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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 2140

FusionGeneSummary for APC_DTWD2

check button Fusion gene summary
Fusion gene informationFusion gene name: APC_DTWD2
Fusion gene ID: 2140
HgeneTgene
Gene symbol

APC

DTWD2

Gene ID

324

285605

Gene nameAPC, WNT signaling pathway regulatorDTW domain containing 2
SynonymsBTPS2|DP2|DP2.5|DP3|GS|PPP1R46-
Cytomap

5q22.2

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionadenomatous polyposis coli proteinWNT signaling pathway regulatoradenomatosis polyposis coli tumor suppressoradenomatous polyposis coli (APC)deleted in polyposis 2.5protein phosphatase 1, regulatory subunit 46truncated adenomatosis polyposis coliDTW domain-containing protein 2
Modification date2018052720180519
UniProtAcc

P25054

Q8NBA8

Ensembl transtripts involved in fusion geneENST00000505350, ENST00000457016, 
ENST00000257430, ENST00000508376, 
ENST00000304058, ENST00000510708, 
ENST00000515439, 
Fusion gene scores* DoF score11 X 7 X 7=5397 X 6 X 4=168
# samples 117
** MAII scorelog2(11/539*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APC [Title/Abstract] AND DTWD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPC

GO:0006974

cellular response to DNA damage stimulus

14728717

HgeneAPC

GO:0007026

negative regulation of microtubule depolymerization

11166179

HgeneAPC

GO:0007050

cell cycle arrest

8521819

HgeneAPC

GO:0008285

negative regulation of cell proliferation

8521819

HgeneAPC

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

8521819

HgeneAPC

GO:0065003

protein-containing complex assembly

16188939


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-EQ-A4SO-01AAPCchr5

112164669

+DTWD2chr5

118183913

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000505350ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
intron-3CDSENST00000505350ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
intron-3CDSENST00000505350ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000457016ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000457016ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000457016ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000257430ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000257430ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000257430ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000508376ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000508376ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000508376ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-

Top

FusionProtFeatures for APC_DTWD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APC

P25054

DTWD2

Q8NBA8

Tumor suppressor. Promotes rapid degradation of CTNNB1and participates in Wnt signaling as a negative regulator. APCactivity is correlated with its phosphorylation state. Activatesthe GEF activity of SPATA13 and ARHGEF4. Plays a role inhepatocyte growth factor (HGF)-induced cell migration. Requiredfor MMP9 up-regulation via the JNK signaling pathway in colorectaltumor cells. Acts as a mediator of ERBB2-dependent stabilizationof microtubules at the cell cortex. It is required for thelocalization of MACF1 to the cell membrane and this localizationof MACF1 is critical for its function in microtubulestabilization. {ECO:0000269|PubMed:10947987,ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759,ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for APC_DTWD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_APC_ENST00000457016_chr5_112164669_+_DTWD2_ENST00000304058_chr5_118183913_-_681aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

>In-frame_APC_ENST00000457016_chr5_112164669_+_DTWD2_ENST00000510708_chr5_118183913_-_681aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

>In-frame_APC_ENST00000457016_chr5_112164669_+_DTWD2_ENST00000515439_chr5_118183913_-_681aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

>In-frame_APC_ENST00000257430_chr5_112164669_+_DTWD2_ENST00000304058_chr5_118183913_-_681aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

>In-frame_APC_ENST00000257430_chr5_112164669_+_DTWD2_ENST00000510708_chr5_118183913_-_681aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

>In-frame_APC_ENST00000257430_chr5_112164669_+_DTWD2_ENST00000515439_chr5_118183913_-_681aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

>In-frame_APC_ENST00000508376_chr5_112164669_+_DTWD2_ENST00000304058_chr5_118183913_-_681aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

>In-frame_APC_ENST00000508376_chr5_112164669_+_DTWD2_ENST00000510708_chr5_118183913_-_681aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

>In-frame_APC_ENST00000508376_chr5_112164669_+_DTWD2_ENST00000515439_chr5_118183913_-_681aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_APC_ENST00000457016_chr5_112164669_+_DTWD2_ENST00000304058_chr5_118183913_-_2043nt
ATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAAT
TCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATG
GCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAA
ATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGA
AGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAA
GAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTA
CAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATG
GAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACA
GAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAAC
ATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCA
CCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATG
TCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTA
CATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATC
ATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGT
TGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTG
TGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAA
GTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTT
GGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTA
CAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAA
GCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAAT
AGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTT
CAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCA

