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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21383

FusionGeneSummary for MDM2_EGFR

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2_EGFR
Fusion gene ID: 21383
HgeneTgene
Gene symbol

MDM2

EGFR

Gene ID

4193

1956

Gene nameMDM2 proto-oncogeneepidermal growth factor receptor
SynonymsACTFS|HDMX|hdm2ERBB|ERBB1|HER1|NISBD2|PIG61|mENA
Cytomap

12q15

7p11.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humepidermal growth factor receptoravian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyrosine kinas
Modification date2018052720180527
UniProtAcc

Q00987

P00533

Ensembl transtripts involved in fusion geneENST00000462284, ENST00000356290, 
ENST00000540827, ENST00000258149, 
ENST00000428863, ENST00000393412, 
ENST00000258148, ENST00000544561, 
ENST00000393410, ENST00000393413, 
ENST00000517852, ENST00000545204, 
ENST00000350057, ENST00000360430, 
ENST00000299252, ENST00000348801, 
ENST00000478070, ENST00000544125, 
ENST00000455089, ENST00000342916, 
ENST00000344576, ENST00000420316, 
ENST00000275493, ENST00000442591, 
ENST00000463948, ENST00000454757, 
Fusion gene scores* DoF score24 X 14 X 8=26889 X 10 X 4=360
# samples 2511
** MAII scorelog2(25/2688*10)=-3.42653313811667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDM2 [Title/Abstract] AND EGFR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922

TgeneEGFR

GO:0001934

positive regulation of protein phosphorylation

20551055

TgeneEGFR

GO:0007165

signal transduction

10572067

TgeneEGFR

GO:0007166

cell surface receptor signaling pathway

7736574

TgeneEGFR

GO:0007173

epidermal growth factor receptor signaling pathway

7736574|12435727

TgeneEGFR

GO:0008283

cell proliferation

17115032

TgeneEGFR

GO:0008284

positive regulation of cell proliferation

7736574

TgeneEGFR

GO:0010750

positive regulation of nitric oxide mediated signal transduction

12828935

TgeneEGFR

GO:0018108

peptidyl-tyrosine phosphorylation

22732145

TgeneEGFR

GO:0030307

positive regulation of cell growth

15467833

TgeneEGFR

GO:0031659

positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle

18483258

TgeneEGFR

GO:0042177

negative regulation of protein catabolic process

17115032

TgeneEGFR

GO:0042327

positive regulation of phosphorylation

15082764

TgeneEGFR

GO:0043406

positive regulation of MAP kinase activity

10572067

TgeneEGFR

GO:0045739

positive regulation of DNA repair

17115032

TgeneEGFR

GO:0045740

positive regulation of DNA replication

17115032

TgeneEGFR

GO:0045944

positive regulation of transcription by RNA polymerase II

20551055

TgeneEGFR

GO:0050679

positive regulation of epithelial cell proliferation

10572067

TgeneEGFR

GO:0050999

regulation of nitric-oxide synthase activity

12828935

TgeneEGFR

GO:0070141

response to UV-A

18483258

TgeneEGFR

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20551055

TgeneEGFR

GO:0071392

cellular response to estradiol stimulus

20551055

TgeneEGFR

GO:1900020

positive regulation of protein kinase C activity

22732145

TgeneEGFR

GO:1903078

positive regulation of protein localization to plasma membrane

22732145


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-19-2624-01AMDM2chr12

69203072

+EGFRchr7

55231426

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000462284ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000462284ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000462284ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000462284ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000462284ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000462284ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000462284ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000462284ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000356290ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000356290ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000356290ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000356290ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000356290ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000356290ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000356290ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000356290ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000540827ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000540827ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000540827ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000540827ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000540827ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000540827ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000540827ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000540827ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000258149ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000258149ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000258149ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000258149ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000258149ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000258149ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000258149ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000258149ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000428863ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000428863ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000428863ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000428863ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000428863ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000428863ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000428863ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000428863ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000393412ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000393412ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000393412ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393412ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393412ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393412ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393412ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393412ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000258148ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000258148ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000258148ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000258148ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000258148ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000258148ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000258148ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000258148ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000544561ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000544561ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000544561ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000544561ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000544561ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000544561ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000544561ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000544561ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000393410ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000393410ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000393410ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393410ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393410ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393410ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393410ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393410ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000393413ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000393413ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000393413ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393413ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393413ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393413ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393413ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000393413ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000517852ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000517852ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000517852ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000517852ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000517852ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000517852ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000517852ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000517852ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000545204ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000545204ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000545204ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000545204ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000545204ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000545204ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000545204ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000545204ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000350057ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000350057ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000350057ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000350057ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000350057ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000350057ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000350057ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000350057ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000360430ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000360430ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000360430ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000360430ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000360430ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000360430ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000360430ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000360430ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000299252ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000299252ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000299252ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000299252ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000299252ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000299252ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000299252ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000299252ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000348801ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000348801ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000348801ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000348801ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000348801ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000348801ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000348801ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000348801ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000478070ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000478070ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
Frame-shitENST00000478070ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000478070ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000478070ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000478070ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000478070ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
5CDS-intronENST00000478070ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+
intron-3CDSENST00000544125ENST00000455089MDM2chr12

