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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21378

FusionGeneSummary for MDM2_CACNA1C

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2_CACNA1C
Fusion gene ID: 21378
HgeneTgene
Gene symbol

MDM2

CACNA1C

Gene ID

4193

775

Gene nameMDM2 proto-oncogenecalcium voltage-gated channel subunit alpha1 C
SynonymsACTFS|HDMX|hdm2CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS
Cytomap

12q15

12p13.33

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humvoltage-dependent L-type calcium channel subunit alpha-1CDHPR, alpha-1 subunitcalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac musclecalcium channel, cardic dihydropyridine-sensitive, alpha-1 subunitcalcium channel, voltage-dependent,
Modification date2018052720180523
UniProtAcc

Q00987

Q13936

Ensembl transtripts involved in fusion geneENST00000462284, ENST00000356290, 
ENST00000540827, ENST00000258149, 
ENST00000428863, ENST00000393412, 
ENST00000258148, ENST00000544561, 
ENST00000393410, ENST00000393413, 
ENST00000517852, ENST00000545204, 
ENST00000350057, ENST00000360430, 
ENST00000299252, ENST00000348801, 
ENST00000478070, ENST00000544125, 
ENST00000335762, ENST00000399655, 
ENST00000480911, ENST00000399644, 
ENST00000344100, ENST00000399638, 
ENST00000399629, ENST00000399597, 
ENST00000327702, ENST00000399621, 
ENST00000399649, ENST00000399637, 
ENST00000402845, ENST00000399591, 
ENST00000399641, ENST00000347598, 
ENST00000399606, ENST00000399595, 
ENST00000399601, ENST00000399603, 
ENST00000399634, ENST00000399617, 
ENST00000406454, ENST00000491104, 
Fusion gene scores* DoF score24 X 14 X 8=268815 X 14 X 8=1680
# samples 2517
** MAII scorelog2(25/2688*10)=-3.42653313811667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(17/1680*10)=-3.30485458152842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDM2 [Title/Abstract] AND CACNA1C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922

TgeneCACNA1C

GO:0007204

positive regulation of cytosolic calcium ion concentration

12130699

TgeneCACNA1C

GO:0061577

calcium ion transmembrane transport via high voltage-gated calcium channel

15454078

TgeneCACNA1C

GO:0070588

calcium ion transmembrane transport

15454078


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-06-A7TK-01AMDM2chr12

69203072

+CACNA1Cchr12

2742795

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000462284ENST00000335762MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399655MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000480911MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399644MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000344100MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399638MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399629MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399597MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000327702MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399621MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399649MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399637MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000402845MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399591MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399641MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000347598MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399606MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399595MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399601MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399603MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399634MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000399617MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000406454MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000462284ENST00000491104MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000335762MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399655MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000480911MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399644MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000344100MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399638MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399629MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399597MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000327702MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399621MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399649MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399637MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000402845MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399591MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399641MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000347598MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399606MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399595MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399601MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399603MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399634MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000399617MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000406454MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000356290ENST00000491104MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000335762MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399655MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000480911MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399644MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000344100MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399638MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399629MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399597MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000327702MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399621MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399649MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399637MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000402845MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399591MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399641MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000347598MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399606MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399595MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399601MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399603MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399634MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000399617MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000406454MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000540827ENST00000491104MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000335762MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399655MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000480911MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399644MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000344100MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399638MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399629MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399597MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000327702MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399621MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399649MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399637MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000402845MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399591MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399641MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000347598MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399606MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399595MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399601MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399603MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399634MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000399617MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000406454MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000258149ENST00000491104MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000335762MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399655MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000480911MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399644MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000344100MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399638MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399629MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399597MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000327702MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399621MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399649MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399637MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000402845MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399591MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399641MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000347598MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399606MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399595MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399601MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399603MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399634MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000399617MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000406454MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000428863ENST00000491104MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000335762MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000399655MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000480911MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000399644MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000344100MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000399638MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000399629MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000399597MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000327702MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000399621MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000399649MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000399637MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000402845MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
5CDS-intronENST00000393412ENST00000399591MDM2chr12

69203072

+CACNA1Cchr12

2742795

+
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5CDS-intronENST00000350057ENST00000399634MDM2chr12

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5CDS-intronENST00000348801ENST00000335762MDM2chr12

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5CDS-intronENST00000348801ENST00000399655MDM2chr12

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5CDS-intronENST00000348801ENST00000480911MDM2chr12

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5CDS-intronENST00000348801ENST00000399644MDM2chr12

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5CDS-intronENST00000348801ENST00000344100MDM2chr12

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5CDS-intronENST00000348801ENST00000399638MDM2chr12

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5CDS-intronENST00000348801ENST00000399597MDM2chr12

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5CDS-intronENST00000348801ENST00000399621MDM2chr12

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5CDS-intronENST00000348801ENST00000347598MDM2chr12

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5CDS-intronENST00000478070ENST00000399629MDM2chr12

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5CDS-intronENST00000478070ENST00000402845MDM2chr12