>In-frame_APC_ENST00000457016_chr5_112164669_+_DTWD2_ENST00000510708_chr5_118183913_-_2043nt
ATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAAT
TCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATG
GCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAA
ATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGA
AGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAA
GAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTA
CAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATG
GAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACA
GAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAAC
ATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCA
CCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATG
TCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTA
CATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATC
ATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGT
TGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTG
TGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAA
GTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTT
GGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTA
CAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAA
GCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAAT
AGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTT
CAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCA

>In-frame_APC_ENST00000457016_chr5_112164669_+_DTWD2_ENST00000515439_chr5_118183913_-_2043nt
ATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAAT
TCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATG
GCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAA
ATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGA
AGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAA
GAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTA
CAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATG
GAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACA
GAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAAC
ATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCA
CCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATG
TCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTA
CATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATC
ATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGT
TGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTG
TGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAA
GTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTT
GGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTA
CAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAA
GCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAAT
AGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTT
CAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCA

>In-frame_APC_ENST00000257430_chr5_112164669_+_DTWD2_ENST00000304058_chr5_118183913_-_2043nt
ATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAAT
TCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATG
GCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAA
ATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGA
AGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAA
GAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTA
CAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATG
GAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACA
GAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAAC
ATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCA
CCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATG
TCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTA
CATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATC
ATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGT
TGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTG
TGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAA
GTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTT
GGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTA
CAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAA
GCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAAT
AGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTT
CAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCA

>In-frame_APC_ENST00000257430_chr5_112164669_+_DTWD2_ENST00000510708_chr5_118183913_-_2043nt
ATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAAT
TCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATG
GCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAA
ATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGA
AGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAA
GAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTA
CAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATG
GAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACA
GAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAAC
ATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCA
CCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATG
TCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTA
CATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATC
ATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGT
TGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTG
TGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAA
GTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTT
GGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTA
CAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAA
GCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAAT
AGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTT
CAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCA

>In-frame_APC_ENST00000257430_chr5_112164669_+_DTWD2_ENST00000515439_chr5_118183913_-_2043nt
ATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAAT
TCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATG
GCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAA
ATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGA
AGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAA
GAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTA
CAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATG
GAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACA
GAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAAC
ATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCA
CCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATG
TCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTA
CATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATC
ATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGT
TGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTG
TGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAA
GTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTT
GGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTA
CAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAA
GCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAAT
AGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTT
CAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCA

>In-frame_APC_ENST00000508376_chr5_112164669_+_DTWD2_ENST00000304058_chr5_118183913_-_2043nt
ATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAAT
TCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATG
GCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAA
ATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGA
AGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAA
GAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTA
CAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATG
GAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACA
GAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAAC
ATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCA
CCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATG
TCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTA
CATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATC
ATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGT
TGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTG
TGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAA
GTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTT
GGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTA
CAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAA
GCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAAT
AGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTT
CAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCA

>In-frame_APC_ENST00000508376_chr5_112164669_+_DTWD2_ENST00000510708_chr5_118183913_-_2043nt
ATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAAT
TCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATG
GCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAA
ATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGA
AGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAA
GAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTA
CAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATG
GAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACA
GAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAAC
ATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCA
CCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATG
TCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTA
CATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATC
ATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGT
TGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTG
TGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAA
GTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTT
GGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTA
CAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAA
GCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAAT
AGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTT
CAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCA

