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Fusion gene ID: 21331 |
FusionGeneSummary for MCRS1_SRRM4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MCRS1_SRRM4 | Fusion gene ID: 21331 | Hgene | Tgene | Gene symbol | MCRS1 | SRRM4 | Gene ID | 10445 | 84530 |
| Gene name | microspherule protein 1 | serine/arginine repetitive matrix 4 | |
| Synonyms | ICP22BP|INO80Q|MCRS2|MSP58|P78 | KIAA1853|MU-MB-2.76|nSR100 | |
| Cytomap | 12q13.12 | 12q24.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microspherule protein 158 kDa microspherule proteinINO80 complex subunit JINO80 complex subunit Qcell cycle-regulated factor (78 kDa)cell cycle-regulated factor p78 | serine/arginine repetitive matrix protein 4medulloblastoma antigen MU-MB-2.76neural-specific SR-related protein of 100 kDaneural-specific serine/arginine repetitive splicing factor of 100 kDa | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96EZ8 | A7MD48 | |
| Ensembl transtripts involved in fusion gene | ENST00000546244, ENST00000343810, ENST00000550165, ENST00000547182, ENST00000357123, | ENST00000267260, ENST00000537597, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 5 X 4=80 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MCRS1 [Title/Abstract] AND SRRM4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MCRS1 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
| Hgene | MCRS1 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
| Hgene | MCRS1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
| Hgene | MCRS1 | GO:1904751 | positive regulation of protein localization to nucleolus | 16571602 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A3LS-01A | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000546244 | ENST00000267260 | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
| 5CDS-intron | ENST00000546244 | ENST00000537597 | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
| Frame-shift | ENST00000343810 | ENST00000267260 | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
| 5CDS-intron | ENST00000343810 | ENST00000537597 | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
| In-frame | ENST00000550165 | ENST00000267260 | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
| 5CDS-intron | ENST00000550165 | ENST00000537597 | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
| 5UTR-3CDS | ENST00000547182 | ENST00000267260 | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
