TCF3chr19

1646426

-
Frame-shitENST00000250974ENST00000344749ABHD17Achr19

1881234

-TCF3chr19

1646426

-
Frame-shitENST00000250974ENST00000262965ABHD17Achr19

1881234

-TCF3chr19

1646426

-
5CDS-intronENST00000250974ENST00000453954ABHD17Achr19

1881234

-TCF3chr19

1646426

-
5CDS-intronENST00000250974ENST00000395423ABHD17Achr19

1881234

-TCF3chr19

1646426

-
5CDS-intronENST00000250974ENST00000588136ABHD17Achr19

1881234

-TCF3chr19

1646426

-
In-frameENST00000590661ENST00000344749ABHD17Achr19

1881234

-TCF3chr19

1646426

-
In-frameENST00000590661ENST00000262965ABHD17Achr19

1881234

-TCF3chr19

1646426

-
5CDS-intronENST00000590661ENST00000453954ABHD17Achr19

1881234

-TCF3chr19

1646426

-
5CDS-intronENST00000590661ENST00000395423ABHD17Achr19

1881234

-TCF3chr19

1646426

-
5CDS-intronENST00000590661ENST00000588136ABHD17Achr19

1881234

-TCF3chr19

1646426

-

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FusionProtFeatures for ABHD17A_TCF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABHD17A

Q96GS6

TCF3

P15923

Hydrolyzes fatty acids from S-acylated cysteine residuesin proteins (PubMed:26701913). Has depalmitoylating activitytowards NRAS (PubMed:26701913). Has depalmitoylating activitytowards DLG4/PSD95 (PubMed:26701913). May have depalmitoylatingactivity towards MAP6 (By similarity).{ECO:0000250|UniProtKB:Q5XIJ5, ECO:0000269|PubMed:26701913}. Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major rolesin determining tissue-specific cell fate during embryogenesis,like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappaimmunoglobulin gene enhancer. Binds to IEB1 and IEB2, which areshort DNA sequences in the insulin gene transcription controlregion. {ECO:0000250|UniProtKB:P15806}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ABHD17A_TCF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ABHD17A_ENST00000590661_chr19_1881234_-_TCF3_ENST00000344749_chr19_1646426_-_738aa
MNGLSLSELCCLFCCPPCPGRIAAKLAFLPPEATYSLVPEPEPGPGGAGAAPLGTLRASSGAPGRWKLHLTERADFQYSQRELDTIEVFP
TKSARGNRVSCMTVRCVPGARCSRCLSPTGRAGPPPWPGRSSEVQVLRTGPAQAPGAAATRAAPPLTPAGPSARAPTSLSRTAASLHPHS
WDRDSEARAVSGAPMPPSGETQAWAA_LRLASCQASWPSTAPGPCPLRA_RGPPSTTPPTPAAPGGERQTAA_TRSPRRSGRSRRVFHPR
CTHPAQVRTTAGMPPPTRPPRPPAAPIPPPSTWQMAACTPQPSSGVPRARRASGPCWVGAHPRCPSRPVAARWAAVEAAARLVACTSTSV
WATSCMEQR_TVGSHLHPPSPQPPEPRTAASPATRRLSAGPTASWAPEGPQLAAPGMPSAKHWPRSTPRITQAITSRPALLPPWAPPRAW
QERHSGLEQEPPVPTRPATTGVSTACRVR_KTTWTRPSTCSAATPWAQPATCTRCCLATGRWPQVSPAPCHWAGGTQAWLEAATPRTASQ
AAPASCTTTRPSPASQAPSLTCLGLPTPTVG_GEQVPRRPPARSSGRRRRTRRTRQRLTTRRRRRRS_RPPGPGPAVRTRCCPWRRKT_G
TGRGAWPITRGSGCACGILTRPSGSWGACARCTSSRTKRRPSCSSCSRPCRSSWGWSSRCESGT_IPKQPV_NGEKRKRCQVWLETPRWC

