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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 21388

FusionGeneSummary for MDM2_MYRFL

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2_MYRFL
Fusion gene ID: 21388
HgeneTgene
Gene symbol

MDM2

MYRFL

Gene ID

4193

196446

Gene nameMDM2 proto-oncogenemyelin regulatory factor like
SynonymsACTFS|HDMX|hdm2C12orf15|C12orf28|bcm1377
Cytomap

12q15

12q15

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hummyelin regulatory factor-like protein
Modification date2018052720180523
UniProtAcc

Q00987

Q96LU7

Ensembl transtripts involved in fusion geneENST00000462284, ENST00000356290, 
ENST00000540827, ENST00000258149, 
ENST00000428863, ENST00000393412, 
ENST00000258148, ENST00000544561, 
ENST00000393410, ENST00000393413, 
ENST00000517852, ENST00000545204, 
ENST00000350057, ENST00000360430, 
ENST00000299252, ENST00000348801, 
ENST00000478070, ENST00000544125, 
ENST00000552032, ENST00000547771, 
ENST00000299350, ENST00000535034, 
Fusion gene scores* DoF score24 X 14 X 8=268824 X 10 X 4=960
# samples 2521
** MAII scorelog2(25/2688*10)=-3.42653313811667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/960*10)=-2.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDM2 [Title/Abstract] AND MYRFL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-FX-A3NK-01AMDM2chr12

69218431

+MYRFLchr12

70249060

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000462284ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
In-frameENST00000462284ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
5CDS-intronENST00000462284ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
5CDS-intronENST00000462284ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000356290ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000356290ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000356290ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000356290ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000540827ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000540827ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000540827ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000540827ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000258149ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000258149ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000258149ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000258149ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000428863ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000428863ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000428863ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000428863ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393412ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393412ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393412ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393412ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000258148ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000258148ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000258148ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000258148ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000544561ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000544561ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000544561ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000544561ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393410ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393410ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393410ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393410ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393413ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000393413ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393413ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000393413ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000517852ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000517852ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000517852ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000517852ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000545204ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000545204ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000545204ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000545204ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
In-frameENST00000350057ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
In-frameENST00000350057ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
5CDS-intronENST00000350057ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
5CDS-intronENST00000350057ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000360430ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000360430ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000360430ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000360430ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000299252ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000299252ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000299252ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000299252ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000348801ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000348801ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000348801ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000348801ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000478070ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000478070ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000478070ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000478070ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000544125ENST00000552032MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-3CDSENST00000544125ENST00000547771MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000544125ENST00000299350MDM2chr12

69218431

+MYRFLchr12

70249060

+
intron-intronENST00000544125ENST00000535034MDM2chr12

69218431

+MYRFLchr12

70249060

+

Top

FusionProtFeatures for MDM2_MYRFL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MDM2

Q00987

MYRFL

Q96LU7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+71127_107174498DomainNote=SWIB
TgeneMYRFLchr12:69218431chr12:70249060ENST00000552032+025543_57515911Coiled coilOntology_term=ECO:0000255
TgeneMYRFLchr12:69218431chr12:70249060ENST00000552032+025142_40515911DNA bindingNDT80
TgeneMYRFLchr12:69218431chr12:70249060ENST00000552032+025451_55915911DomainPeptidase S74
TgeneMYRFLchr12:69218431chr12:70249060ENST00000552032+025628_64815911TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19210_215-102437Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19243_301-102437Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15210_2150322Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15243_3010322Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13210_2150266Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13243_3010266Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16210_215-102322Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16243_301-102322Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14210_2150297Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14243_3010297Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13210_215-92219Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13243_301-92219Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12210_2150219Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12243_3010219Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14210_215-102271Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14243_301-102271Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711210_215174498Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711243_301174498Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15210_215-102297Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15243_301-102297Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+1927_107-102437DomainNote=SWIB
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+1527_1070322DomainNote=SWIB
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+1327_1070266DomainNote=SWIB
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+1627_107-102322DomainNote=SWIB
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+1427_1070297DomainNote=SWIB
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+1327_107-92219DomainNote=SWIB
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+1227_1070219DomainNote=SWIB
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+1427_107-102271DomainNote=SWIB
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+1527_107-102297DomainNote=SWIB
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19179_185-102437MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19190_202-102437MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19466_473-102437MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15179_1850322MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15190_2020322MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15466_4730322MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13179_1850266MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13190_2020266MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13466_4730266MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16179_185-102322MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16190_202-102322MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16466_473-102322MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14179_1850297MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14190_2020297MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14466_4730297MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13179_185-92219MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13190_202-92219MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13466_473-92219MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12179_1850219MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12190_2020219MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12466_4730219MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14179_185-102271MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14190_202-102271MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14466_473-102271MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711179_185174498MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711190_202174498MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711466_473174498MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15179_185-102297MotifNuclear localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15190_202-102297MotifNote=Nuclear export signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15466_473-102297MotifNucleolar localization signal
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19210_304-102437RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19242_331-102437RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15210_3040322RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15242_3310322RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13210_3040266RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13242_3310266RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16210_304-102322RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16242_331-102322RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14210_3040297RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14242_3310297RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13210_304-92219RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13242_331-92219RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12210_3040219RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12242_3310219RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14210_304-102271RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14242_331-102271RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711210_304174498RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711242_331174498RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15210_304-102297RegionNote=ARF-binding
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15242_331-102297RegionNote=Region II
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19299_328-102437Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19438_479-102437Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15299_3280322Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15438_4790322Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13299_3280266Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13438_4790266Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16299_328-102322Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16438_479-102322Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14299_3280297Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14438_4790297Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13299_328-92219Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13438_479-92219Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12299_3280219Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12438_4790219Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14299_328-102271Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14438_479-102271Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711299_328174498Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711438_479174498Zinc fingerRING-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15299_328-102297Zinc fingerRanBP2-type
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15438_479-102297Zinc fingerRING-type