>In-frame_APC_ENST00000508376_chr5_112164669_+_DTWD2_ENST00000515439_chr5_118183913_-_2043nt
ATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAAT
TCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATG
GCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAA
ATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGA
AGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAA
GAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTA
CAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATG
GAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACA
GAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAAC
ATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCA
CCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATG
TCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTA
CATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATC
ATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGT
TGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTG
TGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAA
GTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTT
GGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTA
CAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAA
GCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAAT
AGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTT
CAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_APC_ENST00000457016_chr5_112164669_+_DTWD2_ENST00000304058_chr5_118183913_-_6018nt
ACAAGATGGCGGAGGGCAAGTAGCAAGGGGGCGGGGTGTGGCCGCCGGAAGCCTAGCCGCTGCTCGGGGGGGACCTGCGGGCTCAGGCCC
GGGAGCTGCGGACCGAGGTTGGCTCGATGCTGTTCCCAGGTACTGTTGTTGGCTGTTGGTGAGGAAGGTGAAGCACTCAGTTGCCTTCTC
GGGCCTCGGCGCCCCCTATGTACGCCTCCCTGGGCTCGGGTCCGGTCGCCCCTTTGCCCGCTTCTGTACCACCCTCAGTTCTCGGGTCCT
GGAGCACCGGCGGCAGCAGGAGCTGCGTCCGGCAGGAGACGAAGAGCCCGGGCGGCGCTCGTACTTCTGGCCACTGGGCGAGCGTCTGGC
AGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTC
GACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAA
GTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTG
GAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTC
CTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGC
TTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTT
TAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAAC
TAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGC
TTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTC
AAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTT
CTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTA
CTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTC
CTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCA
GTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATAC
GCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAAC
ATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGG
CCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGG
CTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAA
AATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGC
GAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAA
TTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAG
AGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAA
ATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTT
ATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAA
AGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACT
GAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTG
TGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAAT
TAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAA
TCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATG
ATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATA
AATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGA
ATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAA
AAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAA
GTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGT
TAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTT
TCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACT
ATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCAT
TAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGG
TGAGACTCCATCTCCATACAAAATTAAAAAAAAAATAATTAGCCAGATGTGGTGGTGTGCACTTGTAGTCCTAGCTACTTGGGAGGCTAA
GGTGGGAGGATCGCTGGAGCCCAGGACATCAAGGTTGCAAGGAGCTATGTTCATTCCACTGCACTCCAGCCTGGGCTACAGAGTGAGACC
TGTCTAAAATAAATAAATAAATAAACAAACTAGCTCATTTACAATGTAAAGCACTTAATATCAAATGATTATTTGGTGTACTAGAAAAGA
AACAGCATATAATAATGTATAATAGTTTCTTAACAAGTGGGGCTAAAATCATTTTGTAGTAATTTTTCACATTGATATTAAACTTCATGA
GTTTCTTTTAGTCATTATTATTATTATTATTATTATTTGAGATGGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTTG
GCTCACTGAAAGCTCTGCCTCCTGGGTTCACGCCATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCACCACCACGCC
CGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTATTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGTCTGCCT
TGGCCTCCAAAAGTGCTGGGACCGTGCCCAGCCATCATTATTATTTTTTAAAAAGAAAACTCCCCCTACCCCCAGTATACCATTTTGTAT
CTCAAAATTTTACTTTATTGATTTTTAAGAGTAATTTCTACTTTTATCTTTTAAATAAAACATTTTAGAGTATTTTTGAAGACTTAAAAA
GCTTAAAATTTAGTGTTTTTGGAAATGTATAAAATTTTCTTGAAGTATGTATAGTTTTCCAAATTACTTTACTGACCTGTTAACTCACTG
TACTTGTTTTTTACTTATTTTTTCCTGACCTCTTAACAAGGTGAGTCCATTTAATCATCTGTGGTATAAAATGCTTCTCTAGTCACCTGT
TCTCATTAAACAGTTGTAAGTAAGTTTTAAAAGCCATTATTTTAATTACTAAAAGTTCTCAAGTGTGTAGTATTATCTGAGTATTTTAAT
TGAAAAATTAATCAGGCTTTTAAAAATTACTTTTTTATTGTATTAGTTGGCTTTTAAATTCAGATTCTTTATATTTGCTTGATTTTTCCT
GGAAGTTCCAAGTTTTATGAATTTGTAGCTGATAGTAGGTTTTACTTGTGTACCCCATCTGCACTTTGATGTTGTGTAGATCGTTTTGTG
AGTTATTTGAACCGTGTAACTCAGAGAATAGTATTTCCTCATACATAAAGTGACCTCACTTTTAATCAGCTCCTTTATAGTATGTTGAAA
ATCACTGCGTGTAATGAGAGGTATTGAGAGTTTCTTGCACACATGAGTGTAAAAGGTTGAGAACTAGATTATACAAAGTAGTAAGTCACA
GTGCATGGCAACTTTCTACAGGTTGGATTATAAGACTTATGTGGAATAGGAGAATTATATTGGGAAAAAATTATTTTCTCTAACTTGAAG
ACTCCAGAGACACTTTTCTTAGTCATGACCAGTAATATTTTTCATATATTTTGGAAGAAATAAGCTCCTCACTATACCACCAGTTAGTGA
TTTATTTATTTATGTATTTTAGAGACAGGGCCTCCTTCTGTCACCCAGTTTGGAGTGCAGTGGTGTAATCATAGCTTACTGCAGCATCAA
ACTCCTGGGCTCAAGTGTTCCTCCTGCCTCAGCCTCCCAAGTAGCTAGAACCTCAGCCCCATGCCACCACACTCAGCTAATTTTAAATTT
TACTAATTTCATTTAATTTTTGTGGAGATGGGGGTCTTGCTGTGTTGTTTAGGCTGGTCCTGAACTCCTGGCCTCAAGCGATCCTTCTGC
CTTGGCCTCTCAGTAAATTATATAGAAGAGCACTTCTGTATAATTTACTCAGTTTCTTCATCACATATTTCCAACTGTTGCCCTAAATAG
GTTTAAAAATGTGATCATGTTATTAGAAAATCCTTTCCATTGAATTTCAGGGATGCTGAATTTCAGGGAGCTAAATTGTTGACCCTTGCC
TGTAGTTGTTATTGGTTCAGAAGTAAATTTTATTGATGCTACAAGTAAAAAATTAGATCTGACTTAGTAAACTCAAAAGTTTTACAAAAC