>In-frame_ABHD17A_ENST00000590661_chr19_1881234_-_TCF3_ENST00000262965_chr19_1646426_-_741aa
MNGLSLSELCCLFCCPPCPGRIAAKLAFLPPEATYSLVPEPEPGPGGAGAAPLGTLRASSGAPGRWKLHLTERADFQYSQRELDTIEVFP
TKSARGNRVSCMTVRCVPGARCSRCLSPTGRAGPPPWPGRSSEVQVLRTGPAQAPGAAATRAAPPLTPAGPSARAPTSLSRTAASLHPHS
WDRDSEARAVSGAPMPPSGETQAWAA_LRLASCQASWPSTAPGPCPLRA_RGPPSTTPPTPAAPGGERQTAA_TRSPRRSGRSRRVFHPR
CTHPAQVRTTAGMPPPTRPPRPPAAPIPPPSTWQMAACTPQPSSGVPRARRASGPCWVGAHPRCPSRPVAARWAAVEAAARLVACTSTSV
WATSCMEQR_TVGSHLHPPSPQPPEPRTAASPATRRLSAGPTASWAPEGPQLAAPGMPSAKHWPRSTPRITQAITSRPALLPPWAPPRAW
QERHSGLEQEPPVPTRPATTGVSTACRVR_KTTWTRPSTCSAATPWAQPATCTRCCLATGRWPQVSPAPCHWAGGTQAWLEAATPRTASQ
AAPASCTTTRPSPASQAPSLTCLGLPTPTVG_GEQVPRRPPARSSGRRRRTRRTRQRLTTRRRRRRS_RPPGPGPAQTRTRTTFSPQSRR
PSGRRSAGWPITPGSGCGSVTSTRPLRSWGACANCTSTARSPRPNCSSCTRLSRSS_TWSSKCESGT_IPKQPV_NGEKRKRCQVWLETP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ABHD17A_ENST00000590661_chr19_1881234_-_TCF3_ENST00000344749_chr19_1646426_-_2216nt
ATGAATGGGCTGTCGCTGAGTGAGCTCTGCTGCCTCTTCTGCTGCCCGCCCTGCCCCGGCCGCATCGCTGCCAAGCTCGCCTTCCTGCCG
CCGGAGGCCACCTACTCCCTGGTGCCTGAGCCCGAGCCGGGGCCTGGTGGGGCCGGGGCCGCCCCCTTGGGGACCCTGAGAGCCTCCTCG
GGCGCACCCGGGCGCTGGAAGCTGCACCTGACGGAGCGTGCCGACTTCCAGTACAGCCAGCGCGAGCTGGACACCATCGAGGTCTTCCCC
ACCAAGAGCGCCCGCGGCAACCGCGTCTCCTGCATGTATGTTCGCTGCGTGCCTGGTGCCAGATGTTCCCGCTGCCTGTCACCAACGGGA
AGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACC
AGAGCAGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGCCTCTCTTCATCCACATTCC
TGGGACCGGGACTCGGAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTG
GCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACT
CCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGG
TGTACCCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCT
TCTACGTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCT
CATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTA
TGGGCTACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCG
TCTCCAGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCA
AAGCACTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGG
CAGGAACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAG
AAGACCACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGG
CGCTGGCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAG
GCAGCACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTG
GGCTAGGGCGAGCAGGTGCCACGGCGGCCGCCAGCGAGATCAAGCGGGAGGAGAAGGAGGACGAGGAGAACACGTCAGCGGCTGACCACT
CGGAGGAGGAGAAGAAGGAGCTGAAGGCCCCCCGGGCCCGGACCAGCAGTACGGACGAGGTGCTGTCCCTGGAGGAGAAAGACCTGAGGG
ACCGGGAGAGGCGCATGGCCAATAACGCGCGGGAGCGGGTGCGCGTGCGGGATATTAACGAGGCCTTCCGGGAGCTGGGGCGCATGTGCC
AGATGCACCTCAAGTCGGACAAAGCGCAGACCAAGCTGCTCATCCTGCAGCAGGCCGTGCAGGTCATCCTGGGGCTGGAGCAGCAGGTGC
GAGAGCGGAACCTGAATCCCAAAGCAGCCTGTTTGAAACGGCGAGAAGAGGAAAAGGTGTCAGGTGTGGTTGGAGACCCCCAGATGGTGC