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FusionGeneSequence for MDM2_MYRFL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MDM2_ENST00000462284_chr12_69218431_+_MYRFL_ENST00000552032_chr12_70249060_+_1070aa
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD
LFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETAQGANG
TLENPALDTSLLEEFLGNDFDLGALQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSC
QIHGGFHSCHSNASHLATPLDQSVSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSE
GQNRMPTDQCSPALKWQPCHSVPWHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIE
MFYLKVFGTKVEATNQIIAIEQSQADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFY
LLSAHISERIIVRASNPGQFENDSDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRI
AQMRIVEYDYKPEFASAMGINTAHQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEE
LEIWNRKLARLKRLSSWKSSASEASTISKSSRAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCALTIVALYILSL
KDQDRRVPNLPPSNITSSQEPALLPTASSSAPNTSLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWS
EDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTL

>In-frame_MDM2_ENST00000462284_chr12_69218431_+_MYRFL_ENST00000547771_chr12_70249060_+_1058aa
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD
LFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETAQGANG
TLENPALDTSLLEEFLGNDFDLGALQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSC
QIHGGFHSCHSNASHLATPLDQSVSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSE
GQNRMPTDQCSPALKWQPCHSVPWHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIE
MFYLKVFGTKVEATNQIIAIEQSQADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFY
LLSAHISERIIVRASNPGQFENDSDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRI
AQMRIVEYDYKPEFASAMGINTAHQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEE
LEIWNRKLARLKRLSSWKSSASEASTISKSSRAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCLKDQDRRVPNLP
PSNITSSQEPALLPTASSSAPNTSLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWSDKSKSVLARNA
LSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTK

>In-frame_MDM2_ENST00000350057_chr12_69218431_+_MYRFL_ENST00000552032_chr12_70249060_+_1039aa
MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETAQGANGTLENPALDTSLLEEFLGNDFDLGALQRQLPD
TPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIG
CSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSH
YEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKI
FNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRG
QVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQ
EVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSS
RAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCALTIVALYILSLKDQDRRVPNLPPSNITSSQEPALLPTASSSA
PNTSLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWSEDKSKSVLARNALSGPDWESDWIDTTISSIQ
IMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHI

>In-frame_MDM2_ENST00000350057_chr12_69218431_+_MYRFL_ENST00000547771_chr12_70249060_+_1027aa
MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETAQGANGTLENPALDTSLLEEFLGNDFDLGALQRQLPD
TPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIG
CSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSH
YEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKI
FNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRG
QVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQ
EVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSS
RAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCLKDQDRRVPNLPPSNITSSQEPALLPTASSSAPNTSLVTTPAS
LQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWSDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQY
CIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MDM2_ENST00000462284_chr12_69218431_+_MYRFL_ENST00000552032_chr12_70249060_+_3210nt
ATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAA
GAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTT
TTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGAT
TTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAA
TCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAA
GAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGCTCAGGGAGCCAATGGT
ACTCTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCA
GACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGG
ACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGC
CAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATA
GGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAG
GACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAG
GGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGT
CATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAA
AAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAA
ATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAG
ATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAAT
AATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTAT
CTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGA
GGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATG
AAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATA
GCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCC
CAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATG
GTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAG
TTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCT
AGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGAAAAAGACAGGCGTGTCCT
AATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGTGCTTTGACGATAGTTGCCCTCTATATACTTAGCTTA
AAAGATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCA
GCACCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTAT
TGCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCA
GAAGACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATT
CAGATTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCT
GTTAATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTT
GGAAATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCAC
ATTTGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCT

>In-frame_MDM2_ENST00000462284_chr12_69218431_+_MYRFL_ENST00000547771_chr12_70249060_+_3174nt
ATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAA
GAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTTCTT
TTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGAT
TTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAA
TCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAA
GAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGCTCAGGGAGCCAATGGT
ACTCTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCA
GACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGG
ACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGC
CAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATA
GGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAG
GACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAG
GGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGT
CATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAA
AAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAA
ATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAG
ATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAAT
AATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTAT
CTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGA
GGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATG
AAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATA
GCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCC
CAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATG
GTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAG
TTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCT
AGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGAAAAAGACAGGCGTGTCCT
AATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGCTTAAAAGATCAAGACCGACGTGTCCCAAATCTCCCT
CCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCACCTAATACATCCCTGGTAACCACACCGGCC
TCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGCTGCCCCATCCGGGGAATGAAAGAAGTCTCT
TCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAGACAAAAGCAAATCAGTTTTGGCAAGAAATGCA
CTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAGATTATGGAAATCCAGCAAATAATAGATCATCAG
TATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTTAATAAACACACACCCACCAATGTCAAGTTCTCT
CTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAAATATATGTTTCCATAGTAAAAGGGGAACCAAA
GGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATTTGGAGCCTCCCTGTAGCCCCATTTTCTGACAGC
ATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTATTTTGCTGGGATATTCTTCACCGATTACTTCTTT

>In-frame_MDM2_ENST00000350057_chr12_69218431_+_MYRFL_ENST00000552032_chr12_70249060_+_3117nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGCTCAGGGAGCCAATGGTACT
CTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGAC
ACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGGACT
CCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAA
ATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATAGGT
TGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGAC
TCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGA
CAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGTCAT
TATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAG
AAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAAATG
TTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATT
TTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAATAAT
ATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTATCTG
TTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGAGGA
CAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAA
GTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATAGCC
CAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCCCAG
GAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATGGTG
GATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAGTTA
GAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGC
AGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGAAAAAGACAGGCGTGTCCTAAT
TGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGTGCTTTGACGATAGTTGCCCTCTATATACTTAGCTTAAAA
GATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCA
CCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGC
TGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAGAA
GACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAG
ATTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTT
AATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGA
AATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATT
TGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTAT

