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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 21419

FusionGeneSummary for MECOM_ARMC8

check button Fusion gene summary
Fusion gene informationFusion gene name: MECOM_ARMC8
Fusion gene ID: 21419
HgeneTgene
Gene symbol

MECOM

ARMC8

Gene ID

2122

25852

Gene nameMDS1 and EVI1 complex locusarmadillo repeat containing 8
SynonymsAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2GID5|HSPC056|S863-2|VID28
Cytomap

3q26.2

3q22.3

Type of geneprotein-codingprotein-coding
DescriptionMDS1 and EVI1 complex locus proteinMDS1 and EVI1 complex locus protein EVI1AML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein 1oncarmadillo repeat-containing protein 8GID complex subunit 5, VID28 homolog
Modification date2018052220180523
UniProtAcc

Q03112

Q8IUR7

Ensembl transtripts involved in fusion geneENST00000264674, ENST00000392736, 
ENST00000464456, ENST00000472280, 
ENST00000494292, ENST00000468789, 
ENST00000460814, ENST00000433243, 
ENST00000485957, 		ENST00000481646, 
ENST00000469044, ENST00000491704, 
ENST00000358441, ENST00000489213, 
ENST00000461822, ENST00000485396, 
ENST00000471453, ENST00000470821, 
ENST00000393058, ENST00000538260, 
Fusion gene scores* DoF score15 X 7 X 10=10505 X 5 X 4=100
# samples 215
** MAII scorelog2(21/1050*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MECOM [Title/Abstract] AND ARMC8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

HgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

HgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-43-A474-01AMECOMchr3

169098975

-ARMC8chr3

138007890

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000264674ENST00000481646MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000264674ENST00000469044MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000264674ENST00000491704MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000264674ENST00000358441MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000264674ENST00000489213MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000264674ENST00000461822MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000264674ENST00000485396MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000264674ENST00000471453MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000264674ENST00000470821MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000264674ENST00000393058MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000264674ENST00000538260MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000392736ENST00000481646MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000392736ENST00000469044MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000392736ENST00000491704MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000392736ENST00000358441MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000392736ENST00000489213MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000392736ENST00000461822MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000392736ENST00000485396MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000392736ENST00000471453MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000392736ENST00000470821MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000392736ENST00000393058MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000392736ENST00000538260MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000464456ENST00000481646MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000464456ENST00000469044MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000464456ENST00000491704MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000464456ENST00000358441MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000464456ENST00000489213MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000464456ENST00000461822MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000464456ENST00000485396MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000464456ENST00000471453MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000464456ENST00000470821MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000464456ENST00000393058MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000464456ENST00000538260MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000472280ENST00000481646MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000472280ENST00000469044MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000472280ENST00000491704MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000472280ENST00000358441MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000472280ENST00000489213MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000472280ENST00000461822MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000472280ENST00000485396MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000472280ENST00000471453MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000472280ENST00000470821MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000472280ENST00000393058MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000472280ENST00000538260MECOMchr3

