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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21491

FusionGeneSummary for MED15_TANGO2

check button Fusion gene summary
Fusion gene informationFusion gene name: MED15_TANGO2
Fusion gene ID: 21491
HgeneTgene
Gene symbol

MED15

TANGO2

Gene ID

51586

128989

Gene namemediator complex subunit 15transport and golgi organization 2 homolog
SynonymsARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7C22orf25|MECRCN
Cytomap

22q11.21

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible getransport and Golgi organization protein 2 homolog
Modification date2018052320180523
UniProtAcc

Q96RN5

Q6ICL3

Ensembl transtripts involved in fusion geneENST00000425759, ENST00000292733, 
ENST00000542773, ENST00000263205, 
ENST00000406969, ENST00000382974, 
ENST00000541476, ENST00000478831, 
ENST00000401886, ENST00000447208, 
ENST00000398042, ENST00000432883, 
ENST00000327374, ENST00000479679, 
ENST00000401833, ENST00000434570, 
ENST00000420290, ENST00000456048, 
Fusion gene scores* DoF score12 X 9 X 9=9724 X 2 X 4=32
# samples 134
** MAII scorelog2(13/972*10)=-2.90244469057733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MED15 [Title/Abstract] AND TANGO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-PQ-A6FN-01AMED15chr22

20922918

+TANGO2chr22

20024283

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000425759ENST00000401886MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000425759ENST00000447208MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000425759ENST00000398042MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000425759ENST00000432883MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000425759ENST00000327374MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-3UTRENST00000425759ENST00000479679MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000425759ENST00000401833MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000425759ENST00000434570MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000425759ENST00000420290MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-intronENST00000425759ENST00000456048MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000292733ENST00000401886MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000292733ENST00000447208MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000292733ENST00000398042MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000292733ENST00000432883MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000292733ENST00000327374MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-3UTRENST00000292733ENST00000479679MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000292733ENST00000401833MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000292733ENST00000434570MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000292733ENST00000420290MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-intronENST00000292733ENST00000456048MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000542773ENST00000401886MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000542773ENST00000447208MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000542773ENST00000398042MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000542773ENST00000432883MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000542773ENST00000327374MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-3UTRENST00000542773ENST00000479679MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000542773ENST00000401833MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000542773ENST00000434570MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000542773ENST00000420290MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-intronENST00000542773ENST00000456048MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000263205ENST00000401886MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000263205ENST00000447208MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000263205ENST00000398042MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000263205ENST00000432883MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000263205ENST00000327374MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-3UTRENST00000263205ENST00000479679MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000263205ENST00000401833MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000263205ENST00000434570MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000263205ENST00000420290MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-intronENST00000263205ENST00000456048MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000406969ENST00000401886MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000406969ENST00000447208MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000406969ENST00000398042MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000406969ENST00000432883MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000406969ENST00000327374MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-3UTRENST00000406969ENST00000479679MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000406969ENST00000401833MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000406969ENST00000434570MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000406969ENST00000420290MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-intronENST00000406969ENST00000456048MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000382974ENST00000401886MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000382974ENST00000447208MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000382974ENST00000398042MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000382974ENST00000432883MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000382974ENST00000327374MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-3UTRENST00000382974ENST00000479679MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000382974ENST00000401833MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000382974ENST00000434570MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000382974ENST00000420290MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-intronENST00000382974ENST00000456048MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000541476ENST00000401886MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000541476ENST00000447208MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000541476ENST00000398042MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000541476ENST00000432883MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000541476ENST00000327374MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-3UTRENST00000541476ENST00000479679MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000541476ENST00000401833MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000541476ENST00000434570MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-5UTRENST00000541476ENST00000420290MED15chr22

20922918

+TANGO2chr22

20024283

+
5CDS-intronENST00000541476ENST00000456048MED15chr22

20922918

+TANGO2chr22

20024283

+
3UTR-5UTRENST00000478831ENST00000401886MED15chr22

20922918

+TANGO2chr22

20024283

+
3UTR-5UTRENST00000478831ENST00000447208MED15chr22

20922918

+TANGO2chr22

20024283

+
3UTR-5UTRENST00000478831ENST00000398042MED15chr22

20922918

+TANGO2chr22

20024283

+
3UTR-5UTRENST00000478831ENST00000432883MED15chr22

20922918

+TANGO2chr22

20024283

+
3UTR-5UTRENST00000478831ENST00000327374MED15chr22

20922918

+TANGO2chr22

20024283

+
3UTR-3UTRENST00000478831ENST00000479679MED15chr22

20922918

+TANGO2chr22

20024283

+
3UTR-5UTRENST00000478831ENST00000401833MED15chr22

20922918

+TANGO2chr22

20024283

+
3UTR-5UTRENST00000478831ENST00000434570MED15chr22

20922918

+TANGO2chr22

20024283

+
3UTR-5UTRENST00000478831ENST00000420290MED15chr22

20922918

+TANGO2chr22

20024283

+
3UTR-intronENST00000478831ENST00000456048MED15chr22

20922918

+TANGO2chr22

20024283

+

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FusionProtFeatures for MED15_TANGO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED15

Q96RN5

TANGO2

Q6ICL3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MED15_TANGO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MED15_TANGO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MED15MLLT6, PLSCR1, FHL3, MED10, MED9, MED29, MED19, MED28, MED26, MED25, MED6, ATP5C1, MED1, TRIM11, SMAD1, SMAD2, SMAD3, TRRAP, RELA, SREBF1, MED12, MED18, ZC3H13, TRIP4, QKI, TADA2A, CDK8, MED13, MED14, MED23, MED16, MED17, MED7, CTDP1, ATXN1, IGBP1, UBAP2L, SEC24C, CHEK1, NCOA6, FBXW7, EPAS1, CDK19, CCNC, NR1I3, ALDH8A1, TCL1B, HIF1A, MED11, MED20, MED24, MED27, MED4, MED8, EWSR1, MYO1C, POLR2F, POLR2G, CTDSPL2, MED21, UBE2N, TP73TANGO2ELAVL1, PNLIPRP2, SCO2, SH3GL2, BPNT1, PNPO, PRDX1, ADSS, CAT, CFL1, DPP3, G6PD, GAPDH, GNPDA1, HSPD1, LCMT1, NUTF2, PEPD, PPA2, PPIF, QDPR, SOD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MED15_TANGO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MED15_TANGO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMED15C0036341Schizophrenia2PSYGENET
HgeneMED15C0036337Schizoaffective Disorder1PSYGENET
TgeneTANGO2C4225171METABOLIC ENCEPHALOMYOPATHIC CRISES, RECURRENT, WITH RHABDOMYOLYSIS, CARDIAC ARRHYTHMIAS, AND NEURODEGENERATION1UNIPROT