>In-frame_MDM2_ENST00000350057_chr12_69218431_+_MYRFL_ENST00000547771_chr12_70249060_+_3081nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGCTCAGGGAGCCAATGGTACT
CTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGAC
ACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGGACT
CCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAA
ATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATAGGT
TGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGAC
TCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGA
CAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGTCAT
TATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAG
AAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAAATG
TTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATT
TTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAATAAT
ATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTATCTG
TTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGAGGA
CAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAA
GTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATAGCC
CAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCCCAG
GAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATGGTG
GATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAGTTA
GAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGC
AGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGAAAAAGACAGGCGTGTCCTAAT
TGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGCTTAAAAGATCAAGACCGACGTGTCCCAAATCTCCCTCCA
AGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCACCTAATACATCCCTGGTAACCACACCGGCCTCC
TTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCA
AGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAGACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTC
AGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAGATTATGGAAATCCAGCAAATAATAGATCATCAGTAT
TGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTTAATAAACACACACCCACCAATGTCAAGTTCTCTCTG
GAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAAATATATGTTTCCATAGTAAAAGGGGAACCAAAGGG
CTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATTTGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATG
TTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTATTTTGCTGGGATATTCTTCACCGATTACTTCTTTTAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_MDM2_ENST00000462284_chr12_69218431_+_MYRFL_ENST00000552032_chr12_70249060_+_3704nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTG
ATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAG
CAATTAGTGAGACAGCTCAGGGAGCCAATGGTACTCTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACT
TTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCAT
GCTACCCAACCCTGAGGCCCACAGCTGGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGC
TGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCC
TGGACCAATCCGTGTCCTCCCATCTGGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAA
CCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTC
GCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCC
ATAGTGTTCCTTGGCACAGCTTATTAAACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATT
TTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTG
TTGAAACCGAGATGGGCCTAAAGCCAATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTA
TTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGG
GACGATTACACTTCAGCGAAACCACAGCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTG
GACTGTATGCTGCTAACCAAGACCAGTTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGT
TTGAAAATGACAGTGATGCATTGTGGCAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGC
CGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGG
AGGTTGACACGAATGAACAGCTGAAAAGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAA
TAAACACTGCCCATCAAACAGGAATGATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCG
GAAACGGAGAGACCTTGGAGAACTTCCTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAAC
TAACTAACAACCTTGAGGAAAGAATAGAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCAT
CAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGG
TTTATTTTTCAGGAAAAAGACAGGCGTGTCCTAATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGTGCTT
TGACGATAGTTGCCCTCTATATACTTAGCTTAAAAGATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGG
AGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCACCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTT
TCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTG
AGGAGAAGGAATTCCATCAGAGGCGATGGTCAGAAGACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGA
GTGACTGGATTGATACAACCATCAGTTCTATTCAGATTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGT
GCGGATCTGGAAATTATAATTACAATATTCCTGTTAATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGC
CATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAAATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAA
TCTCCCAGGAGATGACACAGGGATATCAGCACATTTGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTG
CACCGGATTTAGCTGACTGTTCAACTGATCCTTATTTTGCTGGGATATTCTTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCT
AATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAAATACTCAGGAATACATTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCT
TCTTTGTAAAACATTTACGTTTATTGCTGAAGGACTTTTTCAGGCTTTAGCTTCCAACAGTTTTGAGACATTAATGAGGAGAATAAAATG

>In-frame_MDM2_ENST00000462284_chr12_69218431_+_MYRFL_ENST00000547771_chr12_70249060_+_4042nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTG
ATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAG
CAATTAGTGAGACAGCTCAGGGAGCCAATGGTACTCTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACT
TTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCAT
GCTACCCAACCCTGAGGCCCACAGCTGGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGC
TGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCC
TGGACCAATCCGTGTCCTCCCATCTGGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAA
CCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTC
GCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCC
ATAGTGTTCCTTGGCACAGCTTATTAAACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATT
TTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTG
TTGAAACCGAGATGGGCCTAAAGCCAATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTA
TTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGG
GACGATTACACTTCAGCGAAACCACAGCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTG
GACTGTATGCTGCTAACCAAGACCAGTTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGT
TTGAAAATGACAGTGATGCATTGTGGCAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGC
CGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGG
AGGTTGACACGAATGAACAGCTGAAAAGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAA
TAAACACTGCCCATCAAACAGGAATGATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCG
GAAACGGAGAGACCTTGGAGAACTTCCTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAAC
TAACTAACAACCTTGAGGAAAGAATAGAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCAT
CAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGG
TTTATTTTTCAGGAAAAAGACAGGCGTGTCCTAATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGCTTAA
AAGATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAG
CACCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATT
GCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAG
ACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAGA
TTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTTA
ATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAA
ATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATTT
GGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTATT
TTGCTGGGATATTCTTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCTAATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAAA
TACTCAGGAATACATTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCTTCTTTGTAAAACATTTACGTTTATTGCTGAAGGACT
TTTTCAGGCTTTAGCTTCCAACAGTTTTGAGACATTAATGAGGAGAATAAAATGTTTGCTGAAACTTGAAATAATGTGATGTTTGATTTT
GCCATGACTATGAAGAAAACATTTCCTGGAGCAAACAGTTCTGTTGAATTTAAAAATACTATTATTTCTGGTATTAAGGAAGTTGTGAGC
TCAAAATAAGGAGATCTAGCCTCTATTTTGTTTTAATGTATTTTAAAGCTTTTGAAAAAACCAAAAGGGCCATGTCGACTTCGGCCCACT
AAACATAGACTCTTGAGAATGTGTGATATGGTATGTGGAGGAGATGTGGGGGGTGGTATCTGATACTGAGCTCACATTTAGGCAAATTGT