69203072

+EGFRchr7

55231426

+
intron-3CDSENST00000544125ENST00000342916MDM2chr12

69203072

+EGFRchr7

55231426

+
intron-3CDSENST00000544125ENST00000344576MDM2chr12

69203072

+EGFRchr7

55231426

+
intron-intronENST00000544125ENST00000420316MDM2chr12

69203072

+EGFRchr7

55231426

+
intron-intronENST00000544125ENST00000275493MDM2chr12

69203072

+EGFRchr7

55231426

+
intron-intronENST00000544125ENST00000442591MDM2chr12

69203072

+EGFRchr7

55231426

+
intron-intronENST00000544125ENST00000463948MDM2chr12

69203072

+EGFRchr7

55231426

+
intron-intronENST00000544125ENST00000454757MDM2chr12

69203072

+EGFRchr7

55231426

+

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FusionProtFeatures for MDM2_EGFR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MDM2

Q00987

EGFR

P00533


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MDM2_EGFR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MDM2_EGFR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MDM2TP53, MDC1, CTBP1, CTBP2, TP73, PML, RPL11, RPL5, CDKN2A, NUMB, UBE2A, HIF1A, KAT5, HDAC1, EID1, MDM4, KAT2B, EP300, TBP, TAF1, MDM2, ESR1, ARRB2, ABL1, CCNG1, ARRB1, TSG101, RB1, MTBP, FKBP3, RYBP, RRM2B, RPL26, GNAS, FOXO4, IGF1R, DAXX, DHFR, GNL3, CCAR1, PSMD10, PSME3, PTK2, AR, PPM1D, USP7, COPS5, SFN, RBBP6, CDH1, CHEK2, YWHAQ, NCL, UBE2G2, UBE2U, UBE2Z, PYHIN1, BANP, DDX17, E2F1, TRIM28, UBC, GATA3, ATF3, HIST2H2BE, RPL23, YY1, AKT1, RAD23A, CDKN1A, NR3C1, UBE2I, HIST3H3, EHMT1, SUV39H1, RPS27L, RPS27, ADRB2, SIVA1, MTA1, RCHY1, UBE2D1, CASP2, RPS27A, RPS7, G3BP2, PSMD2, PAK1IP1, RPS6KB1, ZNF668, TP63, PCNA, USP10, PSMC1, PSMD4, PSMC3, PSMC5, PSMC6, PSMA7, PSMD1, RUNX3, GNL3L, TERT, APEX1, UIMC1, CREBBP, SOX4, UBE4B, TBRG1, BAIAP2L1, RFWD3, ERBB3, PA2G4, HEXIM1, CDK9, DYRK2, HSP90AA1, HSPA4, HSPA8, LAMP2, RPS3, USP2, TRIM13, XRCC6, GORAB, FOXO1, FOXO3, UCHL1, S100A1, S100A2, S100A4, S100A6, S100B, USP42, CUL1, BTRC, FBXW11, CSNK1D, RFWD2, SMURF1, NOTCH4, CSNK1A1, PDLIM7, SENP3, RN5S1@, PDE4D, NOTCH1, SNAI1, RASSF1, TRIM27, RFFL, RPS14, PPP2R4, TTF1, PSMB6, PSMA8, RASSF3, NR0B2, UBE2B, PIAS1, RANBP1, LATS1, RAD50, NBN, MRE11A, CUL4A, DTL, PIM1, GSK3B, PSMA3, ESR2, ADRBK1, AATF, HNRNPK, BUB1B, SUMO1, RASSF5, UBE2D2, POLH, NPM1, TCAP, CDK5RAP3, ARIH2, IRF2, RPS25, TPT1, ANG, RHOA, PDCD5, CDKN2AIP, LATS2, WWOX, MED1, ERCC6, ERCC8, DDB1, CUL4B, HIPK2, DHRS2, CASP3, ITCH, EEF1A1, DCD, TUBB, TUBB2A, KRT14, RPS20, GAPDH, TUBA1C, GSN, ERBB4, XIAP, HNF4A, PLK1, NME2, NEDD4, DAPK1, DAPK3, ATM, PBX1, UBE2D3, UBE3A, UBE2L3, UBE2E2, UBE2E3, RNF2, EGR1, PAK6, DLG4, IRF1, VCP, STRA13, GADD45A, RABL6, RPS26, RPL37, RPS15, RNF8, TRIM4, TRIM23, TRAF5, TRIM9, MKRN3, PHF7, RNF10, RNF126, UBE2K, LMO7, HLA-DMB, SETDB1, YY1AP1, NACA, ATF4, MYD88, RELA, SDHC, WT1, SORBS2, HRSP12, DNAJB4, GCAT, SHPK, POT1, ANKRD17, GLTSCR2, SESN2, RASSF6, JUND, EZR, RYR2, JUN, CLSTN1, APP, CLU, SREK1, SET, HSP90B1, CWC25, ZNF133, PKM, TAB1, RPL6, AURKA, NOC2L, JAK1, XPC, PGAM1, PGAM2, DNAJB1, ANAPC2, NLK, SNAI2, RBM38, FHIT, AGPS, ALDH16A1, DDX5, DHX9, DLAT, EDC4, EIF2AK1, ESYT1, GTF2I, HMHA1, HNRNPM, HNRNPU, HRNR, HSP90AB1, IARS, IFI16, IGF2BP3, ILF3, KARS, CCAR2, NEK9, OGDH, OGDHL, RARS, RBBP8, RECQL, SF3B1, SFPQ, TOP1, ZNF318, PER2, SIRT6, TSC22D3, RPS6, UBE2M, RAD54B, SMARCA2, ACACA, PTBP1, IYD, ACTB, HNRNPD, U2AF2, FUBP1, TFRC, EEF2, XPO1, KRT2, EIF3B, SND1, DCAF8, USO1, EFTUD2, EXOSC6, IPO7, SF3B3, DET1, UBE2N, RPL10A, DIRAS3, SURF2, RFPL2, CMSS1, PPARD, RPL22L1, IER2, MAGEA2, ZNF420, ELF4, ABL2, SRC, HCK, GTF2E2, ATP2A2, BRINP1, C19orf10, CANX, MS4A1, PDIA3, PPIB, RAB8A, RPS23, RUVBL2, SMARCA4, SMARCE1, SRSF11, TPR, UBTF, PPARG, VDR, FBXO31, TFIP11, SETD7, PPP1CA, RARA, DDX24, NAT10, CCND1, RLIM, IER3, FHL2, RPL23A, SUZ12, EZH2, EED, RRM1, RPL4, NOLC1, DDX42, MAP2, NUCKS1, RRP1, PDS5A, RPL36A, TP53RK, RPL15, NPIPB3, HMGN1, MAP1LC3A, PRDM2, KIAA1551, PBXIP1, SP1, SHARPIN, MAPKAPK2, USP15, USP26, FKBP1A, NGFR, SMG7, RSL1D1, SIRT1, SIRT7, SIRT2, SIRT3, KPNA1, KPNA6, MSI2, PHLDB3, CLPB, XAGE1B, ZNF550, YAF2, PDGFB, ARNTL2, RPS11, TSPYL6, HIST1H2BJ, ZNF764, MAK16, ZNF274, PPAN, RPL37A, CRTC2, CRTC3, TRIM25, CSNK2A1, CSNK2B, CSNK2A2, HEY1, RANBP2EGFRDCN, SHC1, SH3BGRL, STAT5A, PTPN11, CRK, CSK, CBLB, GRB2, STAT3, CTNNB1, CTNND1, JUP, AR, EGFR, CAMLG, PRKCA, HBEGF, TJP1, ATP5C1, SGSM2, WAS, EGF, INPPL1, DUSP3, AREG, PTK2, CBL, CBLC, CDH1, MAPK14, VAV1, VAV2, VAV3, STAT1, SRC, JAK2, HTT, PTK6, PTK2B, DOK2, SOS1, SOS2, CDC25A, NCK1, IGF1R, PRKAR1A, PRKACA, PLD2, ARF4, MAP4K1, NCK2, EPS15, PTPN6, SH2D3A, PLSCR1, GRB14, RASA1, GRB10, PTPN1, NRG1, CD44, PLCG1, SH3KBP1, PIK3C2B, SOCS1, SOCS3, CAV1, CAV3, ERBB3, CD82, SNX6, SNX1, SNX2, SNX4, STAT5B, RGS16, CEBPB, MUC1, GAB1, RIPK1, MAP3K14, PDGFRB, SHC3, CASP1, EREG, FER, ERBB2, HGS, NCAM1, HDAC6, AIP, PSMA7, MEGF6, SORBS2, HEXIM1, AHSA1, ALDOA, UROD, UCHL1, HSP90B1, CBR1, FAH, GOT1, RAB3A, CSRP1, CFL1, EEF1G, PRKAR1B, ATIC, STIP1, HSPA4, MDH1, PTGDS, MATR3, SEPP1, OAZ1, PSMD4, TPI1, GABARAPL2, ARF6, CNTN2, FKBP4, AKAP12, PTPN12, PRDX1, AHNAK, MAP3K12, GPM6B, DCTN2, COL9A3, DYNC1H1, FKBP8, SPCS2, PDK3, UBE2V2, ADRM1, RAP1GDS1, HSPA8, PPP5C, HSPA1A, FN1, TPM1, KCTD9P2, TMCO3, CEND1, RUSC2, SPARCL1, MGARP, PRCC, AP2M1, NDN, OLFM1, DNAJC4, VAPA, STUB1, PIN4, MAST1, MOB4, CCDC50, USP8, PCNA, EPN1, PDCD6IP, SH3GL2, LRIG1, UBASH3A, UBASH3B, HSP90AA1, TNK2, NDFIP1, NDFIP2, LGALS1, LGALS3, NEDD4, ZFYVE28, UBC, PIK3R2, SNRPD2, ACTA2, PIK3R1, ERRFI1, MTCO2P1, YWHAZ, SMURF2, OTUD7B, CALM1, USP2, YAP1, ATXN2, CD2AP, PRKCB, H2AFX, PPP2R3A, RABGEF1, PTPRJ, SOCS4, EPS8, STAM2, RIN1, SEC61B, EMD, TOM1L1, RBM10, TRAF2, HNRNPH1, BCLAF1, C11orf84, DOCK4, MYCBP, CRKL, TAB1, RIOK1, JAK1, CDK1, DDX60, ODF3L2, HCFC1, IRS2, RBM41, PICALM, MPV17, CALU, TRPV1, ESR1, ERBB4, HSP90AB1, HSPA5, CDC37, CTGF, RNF115, RNF126, APBB1, IRS4, SH2D1A, APBB3, APBA3, ABL1, FES, PLCG2, IRS1, ABL2, ZAP70, SYK, NUMB, BLK, BMX, SHC2, SLA, MAPK8IP2, DOK6, ANKS1B, CLNK, TNS4, DOK4, RIN2, PIK3R3, ANKS1A, APBB2, SH2D2A, SH2B1, CISH, DOK5, APPL1, MAPK8IP1, SH2B3, TLN1, NUMBL, ANKRD13A, ANKRD13B, ANKRD13D, MAP1LC3A, PTPN23, CHMP4A, DNAJA3, FBXO25, IGKC, IGHG1, TUBB, TUBA4A, TUBB4B, TUBB4A, TUBB2A, TUBB3, IGHG3, TUBB6, HBA1, CSE1L, EEF1A1, KRT86, AP1S1, IPO9, ATXN10, KPNB1, SNRPD1, HSPA2, XPO1, KIAA1524, AP1M2, IPO7, XPOT, PTRF, TNPO1, IPO5, PPP2R1A, DNAJA1, BAG2, HSD17B12, SGPL1, EXOC7, XPO4, PPP2R2A, GCN1L1, EIF2B2, PHGDH, FBXO6, LANCL2, SAAL1, SPTLC1, GEMIN6, DNAJA2, HOOK2, RANBP1, PEX19, ARL1, PPP6C, TNPO3, AP1G2, AP2A1, PPP2R1B, TNPO2, PPP2R5E, AP2B1, RPN1, LTN1, THADA, SEC61A1, EXOC5, TRAPPC3, PDIA3, COG7, IQGAP3, PIK3CB, GAPDH, MMS19, STRAP, MON2, EIF2B3, DARS, DFNA5, EXOC4, COG5, BZW2, DNAAF5, RCN2, COG6, THEM6, SLC39A11, COG4, PFKP, TECR, BUB3, TIMM50, AP1M1, ATP6V1H, OS9, XPO7, DNAJB12, P4HB, IPO4, PPP6R1, SEL1L, USP9X, EPRS, NCDN, EXOC8, PFKL, XPO5, TTC27, AP2A2, ITIH2, PRKDC, PHLDA1, HEATR3, DDX20, IPO11, LGALS8, PSMD2, IPO13, TPP1, EXOC6B, MARS, TBRG4, ZW10, ARHGEF5, AP1G1, IPO8, FDPS, COG1, ATP2A2, NUP85, XPO6, GEMIN4, ALDH3A2, NUP93, RANGAP1, ARFGEF1, EXOC6, ARMC8, TELO2, EIF2B5, PPARGC1A, IARS, EXOC3, NLRP10, KIAA1244, MTOR, DOPEY2, NCAPG2, TTI1, GBF1, SMC2, RNF213, ATR, NBEAL2, FDFT1, RARS, ACOT9, TOR4A, PLAA, TTI2, WDR26, NCAPH2, VAC14, CD59, BIRC3, BIRC2, RQCD1, CAV2, CLTA, CLTCL1, HOXC10, LYN, S100A7, S100A9, SEC13, SFN, SLC3A2, ATP1A1, ATP1B1, ALCAM, ICAM1, TUBA1A, RPA3, RPA2, RPA1, PANK4, HUWE1, OXSR1, PRKAG1, RPS6KA3, PLK1, PFKFB3, EPHA2, DNM1L, UBA2, MAP2K2, HK2, MAP2K4, AP3D1, DNM2, UBR4, RIOK2, SLC12A2, MAP2K3, HK1, ATP5L, PTPRF, ARHGAP1, ITCH, PDK1, TBK1, PLD3, STK26, PPP2R5C, UBE2G2, AP3M1, YES1, PFKM, PRKAA1, AP1S2, AP1B1, CSNK1A1, ACP1, CSNK2A1, AP2S1, CDK5, EIF2AK2, UCK2, UBE2S, AP3S1, VRK1, AKT2, SOCS5, DERL1, PML, DCBLD2, LRSAM1, DSG2, SSBP1, MYO1B, NGLY1, CANX, DPM1, DNAJB11, HSD17B10, DYNC1LI1, FAF2, YARS, IDH2, KIAA0368, SULT1A1, TFRC, CLPX, SRPR, VARS, LRRC40, MRTO4, EIF3M, TRMT10C, TIMM23, SSR4, EHD4, RPRD1A, MYO1D, FBL, HADHB, AFG3L2, CCDC47, SMC1A, SMC3, NDUFA9, UMPS, ITPA, SLFN11, CLPP, CPVL, TM9SF3, LONP1, RPL38, SNRPA1, COPA, APRT, NSF, NSUN5, ATAD1, AIFM1, POLDIP2, WDR6, SCFD1, NDUFS1, OAT, SAMHD1, MGST1, NDUFS3, SNRPF, CNP, ACADSB, ORC5, EIF2B4, PUS1, SDF2L1, IMMT, TARS, DDX47, ACTR2, EIF2B1, HLA-A, VPS4B, EHD1, PYCR2, MYO1C, CUL4B, DHRS7B, RFC5, OSBP, YBEY, EEF1B2, GCLM, GSTK1, TTC37, AK4, CARS2, MINOS1, PELO, MRPL10, FAR1, CTBP1, ABCF2, MPC2, LIMA1, ILVBL, NCAPG, TARS2, COX2, PNO1, IFIT5, EIF3K, CHCHD3, PUM1, TOR1AIP1, GNAS, EIF3F, CMSS1, RPS15A, TMEM97, ETF1, NCAPH, RFC3, TOMM22, STT3A, TUBGCP2, ASNS, HELLS, LARP4, PON2, ABCD3, CDIPT, SDF2, DIMT1, BCCIP, PTGES3, PC, SRPRB, SCAMP3, NAA10, UTP15, GNB2, TRMT2A, ADCK3, CTTN, RER1, IDH3B, LRWD1, C6orf120, BZW1, SLC1A5, TRMT1L, NSUN2, SFXN3, UFL1, SUGP2, IKBKAP, PDS5A, TNFRSF10B, ACACA, HYOU1, ATP5F1, FLOT2, NTPCR, CERS2, SCD, UQCRC2, ATP2B1, EIF4G2, SAMM50, NUBP2, DNAJC11, NCLN, SKIV2L, DIS3, LSR, ATXN7L3B, EMC3, CALR, PRIM1, RNMTL1, AAMP, ATAD3B, RAB18, RPL23, PRMT3, PDXDC1, AAAS, SUCLA2, CTBP2, KIF1A, TRAPPC5, ARMC6, SLC25A13, TBL3, CLU, ARHGEF2, ATP5A1, RPL22, FAM98A, IDH3A, DHCR24, FADS2, CKAP2, FARSA, CEBPZ, ADAR, NUP153, LRPPRC, OPA1, STOM, RFC4, TUBG1, LANCL1, TAF4, PSPC1, EWSR1, AAMDC, GRN, PSMD1, FN3KRP, TPM3, THOP1, CAP2, RPL4, BLM, PLS3, TPM4, NT5DC2, XRCC5, H1FX, MRPL9, LAT, PDGFRA, TNFRSF1A, IKBKG, SNCA, YWHAQ, YWHAB, PRKCE, MAPT, SHC4, DOK1, RAF1, BAIAP2, FGR, ACTN4, AKT1, HCK, RAPGEF1, SH3GL3, MAPK8, NR3C1, PTPN22, FRK, STAP2, ARRB1, LCP2, ITGB2, TGFA, ARRB2, PRKCZ, HDAC7, RET, SH2D3C, SLA2, CDH5, ITK, CDC25C, ITSN2, MAP3K3, PIM1, GRAP2, S100A4, SNX9, NTRK2, PTPN18, PAK1, MAPK9, WASL, TNS3, WASF3, ARHGEF7, SOCS6, APP, LRP1, STAT2, TLR2, RGS4, TMEM25, PTCH1, PTPRK, AKTIP, NTRK1, PIGS, TP53, ARHGAP32, PARK2, CTNNA1, FOS, HSPA1B, EZR, TXN, PPARG, KEAP1, NELL1, SUSD1, CSTA, HSPA9, ANO5, ANXA1, COL17A1, CTNNA2, HIST1H2AA, HSPB1, RPS15, RBM25, RPS26P11, SPRR1A, SERPINB4, SERAC1, SFPQ, PTPRD, MET, ITGB4, XRN2, GSTT1, DBR1, SLC7A5, VPS13A, YTHDF1, RPL17, ATP2B4, APOB, ESRRB, OSMR, HBA2, ACTB, MYH9, IQGAP1, PTPRU, PTPRB, FAM129B, LRIG2, KRAS, BBC3, GSTP1, L1CAM, RRAD, MIF, HIP1, ERCC1, ERCC4, CLCN5, MCM4, APEX1, NCL, NPM1, PARP1, LMNA, FUS, ERCC2, TRIM28, MCM3, MCM6, FEN1, ILF2, ILF3, DHX9, BRE, TOP1, BRAF, LTK, IGFBP2, CDH2, ITGB1, CCDC88A, PDP1, PTPRR, PTPN7, PTPRA, PTPRH, PTPRT, PPM1A, PPM1F, DUSP14, DUSP18, MPZL2, SSH1, FAM186A, SRRM4, CD300LB, SMTNL1, KRTAP16-1, MYO9A, BTBD18, IGLL5, RASA4B, PGRMC1, SUPT5H, ACACB, TRAFD1, EIF1AY, SEC16A, ZBTB22, PMM2, EPB41L2, FOXO3, HTATSF1, DYRK3, ZBTB14, DHX16, CEP104, EIF5B, NPHP4, DNAJC13, SPAG7, TOMM70A, SLITRK3, OR2F2, LUC7L3, LCA5L, ABCA1, HERC2, PAK4, DHFR, HLA-B, COL1A1, AHSG, MAS1, KRT1, HMGN2, RPLP2, SSB, CTSD, COL1A2, KRT16, HMGB1, FAM66E, ZCCHC18, CKMT1A, DRD2, GLUL, HMGA1, DDX5, TCP1, RPL7, CD58, NF1, IGHV1-2, PPIB, RPS3, EIF4B, TNC, PSMA3, PSMA4, U2AF2, CNTF, HMGB2, DPP4, MAP4, HSD11B1, POLR2A, GABRA3, KRT9, TRIM23, RPL3, RPS27, GRIK4, TUFM, ALDH7A1, RPL14, IDH3G, IRAK1, KCNQ1, HDGF, BTAF1, SUB1, MFAP1, EIF3B, SESN2, KRTAP10-9, RPS20, S100A10, HNRNPK, CNBP, RAB1A, TRA2B, YBX1, NTHL1, XIAP, SRSF2, AKAP17A, RPL6, SRSF11, SLC3A1, SSRP1, RASGEF1B, MIR22HG, C5orf28, BPTF, CSTF3, G3BP1, TCOF1, PDAP1, TCIRG1, HDAC1, CDK13, CIRBP, LRP8, PDE1C, UBAP2L, CAPRIN1, RBM39, DIP2A, CBX2, GRM4, STIL, DIXDC1, HERC1, E2F4, MICB, MRGPRG-AS1, P3H1, LRRK1, KRTAP15-1, PTPN20B, AASDH, ARHGAP29, FBLN7, SLC45A4, PAGE3, DOPEY1, CEP170, EYS, SWT1, KIAA1217, ATF7IP2, ZMYM4, CES4A, WWC2, HIST2H2AA3, NADSYN1, PLEKHA7, ADAM5, MAST2, ARMCX5, XRRA1, SCYL2, GIGYF2, EML6, LOC400499, USP34, USP31, CYS1, SMIM5, RSRC2, ZC3HAV1, PID1, SETX, OR2W3, PRSS42, NEK8, LRRTM4, HEATR4, ZNF573, SLC13A5, HRNR, CCDC60, FAM126B, SRRM1, CCDC146, ZZZ3, CENPL, MIER1, UNC80, EFCAB3, TRIML2, C2orf61, MRPL43, TOPAZ1, ZNF114, SERBP1, LSM14A, CTCFL, BBS10, MAPK15, CHD6, TRAF3IP1, HEXDC, LMBR1, KBTBD7, MUC16, DNAH7, TTN, ROBO4, SLC39A7, EDEM1, ZNF516, DHX38, DAZL, TMBIM1, TMEM159, DOCK10, MTBP, ELP4, MTMR8, RNF125, DNAH8, SCYL1, ZFR, PRICKLE1, RUNDC3B, SERPINB12, SMG1, PCNX, SPEN, TSG101, SPAG8, NABP2, ZFYVE21, SYT17, CNPY3, MTG1, C2orf49, PRR14, PLVAP, API5, NXF2, KATNBL1, SPATC1L, NUCKS1, RWDD1, DPEP3, REEP4, NOL6, RPF1, SNX29, TRPM3, IL1RAPL2, MLXIPL, INCENP, EXOSC3, SERTAD4, RLIM, GPATCH2, RCC2, HECW2, CRCT1, TMEM2, TEKT2, SLCO3A1, HN1, TNIK, GPATCH8, TRHDE, BAG5, GRID1, SLC45A2, MAGED2, ING4, ZC3H4, AGTPBP1, SHANK2, SRRM2, RUVBL2, COA3, NOSIP, CBY1, WIPI2, PCDHGA3, KRT3, KRT10, KRT2, KRT5, GOLGB1, GPR149, NF2, CTDSPL, SCGB1D4, DEFA1, ST8SIA4, HTR3A, PCDHB11, RAB31, PPP3CB, PPM1B, ILKAP, DUSP19, STYX, WBP2, PTEN, LINC01139, GPNMB, RGS2, PTPN2, HPN, UBE2J2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MDM2_EGFR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMDM2Q00987DB01593ZincE3 ubiquitin-protein ligase Mdm2small moleculeapproved|investigational
TgeneEGFRP00533DB00002CetuximabEpidermal growth factor receptorbiotechapproved
TgeneEGFRP00533DB05294VandetanibEpidermal growth factor receptorsmall moleculeapproved
TgeneEGFRP00533DB08916AfatinibEpidermal growth factor receptorsmall moleculeapproved
TgeneEGFRP00533DB00072TrastuzumabEpidermal growth factor receptorbiotechapproved|investigational
TgeneEGFRP00533DB00317GefitinibEpidermal growth factor receptorsmall moleculeapproved|investigational
TgeneEGFRP00533DB00530ErlotinibEpidermal growth factor receptorsmall moleculeapproved|investigational
TgeneEGFRP00533DB01259LapatinibEpidermal growth factor receptorsmall moleculeapproved|investigational
TgeneEGFRP00533DB01269PanitumumabEpidermal growth factor receptorbiotechapproved|investigational
TgeneEGFRP00533DB09559NecitumumabEpidermal growth factor receptorbiotechapproved|investigational
TgeneEGFRP00533DB00281LidocaineEpidermal growth factor receptorsmall moleculeapproved|vet_approved