| 5UTR-intron | ENST00000547182 | ENST00000537597 | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
| Frame-shift | ENST00000357123 | ENST00000267260 | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
| 5CDS-intron | ENST00000357123 | ENST00000537597 | MCRS1 | chr12 | 49956784 | - | SRRM4 | chr12 | 119594300 | + |
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FusionProtFeatures for MCRS1_SRRM4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MCRS1 | SRRM4 |
| Modulates the transcription repressor activity of DAXXby recruiting it to the nucleolus (PubMed:11948183). As part ofthe NSL complex it may be involved in acetylation of nucleosomalhistone H4 on several lysine residues (PubMed:20018852). Putativeregulatory component of the chromatin remodeling INO80 complexwhich is involved in transcriptional regulation, DNA replicationand probably DNA repair. May also be an inhibitor of TERTtelomerase activity (PubMed:15044100). Binds to G-quadruplexstructures in mRNA (PubMed:16571602). Binds to RNA homopolymerpoly(G) and poly(U) (PubMed:16571602).{ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100,ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852}. | Splicing factor specifically required for neural celldifferentiation. Acts in conjunction with nPTB/PTBP2 by bindingdirectly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural celldifferentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression ofneural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16in DAAM1 in neuron extracts (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MCRS1_SRRM4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MCRS1_ENST00000550165_chr12_49956784_-_SRRM4_ENST00000267260_chr12_119594300_+_369aa MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPKRRSSSRFIKRKKFDDELVESSLAKSSTRAKGASGVEPGRCSGSEPS SSEKKKVSKAPSTPVPPSPAPAPGLTKRVKKSKQPLQVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRFTLREVQERWYALLY DPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLSKVGSTSQPTLETFQDLLHRHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVP GNAPSPTIGPAPPHPAASAAPPPGTAAAVAARPAAATPGAGVGAGAGDGAGPARAAALAPAALVRAPAAGAGAGAGAGAGAGARAGATAQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MCRS1_ENST00000550165_chr12_49956784_-_SRRM4_ENST00000267260_chr12_119594300_+_1109nt ATGGACAAAGATTCTCAGGGGCTGCTAGATTCATCCCTGATGGCATCAGGCACTGCCAGCCGCTCAGAGGATGAGGAGTCACTGGCAGGG CAGAAGCGAGCCTCCTCCCAGGCCTTGGGCACCATCCCTAAACGGAGAAGCTCCTCCAGGTTCATCAAGAGGAAGAAGTTCGATGATGAG