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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21426

FusionGeneSummary for MECOM_LRRC31

check button Fusion gene summary
Fusion gene informationFusion gene name: MECOM_LRRC31
Fusion gene ID: 21426
HgeneTgene
Gene symbol

MECOM

LRRC31

Gene ID

2122

79782

Gene nameMDS1 and EVI1 complex locusleucine rich repeat containing 31
SynonymsAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2HEL-S-293
Cytomap

3q26.2

3q26.2

Type of geneprotein-codingprotein-coding
DescriptionMDS1 and EVI1 complex locus proteinMDS1 and EVI1 complex locus protein EVI1AML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein 1oncleucine-rich repeat-containing protein 31epididymis secretory protein Li 293
Modification date2018052220180519
UniProtAcc

Q03112

Q6UY01

Ensembl transtripts involved in fusion geneENST00000264674, ENST00000392736, 
ENST00000464456, ENST00000472280, 
ENST00000494292, ENST00000468789, 
ENST00000460814, ENST00000433243, 
ENST00000485957, 
ENST00000316428, 
ENST00000264676, ENST00000523069, 
ENST00000397805, 
Fusion gene scores* DoF score15 X 7 X 10=10501 X 2 X 1=2
# samples 216
** MAII scorelog2(21/1050*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/2*10)=4.90689059560852
Context

PubMed: MECOM [Title/Abstract] AND LRRC31 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

HgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

HgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0801-01AMECOMchr3

169381124

-LRRC31chr3

169587660

-
TCGALDOVTCGA-24-1469-01AMECOMchr3

169381124

-LRRC31chr3

169587660

-
TCGALDOVTCGA-24-1842-01AMECOMchr3

169381124

-LRRC31chr3

169587660

-
TCGALDOVTCGA-24-2271-01AMECOMchr3

169381124

-LRRC31chr3

169574660

-
TCGALDOVTCGA-29-1781-01AMECOMchr3

169381124

-LRRC31chr3

169587660

-
TCGALDOVTCGA-61-1911-01AMECOMchr3

169381124

-LRRC31chr3

169587660

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000264674ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-5UTRENST00000264674ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000264674ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000264674ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000392736ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-5UTRENST00000392736ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000392736ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000392736ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000464456ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-5UTRENST00000464456ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000464456ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000464456ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000472280ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-5UTRENST00000472280ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000472280ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000472280ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169587660

-
5CDS-intronENST00000494292ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169587660

-
5CDS-5UTRENST00000494292ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169587660

-
5CDS-intronENST00000494292ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169587660

-
5CDS-intronENST00000494292ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000468789ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-5UTRENST00000468789ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000468789ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000468789ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000460814ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-5UTRENST00000460814ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000460814ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000460814ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000433243ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-5UTRENST00000433243ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000433243ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-intronENST00000433243ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169587660

-
5UTR-intronENST00000485957ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169587660

-
5UTR-5UTRENST00000485957ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169587660

-
5UTR-intronENST00000485957ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169587660

-
5UTR-intronENST00000485957ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169587660

-
intron-3CDSENST00000264674ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000264674ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000264674ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-5UTRENST00000264674ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000392736ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000392736ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000392736ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-5UTRENST00000392736ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000464456ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000464456ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000464456ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-5UTRENST00000464456ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000472280ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000472280ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000472280ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-5UTRENST00000472280ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169574660

-
Frame-shiftENST00000494292ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169574660

-
Frame-shiftENST00000494292ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169574660

-
Frame-shiftENST00000494292ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169574660

-
5CDS-5UTRENST00000494292ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000468789ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000468789ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000468789ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-5UTRENST00000468789ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000460814ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000460814ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000460814ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-5UTRENST00000460814ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000433243ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000433243ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-3CDSENST00000433243ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169574660

-
intron-5UTRENST00000433243ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169574660

-
5UTR-3CDSENST00000485957ENST00000316428MECOMchr3

169381124

-LRRC31chr3

169574660

-
5UTR-3CDSENST00000485957ENST00000264676MECOMchr3

169381124

-LRRC31chr3

169574660

-
5UTR-3CDSENST00000485957ENST00000523069MECOMchr3

169381124

-LRRC31chr3

169574660

-
5UTR-5UTRENST00000485957ENST00000397805MECOMchr3

169381124

-LRRC31chr3

169574660

-

Top

FusionProtFeatures for MECOM_LRRC31


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MECOM

Q03112

LRRC31

Q6UY01


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MECOM_LRRC31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MECOM_LRRC31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MECOMHDAC1, CTBP1, HDAC4, CREBBP, KAT2B, SMAD3, MBD3, SUV39H1, EHMT2, SMAD1, SMAD2, SMAD4, SIRT1, ELAVL1, SOX2, PIAS4, PRMT1, UBE2I, SPDEF, NLRP14, PIK3R3, RABGAP1L, MED23, HIC1, FOXJ2, ERMAP, L3MBTL1LRRC31TRIP10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MECOM_LRRC31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MECOM_LRRC31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMECOMC0009375Colonic Neoplasms1CTD_human
HgeneMECOMC0023448Lymphoid leukemia1CTD_human
HgeneMECOMC0023470Myeloid Leukemia1CTD_human
HgeneMECOMC0027439Nasopharyngeal Neoplasms1CTD_human
HgeneMECOMC0919267ovarian neoplasm1CTD_human
HgeneMECOMC1458155Mammary Neoplasms1CTD_human
HgeneMECOMC4225221RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 21UNIPROT