>In-frame_APC_ENST00000457016_chr5_112164669_+_DTWD2_ENST00000510708_chr5_118183913_-_3799nt
ACAAGATGGCGGAGGGCAAGTAGCAAGGGGGCGGGGTGTGGCCGCCGGAAGCCTAGCCGCTGCTCGGGGGGGACCTGCGGGCTCAGGCCC
GGGAGCTGCGGACCGAGGTTGGCTCGATGCTGTTCCCAGGTACTGTTGTTGGCTGTTGGTGAGGAAGGTGAAGCACTCAGTTGCCTTCTC
GGGCCTCGGCGCCCCCTATGTACGCCTCCCTGGGCTCGGGTCCGGTCGCCCCTTTGCCCGCTTCTGTACCACCCTCAGTTCTCGGGTCCT
GGAGCACCGGCGGCAGCAGGAGCTGCGTCCGGCAGGAGACGAAGAGCCCGGGCGGCGCTCGTACTTCTGGCCACTGGGCGAGCGTCTGGC
AGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTC
GACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAA
GTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTG
GAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTC
CTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGC
TTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTT
TAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAAC
TAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGC
TTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTC
AAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTT
CTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTA
CTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTC
CTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCA
GTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATAC
GCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAAC
ATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGG
CCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGG
CTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAA
AATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGC
GAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAA
TTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAG
AGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAA
ATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTT
ATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAA
AGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACT
GAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTG
TGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAAT
TAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAA
TCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATG
ATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATA
AATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGA
ATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAA
AAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAA
GTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGT
TAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTT
TCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACT
ATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCAT
TAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGG

>In-frame_APC_ENST00000457016_chr5_112164669_+_DTWD2_ENST00000515439_chr5_118183913_-_3061nt
ACAAGATGGCGGAGGGCAAGTAGCAAGGGGGCGGGGTGTGGCCGCCGGAAGCCTAGCCGCTGCTCGGGGGGGACCTGCGGGCTCAGGCCC
GGGAGCTGCGGACCGAGGTTGGCTCGATGCTGTTCCCAGGTACTGTTGTTGGCTGTTGGTGAGGAAGGTGAAGCACTCAGTTGCCTTCTC
GGGCCTCGGCGCCCCCTATGTACGCCTCCCTGGGCTCGGGTCCGGTCGCCCCTTTGCCCGCTTCTGTACCACCCTCAGTTCTCGGGTCCT
GGAGCACCGGCGGCAGCAGGAGCTGCGTCCGGCAGGAGACGAAGAGCCCGGGCGGCGCTCGTACTTCTGGCCACTGGGCGAGCGTCTGGC
AGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTC
GACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAA
GTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTG
GAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTC
CTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGC
TTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTT
TAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAAC
TAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGC
TTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTC
AAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTT
CTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTA
CTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTC
CTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCA
GTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATAC
GCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAAC
ATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGG
CCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGG
CTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAA
AATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGC
GAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAA
TTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAG
AGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAA
ATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTT
ATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAA
AGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACT
GAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTG
TGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAAT
TAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAA
TCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATG
ATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATA

>In-frame_APC_ENST00000257430_chr5_112164669_+_DTWD2_ENST00000304058_chr5_118183913_-_5694nt
GGAGACAGAATGGAGGTGCTGCCGGACTCGGAAATGGGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGC
AAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCAT
CTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTC
TTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGAT
CTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTG
GATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAAC
TTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATG
AAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTC
AGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAA
CCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTA
CACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGG
TGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAG
ACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAA
ATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGC
GTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGG
ACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGC
ATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACC
ACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTA
TGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGT
CTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGG
TGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTG
CTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTG
CCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGG
AATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTT
CATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATT
CATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATG
TTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATT
GGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTA
CAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGT
ATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGA
AATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTAT
TTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAA
CCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAG
AGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCT
TTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATT
TATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATG
CTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTA
TTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTT
GAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGGTGAGACTCCATCTCCATACAAAATTAAAAAAAAAATAATTAGCCAGATGTGGTG
GTGTGCACTTGTAGTCCTAGCTACTTGGGAGGCTAAGGTGGGAGGATCGCTGGAGCCCAGGACATCAAGGTTGCAAGGAGCTATGTTCAT
TCCACTGCACTCCAGCCTGGGCTACAGAGTGAGACCTGTCTAAAATAAATAAATAAATAAACAAACTAGCTCATTTACAATGTAAAGCAC
TTAATATCAAATGATTATTTGGTGTACTAGAAAAGAAACAGCATATAATAATGTATAATAGTTTCTTAACAAGTGGGGCTAAAATCATTT
TGTAGTAATTTTTCACATTGATATTAAACTTCATGAGTTTCTTTTAGTCATTATTATTATTATTATTATTATTTGAGATGGAATCTCGCT
CTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGAAAGCTCTGCCTCCTGGGTTCACGCCATTCTTCTGCCTCAGCCTCC
TGAGTAGCTGGGACTACAGGTGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTATTAGCCAGGA
TGGTCTCGATCTCCTGACCTCGTGATCTGTCTGCCTTGGCCTCCAAAAGTGCTGGGACCGTGCCCAGCCATCATTATTATTTTTTAAAAA
GAAAACTCCCCCTACCCCCAGTATACCATTTTGTATCTCAAAATTTTACTTTATTGATTTTTAAGAGTAATTTCTACTTTTATCTTTTAA
ATAAAACATTTTAGAGTATTTTTGAAGACTTAAAAAGCTTAAAATTTAGTGTTTTTGGAAATGTATAAAATTTTCTTGAAGTATGTATAG
TTTTCCAAATTACTTTACTGACCTGTTAACTCACTGTACTTGTTTTTTACTTATTTTTTCCTGACCTCTTAACAAGGTGAGTCCATTTAA
TCATCTGTGGTATAAAATGCTTCTCTAGTCACCTGTTCTCATTAAACAGTTGTAAGTAAGTTTTAAAAGCCATTATTTTAATTACTAAAA
GTTCTCAAGTGTGTAGTATTATCTGAGTATTTTAATTGAAAAATTAATCAGGCTTTTAAAAATTACTTTTTTATTGTATTAGTTGGCTTT
TAAATTCAGATTCTTTATATTTGCTTGATTTTTCCTGGAAGTTCCAAGTTTTATGAATTTGTAGCTGATAGTAGGTTTTACTTGTGTACC
CCATCTGCACTTTGATGTTGTGTAGATCGTTTTGTGAGTTATTTGAACCGTGTAACTCAGAGAATAGTATTTCCTCATACATAAAGTGAC
CTCACTTTTAATCAGCTCCTTTATAGTATGTTGAAAATCACTGCGTGTAATGAGAGGTATTGAGAGTTTCTTGCACACATGAGTGTAAAA
GGTTGAGAACTAGATTATACAAAGTAGTAAGTCACAGTGCATGGCAACTTTCTACAGGTTGGATTATAAGACTTATGTGGAATAGGAGAA
TTATATTGGGAAAAAATTATTTTCTCTAACTTGAAGACTCCAGAGACACTTTTCTTAGTCATGACCAGTAATATTTTTCATATATTTTGG
AAGAAATAAGCTCCTCACTATACCACCAGTTAGTGATTTATTTATTTATGTATTTTAGAGACAGGGCCTCCTTCTGTCACCCAGTTTGGA
GTGCAGTGGTGTAATCATAGCTTACTGCAGCATCAAACTCCTGGGCTCAAGTGTTCCTCCTGCCTCAGCCTCCCAAGTAGCTAGAACCTC
AGCCCCATGCCACCACACTCAGCTAATTTTAAATTTTACTAATTTCATTTAATTTTTGTGGAGATGGGGGTCTTGCTGTGTTGTTTAGGC
TGGTCCTGAACTCCTGGCCTCAAGCGATCCTTCTGCCTTGGCCTCTCAGTAAATTATATAGAAGAGCACTTCTGTATAATTTACTCAGTT
TCTTCATCACATATTTCCAACTGTTGCCCTAAATAGGTTTAAAAATGTGATCATGTTATTAGAAAATCCTTTCCATTGAATTTCAGGGAT
GCTGAATTTCAGGGAGCTAAATTGTTGACCCTTGCCTGTAGTTGTTATTGGTTCAGAAGTAAATTTTATTGATGCTACAAGTAAAAAATT
AGATCTGACTTAGTAAACTCAAAAGTTTTACAAAACTGTATTTTACTATGTAGATGTATTTCTTTAAAATAGGTATGGATGGATATTTTT