CTGGTGGAGAGCAGCCTGGCAAAATCTTCTACCCGGGCAAAGGGGGCCAGTGGGGTGGAACCAGGGCGCTGTTCGGGGAGTGAACCCTCC TCCAGTGAGAAGAAGAAGGTATCCAAAGCCCCCAGCACTCCTGTGCCACCCAGCCCAGCCCCAGCCCCTGGACTCACCAAGCGTGTGAAG AAGAGTAAACAGCCACTTCAGGTGACCAAGGATCTGGGCCGCTGGAAGCCTGCAGATGACCTCCTGCTCATAAATGCTGTGTTGCAGACC AACGACCTGACCTCCGTCCACCTGGGCGTGAAATTCAGCTGCCGCTTCACCCTTCGGGAGGTCCAGGAGCGTTGGTACGCCCTGCTCTAC GATCCTGTCATCTCCAAGTTGGCCTGTCAGGCCATGAGGCAGCTGCACCCAGAGGCTATTGCAGCCATCCAGAGCAAGGCCCTGTTTAGC AAGGCTGAGGAGCAGCTGCTGAGCAAAGTGGGATCGACCAGCCAGCCCACCTTGGAGACCTTCCAGGACCTGCTGCACAGACACCCTGAT GCCTTCTACCTGGCCCGTACCGCGAAGGCCCTGCAGGCCCACTGGCAGCTCATGAAGCAGTATTACCTGCTGGAGGACCAGACAGTGCCC GGAAACGCCCCATCCCCTACTATCGGCCCAGCCCCTCCTCATCCGGCAGCCTCAGCAGCACCTCCTCCTGGTACAGCAGCAGCAGTAGCC GCTCGGCCAGCCGCAGCTACTCCCGGAGCCGGAGTCGGAGCCGGAGCCGGAGACGGAGCCGGACCCGCACGAGCAGCAGCTCTAGCTCCC GCAGCCCTAGTCCGGGCTCCCGCAGCCGGAGCCGGAGCAGGAGCCGGAGCCGGAGCCGGAGCAGGAGCCAGAGCCGGAGCTACAGCTCAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MCRS1_ENST00000550165_chr12_49956784_-_SRRM4_ENST00000267260_chr12_119594300_+_7629nt TGCGGCTGCTACCGTCGCCGCGGAGAAATTGTTGGATCTGGCAGTCTAGGAATGAGGTGACTTCATCAATGCTCCTACCCCGAGTTCTTG AGACAGACCTGGACCGATCCCCTACCTTGGGTGTGCACTCTTGGGAGAACGAGGGGCGGAGGGTCCGAATCTCCTCTCAGCCTTTAAGCT CACCTGGTCAGAATCCTTGGATGAGCCTGTGGGACCGTTCCTCCTAGCCCGGTGGTTTGGAACCAGTGGCTTTGGGACTGTAAGAGGATG GACAAAGATTCTCAGGGGCTGCTAGATTCATCCCTGATGGCATCAGGCACTGCCAGCCGCTCAGAGGATGAGGAGTCACTGGCAGGGCAG AAGCGAGCCTCCTCCCAGGCCTTGGGCACCATCCCTAAACGGAGAAGCTCCTCCAGGTTCATCAAGAGGAAGAAGTTCGATGATGAGCTG GTGGAGAGCAGCCTGGCAAAATCTTCTACCCGGGCAAAGGGGGCCAGTGGGGTGGAACCAGGGCGCTGTTCGGGGAGTGAACCCTCCTCC AGTGAGAAGAAGAAGGTATCCAAAGCCCCCAGCACTCCTGTGCCACCCAGCCCAGCCCCAGCCCCTGGACTCACCAAGCGTGTGAAGAAG AGTAAACAGCCACTTCAGGTGACCAAGGATCTGGGCCGCTGGAAGCCTGCAGATGACCTCCTGCTCATAAATGCTGTGTTGCAGACCAAC GACCTGACCTCCGTCCACCTGGGCGTGAAATTCAGCTGCCGCTTCACCCTTCGGGAGGTCCAGGAGCGTTGGTACGCCCTGCTCTACGAT CCTGTCATCTCCAAGTTGGCCTGTCAGGCCATGAGGCAGCTGCACCCAGAGGCTATTGCAGCCATCCAGAGCAAGGCCCTGTTTAGCAAG GCTGAGGAGCAGCTGCTGAGCAAAGTGGGATCGACCAGCCAGCCCACCTTGGAGACCTTCCAGGACCTGCTGCACAGACACCCTGATGCC TTCTACCTGGCCCGTACCGCGAAGGCCCTGCAGGCCCACTGGCAGCTCATGAAGCAGTATTACCTGCTGGAGGACCAGACAGTGCCCGGA AACGCCCCATCCCCTACTATCGGCCCAGCCCCTCCTCATCCGGCAGCCTCAGCAGCACCTCCTCCTGGTACAGCAGCAGCAGTAGCCGCT CGGCCAGCCGCAGCTACTCCCGGAGCCGGAGTCGGAGCCGGAGCCGGAGACGGAGCCGGACCCGCACGAGCAGCAGCTCTAGCTCCCGCA GCCCTAGTCCGGGCTCCCGCAGCCGGAGCCGGAGCAGGAGCCGGAGCCGGAGCCGGAGCAGGAGCCAGAGCCGGAGCTACAGCTCAGCAG