>In-frame_ABHD17A_ENST00000590661_chr19_1881234_-_TCF3_ENST00000262965_chr19_1646426_-_2225nt
ATGAATGGGCTGTCGCTGAGTGAGCTCTGCTGCCTCTTCTGCTGCCCGCCCTGCCCCGGCCGCATCGCTGCCAAGCTCGCCTTCCTGCCG
CCGGAGGCCACCTACTCCCTGGTGCCTGAGCCCGAGCCGGGGCCTGGTGGGGCCGGGGCCGCCCCCTTGGGGACCCTGAGAGCCTCCTCG
GGCGCACCCGGGCGCTGGAAGCTGCACCTGACGGAGCGTGCCGACTTCCAGTACAGCCAGCGCGAGCTGGACACCATCGAGGTCTTCCCC
ACCAAGAGCGCCCGCGGCAACCGCGTCTCCTGCATGTATGTTCGCTGCGTGCCTGGTGCCAGATGTTCCCGCTGCCTGTCACCAACGGGA
AGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACC
AGAGCAGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGCCTCTCTTCATCCACATTCC
TGGGACCGGGACTCGGAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTG
GCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACT
CCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGG
TGTACCCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCT
TCTACGTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCT
CATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTA
TGGGCTACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCG
TCTCCAGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCA
AAGCACTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGG
CAGGAACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAG
AAGACCACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGG
CGCTGGCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAG
GCAGCACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTG
GGCTAGGGCGAGCAGGTGCCACGGCGGCCGCCAGCGAGATCAAGCGGGAGGAGAAGGAGGACGAGGAGAACACGTCAGCGGCTGACCACT
CGGAGGAGGAGAAGAAGGAGCTGAAGGCCCCCCGGGCCCGGACCAGCCCAGACGAGGACGAGGACGACCTTCTCCCCCCAGAGCAGAAGG
CCGAGCGGGAGAAGGAGCGCCGGGTGGCCAATAACGCCCGGGAGCGGCTGCGGGTCCGTGACATCAACGAGGCCTTTAAGGAGCTGGGGC
GCATGTGCCAACTGCACCTCAACAGCGAGAAGCCCCAGACCAAACTGCTCATCCTGCACCAGGCTGTCTCGGTCATCCTGAACTTGGAGC
AGCAAGTGCGAGAGCGGAACCTGAATCCCAAAGCAGCCTGTTTGAAACGGCGAGAAGAGGAAAAGGTGTCAGGTGTGGTTGGAGACCCCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ABHD17A_ENST00000590661_chr19_1881234_-_TCF3_ENST00000344749_chr19_1646426_-_4648nt
GGCCTGGGCGGCGCCCGCCATGAATGGGCTGTCGCTGAGTGAGCTCTGCTGCCTCTTCTGCTGCCCGCCCTGCCCCGGCCGCATCGCTGC
CAAGCTCGCCTTCCTGCCGCCGGAGGCCACCTACTCCCTGGTGCCTGAGCCCGAGCCGGGGCCTGGTGGGGCCGGGGCCGCCCCCTTGGG
GACCCTGAGAGCCTCCTCGGGCGCACCCGGGCGCTGGAAGCTGCACCTGACGGAGCGTGCCGACTTCCAGTACAGCCAGCGCGAGCTGGA
CACCATCGAGGTCTTCCCCACCAAGAGCGCCCGCGGCAACCGCGTCTCCTGCATGTATGTTCGCTGCGTGCCTGGTGCCAGATGTTCCCG
CTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGC
TCCTGGGGCAGCGGCGACCAGAGCAGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGC
CTCTCTTCATCCACATTCCTGGGACCGGGACTCGGAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTG
GGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCC
CAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCG
CCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGC
AGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGG
CCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGC
CTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCC
GGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGC
TCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTG
GGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCAC
GGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACG
CTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCAC
CCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGG
CCTCCCGACTCCTACAGTGGGCTAGGGCGAGCAGGTGCCACGGCGGCCGCCAGCGAGATCAAGCGGGAGGAGAAGGAGGACGAGGAGAAC
ACGTCAGCGGCTGACCACTCGGAGGAGGAGAAGAAGGAGCTGAAGGCCCCCCGGGCCCGGACCAGCAGTACGGACGAGGTGCTGTCCCTG
GAGGAGAAAGACCTGAGGGACCGGGAGAGGCGCATGGCCAATAACGCGCGGGAGCGGGTGCGCGTGCGGGATATTAACGAGGCCTTCCGG
GAGCTGGGGCGCATGTGCCAGATGCACCTCAAGTCGGACAAAGCGCAGACCAAGCTGCTCATCCTGCAGCAGGCCGTGCAGGTCATCCTG
GGGCTGGAGCAGCAGGTGCGAGAGCGGAACCTGAATCCCAAAGCAGCCTGTTTGAAACGGCGAGAAGAGGAAAAGGTGTCAGGTGTGGTT
GGAGACCCCCAGATGGTGCTTTCAGCTCCCCACCCAGGCCTGAGCGAAGCCCACAACCCCGCCGGGCACATGTGAAAGGTATGCCTCCGT
GGGACGAGCCACCCGCTTTCAGCCCTGTGCTCTGGCCCCAGAACGGCCACTCGAGACCCCGGGCTTCATCCACATCCACACCTCACACAC
CTGTTGTCAGCATCGAGCCAACACCAACCTGACAAGGTTCGGAGTGATGGGGGCGGCCAAGGTGACACTGGGTCCAGGAGCTCCCTGGGG
CCCTGGCCTACCACTCACTGGCCTCGCTCCCCCTGTCCCCGAATCTCAGCCACCGTGTCACTCTGTGACCTGTCCCATGGATCCTGAAAC
TGCATCTTGGCCCTGTTGCCTGGGCTGACAGGAGCATTTTTTTTTTTTCCAGTAAACAAAACCTGAAAGCAAGCAACAAAACATACACTT
TGTCAGAGAAGAAAAAAATGCCTTAACTATAAAAAGCGGAGAAATGGAAACATATCACTCAAGGGGGATGCTGTGGAAACCTGGCTTATT
CTTCTAAAGCCACCAGCAAATTGTGCCTAAGCGAAATATTTTTTTTAAGGAAAATAAAAACATTAGTTACAAGATTTTTTTTTTCTTAAT
GTAGATGAAAATTAGCAAGGATGCTGCCTTTGGTCTCTGGTTTTTTTAAGCTTTTTTTGCATATGTTTTGTAAGCAACAAATTTTTTTGT
ATAAAAGTCCCGTGTCTCTCGCTATTTCTGCTGCTGTTCCTAGACTGAGCATTGCATTTCTTGATCAACCAGATGATTAAACGTTGTATT
AAAAAGACCCCGTGTAAACCTGAGCCCCCCCGTCCCCCCCCCCCCCCGGAAGCCACTGCACACAGACAGAACGGGGACAGGCGGCGGGTC
TTTTGTTTTTTTGATGTTGGGGGTTCTCTTGGTTTTGTCATGTGGAAAGTGATGCGTGGGCGTTCCCTGATGAAGGCACCTTGGGGCTTC
CCTGCCGCATCCTCTCCCCTCAGGAAGGGGACTGACCTGGGCTTGGGGGAAGGGACGTCAGCAAGGTGGCTCTGACCCTCCCAGGTGACT
CTGCCAAGCAGCTGTGGCCCCCAGGGCTACCCTACACAACGCCCTCCCCAGGCCCCCCTAAGCTGCTCTCCCTTGGAACCTGCACAGCTC
TCTGAAATGGGGCATTTTGTTGGGACCAGTGACCCCTGGCATGGGGACCACACCCTGGAGCCCGGTGCTGGGGACCTCCTGGACACCCTG
TCCTTCACTCCTTTGCCCCAGGGACCCAGGCTCATGCTCTGAACTCTGGCTGAGAGGATGCTGCTCAGGAGCCAGCACAGGACACCCCCC
ACCCCACCCCACCATGTCCCCATTACACCAGAGGGCCATCGTGACGTAGACAGGATGCCAGGGGCCTGGCCAGCCTCCCCCAATGCTGGG
GAGCATCCCTGGGCCTGGGGCCACACCTGCTGCCCTCCCTCTGTGTGGTCCAAGGGCAAGAGTGGCTGGAGCCGGGGGACTGTGCTGGTC
TGAGCCCCACGAAGGCCTTGGGCTGTGCGTCCGACCCTGCTGCAGAACCAGCAGGGTGTCCCCTCGGGCCCATCTGTGTCCCATGTCCCA
GCACCCAGGCCTCTCTCCAGGTCTCCTTTTCTGGTCTTTTGCCATGAGGGTAACCAGCTCTTCCCAGCTGGCTGGGGACTGTCTTGGGTT
TAAAACTGCAAGTCTCCTACCCTGGGATCCCATCCAGTTCCACACGAACTAGGGCAGTGGTCACTGTGGCACCCAGGTGTGGGCCTGGCT
AGCTGGGGGCCTTCATGTGCCCTTCATGCCCCTCCCTGCATTGAGGCCTTGTGGACCCCTGGGCTGGCTGTGTTCATCCCCGCTGCAGGT
CGGGCGTCTCCCCCCGTGCCACTCCTGAGACTCCCACCGTTACCCCCAGGAGATCCTGGACTGCCTGACTCCCCTCCCCAGACTGGCTTG
GGAGCCTGGGCCCCATGGTAGATGCAAGGGAAACCTCAAGGCCAGCTCAATGCCTGGTATCTGCCCCCAGTCCAGGCCAGGCGGAGGGGA
GGGGCTGTCCGGCTGCCTCTCCCTTCTCGGTGGCTTCCCCTACGCCCTGGGAGTTTGATCTCTTAAGGGAACTTGCCTCTCCCTCTTGTT
TTGCTCCTGGCCCTGCCCCTAGGTCTGGGTGGGCAGTGGCCCCATAGCCTCTGGAACTGTGCGTTCTGCATAGAATTCAAACGAGATTCA
CCCAGCGCGAGGAGGAAGAAACAGCAGTTCCTGGGAACCACAATTATGGGGGGTGGGGGGTGTGATCTGAGTGCCTCAAGATGGTTTTCA
AAAAAATTTTTTTAAAGAAAATAATTGTATACGTGTCAACACAGCTGGCTGGATGATTGGGACTTTAAAACGACCCTCTTTCAGGTGGAT