>In-frame_MDM2_ENST00000350057_chr12_69218431_+_MYRFL_ENST00000552032_chr12_70249060_+_3309nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGCTCAGGGAGCCAATGGTACT
CTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGAC
ACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGGACT
CCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAA
ATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATAGGT
TGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGAC
TCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGA
CAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGTCAT
TATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAG
AAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAAATG
TTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATT
TTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAATAAT
ATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTATCTG
TTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGAGGA
CAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAA
GTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATAGCC
CAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCCCAG
GAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATGGTG
GATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAGTTA
GAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGC
AGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGAAAAAGACAGGCGTGTCCTAAT
TGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGTGCTTTGACGATAGTTGCCCTCTATATACTTAGCTTAAAA
GATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCA
CCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGC
TGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAGAA
GACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAG
ATTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTT
AATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGA
AATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATT
TGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTAT
TTTGCTGGGATATTCTTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCTAATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAA
ATACTCAGGAATACATTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCTTCTTTGTAAAACATTTACGTTTATTGCTGAAGGAC

>In-frame_MDM2_ENST00000350057_chr12_69218431_+_MYRFL_ENST00000547771_chr12_70249060_+_3647nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGCTCAGGGAGCCAATGGTACT
CTGGAGAACCCAGCCCTGGACACAAGTCTGTTGGAGGAATTTCTGGGCAATGACTTTGATTTGGGGGCCTTGCAACGCCAGCTCCCAGAC
ACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCTGGGAGGACT
CCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGACTCCTGCCAA
ATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTGGGGATAGGT
TGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCACTGGAGGAC
TCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGACAGTGAGGGA
CAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTAAACAGTCAT
TATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTTTGCCAAAAG
AAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCAATAGAAATG
TTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGCAAAAAGATT
TTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACAGCAAATAAT
ATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAGTTCTATCTG
TTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGGCAGCGAGGA
CAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGCAACATGAAA
GTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAAAGAATAGCC
CAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATGATTGCCCAG
GAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTCCTCATGGTG
GATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATAGAAGAGTTA
GAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGCAAATCTAGC
AGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGAAAAAGACAGGCGTGTCCTAAT
TGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGCTTAAAAGATCAAGACCGACGTGTCCCAAATCTCCCTCCA
AGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCACCTAATACATCCCTGGTAACCACACCGGCCTCC
TTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCA
AGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAGACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTC
AGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAGATTATGGAAATCCAGCAAATAATAGATCATCAGTAT
TGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTTAATAAACACACACCCACCAATGTCAAGTTCTCTCTG
GAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAAATATATGTTTCCATAGTAAAAGGGGAACCAAAGGG
CTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATTTGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATG
TTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTATTTTGCTGGGATATTCTTCACCGATTACTTCTTTTAC
TTCTATCGACGCTGTGCCTAATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAAATACTCAGGAATACATTTAACAGAAACGAACATCCT
CTTGCAACTTCTTTTTTCTTCTTTGTAAAACATTTACGTTTATTGCTGAAGGACTTTTTCAGGCTTTAGCTTCCAACAGTTTTGAGACAT
TAATGAGGAGAATAAAATGTTTGCTGAAACTTGAAATAATGTGATGTTTGATTTTGCCATGACTATGAAGAAAACATTTCCTGGAGCAAA
CAGTTCTGTTGAATTTAAAAATACTATTATTTCTGGTATTAAGGAAGTTGTGAGCTCAAAATAAGGAGATCTAGCCTCTATTTTGTTTTA
ATGTATTTTAAAGCTTTTGAAAAAACCAAAAGGGCCATGTCGACTTCGGCCCACTAAACATAGACTCTTGAGAATGTGTGATATGGTATG
TGGAGGAGATGTGGGGGGTGGTATCTGATACTGAGCTCACATTTAGGCAAATTGTCCTATGTGTGTGTGTATTGTATAAACACATACACT