ACAGCTACTCCAGCACGAGGCGCTAAGTGCCCCTGAGCCAGCTGCCCGTGGGGGCCCCTTCGCGCTGCCAGCCTCCCCCAACCACCTGCC CTCCCCGCCTTCTTGGTGACAAATAGTGAGGGCTCCTATACCTTGTCCTTCCTGCTTGCCTAGGGGAAGAGGAGAAGAGGGTAAGGGGGC TTCACTCTCTAGATCAGCCTGCTAGGAGCCTCTACCAGCATCATCCTGGGGCCCAGCTCAGGCCTGGGCATATGGAAAGAACCATCATCT TGTGGCACAAAAAAAGAAGAAAGAAAAGAAAACTTCAAGGTTTTGTGAGAAGCAATGGGTCTGTGACTCAAAAATTGAGCCCTGGCCAGG AAAATGTGGAGACAGTTCTTCTCCTCCACTGCTCACAGGAGGCCCGTGGTAATTCTCCCCACCTCCCCGGATGCCCCACTAGTCCAACTT CATGGCTGCACGTGGATGGACCCCCATGTCTGAGAGGGGTGAAAGAGGAGACCAATGGCAGTTCAGGTTCAAGATAACGGGGTCAGGCCT TTAACTTCCTCAAACAGGCCCAAGCAAAGGCTGGAAGACATTTGGGTCCTAGAAGAAGGGATATCCTTGAATACCAGATGGGGACGTTTG ACTTGGTGGGAGGTGTCAGGAGATAGGAGTTGGTTAAGATGATAGATAGAAAAACGGAAGGGTTCAGCTGCTGCTCCCAATACCTCAGCA TGGTAAGGGGACAGAGCCCAGCAGATCCCAGCTGTGAAGAGGCCACTGCATGGCTGACACAAAACACCTCTTGGCCATTCACAGGGGCCC TGCAACCTCACGAGAAAGGAGATAGTGGAAGAGTCAGGACAGGTTGGTCTCCAGCCCCACTTCCCAAATATGCCTCAGCCCCACTAGCTG GCACCAACTTAATTCCACGGGACCATCTGCTGAACATTCCCCAGTGCCATGGCCAGTTGCCAGGCCCCAGCGCCAGCCAGTCTGGCCTTA CCCTCCGGTTGGCGCCTGCCAGCCCCCTCCCCTCTGCCCAGGCTGCCACGCCCTGGATGCCACCCAGTGCAGCCTGGCACCTACCCACCC ACCCTTCAGCTTAAGCCACTCCCCTTGCCTCTCAGGAATTTTGCCAGGATGGGGCACAGCAGCTCAGGTTTGGGGGAAAAGACCCGAATC CAGAGTGCAGGGGAGAGGGGCTTGGATATGCCATGTCTTGGGCTCCTGCTGGCTTCTGAGGTTTCTTGTCAGCTTGGGAAAGACCCACCT TTATTTTTGCCCTCACCCCAAGTCCCCCCTGGCTGGGGCTGGGCAGAGAGGGTAAGCTGATCTCCGATCCACAAATACCACCAGCTGCTT CATCCACAGAAGGCGCTAAGAACGGGGAGGTGAGGAATAAGATCCTTAAAATAAACTCTTGGGCATCCCCCTCACCAGCTGACTGGCTTT CCGGAGGCTTGTGGGTGAGTTTCAAGTTTGTGGTGGCAACAGCAGCAGGACAGGGCACGGAGGGAGCGAGGGAGAGAGGACCGGTCCCAG CTTTTGGATATTTTGGGTTATGGGGAAGCAAGGGCCAAACATTCTTTATCCCTCCCACCCCAGGGAAAACATTTGGAAAATAGTCCTTTT TCTTGGAAGCAGTGACGTCTCCCTACCCAATCTTTCCCATCCTATCAACCCATGGGGCTAGAGACTGCCATGCAACCACCACCACGACAG CCCTTCCTCCATCAGAAGACAGGAGTGAGGGCCCCGGGCAGCAGTGGACGACCCAGCCTCCCCATACCGGGCCTCTGGCCCAGACCTAAG CCCTGCCCACAAAGACTAATGGATGCCAGTGCTGTCACTGCAGAAGGCCAGATGGCAGGTGCCTGGGACAGGGGCAGGTGCCCCGGGGAG GGCAAGTACAGCCACTGTAAATAACCCTCGTCCCTGCCCAGGAACCCAGACTGGACTTCAGTCTCCCTCCATGGAGACAAAGGCTTCCCA GAGCCACCAAAAACCTTCTTAGCAGGACAGCTGTGAGAGGCATCAGAACCTCACGTTCGGACTGCCTTCATCAAGACAACTCTAGGGGAC CATTTTGCCTGGGGCTCCTAGCAAACCTTTTTATTTATTTTATTTATTTATCTATTTATTTATTTGATGACTGTCTCTCTTTCTCGCCAT TAGCAGTATTGAATTATTTATTTATACAGAGGTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGGG GGGATCTCCTAAATTATTTCTGTGCATCTCCTTTTTTTTTCTGCTGTTTTTTATGGATGGGATTTGAGAGGCCAAAGGTGAGTGGGCTAT TGGCCTTCTCCCTGAAGGCTCTAAGCCTGGAACACCCTGGGGTTGGCCCAGAAGGAGGCACATCAGTCCCAAAATTCATCACTTAACCCA