	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 21400

FusionGeneSummary for MDM4_MDM4

Fusion gene summary

Fusion gene information	Fusion gene name: MDM4_MDM4
	Fusion gene ID: 21400
		Hgene	Tgene
	Gene symbol	MDM4	MDM4
	Gene ID	4194	4194
	Gene name	MDM4, p53 regulator	MDM4, p53 regulator
	Synonyms	HDMX\|MDMX\|MRP1	HDMX\|MDMX\|MRP1
	Cytomap	1q32.1	1q32.1
	Type of gene	protein-coding	protein-coding
	Description	protein Mdm4MDM4 protein variant GMDM4 protein variant YMDM4-related protein 1Mdm4 p53 binding protein homologdouble minute 4, human homolog of; p53-binding proteinmdm2-like p53-binding proteinprotein Mdmx	protein Mdm4MDM4 protein variant GMDM4 protein variant YMDM4-related protein 1Mdm4 p53 binding protein homologdouble minute 4, human homolog of; p53-binding proteinmdm2-like p53-binding proteinprotein Mdmx
	Modification date	20180519	20180519
	UniProtAcc	O15151	O15151
	Ensembl transtripts involved in fusion gene	ENST00000367182, ENST00000463049, ENST00000507825, ENST00000454264, ENST00000367183, ENST00000367180, ENST00000391947,	ENST00000367182, ENST00000463049, ENST00000507825, ENST00000454264, ENST00000367183, ENST00000367180, ENST00000391947,
Fusion gene scores	* DoF score	2 X 3 X 1=6	6 X 7 X 3=126
	# samples	4	7
	** MAII score	log2(4/6*10)=2.73696559416621	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MDM4 [Title/Abstract] AND MDM4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MDM4	GO:0000122	negative regulation of transcription by RNA polymerase II	9226370
Hgene	MDM4	GO:0065003	protein-containing complex assembly	10608892
Tgene	MDM4	GO:0000122	negative regulation of transcription by RNA polymerase II	9226370
Tgene	MDM4	GO:0065003	protein-containing complex assembly	10608892

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			DA013430	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
ChiTaRS3.1			BG008529	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000367182	ENST00000367182	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
3UTR-3UTR	ENST00000367182	ENST00000463049	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
3UTR-intron	ENST00000367182	ENST00000507825	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
3UTR-intron	ENST00000367182	ENST00000454264	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
3UTR-intron	ENST00000367182	ENST00000367183	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
3UTR-intron	ENST00000367182	ENST00000367180	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
3UTR-intron	ENST00000367182	ENST00000391947	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000463049	ENST00000367182	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000463049	ENST00000463049	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000463049	ENST00000507825	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000463049	ENST00000454264	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000463049	ENST00000367183	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000463049	ENST00000367180	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000463049	ENST00000391947	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000507825	ENST00000367182	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000507825	ENST00000463049	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000507825	ENST00000507825	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000507825	ENST00000454264	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000507825	ENST00000367183	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000507825	ENST00000367180	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000507825	ENST00000391947	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000454264	ENST00000367182	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000454264	ENST00000463049	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000454264	ENST00000507825	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000454264	ENST00000454264	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000454264	ENST00000367183	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000454264	ENST00000367180	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000454264	ENST00000391947	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000367183	ENST00000367182	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000367183	ENST00000463049	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000367183	ENST00000507825	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000367183	ENST00000454264	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000367183	ENST00000367183	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000367183	ENST00000367180	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000367183	ENST00000391947	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000367180	ENST00000367182	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000367180	ENST00000463049	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000367180	ENST00000507825	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000367180	ENST00000454264	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000367180	ENST00000367183	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000367180	ENST00000367180	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000367180	ENST00000391947	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000391947	ENST00000367182	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-3UTR	ENST00000391947	ENST00000463049	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000391947	ENST00000507825	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000391947	ENST00000454264	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000391947	ENST00000367183	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000391947	ENST00000367180	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
intron-intron	ENST00000391947	ENST00000391947	MDM4	chr1	204525522	+	MDM4	chr1	204519508	+
In-frame	ENST00000367182	ENST00000367182	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-3UTR	ENST00000367182	ENST00000463049	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-intron	ENST00000367182	ENST00000507825	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-intron	ENST00000367182	ENST00000454264	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-intron	ENST00000367182	ENST00000367183	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-intron	ENST00000367182	ENST00000367180	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-3UTR	ENST00000367182	ENST00000391947	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-3CDS	ENST00000463049	ENST00000367182	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-3UTR	ENST00000463049	ENST00000463049	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-intron	ENST00000463049	ENST00000507825	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-intron	ENST00000463049	ENST00000454264	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-intron	ENST00000463049	ENST00000367183	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-intron	ENST00000463049	ENST00000367180	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-3UTR	ENST00000463049	ENST00000391947	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-3CDS	ENST00000507825	ENST00000367182	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-3UTR	ENST00000507825	ENST00000463049	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000507825	ENST00000507825	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000507825	ENST00000454264	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000507825	ENST00000367183	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000507825	ENST00000367180	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-3UTR	ENST00000507825	ENST00000391947	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
In-frame	ENST00000454264	ENST00000367182	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-3UTR	ENST00000454264	ENST00000463049	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-intron	ENST00000454264	ENST00000507825	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-intron	ENST00000454264	ENST00000454264	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-intron	ENST00000454264	ENST00000367183	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-intron	ENST00000454264	ENST00000367180	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
5CDS-3UTR	ENST00000454264	ENST00000391947	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-3CDS	ENST00000367183	ENST00000367182	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-3UTR	ENST00000367183	ENST00000463049	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000367183	ENST00000507825	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000367183	ENST00000454264	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000367183	ENST00000367183	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000367183	ENST00000367180	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-3UTR	ENST00000367183	ENST00000391947	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-3CDS	ENST00000367180	ENST00000367182	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-3UTR	ENST00000367180	ENST00000463049	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000367180	ENST00000507825	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000367180	ENST00000454264	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000367180	ENST00000367183	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-intron	ENST00000367180	ENST00000367180	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
intron-3UTR	ENST00000367180	ENST00000391947	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-3CDS	ENST00000391947	ENST00000367182	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-3UTR	ENST00000391947	ENST00000463049	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-intron	ENST00000391947	ENST00000507825	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-intron	ENST00000391947	ENST00000454264	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-intron	ENST00000391947	ENST00000367183	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-intron	ENST00000391947	ENST00000367180	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+
3UTR-3UTR	ENST00000391947	ENST00000391947	MDM4	chr1	204511966	-	MDM4	chr1	204513661	+