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FusionGenePPI for MDM2_MYRFL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MDM2TP53, MDC1, CTBP1, CTBP2, TP73, PML, RPL11, RPL5, CDKN2A, NUMB, UBE2A, HIF1A, KAT5, HDAC1, EID1, MDM4, KAT2B, EP300, TBP, TAF1, MDM2, ESR1, ARRB2, ABL1, CCNG1, ARRB1, TSG101, RB1, MTBP, FKBP3, RYBP, RRM2B, RPL26, GNAS, FOXO4, IGF1R, DAXX, DHFR, GNL3, CCAR1, PSMD10, PSME3, PTK2, AR, PPM1D, USP7, COPS5, SFN, RBBP6, CDH1, CHEK2, YWHAQ, NCL, UBE2G2, UBE2U, UBE2Z, PYHIN1, BANP, DDX17, E2F1, TRIM28, UBC, GATA3, ATF3, HIST2H2BE, RPL23, YY1, AKT1, RAD23A, CDKN1A, NR3C1, UBE2I, HIST3H3, EHMT1, SUV39H1, RPS27L, RPS27, ADRB2, SIVA1, MTA1, RCHY1, UBE2D1, CASP2, RPS27A, RPS7, G3BP2, PSMD2, PAK1IP1, RPS6KB1, ZNF668, TP63, PCNA, USP10, PSMC1, PSMD4, PSMC3, PSMC5, PSMC6, PSMA7, PSMD1, RUNX3, GNL3L, TERT, APEX1, UIMC1, CREBBP, SOX4, UBE4B, TBRG1, BAIAP2L1, RFWD3, ERBB3, PA2G4, HEXIM1, CDK9, DYRK2, HSP90AA1, HSPA4, HSPA8, LAMP2, RPS3, USP2, TRIM13, XRCC6, GORAB, FOXO1, FOXO3, UCHL1, S100A1, S100A2, S100A4, S100A6, S100B, USP42, CUL1, BTRC, FBXW11, CSNK1D, RFWD2, SMURF1, NOTCH4, CSNK1A1, PDLIM7, SENP3, RN5S1@, PDE4D, NOTCH1, SNAI1, RASSF1, TRIM27, RFFL, RPS14, PPP2R4, TTF1, PSMB6, PSMA8, RASSF3, NR0B2, UBE2B, PIAS1, RANBP1, LATS1, RAD50, NBN, MRE11A, CUL4A, DTL, PIM1, GSK3B, PSMA3, ESR2, ADRBK1, AATF, HNRNPK, BUB1B, SUMO1, RASSF5, UBE2D2, POLH, NPM1, TCAP, CDK5RAP3, ARIH2, IRF2, RPS25, TPT1, ANG, RHOA, PDCD5, CDKN2AIP, LATS2, WWOX, MED1, ERCC6, ERCC8, DDB1, CUL4B, HIPK2, DHRS2, CASP3, ITCH, EEF1A1, DCD, TUBB, TUBB2A, KRT14, RPS20, GAPDH, TUBA1C, GSN, ERBB4, XIAP, HNF4A, PLK1, NME2, NEDD4, DAPK1, DAPK3, ATM, PBX1, UBE2D3, UBE3A, UBE2L3, UBE2E2, UBE2E3, RNF2, EGR1, PAK6, DLG4, IRF1, VCP, STRA13, GADD45A, RABL6, RPS26, RPL37, RPS15, RNF8, TRIM4, TRIM23, TRAF5, TRIM9, MKRN3, PHF7, RNF10, RNF126, UBE2K, LMO7, HLA-DMB, SETDB1, YY1AP1, NACA, ATF4, MYD88, RELA, SDHC, WT1, SORBS2, HRSP12, DNAJB4, GCAT, SHPK, POT1, ANKRD17, GLTSCR2, SESN2, RASSF6, JUND, EZR, RYR2, JUN, CLSTN1, APP, CLU, SREK1, SET, HSP90B1, CWC25, ZNF133, PKM, TAB1, RPL6, AURKA, NOC2L, JAK1, XPC, PGAM1, PGAM2, DNAJB1, ANAPC2, NLK, SNAI2, RBM38, FHIT, AGPS, ALDH16A1, DDX5, DHX9, DLAT, EDC4, EIF2AK1, ESYT1, GTF2I, HMHA1, HNRNPM, HNRNPU, HRNR, HSP90AB1, IARS, IFI16, IGF2BP3, ILF3, KARS, CCAR2, NEK9, OGDH, OGDHL, RARS, RBBP8, RECQL, SF3B1, SFPQ, TOP1, ZNF318, PER2, SIRT6, TSC22D3, RPS6, UBE2M, RAD54B, SMARCA2, ACACA, PTBP1, IYD, ACTB, HNRNPD, U2AF2, FUBP1, TFRC, EEF2, XPO1, KRT2, EIF3B, SND1, DCAF8, USO1, EFTUD2, EXOSC6, IPO7, SF3B3, DET1, UBE2N, RPL10A, DIRAS3, SURF2, RFPL2, CMSS1, PPARD, RPL22L1, IER2, MAGEA2, ZNF420, ELF4, ABL2, SRC, HCK, GTF2E2, ATP2A2, BRINP1, C19orf10, CANX, MS4A1, PDIA3, PPIB, RAB8A, RPS23, RUVBL2, SMARCA4, SMARCE1, SRSF11, TPR, UBTF, PPARG, VDR, FBXO31, TFIP11, SETD7, PPP1CA, RARA, DDX24, NAT10, CCND1, RLIM, IER3, FHL2, RPL23A, SUZ12, EZH2, EED, RRM1, RPL4, NOLC1, DDX42, MAP2, NUCKS1, RRP1, PDS5A, RPL36A, TP53RK, RPL15, NPIPB3, HMGN1, MAP1LC3A, PRDM2, KIAA1551, PBXIP1, SP1, SHARPIN, MAPKAPK2, USP15, USP26, FKBP1A, NGFR, SMG7, RSL1D1, SIRT1, SIRT7, SIRT2, SIRT3, KPNA1, KPNA6, MSI2, PHLDB3, CLPB, XAGE1B, ZNF550, YAF2, PDGFB, ARNTL2, RPS11, TSPYL6, HIST1H2BJ, ZNF764, MAK16, ZNF274, PPAN, RPL37A, CRTC2, CRTC3, TRIM25, CSNK2A1, CSNK2B, CSNK2A2, HEY1, RANBP2MYRFL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19170_306-102437MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15170_3060322MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13170_3060266MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16170_306-102322MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14170_3060297MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13170_306-92219MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12170_3060219MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14170_306-102271MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711170_306174498MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15170_306-102297MTBP
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19150_230-102437PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15150_2300322PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13150_2300266PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16150_230-102322PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14150_2300297PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13150_230-92219PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12150_2300219PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14150_230-102271PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711150_230174498PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15150_230-102297PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69218431chr12:70249060ENST00000258149+19223_232-102437USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000299252+15223_2320322USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000348801+13223_2320266USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000356290+16223_232-102322USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000360430+14223_2320297USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000393412+13223_232-92219USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000393413+12223_2320219USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000428863+14223_232-102271USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000462284+711223_232174498USP7
HgeneMDM2chr12:69218431chr12:70249060ENST00000540827+15223_232-102297USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MDM2_MYRFL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMDM2Q00987DB01593ZincE3 ubiquitin-protein ligase Mdm2small moleculeapproved|investigational

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RelatedDiseases for MDM2_MYRFL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMDM2C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneMDM2C0007621Neoplastic Cell Transformation1CTD_human
HgeneMDM2C0019693HIV Infections1CTD_human
HgeneMDM2C0021364Male infertility1CTD_human
HgeneMDM2C0025202melanoma1CTD_human
HgeneMDM2C0032927Precancerous Conditions1CTD_human
HgeneMDM2C0033578Prostatic Neoplasms1CTD_human
HgeneMDM2C1458155Mammary Neoplasms1CTD_human