>In-frame_APC_ENST00000257430_chr5_112164669_+_DTWD2_ENST00000510708_chr5_118183913_-_3475nt
GGAGACAGAATGGAGGTGCTGCCGGACTCGGAAATGGGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGC
AAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCAT
CTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTC
TTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGAT
CTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTG
GATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAAC
TTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATG
AAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTC
AGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAA
CCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTA
CACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGG
TGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAG
ACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAA
ATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGC
GTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGG
ACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGC
ATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACC
ACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTA
TGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGT
CTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGG
TGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTG
CTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTG
CCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGG
AATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTT
CATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATT
CATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATG
TTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATT
GGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTA
CAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGT
ATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGA
AATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTAT
TTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAA
CCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAG
AGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCT
TTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATT
TATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATG
CTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTA
TTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTT

>In-frame_APC_ENST00000257430_chr5_112164669_+_DTWD2_ENST00000515439_chr5_118183913_-_2737nt
GGAGACAGAATGGAGGTGCTGCCGGACTCGGAAATGGGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGC
AAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCAT
CTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTC
TTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGAT
CTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTG
GATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAAC
TTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATG
AAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTC
AGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAA
CCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTA
CACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGG
TGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAG
ACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAA
ATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGC
GTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGG
ACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGC
ATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACC
ACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTA
TGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGT
CTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGG
TGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTG
CTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTG
CCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGG
AATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTT
CATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATT
CATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATG
TTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATT
GGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTA
CAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGT
ATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGA

>In-frame_APC_ENST00000508376_chr5_112164669_+_DTWD2_ENST00000304058_chr5_118183913_-_5795nt
GAATGGAGGTGCTGCCGGACTCGGAAATGGGGACACATGCATTGGTGGCCAAAAGAGAGAGGAGACAAAACCGCTGCAGATGGCTGATGT
GAATCTAGTGGAAAGAGCTACTGGGGATGAGAGAAAGAGGAGGAGGCAGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCA
GTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGA
AACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTT
ATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAG
CCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAG
AGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTA
TTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCA
ATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAAT
AGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAA
CAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCA
GGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCT
GGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTC
TAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGT
ATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAA
GAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGA
ACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATT
TGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCT
TACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTAC
GCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTT
GAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGA
AGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTG
TGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACT
TCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACT
CAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCA
AATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTA
AACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCC
TCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGT
TGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAG
TCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGG
AAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCA
TGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCT
GGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCT
ATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTG
TATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATT
TTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACT
TGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAA
AAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTA
TTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGT
GAGAATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGGTGAGACTCCATCTCCATACAAAATTAAAAAAAAAATAATTAGC
CAGATGTGGTGGTGTGCACTTGTAGTCCTAGCTACTTGGGAGGCTAAGGTGGGAGGATCGCTGGAGCCCAGGACATCAAGGTTGCAAGGA
GCTATGTTCATTCCACTGCACTCCAGCCTGGGCTACAGAGTGAGACCTGTCTAAAATAAATAAATAAATAAACAAACTAGCTCATTTACA
ATGTAAAGCACTTAATATCAAATGATTATTTGGTGTACTAGAAAAGAAACAGCATATAATAATGTATAATAGTTTCTTAACAAGTGGGGC
TAAAATCATTTTGTAGTAATTTTTCACATTGATATTAAACTTCATGAGTTTCTTTTAGTCATTATTATTATTATTATTATTATTTGAGAT
GGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGAAAGCTCTGCCTCCTGGGTTCACGCCATTCTTCTG
CCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGT
ATTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGTCTGCCTTGGCCTCCAAAAGTGCTGGGACCGTGCCCAGCCATCATTATTA
TTTTTTAAAAAGAAAACTCCCCCTACCCCCAGTATACCATTTTGTATCTCAAAATTTTACTTTATTGATTTTTAAGAGTAATTTCTACTT
TTATCTTTTAAATAAAACATTTTAGAGTATTTTTGAAGACTTAAAAAGCTTAAAATTTAGTGTTTTTGGAAATGTATAAAATTTTCTTGA
AGTATGTATAGTTTTCCAAATTACTTTACTGACCTGTTAACTCACTGTACTTGTTTTTTACTTATTTTTTCCTGACCTCTTAACAAGGTG
AGTCCATTTAATCATCTGTGGTATAAAATGCTTCTCTAGTCACCTGTTCTCATTAAACAGTTGTAAGTAAGTTTTAAAAGCCATTATTTT
AATTACTAAAAGTTCTCAAGTGTGTAGTATTATCTGAGTATTTTAATTGAAAAATTAATCAGGCTTTTAAAAATTACTTTTTTATTGTAT
TAGTTGGCTTTTAAATTCAGATTCTTTATATTTGCTTGATTTTTCCTGGAAGTTCCAAGTTTTATGAATTTGTAGCTGATAGTAGGTTTT
ACTTGTGTACCCCATCTGCACTTTGATGTTGTGTAGATCGTTTTGTGAGTTATTTGAACCGTGTAACTCAGAGAATAGTATTTCCTCATA
CATAAAGTGACCTCACTTTTAATCAGCTCCTTTATAGTATGTTGAAAATCACTGCGTGTAATGAGAGGTATTGAGAGTTTCTTGCACACA
TGAGTGTAAAAGGTTGAGAACTAGATTATACAAAGTAGTAAGTCACAGTGCATGGCAACTTTCTACAGGTTGGATTATAAGACTTATGTG
GAATAGGAGAATTATATTGGGAAAAAATTATTTTCTCTAACTTGAAGACTCCAGAGACACTTTTCTTAGTCATGACCAGTAATATTTTTC
ATATATTTTGGAAGAAATAAGCTCCTCACTATACCACCAGTTAGTGATTTATTTATTTATGTATTTTAGAGACAGGGCCTCCTTCTGTCA
CCCAGTTTGGAGTGCAGTGGTGTAATCATAGCTTACTGCAGCATCAAACTCCTGGGCTCAAGTGTTCCTCCTGCCTCAGCCTCCCAAGTA
GCTAGAACCTCAGCCCCATGCCACCACACTCAGCTAATTTTAAATTTTACTAATTTCATTTAATTTTTGTGGAGATGGGGGTCTTGCTGT
GTTGTTTAGGCTGGTCCTGAACTCCTGGCCTCAAGCGATCCTTCTGCCTTGGCCTCTCAGTAAATTATATAGAAGAGCACTTCTGTATAA
TTTACTCAGTTTCTTCATCACATATTTCCAACTGTTGCCCTAAATAGGTTTAAAAATGTGATCATGTTATTAGAAAATCCTTTCCATTGA
ATTTCAGGGATGCTGAATTTCAGGGAGCTAAATTGTTGACCCTTGCCTGTAGTTGTTATTGGTTCAGAAGTAAATTTTATTGATGCTACA
AGTAAAAAATTAGATCTGACTTAGTAAACTCAAAAGTTTTACAAAACTGTATTTTACTATGTAGATGTATTTCTTTAAAATAGGTATGGA