>In-frame_ABHD17A_ENST00000590661_chr19_1881234_-_TCF3_ENST00000262965_chr19_1646426_-_4657nt
GGCCTGGGCGGCGCCCGCCATGAATGGGCTGTCGCTGAGTGAGCTCTGCTGCCTCTTCTGCTGCCCGCCCTGCCCCGGCCGCATCGCTGC
CAAGCTCGCCTTCCTGCCGCCGGAGGCCACCTACTCCCTGGTGCCTGAGCCCGAGCCGGGGCCTGGTGGGGCCGGGGCCGCCCCCTTGGG
GACCCTGAGAGCCTCCTCGGGCGCACCCGGGCGCTGGAAGCTGCACCTGACGGAGCGTGCCGACTTCCAGTACAGCCAGCGCGAGCTGGA
CACCATCGAGGTCTTCCCCACCAAGAGCGCCCGCGGCAACCGCGTCTCCTGCATGTATGTTCGCTGCGTGCCTGGTGCCAGATGTTCCCG
CTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGC
TCCTGGGGCAGCGGCGACCAGAGCAGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGC
CTCTCTTCATCCACATTCCTGGGACCGGGACTCGGAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTG
GGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCC
CAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCG
CCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGC
AGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGG
CCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGC
CTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCC
GGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGC
TCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTG
GGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCAC
GGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACG
CTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCAC
CCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGG
CCTCCCGACTCCTACAGTGGGCTAGGGCGAGCAGGTGCCACGGCGGCCGCCAGCGAGATCAAGCGGGAGGAGAAGGAGGACGAGGAGAAC
ACGTCAGCGGCTGACCACTCGGAGGAGGAGAAGAAGGAGCTGAAGGCCCCCCGGGCCCGGACCAGCCCAGACGAGGACGAGGACGACCTT
CTCCCCCCAGAGCAGAAGGCCGAGCGGGAGAAGGAGCGCCGGGTGGCCAATAACGCCCGGGAGCGGCTGCGGGTCCGTGACATCAACGAG
GCCTTTAAGGAGCTGGGGCGCATGTGCCAACTGCACCTCAACAGCGAGAAGCCCCAGACCAAACTGCTCATCCTGCACCAGGCTGTCTCG
GTCATCCTGAACTTGGAGCAGCAAGTGCGAGAGCGGAACCTGAATCCCAAAGCAGCCTGTTTGAAACGGCGAGAAGAGGAAAAGGTGTCA
GGTGTGGTTGGAGACCCCCAGATGGTGCTTTCAGCTCCCCACCCAGGCCTGAGCGAAGCCCACAACCCCGCCGGGCACATGTGAAAGGTA
TGCCTCCGTGGGACGAGCCACCCGCTTTCAGCCCTGTGCTCTGGCCCCAGAACGGCCACTCGAGACCCCGGGCTTCATCCACATCCACAC
CTCACACACCTGTTGTCAGCATCGAGCCAACACCAACCTGACAAGGTTCGGAGTGATGGGGGCGGCCAAGGTGACACTGGGTCCAGGAGC