GCGTCCAGGAGGGTCAGGCCTGTACCCCAGCCTCCTGTCCCCCAGGAACCTCACAGGGGTATCAAAAAGATGTAAACAGCCCAGAGGCTT ATGAGCTACAGTGATGAATTGACACAGTGGAGTTGCAACTTAGGTGGGGGTTGGAGTCGAAAGTTGGCAAATGGGGCCAAGGCTGCACAA AGTCGAAATCCCTTGTGAATGTCCCTTAGGGAGGCACCAGATTGGAGACAGATGTGCTATCTCCTAACAGAGTGATGAGGCTTCAGTTGA GTACTTGCTGAAGTAGTTGCCTTGTATTTTGAGGGCCATGGTGGATGAAAATGATGTCTGGTTTAGTACTGGAATTGCACTTGGGGTTGA CAAGGTGCTCACACCATGAGAATGGAGGCAGGAATTGAGCTGACTGAGGGAAGATGCACCTTGATCTCACCCTCACTCCAAGGCACATAG CAGGATCACTCCCTAGCTTCTCTGAGCACACCTAGTTGGTTTCATGTATGTTACACATGCTTCCACTCCACAGTACCTAATTTCTCTCTG TCCCCTGAGATCTGAAGGCTACCTTGGGAAGAGGCATCAGCCATCTTGCTTGAGAACCACCAAGCCAAAAGCAAAAGCTTTTATCTATGA TCTCTTGCTGTTTCATCAGGGGAAAGCACAAAGCTATTTCTGAAATTAGGAAAAAAAAAAAAAAGGTGGAAGGAGCAGCCAGATGTTCCA CAGGACCCCACCAAGAAGGTCATTTCCAAACCCATCCTGGAAGGGCCCAGGATCCAAAGGTCATCAGTCCTGCTTATCTGACCAACTGGC AGTGTCTTCTGGCTGCTGGCCGGAGACAGCTCTTGCCCTTTCCAAAGTCACTGTCCACTGCCTTGCAATTGCCAGCTTGTCTGGTCCAGC TTTGGGTTTGGTGAGACTTTTGCAACATCCCTGGTTGTTTCCCTGGCAATGTGACTATCCAGCCCTAACCCAAAGCAAGGGAGTGCCCCT TTCCTGGGTGAAGTTTACAAGAAGGCTGCTTAAATGCCTGCTTCGGGGAAATCTCTGCCTCTCTCTCTCTCTGTCTCTCTCTCTGTCTCT CTCTCTGTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCAGTGTATTTCTCTACTTTCTTTTACATTTCCTTTTTTTCTATCCAAAAA CAATGTGCTTGTTGAGGCACTGGTAACCCTGATTAACCAGAACCTCCCATTCCCAGTATCGCTGTTCCTACGCCCATTTCACCCTCATTA CCTTCTGCTTCCAAGGAATATGACAGATCACCAGGATGCTGCTCGTCGTGAGGATTTATCTCAAAAACCAACATCCAAAATGGGAGGGAG ATGTGGCTTGAGGTCAAGCGCCATGCATCCCAAGCCTTTGACCTTCCCGCTATGGAAGTGCACTGGATGACAGAAACTGAATACATTGCT CCCTTTCCCTAGGGCAAAGTTCGACCTCTGTTAAGTGGAGGGATTTGTGAGATAAAAATTCAAAATGTTGGCCTGAGGCCTGAGAGTGTC ACCAAAGACAGAGGGAGCTTCACTGAGACTCAGAGGGAAAAGGAAAAGAGCCTCAAACATTTTTAGGAGGTTGTCCATCATGAAAGTAAA AACGAAAAGCAAGATTTGATCTCCCTTCAGTTAATTAGGCAAGGCTAAGTAACTCAAAGCCCCCTATTAGTAACATTCTGGTTCACTGAG GTTTGATCATATTCCTATCTGCATTCCTTCCCTTCTTTGAAGGACAGCTGATCTTTCAGAAGCAGAATAAAATTAAGATGTTAGAACAAA GGTCTCAGTCTCAGAGAACCGCATCACTTCATTTGCTCAGACCCATCCTCTTTTGCAAAAGGGTCTGCTTGGAGAGGCCAAAATTCAGGG TGCTCTCAAAGGCAAAGAAAGCACATTGTTTTCCTTCTCCAGTCCAACTTTCATCTTTTCTTCTGCTGTTTTCTTTTCCCCTCTTCTTTT TCACAAATGTTCAAAATGGTCTCATGCGCATGTGTCTTGCCCCACTTTCCCCTTTAGCTGAACAGAAAATTTTGTCTCAGTAAAACGAAG TCAAAAAACAGGATTCCTCCAAACATGCCTCCTCCCGCACTGGCCAGCCGAGTCCAGCTGAGAAACTTATGCTAGATTCAATGTCATTGA GCAATGCTTTATTGAAGTCTCGTTCTTCTCACTTCTGCACCAGTGAGCCAATGATACTGACAGAAATGTCATCTCTCTTCTATCTGTGGT TGCTGTTTTTGGAGTAAAAGTTTCTGTGTGTGTTTTTTTAGTTCTTTTGATGGCTGTTGTTTTGCATTGTAAATACCATGATGGGGGACC CCCATCAGAACATGGCTTATTTAATAATTTATTTCGTATTTATTGAGTAATATTGGGAAAAGAGAAGGACCACCTCTTTCCCTGAATTGC