>In-frame_APC_ENST00000508376_chr5_112164669_+_DTWD2_ENST00000510708_chr5_118183913_-_3576nt
GAATGGAGGTGCTGCCGGACTCGGAAATGGGGACACATGCATTGGTGGCCAAAAGAGAGAGGAGACAAAACCGCTGCAGATGGCTGATGT
GAATCTAGTGGAAAGAGCTACTGGGGATGAGAGAAAGAGGAGGAGGCAGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCA
GTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGA
AACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTT
ATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAG
CCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAG
AGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTA
TTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCA
ATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAAT
AGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAA
CAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCA
GGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCT
GGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTC
TAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGT
ATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAA
GAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGA
ACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATT
TGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCT
TACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTAC
GCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTT
GAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGA
AGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTG
TGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACT
TCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACT
CAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCA
AATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTA
AACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCC
TCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGT
TGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAG
TCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGG
AAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCA
TGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCT
GGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCT
ATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTG
TATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATT
TTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACT
TGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAA
AAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTA
TTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGT

>In-frame_APC_ENST00000508376_chr5_112164669_+_DTWD2_ENST00000515439_chr5_118183913_-_2838nt
GAATGGAGGTGCTGCCGGACTCGGAAATGGGGACACATGCATTGGTGGCCAAAAGAGAGAGGAGACAAAACCGCTGCAGATGGCTGATGT
GAATCTAGTGGAAAGAGCTACTGGGGATGAGAGAAAGAGGAGGAGGCAGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCA
GTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGA
AACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTT
ATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAG
CCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAG
AGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTA
TTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCA
ATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAAT
AGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAA
CAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCA
GGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCT
GGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTC
TAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGT
ATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAA
GAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGA
ACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATT
TGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCT
TACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTAC
GCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTT
GAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGA
AGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTG
TGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACT
TCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACT
CAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCA
AATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTA
AACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCC
TCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGT
TGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAG
TCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGG
AAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCA