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RelatedDiseases for MDM2_EGFR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMDM2C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneMDM2C0007621Neoplastic Cell Transformation1CTD_human
HgeneMDM2C0019693HIV Infections1CTD_human
HgeneMDM2C0021364Male infertility1CTD_human
HgeneMDM2C0025202melanoma1CTD_human
HgeneMDM2C0032927Precancerous Conditions1CTD_human
HgeneMDM2C0033578Prostatic Neoplasms1CTD_human
HgeneMDM2C1458155Mammary Neoplasms1CTD_human
TgeneEGFRC0007131Non-Small Cell Lung Carcinoma16CTD_human
TgeneEGFRC1458155Mammary Neoplasms6CTD_human
TgeneEGFRC0024121Lung Neoplasms5CTD_human
TgeneEGFRC0001418Adenocarcinoma4CTD_human
TgeneEGFRC0007137Squamous cell carcinoma3CTD_human
TgeneEGFRC0007873Uterine Cervical Neoplasm3CTD_human
TgeneEGFRC0014859Esophageal Neoplasms3CTD_human
TgeneEGFRC0017636Glioblastoma3CTD_human
TgeneEGFRC0018671Head and Neck Neoplasms3CTD_human
TgeneEGFRC0027627Neoplasm Metastasis3CTD_human
TgeneEGFRC0033578Prostatic Neoplasms3CTD_human
TgeneEGFRC0038356Stomach Neoplasms3CTD_human
TgeneEGFRC0005695Bladder Neoplasm2CTD_human
TgeneEGFRC0009375Colonic Neoplasms2CTD_human
TgeneEGFRC0009404Colorectal Neoplasms2CTD_human
TgeneEGFRC0024668Mammary Neoplasms, Experimental2CTD_human
TgeneEGFRC0027626Neoplasm Invasiveness2CTD_human
TgeneEGFRC0027643Neoplasm Recurrence, Local2CTD_human
TgeneEGFRC0152013Adenocarcinoma of lung (disorder)2CTD_human
TgeneEGFRC0919267ovarian neoplasm2CTD_human
TgeneEGFRC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneEGFRC0005396Bile Duct Neoplasms1CTD_human
TgeneEGFRC0007193Cardiomyopathy, Dilated1CTD_human
TgeneEGFRC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneEGFRC0014175Endometriosis1CTD_human
TgeneEGFRC0016978gallbladder neoplasm1CTD_human
TgeneEGFRC0021655Insulin Resistance1CTD_human
TgeneEGFRC0024667Animal Mammary Neoplasms1CTD_human
TgeneEGFRC0024809Marijuana Abuse1PSYGENET
TgeneEGFRC0025500Mesothelioma1CTD_human
TgeneEGFRC0027439Nasopharyngeal Neoplasms1CTD_human
TgeneEGFRC0029463Osteosarcoma1CTD_human
TgeneEGFRC0030354Papilloma1CTD_human
TgeneEGFRC0032580Adenomatous Polyposis Coli1CTD_human
TgeneEGFRC0034885Rectal Neoplasms1CTD_human
TgeneEGFRC0041696Unipolar Depression1PSYGENET
TgeneEGFRC0085548Autosomal Recessive Polycystic Kidney Disease1CTD_human
TgeneEGFRC0085762Alcohol abuse1PSYGENET
TgeneEGFRC0149925Small cell carcinoma of lung1CTD_human
TgeneEGFRC0206686Adrenocortical carcinoma1CTD_human
TgeneEGFRC0206698Cholangiocarcinoma1CTD_human
TgeneEGFRC0263454Chloracne1CTD_human
TgeneEGFRC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneEGFRC0345967Malignant mesothelioma1CTD_human
TgeneEGFRC0376634Craniofacial Abnormalities1CTD_human
TgeneEGFRC0993582Arthritis, Experimental1CTD_human
TgeneEGFRC1269683Major Depressive Disorder1PSYGENET
TgeneEGFRC2239176Liver carcinoma1CTD_human
TgeneEGFRC2609414Acute kidney injury1CTD_human
TgeneEGFRC4015130INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 21UNIPROT