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5CDS-intronENST00000478070ENST00000347598MDM2chr12

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5CDS-intronENST00000478070ENST00000399595MDM2chr12

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intron-intronENST00000544125ENST00000399634MDM2chr12

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intron-intronENST00000544125ENST00000399617MDM2chr12

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intron-intronENST00000544125ENST00000406454MDM2chr12

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intron-intronENST00000544125ENST00000491104MDM2chr12

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2742795

+

Top

FusionProtFeatures for MDM2_CACNA1C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MDM2

Q00987

CACNA1C

Q13936


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MDM2_CACNA1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MDM2_CACNA1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MDM2TP53, MDC1, CTBP1, CTBP2, TP73, PML, RPL11, RPL5, CDKN2A, NUMB, UBE2A, HIF1A, KAT5, HDAC1, EID1, MDM4, KAT2B, EP300, TBP, TAF1, MDM2, ESR1, ARRB2, ABL1, CCNG1, ARRB1, TSG101, RB1, MTBP, FKBP3, RYBP, RRM2B, RPL26, GNAS, FOXO4, IGF1R, DAXX, DHFR, GNL3, CCAR1, PSMD10, PSME3, PTK2, AR, PPM1D, USP7, COPS5, SFN, RBBP6, CDH1, CHEK2, YWHAQ, NCL, UBE2G2, UBE2U, UBE2Z, PYHIN1, BANP, DDX17, E2F1, TRIM28, UBC, GATA3, ATF3, HIST2H2BE, RPL23, YY1, AKT1, RAD23A, CDKN1A, NR3C1, UBE2I, HIST3H3, EHMT1, SUV39H1, RPS27L, RPS27, ADRB2, SIVA1, MTA1, RCHY1, UBE2D1, CASP2, RPS27A, RPS7, G3BP2, PSMD2, PAK1IP1, RPS6KB1, ZNF668, TP63, PCNA, USP10, PSMC1, PSMD4, PSMC3, PSMC5, PSMC6, PSMA7, PSMD1, RUNX3, GNL3L, TERT, APEX1, UIMC1, CREBBP, SOX4, UBE4B, TBRG1, BAIAP2L1, RFWD3, ERBB3, PA2G4, HEXIM1, CDK9, DYRK2, HSP90AA1, HSPA4, HSPA8, LAMP2, RPS3, USP2, TRIM13, XRCC6, GORAB, FOXO1, FOXO3, UCHL1, S100A1, S100A2, S100A4, S100A6, S100B, USP42, CUL1, BTRC, FBXW11, CSNK1D, RFWD2, SMURF1, NOTCH4, CSNK1A1, PDLIM7, SENP3, RN5S1@, PDE4D, NOTCH1, SNAI1, RASSF1, TRIM27, RFFL, RPS14, PPP2R4, TTF1, PSMB6, PSMA8, RASSF3, NR0B2, UBE2B, PIAS1, RANBP1, LATS1, RAD50, NBN, MRE11A, CUL4A, DTL, PIM1, GSK3B, PSMA3, ESR2, ADRBK1, AATF, HNRNPK, BUB1B, SUMO1, RASSF5, UBE2D2, POLH, NPM1, TCAP, CDK5RAP3, ARIH2, IRF2, RPS25, TPT1, ANG, RHOA, PDCD5, CDKN2AIP, LATS2, WWOX, MED1, ERCC6, ERCC8, DDB1, CUL4B, HIPK2, DHRS2, CASP3, ITCH, EEF1A1, DCD, TUBB, TUBB2A, KRT14, RPS20, GAPDH, TUBA1C, GSN, ERBB4, XIAP, HNF4A, PLK1, NME2, NEDD4, DAPK1, DAPK3, ATM, PBX1, UBE2D3, UBE3A, UBE2L3, UBE2E2, UBE2E3, RNF2, EGR1, PAK6, DLG4, IRF1, VCP, STRA13, GADD45A, RABL6, RPS26, RPL37, RPS15, RNF8, TRIM4, TRIM23, TRAF5, TRIM9, MKRN3, PHF7, RNF10, RNF126, UBE2K, LMO7, HLA-DMB, SETDB1, YY1AP1, NACA, ATF4, MYD88, RELA, SDHC, WT1, SORBS2, HRSP12, DNAJB4, GCAT, SHPK, POT1, ANKRD17, GLTSCR2, SESN2, RASSF6, JUND, EZR, RYR2, JUN, CLSTN1, APP, CLU, SREK1, SET, HSP90B1, CWC25, ZNF133, PKM, TAB1, RPL6, AURKA, NOC2L, JAK1, XPC, PGAM1, PGAM2, DNAJB1, ANAPC2, NLK, SNAI2, RBM38, FHIT, AGPS, ALDH16A1, DDX5, DHX9, DLAT, EDC4, EIF2AK1, ESYT1, GTF2I, HMHA1, HNRNPM, HNRNPU, HRNR, HSP90AB1, IARS, IFI16, IGF2BP3, ILF3, KARS, CCAR2, NEK9, OGDH, OGDHL, RARS, RBBP8, RECQL, SF3B1, SFPQ, TOP1, ZNF318, PER2, SIRT6, TSC22D3, RPS6, UBE2M, RAD54B, SMARCA2, ACACA, PTBP1, IYD, ACTB, HNRNPD, U2AF2, FUBP1, TFRC, EEF2, XPO1, KRT2, EIF3B, SND1, DCAF8, USO1, EFTUD2, EXOSC6, IPO7, SF3B3, DET1, UBE2N, RPL10A, DIRAS3, SURF2, RFPL2, CMSS1, PPARD, RPL22L1, IER2, MAGEA2, ZNF420, ELF4, ABL2, SRC, HCK, GTF2E2, ATP2A2, BRINP1, C19orf10, CANX, MS4A1, PDIA3, PPIB, RAB8A, RPS23, RUVBL2, SMARCA4, SMARCE1, SRSF11, TPR, UBTF, PPARG, VDR, FBXO31, TFIP11, SETD7, PPP1CA, RARA, DDX24, NAT10, CCND1, RLIM, IER3, FHL2, RPL23A, SUZ12, EZH2, EED, RRM1, RPL4, NOLC1, DDX42, MAP2, NUCKS1, RRP1, PDS5A, RPL36A, TP53RK, RPL15, NPIPB3, HMGN1, MAP1LC3A, PRDM2, KIAA1551, PBXIP1, SP1, SHARPIN, MAPKAPK2, USP15, USP26, FKBP1A, NGFR, SMG7, RSL1D1, SIRT1, SIRT7, SIRT2, SIRT3, KPNA1, KPNA6, MSI2, PHLDB3, CLPB, XAGE1B, ZNF550, YAF2, PDGFB, ARNTL2, RPS11, TSPYL6, HIST1H2BJ, ZNF764, MAK16, ZNF274, PPAN, RPL37A, CRTC2, CRTC3, TRIM25, CSNK2A1, CSNK2B, CSNK2A2, HEY1, RANBP2CACNA1CPCBD1, CACNB3, CABP1, RYR2, SRI, HDAC4, SIRT1, VCP, DERL1, TRIM13, CUL1, CAND1, COPS5, CALM1, KCNE2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MDM2_CACNA1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMDM2Q00987DB01593ZincE3 ubiquitin-protein ligase Mdm2small moleculeapproved|investigational
TgeneCACNA1CQ13936DB00308IbutilideVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB00401NisoldipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB00898EthanolVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB04855DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB09089TrimebutineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB09227BarnidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved
TgeneCACNA1CQ13936DB00270IsradipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB00568CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB01023FelodipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB01054NitrendipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB04920ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB06712NilvadipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB06751DrotaverineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB09231BenidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB09232CilnidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB09236LacidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB09238ManidipineVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational
TgeneCACNA1CQ13936DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|investigational|vet_approved
TgeneCACNA1CQ13936DB01373CalciumVoltage-dependent L-type calcium channel subunit alpha-1Csmall moleculeapproved|nutraceutical