169098975

-ARMC8chr3

138007890

+
In-frameENST00000494292ENST00000481646MECOMchr3

169098975

-ARMC8chr3

138007890

+
In-frameENST00000494292ENST00000469044MECOMchr3

169098975

-ARMC8chr3

138007890

+
In-frameENST00000494292ENST00000491704MECOMchr3

169098975

-ARMC8chr3

138007890

+
5CDS-intronENST00000494292ENST00000358441MECOMchr3

169098975

-ARMC8chr3

138007890

+
5CDS-intronENST00000494292ENST00000489213MECOMchr3

169098975

-ARMC8chr3

138007890

+
5CDS-intronENST00000494292ENST00000461822MECOMchr3

169098975

-ARMC8chr3

138007890

+
5CDS-intronENST00000494292ENST00000485396MECOMchr3

169098975

-ARMC8chr3

138007890

+
5CDS-intronENST00000494292ENST00000471453MECOMchr3

169098975

-ARMC8chr3

138007890

+
5CDS-intronENST00000494292ENST00000470821MECOMchr3

169098975

-ARMC8chr3

138007890

+
5CDS-intronENST00000494292ENST00000393058MECOMchr3

169098975

-ARMC8chr3

138007890

+
5CDS-intronENST00000494292ENST00000538260MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000468789ENST00000481646MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000468789ENST00000469044MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000468789ENST00000491704MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000468789ENST00000358441MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000468789ENST00000489213MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000468789ENST00000461822MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000468789ENST00000485396MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000468789ENST00000471453MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000468789ENST00000470821MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000468789ENST00000393058MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000468789ENST00000538260MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000460814ENST00000481646MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000460814ENST00000469044MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000460814ENST00000491704MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000460814ENST00000358441MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000460814ENST00000489213MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000460814ENST00000461822MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000460814ENST00000485396MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000460814ENST00000471453MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000460814ENST00000470821MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000460814ENST00000393058MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000460814ENST00000538260MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000433243ENST00000481646MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000433243ENST00000469044MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-3CDSENST00000433243ENST00000491704MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000433243ENST00000358441MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000433243ENST00000489213MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000433243ENST00000461822MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000433243ENST00000485396MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000433243ENST00000471453MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000433243ENST00000470821MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000433243ENST00000393058MECOMchr3

169098975

-ARMC8chr3

138007890

+
intron-intronENST00000433243ENST00000538260MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-3CDSENST00000485957ENST00000481646MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-3CDSENST00000485957ENST00000469044MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-3CDSENST00000485957ENST00000491704MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-intronENST00000485957ENST00000358441MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-intronENST00000485957ENST00000489213MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-intronENST00000485957ENST00000461822MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-intronENST00000485957ENST00000485396MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-intronENST00000485957ENST00000471453MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-intronENST00000485957ENST00000470821MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-intronENST00000485957ENST00000393058MECOMchr3

169098975

-ARMC8chr3

138007890

+
5UTR-intronENST00000485957ENST00000538260MECOMchr3

169098975

-ARMC8chr3

138007890

+

Top

FusionProtFeatures for MECOM_ARMC8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MECOM

Q03112

ARMC8

Q8IUR7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MECOM_ARMC8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MECOM_ENST00000494292_chr3_169098975_-_ARMC8_ENST00000481646_chr3_138007890_+_192aa
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCD

>In-frame_MECOM_ENST00000494292_chr3_169098975_-_ARMC8_ENST00000469044_chr3_138007890_+_192aa
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCD

>In-frame_MECOM_ENST00000494292_chr3_169098975_-_ARMC8_ENST00000491704_chr3_138007890_+_192aa
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MECOM_ENST00000494292_chr3_169098975_-_ARMC8_ENST00000481646_chr3_138007890_+_576nt
ATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAGAAATGCCA
GATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTCCAAAGGAG
GGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGCCTGGGGCA
GGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGAAAGACCCC
AGTTATGGATGGGAGGGCCATTCACATGTTAAACTGCAGCTTGCAGCCATGTTTTGTATATCAAACCTCATATGGAATGAAGAGGAAGGT
TCACAAGAACGCCAGGATAAATTACGAGACATGGGCATCGTAGATATTCTACACAAACTGAGTCAGTCACCAGATTCAAACCTTTGTGAC

>In-frame_MECOM_ENST00000494292_chr3_169098975_-_ARMC8_ENST00000469044_chr3_138007890_+_576nt
ATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAGAAATGCCA
GATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTCCAAAGGAG
GGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGCCTGGGGCA
GGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGAAAGACCCC
AGTTATGGATGGGAGGGCCATTCACATGTTAAACTGCAGCTTGCAGCCATGTTTTGTATATCAAACCTCATATGGAATGAAGAGGAAGGT
TCACAAGAACGCCAGGATAAATTACGAGACATGGGCATCGTAGATATTCTACACAAACTGAGTCAGTCACCAGATTCAAACCTTTGTGAC

