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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21488

FusionGeneSummary for MED15_KLHL22

check button Fusion gene summary
Fusion gene informationFusion gene name: MED15_KLHL22
Fusion gene ID: 21488
HgeneTgene
Gene symbol

MED15

KLHL22

Gene ID

51586

84861

Gene namemediator complex subunit 15kelch like family member 22
SynonymsARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7KELCHL
Cytomap

22q11.21

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible gekelch-like protein 22kelch-like 22
Modification date2018052320180523
UniProtAcc

Q96RN5

Q53GT1

Ensembl transtripts involved in fusion geneENST00000425759, ENST00000292733, 
ENST00000542773, ENST00000263205, 
ENST00000406969, ENST00000382974, 
ENST00000541476, ENST00000478831, 
ENST00000328879, ENST00000440659, 
ENST00000470335, 
Fusion gene scores* DoF score12 X 9 X 9=9724 X 4 X 3=48
# samples 134
** MAII scorelog2(13/972*10)=-2.90244469057733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED15 [Title/Abstract] AND KLHL22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKLHL22

GO:0006513

protein monoubiquitination

23455478


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-BB-8601-01AMED15chr22

20862033

+KLHL22chr22

20843531

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000425759ENST00000328879MED15chr22

20862033

+KLHL22chr22

20843531

-
5UTR-5UTRENST00000425759ENST00000440659MED15chr22

20862033

+KLHL22chr22

20843531

-
5UTR-5UTRENST00000425759ENST00000470335MED15chr22

20862033

+KLHL22chr22

20843531

-
5CDS-5UTRENST00000292733ENST00000328879MED15chr22

20862033

+KLHL22chr22

20843531

-
5CDS-5UTRENST00000292733ENST00000440659MED15chr22

20862033

+KLHL22chr22

20843531

-
5CDS-5UTRENST00000292733ENST00000470335MED15chr22

20862033

+KLHL22chr22

20843531

-
5UTR-5UTRENST00000542773ENST00000328879MED15chr22

20862033

+KLHL22chr22

20843531

-
5UTR-5UTRENST00000542773ENST00000440659MED15chr22

20862033

+KLHL22chr22

20843531

-
5UTR-5UTRENST00000542773ENST00000470335MED15chr22

20862033

+KLHL22chr22

20843531

-
5CDS-5UTRENST00000263205ENST00000328879MED15chr22

20862033

+KLHL22chr22

20843531

-
5CDS-5UTRENST00000263205ENST00000440659MED15chr22

20862033

+KLHL22chr22

20843531

-
5CDS-5UTRENST00000263205ENST00000470335MED15chr22

20862033

+KLHL22chr22

20843531

-
intron-5UTRENST00000406969ENST00000328879MED15chr22

20862033

+KLHL22chr22

20843531

-
intron-5UTRENST00000406969ENST00000440659MED15chr22

20862033

+KLHL22chr22

20843531

-
intron-5UTRENST00000406969ENST00000470335MED15chr22

20862033

+KLHL22chr22

20843531

-
5CDS-5UTRENST00000382974ENST00000328879MED15chr22

20862033

+KLHL22chr22

20843531

-
5CDS-5UTRENST00000382974ENST00000440659MED15chr22

20862033

+KLHL22chr22

20843531

-
5CDS-5UTRENST00000382974ENST00000470335MED15chr22

20862033

+KLHL22chr22

20843531

-
intron-5UTRENST00000541476ENST00000328879MED15chr22

20862033

+KLHL22chr22

20843531

-
intron-5UTRENST00000541476ENST00000440659MED15chr22

20862033

+KLHL22chr22

20843531

-
intron-5UTRENST00000541476ENST00000470335MED15chr22

20862033

+KLHL22chr22

20843531

-
intron-5UTRENST00000478831ENST00000328879MED15chr22

20862033

+KLHL22chr22

20843531

-
intron-5UTRENST00000478831ENST00000440659MED15chr22

20862033

+KLHL22chr22

20843531

-
intron-5UTRENST00000478831ENST00000470335MED15chr22

20862033

+KLHL22chr22

20843531

-

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FusionProtFeatures for MED15_KLHL22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED15

Q96RN5

KLHL22

Q53GT1

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin ligase complex required for chromosome alignment andlocalization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitinligase complex mediates monoubiquitination of PLK1, leading toPLK1 dissociation from phosphoreceptor proteins and subsequentremoval from kinetochores, allowing silencing of the spindleassembly checkpoint (SAC) and chromosome segregation.Monoubiquitination of PLK1 does not lead to PLK1 degradation(PubMed:19995937, PubMed:23455478). The BCR(KLHL22) ubiquitinligase complex is also responsible for the amino acid-stimulated'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5.Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an aminoacid-dependent activator within the amino acid-sensing branch ofthe TORC1 pathway, indirectly regulating different cellularprocesses including cell growth and autophagy (PubMed:29769719).{ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:23455478,ECO:0000269|PubMed:29769719}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MED15_KLHL22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MED15_KLHL22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MED15MLLT6, PLSCR1, FHL3, MED10, MED9, MED29, MED19, MED28, MED26, MED25, MED6, ATP5C1, MED1, TRIM11, SMAD1, SMAD2, SMAD3, TRRAP, RELA, SREBF1, MED12, MED18, ZC3H13, TRIP4, QKI, TADA2A, CDK8, MED13, MED14, MED23, MED16, MED17, MED7, CTDP1, ATXN1, IGBP1, UBAP2L, SEC24C, CHEK1, NCOA6, FBXW7, EPAS1, CDK19, CCNC, NR1I3, ALDH8A1, TCL1B, HIF1A, MED11, MED20, MED24, MED27, MED4, MED8, EWSR1, MYO1C, POLR2F, POLR2G, CTDSPL2, MED21, UBE2N, TP73KLHL22COPS5, COPS6, KLHL13, UBXN7, FAF1, UBXN1, CUL3, DCUN1D1, NEDD8, HSP90AA1, PLK1, KLHL9, NTRK1, GLUD2, SCARF2, LYRM4, METTL15, ATG4C, KLHL20, SCAF8, NFS1, C7orf55, MICU2, ATPAF2, KLHL26, MICU1, NDUFAF5, NUDCD3, NDUFB9, TRMT6, TMEM223, LYRM7, NOB1, GMNN, RBM15B, NOA1, GBAS, RBM14-RBM4, ZBTB34, CIZ1, EMC7, GLUD1, GFER, ZBTB33, POLDIP3, CCL21, LYRM5, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MED15_KLHL22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MED15_KLHL22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMED15C0036341Schizophrenia2PSYGENET
HgeneMED15C0036337Schizoaffective Disorder1PSYGENET