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FusionGenePPI for APC_DTWD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
APCCTNNA1, CTNNB1, MUC1, PPP2R5A, TUBA4A, XPO1, APC, TFAP2A, MAPRE2, CSNK2A1, CSNK2B, SFN, AXIN1, GSK3B, KIFAP3, DLG3, JUP, SIAH1, MAPRE1, DLGAP1, ARHGEF4, MAD2L1, BUB1, BUB3, BUB1B, AXIN2, CSNK1A1, BTRC, ACTN1, AP2B1, ANXA7, DST, C4A, CREBBP, EPAS1, FLNA, GOLGA2, AGFG1, HSPA5, KIF5B, KRT5, KRT13, KRT14, KRT15, KRT17, KRT19, LAMA3, LAMA4, ND4, MYH10, MYH11, MYO6, HNRNPM, NEB, NUP98, PSMD1, RANBP2, RPS27, SPTBN1, SPTBN2, TRIM21, TAF1, TPR, NUP214, MCM3AP, SMC3, HGS, CYTH2, NUPL1, SETDB1, POM121, NUP153, RANBP9, COG5, NUPL2, LPHN1, SEC31A, SNRNP200, EXPH5, SYNE1, PPP1R13B, SPECC1L, MACF1, COG4, PNISR, KRT23, ANKRD17, GIGYF2, FHOD1, NUP54, MBD5, ERBB2IP, FAM214A, KIAA1328, ZNF106, RBM4B, FBXO30, ING5, CGNL1, NAV3, NAV1, NAV2, NOSTRIN, NCKAP5L, NCKAP5, POM121C, CTBP1, UBC, ZRANB1, COPS5, PCNA, RPA2, SCRIB, HTRA2, STRN, STRN3, STRN4, TNKS, HECTD1, RNF146, CFTR, YWHAQ, ANKRD28, LATS2, KCTD1, CEP250, FBXW11, AP2M1, LIN7C, AGR3, CASC3, CCL5, CYP17A1, DIRAS3, DKK3, HOXC6, IL24, NAT2, PDLIM2, ST14, TFF1, TRIM25, NUP107, CEP128, RPGRIP1L, SASS6, SYNPO, KIF7, DVL2, EEF1D, MARK2, PKP2, MAD1L1, MBD4, TELO2, AKAP13, RBFOX2, MRPL18, SENP1, BBX, ARHGAP21, WIZ, SAV1, AMER1, FAM83B, CSNK1E, PTK2, TRAF1, CDK9, VHL, SMARCB1, UBR5, CTNNA3, SYNC, ZNF408, ACADVL, KIAA1683, CTNNBIP1, ZNF785, CCDC6, LZTS2, ALDH2, CSNK1D, USP7, USP30, RNF114, ZFP91, TRIM32, HEY1DTWD2MFAP3, POLE, FREM2, PCDH7, PC, TUBB8, CBWD1, ERBB2, PEX1, FAT3, CELSR2, CCRN4L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for APC_DTWD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for APC_DTWD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPCC0032580Adenomatous Polyposis Coli14CTD_human;ORPHANET;UNIPROT
HgeneAPCC0009375Colonic Neoplasms7CTD_human
HgeneAPCC0009404Colorectal Neoplasms6CTD_human
HgeneAPCC0021841Intestinal Neoplasms5CTD_human
HgeneAPCC0001430Adenoma4CTD_human
HgeneAPCC0021846Intestinal Polyps3CTD_human
HgeneAPCC0001418Adenocarcinoma2CTD_human
HgeneAPCC0004352Autistic Disorder2CTD_human
HgeneAPCC0007621Neoplastic Cell Transformation2CTD_human
HgeneAPCC0025149Medulloblastoma2CTD_human;UNIPROT
HgeneAPCC0034885Rectal Neoplasms2CTD_human
HgeneAPCC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneAPCC0009405Hereditary Nonpolyposis Colorectal Neoplasms1CTD_human
HgeneAPCC0015393Eye Abnormalities1CTD_human
HgeneAPCC0017185Gastrointestinal Neoplasms1CTD_human
HgeneAPCC0017636Glioblastoma1CTD_human
HgeneAPCC0020473Hyperlipidemia1CTD_human
HgeneAPCC0021390Inflammatory Bowel Diseases1CTD_human
HgeneAPCC0023903Liver neoplasms1CTD_human
HgeneAPCC0024121Lung Neoplasms1CTD_human
HgeneAPCC0024667Animal Mammary Neoplasms1CTD_human
HgeneAPCC0025500Mesothelioma1CTD_human
HgeneAPCC0033578Prostatic Neoplasms1CTD_human
HgeneAPCC0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneAPCC0036341Schizophrenia1PSYGENET
HgeneAPCC0079218Fibromatosis, Aggressive1CTD_human;HPO;ORPHANET
HgeneAPCC0206646Fibromatosis, Abdominal1CTD_human
HgeneAPCC0206677Adenomatous Polyps1CTD_human
HgeneAPCC0265325Turcot syndrome (disorder)1CTD_human
HgeneAPCC0699791Stomach Carcinoma1HPO;UNIPROT
HgeneAPCC1879526Aberrant Crypt Foci1CTD_human
HgeneAPCC3714756Intellectual Disability1CTD_human