>In-frame_MECOM_ENST00000494292_chr3_169098975_-_ARMC8_ENST00000491704_chr3_138007890_+_576nt
ATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAGAAATGCCA
GATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTCCAAAGGAG
GGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGCCTGGGGCA
GGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGAAAGACCCC
AGTTATGGATGGGAGGGCCATTCACATGTTAAACTGCAGCTTGCAGCCATGTTTTGTATATCAAACCTCATATGGAATGAAGAGGAAGGT
TCACAAGAACGCCAGGATAAATTACGAGACATGGGCATCGTAGATATTCTACACAAACTGAGTCAGTCACCAGATTCAAACCTTTGTGAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_MECOM_ENST00000494292_chr3_169098975_-_ARMC8_ENST00000481646_chr3_138007890_+_1331nt
AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG
GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAG
AAATGCCAGATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTC
CAAAGGAGGGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGC
CTGGGGCAGGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGA
AAGACCCCAGTTATGGATGGGAGGGCCATTCACATGTTAAACTGCAGCTTGCAGCCATGTTTTGTATATCAAACCTCATATGGAATGAAG
AGGAAGGTTCACAAGAACGCCAGGATAAATTACGAGACATGGGCATCGTAGATATTCTACACAAACTGAGTCAGTCACCAGATTCAAACC
TTTGTGACAAGGCAAAGATGGCACTGCAGCAGTACCTGGCATGATGGGAGTGCCCCTGGGCACCTGCGAGCATCCCACCTCCTTGTTTAA
GGAAGTACAGGAACCAGCCTCATTTGATTCCTTCTATTTGCACAAGTCACCTTGGACTGCAGGGAGCTGTTTTGCAAAAGCAGTTTAGTA
GGCTTAGATCTCAAATTCATCTTGAGAACATTTTTTTGAGGTAGTAATTTCCTCAGAAGACTCTTGTGTTTTGTTTTGGTTTTTTTTTCT
GAGCTACTCGGACTCTTTATTAGAACAATCAATCATTTTCCTTTGGACCTACAATTTTTGCCTATGCTGCAGCCACTTTGTGAGTGAGAA
TGAATATGTCTGTGTGAACACACAGGCATGCGTGTGTATGTGCACGTACATGGGCCAGAATGAATGGATGTGTGTGTGTGAGGGATACCT
CAGATTTTTCTTTTCTTATTTTGTGTGAAAATCTCTTTTCTACAGATTTTCCAGGGTTTAAGCATTGCTTGCTGTATAAAAAACTTTACT
GAATTATATACAGTTTGAATGAAATGTTATTTTAAAAACAAAACAATTGTTAAGTGTTCCATAAAGGTTATGTTGAATTTTGGTCAGATG