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RelatedDiseases for MDM2_CACNA1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMDM2C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneMDM2C0007621Neoplastic Cell Transformation1CTD_human
HgeneMDM2C0019693HIV Infections1CTD_human
HgeneMDM2C0021364Male infertility1CTD_human
HgeneMDM2C0025202melanoma1CTD_human
HgeneMDM2C0032927Precancerous Conditions1CTD_human
HgeneMDM2C0033578Prostatic Neoplasms1CTD_human
HgeneMDM2C1458155Mammary Neoplasms1CTD_human
TgeneCACNA1CC0005586Bipolar Disorder8CTD_human;PSYGENET
TgeneCACNA1CC1832916Timothy syndrome6CTD_human;ORPHANET;UNIPROT
TgeneCACNA1CC0011570Mental Depression5PSYGENET
TgeneCACNA1CC0011581Depressive disorder5PSYGENET
TgeneCACNA1CC0041696Unipolar Depression5PSYGENET
TgeneCACNA1CC0525045Mood Disorders5PSYGENET
TgeneCACNA1CC1269683Major Depressive Disorder5PSYGENET
TgeneCACNA1CC0036341Schizophrenia4PSYGENET
TgeneCACNA1CC0033975Psychotic Disorders3PSYGENET
TgeneCACNA1CC0178417Anhedonia2PSYGENET
TgeneCACNA1CC0003811Cardiac Arrhythmia1CTD_human
TgeneCACNA1CC0004352Autistic Disorder1CTD_human
TgeneCACNA1CC0020538Hypertensive disease1CTD_human
TgeneCACNA1CC0020615Hypoglycemia1CTD_human
TgeneCACNA1CC0021051Immunologic Deficiency Syndromes1CTD_human
TgeneCACNA1CC0206762Limb Deformities, Congenital1CTD_human
TgeneCACNA1CC0349204Nonorganic psychosis1PSYGENET
TgeneCACNA1CC2678478Brugada Syndrome 31CTD_human;UNIPROT