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FusionProtFeatures for MDM4_MDM4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MDM4 O15151	MDM4 O15151
Inhibits p53/TP53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activationdomain. Inhibits degradation of MDM2. Can reverse MDM2-targeteddegradation of TP53 while maintaining suppression of TP53transactivation and apoptotic functions.{ECO:0000269\|PubMed:16163388, ECO:0000269\|PubMed:16511572}.	Inhibits p53/TP53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activationdomain. Inhibits degradation of MDM2. Can reverse MDM2-targeteddegradation of TP53 while maintaining suppression of TP53transactivation and apoptotic functions.{ECO:0000269\|PubMed:16163388, ECO:0000269\|PubMed:16511572}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

>>>>>>>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000367182

243_308

-54

491

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000367183

243_308

-18

165

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000454264

243_308

-20

441

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000367182

26_106

-54

491

Domain

Note=SWIB

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000367183

26_106

-18

165

Domain

Note=SWIB

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000454264

26_106

-20

441

Domain

Note=SWIB

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000367182

246_332

-54

491

Region

Note=Region II

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000367183

246_332

-18

165

Region

Note=Region II

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000454264

246_332

-20

441

Region

Note=Region II

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000367182

300_329

-54

491

Zinc finger

RanBP2-type

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000367182

437_478

-54

491

Zinc finger

RING-type

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000367183

300_329

-18

165

Zinc finger

RanBP2-type

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000367183

437_478

-18

165

Zinc finger

RING-type

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000454264

300_329

-20

441

Zinc finger

RanBP2-type

Hgene

MDM4

chr1:204511966

chr1:204513661

ENST00000454264

437_478

-20

441

Zinc finger

RING-type

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FusionGeneSequence for MDM4_MDM4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MDM4_MDM4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MDM4_MDM4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MDM4_MDM4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MDM4	C0017636	Glioblastoma	1	CTD_human
Hgene	MDM4	C0032273	Pneumoconiosis	1	CTD_human
Hgene	MDM4	C0041696	Unipolar Depression	1	PSYGENET
Hgene	MDM4	C1269683	Major Depressive Disorder	1	PSYGENET
Hgene	MDM4	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	MDM4	C0017636	Glioblastoma	1	CTD_human
Tgene	MDM4	C0032273	Pneumoconiosis	1	CTD_human
Tgene	MDM4	C0041696	Unipolar Depression	1	PSYGENET
Tgene	MDM4	C1269683	Major Depressive Disorder	1	PSYGENET
Tgene	MDM4	C1458155	Mammary Neoplasms	1	CTD_human

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Fusion gene ID: 21400

FusionGeneSummary for MDM4_MDM4

FusionProtFeatures for MDM4_MDM4

FusionGeneSequence for MDM4_MDM4

FusionGenePPI for MDM4_MDM4

RelatedDrugs for MDM4_MDM4

RelatedDiseases for MDM4_MDM4