>In-frame_MECOM_ENST00000494292_chr3_169098975_-_ARMC8_ENST00000469044_chr3_138007890_+_3171nt
AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG
GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAG
AAATGCCAGATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTC
CAAAGGAGGGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGC
CTGGGGCAGGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGA
AAGACCCCAGTTATGGATGGGAGGGCCATTCACATGTTAAACTGCAGCTTGCAGCCATGTTTTGTATATCAAACCTCATATGGAATGAAG
AGGAAGGTTCACAAGAACGCCAGGATAAATTACGAGACATGGGCATCGTAGATATTCTACACAAACTGAGTCAGTCACCAGATTCAAACC
TTTGTGACAAGGCAAAGATGGCACTGCAGCAGTACCTGGCATGATGGGAGTGCCCCTGGGCACCTGCGAGCATCCCACCTCCTTGTTTAA
GGAAGTACAGGAACCAGCCTCATTTGATTCCTTCTATTTGCACAAGTCACCTTGGACTGCAGGGAGCTGTTTTGCAAAAGCAGTTTAGTA
GGCTTAGATCTCAAATTCATCTTGAGAACATTTTTTTGAGGTAGTAATTTCCTCAGAAGACTCTTGTGTTTTGTTTTGGTTTTTTTTTCT
GAGCTACTCGGACTCTTTATTAGAACAATCAATCATTTTCCTTTGGACCTACAATTTTTGCCTATGCTGCAGCCACTTTGTGAGTGAGAA
TGAATATGTCTGTGTGAACACACAGGCATGCGTGTGTATGTGCACGTACATGGGCCAGAATGAATGGATGTGTGTGTGTGAGGGATACCT
CAGATTTTTCTTTTCTTATTTTGTGTGAAAATCTCTTTTCTACAGATTTTCCAGGGTTTAAGCATTGCTTGCTGTATAAAAAACTTTACT
GAATTATATACAGTTTGAATGAAATGTTATTTTAAAAACAAAACAATTGTTAAGTGTTCCATAAAGGTTATGTTGAATTTTGGTCAGATG
AATATTTGTAAGTAAAAAATATATGCATTTCTGAACCTCAACTTACATAGATTTTCTTTATATAAAAAAAAAGAAAAAAAAAGAAAAAGT
TGGCTATAGTTGGCCTGATTAACAGGCACTATACATGGTGCTGTGCAAAATAGTAAGCTAGCATCTTACTGCCGTCAATATTAGCAGGTA
CAGAGCCTTTTTTCATCCTAATTCAGTAAGTTCTCAGGCTTCCAAGTCAAATGGAGAAGTAAAGTGAGGCAACAGATTCACCATAGGCTT
TTTGAAGCATCAAAGGGAAATATAACTACTGATAGTGAAAGCCCAGCCATGACCCAGATGGGCTTACCCTTGACAGGAACTGGGGACCAA
GAGCCTCCCAATTGCCCTAACTCCTGTCATTGGTATTAGCAATATCTGGCCAGATTTAGAACCAGTCATGGAAACTTGTGCTCAAACTAA
AAGTAGGTCATCACTTCCCAGAAACAGAATACCTTGTGCTTCCTGAAACAGCATATATCACTGTGAAACTAAAGAATATTCTACAGACAC
CCCTGTAGAAAGAAACAAAGAACAGGATAGTTTAGAAAGCTTTCTGTTAGCTGTATTCAGCAAATTTCATACTAGTTGCTCAGGACTGCT
AGTTGGTATGCTTTTGTAAAACGAGATTGAAATTTAATAAAAGATGCAACTAAAATCTTTCCTGCATGAAGCTAAAAGCACTCAAGTTGA
GAGAGGGGCAAGGGAATCTCCCCAGGATGACTGAAGATGACTTCTTTTTACAGCAAGTACTGTTAGCCTTTCTGCACCCCTTAGCTTGGC
CCCTGCTCCAACTTCTGGGTCAGCAGCAAGGTGAACTCAACAGAAGTTGCTCTTGACTGTTTGAAGGTAGAAGCAGCCTACCTTTTCTCT
TTGCTAAAAGAAGGTCAAAGGCTTCGCAACCAGGATGCAAGGTCTGCGGTCCAGAAGCTTGCGGTGAGTGTGTGCCACTGATGGAGCTCC
AAGCCCACCCACCAGCCACTCCTGATGGGGTTGCTCACACTGCAGCTGCCCTATCACCACCCTGCACGTTCCTTGGAAGATTTAAATGTT
TGGTTGCAAATGAATGTTTTAAAAATGTATTTAATGCAATTTTTCCTGCTCTCAACATGACCACCCAAGATTCAAACACAGAGACTTCCA
AGTTACTATTTTTTCAGAACATCACCGATTTTAAAATCTGTCACAACAGGACTTGGTTTTGTGCAGATATCAGAGTGCTAATGTGAGAAA
CCCAGTTAAAAGAAAACTTAGTTTATTGGGAAGAAAGCCTCAGGCCCACTCGTTTCTAGAACTGTGAAAATATCCTTGGTTGGCATTTTT
AACACAAAACACTATAGTGTTGGTATTAAATAGTACTAGGTAAATATAAAGAAACCAATAATGAATTGCTGAGACAATCTTGAACCCAAA
TAGCATTAGAAAGCTGAAGGCCCAATGAAATAACACTTTCACACTTAAACTCTGTGGATAAATTTTGCCTGTGGGTATAAACAGATGGTC
AAATTAAAAATGCTTTACTATAATTAACTTTTCTGATTTGAATGAAGGGAAATGTATTTATTGAAACAAAGCTGTTTGCTGCTTTATGCA
GGTGCAGTGTTCAGTCAGCAAGGAAGTGGGAAGAGTGGACATGGTATTGTGTCTACACCCAAGTTCTTAACTAAGCTTCTCGCTCTAATA
CTGCATTCTGTTTCTCCTTTTGTGCCCTGATTGTAATCCAAAATTTATGAACTAGAAAAGAATGTCCAATTTAATAAGTTGCATTTTTTT
TTCTTTAAGCACTTTATTCAGAACAATACATGTTCTTCTGGTAGTGTTTGGATAATATGATTTTAACACATGCTAATAAAAGCCAAGAAA