TCCCTGGGGCCCTGGCCTACCACTCACTGGCCTCGCTCCCCCTGTCCCCGAATCTCAGCCACCGTGTCACTCTGTGACCTGTCCCATGGA
TCCTGAAACTGCATCTTGGCCCTGTTGCCTGGGCTGACAGGAGCATTTTTTTTTTTTCCAGTAAACAAAACCTGAAAGCAAGCAACAAAA
CATACACTTTGTCAGAGAAGAAAAAAATGCCTTAACTATAAAAAGCGGAGAAATGGAAACATATCACTCAAGGGGGATGCTGTGGAAACC
TGGCTTATTCTTCTAAAGCCACCAGCAAATTGTGCCTAAGCGAAATATTTTTTTTAAGGAAAATAAAAACATTAGTTACAAGATTTTTTT
TTTCTTAATGTAGATGAAAATTAGCAAGGATGCTGCCTTTGGTCTCTGGTTTTTTTAAGCTTTTTTTGCATATGTTTTGTAAGCAACAAA
TTTTTTTGTATAAAAGTCCCGTGTCTCTCGCTATTTCTGCTGCTGTTCCTAGACTGAGCATTGCATTTCTTGATCAACCAGATGATTAAA
CGTTGTATTAAAAAGACCCCGTGTAAACCTGAGCCCCCCCGTCCCCCCCCCCCCCCGGAAGCCACTGCACACAGACAGAACGGGGACAGG
CGGCGGGTCTTTTGTTTTTTTGATGTTGGGGGTTCTCTTGGTTTTGTCATGTGGAAAGTGATGCGTGGGCGTTCCCTGATGAAGGCACCT
TGGGGCTTCCCTGCCGCATCCTCTCCCCTCAGGAAGGGGACTGACCTGGGCTTGGGGGAAGGGACGTCAGCAAGGTGGCTCTGACCCTCC
CAGGTGACTCTGCCAAGCAGCTGTGGCCCCCAGGGCTACCCTACACAACGCCCTCCCCAGGCCCCCCTAAGCTGCTCTCCCTTGGAACCT
GCACAGCTCTCTGAAATGGGGCATTTTGTTGGGACCAGTGACCCCTGGCATGGGGACCACACCCTGGAGCCCGGTGCTGGGGACCTCCTG
GACACCCTGTCCTTCACTCCTTTGCCCCAGGGACCCAGGCTCATGCTCTGAACTCTGGCTGAGAGGATGCTGCTCAGGAGCCAGCACAGG
ACACCCCCCACCCCACCCCACCATGTCCCCATTACACCAGAGGGCCATCGTGACGTAGACAGGATGCCAGGGGCCTGGCCAGCCTCCCCC
AATGCTGGGGAGCATCCCTGGGCCTGGGGCCACACCTGCTGCCCTCCCTCTGTGTGGTCCAAGGGCAAGAGTGGCTGGAGCCGGGGGACT
GTGCTGGTCTGAGCCCCACGAAGGCCTTGGGCTGTGCGTCCGACCCTGCTGCAGAACCAGCAGGGTGTCCCCTCGGGCCCATCTGTGTCC
CATGTCCCAGCACCCAGGCCTCTCTCCAGGTCTCCTTTTCTGGTCTTTTGCCATGAGGGTAACCAGCTCTTCCCAGCTGGCTGGGGACTG
TCTTGGGTTTAAAACTGCAAGTCTCCTACCCTGGGATCCCATCCAGTTCCACACGAACTAGGGCAGTGGTCACTGTGGCACCCAGGTGTG
GGCCTGGCTAGCTGGGGGCCTTCATGTGCCCTTCATGCCCCTCCCTGCATTGAGGCCTTGTGGACCCCTGGGCTGGCTGTGTTCATCCCC
GCTGCAGGTCGGGCGTCTCCCCCCGTGCCACTCCTGAGACTCCCACCGTTACCCCCAGGAGATCCTGGACTGCCTGACTCCCCTCCCCAG
ACTGGCTTGGGAGCCTGGGCCCCATGGTAGATGCAAGGGAAACCTCAAGGCCAGCTCAATGCCTGGTATCTGCCCCCAGTCCAGGCCAGG
CGGAGGGGAGGGGCTGTCCGGCTGCCTCTCCCTTCTCGGTGGCTTCCCCTACGCCCTGGGAGTTTGATCTCTTAAGGGAACTTGCCTCTC
CCTCTTGTTTTGCTCCTGGCCCTGCCCCTAGGTCTGGGTGGGCAGTGGCCCCATAGCCTCTGGAACTGTGCGTTCTGCATAGAATTCAAA
CGAGATTCACCCAGCGCGAGGAGGAAGAAACAGCAGTTCCTGGGAACCACAATTATGGGGGGTGGGGGGTGTGATCTGAGTGCCTCAAGA
TGGTTTTCAAAAAAATTTTTTTAAAGAAAATAATTGTATACGTGTCAACACAGCTGGCTGGATGATTGGGACTTTAAAACGACCCTCTTT