TATTGAGAATTGGTCCATCTCCCAGCTCCAGGTGCTGCTGTCTGCAGCAAGGGCATTACTGCCCAGGTAAGGAGTGCTAGAATCACCAAG CAAATTGAAATTGGCAGAAATGGAGGCTTCAGTCACACAAATTAGACTCAAATGGAACTAAAACACTGGTTATCTCCAGGAAAACCTCAT TTAGATGGAAATTAATGGAAGAATAAAATGCCTACACATGAACCAACTTCTATTAAAAAGTCACAACTCCTTGAAAAAAAAAATAAAGAA AAATTGTAAACTCTTTTTTTTTTCTGGCCAAGGAAAGCTATGCCTCATCTTCTAACGAGCCAAGCCAAAAAGACTGCAATGGTATTCCTA TGTGTTTCTTTGGCCTGTGTATCAGTCTGAATGAAATGGAATGGGTCTCTAGCCTCAGTCTTGTCATCTGTAAAATGGGGCTTGTCCTAT ATATTATCTGCAAGACGTGGGAAATGGGGGCTCAAGCCCTGATGCTATGGACTCCATACTGTTGGATATATTGTCTCTTGTGTCTTCTGC TGACTGCAGATTAAAGGGTGTCAACCAAGGAAGGAAACAAAAAAGTAGGGCCTGGACTTCATTTGCAGAATGAGGTCATAGTCGTTGAGT CCCACAGTCATATATGGGAGACCTCAAGTTGCTGTCACCTTGATAACTCTTGTATCCTGGGTTAAAGCCCTCTGTATTTAGTTTGAACTT CTCTCTAAGCCCCGTGGTCCAAAGTCATCACGGGAGAGACCAAGATGGGCTTACCTTGCCCTGCTCTGGATTTAACCATTGTTCATTGTC AGGCTATATTTTTGTACAATCATTCAAATAACCCAGTGACATAGGTCATATTGCCACTTTTCAGAGGAGAAAACTGAGGCTCAGGAGGGG GAGTTGACATGCCCAAGCTCCCTTGAGCTCAGATCAGCTTGACTCAATGTCCAACATTCCCTTGGTAGCTTTTTCTCCGGGGTCCTGTGC TATAAGAACTTCTCTCTGCACTGTATTTTTTTTTCTCCCAATTCTTAGCTATTTCCTCAAGCAATGATTGGCCAAGGACCTAGCATAATC CACCACATTGGCCAAGGGGACGTGGTGCACCCCAAGGCCATTTCTCTGCATTGGAGGCTGCGAATCTCCTCTGGAAAATTCCCAACCCGA GGACCCACCATGAGCCCAGCTCAGCCTGACCAGACAGCCTCTGCCTGGAGCATTCACATCAGATGGAAAGAAGCTGCTGTGTCCTCCAGC ATCCTGGGACCCTGTCCTCTGCCCAGTGACACAGCAGCCATGGCTAGCTTGATTTCTGGTCTCCAAAGCTAAGCATAACCTTCCCGGGGT |
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FusionGenePPI for MCRS1_SRRM4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MCRS1 | NOP2, UPF3B, DAXX, PINX1, LSM6, KXD1, CEP44, DVL2, MAGEA11, RALYL, CCDC85B, MED4, CCDC53, FXR2, TRIM37, PHC2, WBP11, CSNK2B, UBR4, UBR5, PRKAR1A, TERT, FBL, CHD4, RET, UBTF, BLM, INO80, KAT8, INO80E, YY1, RUVBL1, RUVBL2, ACTR5, ACTR8, TFPT, INO80B, INO80D, ACTL6A, INO80C, NFRKB, UCHL5, LIG4, MAP3K5, GPBP1, GCC1, KDM1A, PRMT5, SUV39H1, ZBTB22, IKZF1, USHBP1, KIAA1958, BRCA1, RTN2, PCM1, XPO1, COPS7A, FOXK2, BAP1, NFATC2, PHF20, KANSL1, GPBP1L1, TRIM44, GPR156, TULP3, MRPS15, NECAB1, TNFRSF1A, CDH5, INTU, PTEN | SRRM4 | CACNA1A, EGFR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MCRS1_SRRM4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MCRS1_SRRM4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SRRM4 | C0042594 | Vestibular Diseases | 1 | CTD_human |
| Tgene | SRRM4 | C0260662 | Hearing problem | 1 | CTD_human |
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