>In-frame_MECOM_ENST00000494292_chr3_169098975_-_ARMC8_ENST00000491704_chr3_138007890_+_1176nt
AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG
GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAG
AAATGCCAGATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTC
CAAAGGAGGGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGC
CTGGGGCAGGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGA
AAGACCCCAGTTATGGATGGGAGGGCCATTCACATGTTAAACTGCAGCTTGCAGCCATGTTTTGTATATCAAACCTCATATGGAATGAAG
AGGAAGGTTCACAAGAACGCCAGGATAAATTACGAGACATGGGCATCGTAGATATTCTACACAAACTGAGTCAGTCACCAGATTCAAACC
TTTGTGACAAGGCAAAGATGGCACTGCAGCAGTACCTGGCATGATGGGAGTGCCCCTGGGCACCTGCGAGCATCCCACCTCCTTGTTTAA
GGAAGTACAGGAACCAGCCTCATTTGATTCCTTCTATTTGCACAAGTCACCTTGGACTGCAGGGAGCTGTTTTGCAAAAGCAGTTTAGTA
GGCTTAGATCTCAAATTCATCTTGAGAACATTTTTTTGAGGTAGTAATTTCCTCAGAAGACTCTTGTGTTTTGTTTTGGTTTTTTTTTCT
GAGCTACTCGGACTCTTTATTAGAACAATCAATCATTTTCCTTTGGACCTACAATTTTTGCCTATGCTGCAGCCACTTTGTGAGTGAGAA
TGAATATGTCTGTGTGAACACACAGGCATGCGTGTGTATGTGCACGTACATGGGCCAGAATGAATGGATGTGTGTGTGTGAGGGATACCT
CAGATTTTTCTTTTCTTATTTTGTGTGAAAATCTCTTTTCTACAGATTTTCCAGGGTTTAAGCATTGCTTGCTGTATAAAAAACTTTACT


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FusionGenePPI for MECOM_ARMC8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MECOMHDAC1, CTBP1, HDAC4, CREBBP, KAT2B, SMAD3, MBD3, SUV39H1, EHMT2, SMAD1, SMAD2, SMAD4, SIRT1, ELAVL1, SOX2, PIAS4, PRMT1, UBE2I, SPDEF, NLRP14, PIK3R3, RABGAP1L, MED23, HIC1, FOXJ2, ERMAP, L3MBTL1ARMC8RAE1, TNNT1, CTNNB1, CTNNA1, HGS, CUL3, NOTCH1, SOX2, EGFR, TCF12, GDNF, GLIPR1L2, MMP7, SFRP2, TDGF1, MRPL4, GPS2, MRPL39, PDHB, HLA-DPB1, RMND5A, MRPS30, IKZF3, PRG2, TCF4, TIGD5, BMP1, PRG3, PIGT, PRICKLE3, CCDC120, MRPS24, CUTA, MPP2, INSL6, MRPL38, NDUFS6, LILRB4, NKAP, SPINK7, JPH4, NFATC1, TLE4, LCA5, ADCYAP1, NCKIPSD, IKZF1, CDK5RAP1, ANGPTL4, ARHGAP22, HAPLN3, PTPN14, PTPN21, MKLN1, RANBP10, MAEA, WDR26, RANBP9, YPEL5, RMND5B, GID4, UBE2H, ZMYND19, HTRA2, GID8, DDX5, EFHC2, RAB8A, WWC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MECOM_ARMC8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MECOM_ARMC8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMECOMC0009375Colonic Neoplasms1CTD_human
HgeneMECOMC0023448Lymphoid leukemia1CTD_human
HgeneMECOMC0023470Myeloid Leukemia1CTD_human
HgeneMECOMC0027439Nasopharyngeal Neoplasms1CTD_human
HgeneMECOMC0919267ovarian neoplasm1CTD_human
HgeneMECOMC1458155Mammary Neoplasms1CTD_human
HgeneMECOMC4225221RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 21UNIPROT