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FusionGenePPI for ABHD17A_TCF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABHD17AHPGDS, VPS28, TCTEX1D2, TNIP1, EHMT2, GPC4, GOLGA2, BIRC2, KRTAP5-9, MDFI, PLSCR4, TRIM27, TRAF1, RGS20, PNMA1, C5AR2, LPAR6, APLNRTCF3HAND2, ID3, SKP2, NHLH1, TCF3, EP300, CREBBP, KAT2B, CALM1, LMX1A, TAL1, LDB1, CBFA2T3, ELK3, MYOD1, ID1, ID2, MYF5, MYF6, MYOG, UBE2I, LYL1, MAPKAPK3, TWIST1, DAXX, MEN1, TCF4, RUNX1T1, RUNX1, VDR, HDAC2, DNMT1, TRIM33, INO80E, YY1, RB1, ASB2, SOX2, ELAVL1, ID4, KDM1A, PRMT5, MRPL37, RPL23A, UQCRC2, MRPL49, DDX17, SAFB, EIF5A, MYO1B, GSE1, SLC25A10, BHLHA15, PIP, ALDH18A1, SF3A3, DNAJC10, RPL36A, IMMT, RPS13, DDX20, TET2, PRPF8, RCOR1, TCF24, RPL14, PON2, SSBP1, RPL31, MRPL44, C14orf166, SPIN1, CCT2, MYL6B, CHCHD3, ATP2A3, LANCL2, SLC9A3R1, TIMM50, ERLIN2, MRPL39, ATOH8, SERPINH1, SETSIP, SON, FBL, SLC25A4, EEF1A2, LGALS7, C1QBP, CPD, MRPL23, NHLH2, RPL13, COX7A2, CSTA, PCBP1, NDUFB4, TFF3, FLG2, HNRNPR, ERAL1, RPN2, RBM39, RPL24, LBR, CASP14, STK38, CANX, TCF12, FOXH1, TLE1, KAT2A, TRRAP, SUPT3H, TADA2A, USF1, SCX, TCF21, RPL37, MAPKAPK2, RNF14, FAM115A, PTF1A, HAND1, NEUROD1, MESP2, BHLHE40, PARP1, PSMD4, NEDD9, XPO1, BCOR, KIF18A, ATOH1, FERD3L, NEUROG3, FKBP9, COLGALT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABHD17A_TCF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABHD17A_TCF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTCF3C0006413Burkitt Lymphoma2CTD_human
TgeneTCF3C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneTCF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human