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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21315

FusionGeneSummary for MCM7_TSC22D4

check button Fusion gene summary
Fusion gene informationFusion gene name: MCM7_TSC22D4
Fusion gene ID: 21315
HgeneTgene
Gene symbol

MCM7

TSC22D4

Gene ID

4176

81628

Gene nameminichromosome maintenance complex component 7TSC22 domain family member 4
SynonymsCDC47|MCM2|P1.1-MCM3|P1CDC47|P85MCM|PNAS146|PPP1R104THG-1|THG1|TILZ2
Cytomap

7q22.1

7q22.1

Type of geneprotein-codingprotein-coding
DescriptionDNA replication licensing factor MCM7CDC47 homologhomolog of S. cerevisiae Cdc47minichromosome maintenance deficient 7protein phosphatase 1, regulatory subunit 104TSC22 domain family protein 4TSC22-related-inducible leucine zipper protein 2tsc-22-like protein THG-1
Modification date2018052720180522
UniProtAcc

P33993

Q9Y3Q8

Ensembl transtripts involved in fusion geneENST00000343023, ENST00000354230, 
ENST00000303887, 
ENST00000496728, 
ENST00000300181, ENST00000393991, 
Fusion gene scores* DoF score5 X 6 X 2=602 X 1 X 2=4
# samples 62
** MAII scorelog2(6/60*10)=0log2(2/4*10)=2.32192809488736
Context

PubMed: MCM7 [Title/Abstract] AND TSC22D4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-55-8301-01AMCM7chr7

99693397

-TSC22D4chr7

100065223

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000343023ENST00000496728MCM7chr7

99693397

-TSC22D4chr7

100065223

-
intron-5UTRENST00000343023ENST00000300181MCM7chr7

99693397

-TSC22D4chr7

100065223

-
intron-5UTRENST00000343023ENST00000393991MCM7chr7

99693397

-TSC22D4chr7

100065223

-
5CDS-5UTRENST00000354230ENST00000496728MCM7chr7

99693397

-TSC22D4chr7

100065223

-
5CDS-5UTRENST00000354230ENST00000300181MCM7chr7

99693397

-TSC22D4chr7

100065223

-
5CDS-5UTRENST00000354230ENST00000393991MCM7chr7

99693397

-TSC22D4chr7

100065223

-
5CDS-5UTRENST00000303887ENST00000496728MCM7chr7

99693397

-TSC22D4chr7

100065223

-
5CDS-5UTRENST00000303887ENST00000300181MCM7chr7

99693397

-TSC22D4chr7

100065223

-
5CDS-5UTRENST00000303887ENST00000393991MCM7chr7

99693397

-TSC22D4chr7

100065223

-

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FusionProtFeatures for MCM7_TSC22D4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCM7

P33993

TSC22D4

Q9Y3Q8

Acts as component of the MCM2-7 complex (MCM complex)which is the putative replicative helicase essential for 'once percell cycle' DNA replication initiation and elongation ineukaryotic cells. The active ATPase sites in the MCM2-7 ring areformed through the interaction surfaces of two neighboringsubunits such that a critical structure of a conserved argininefinger motif is provided in trans relative to the ATP-binding siteof the Walker A box of the adjacent subunit. The six ATPase activesites, however, are likely to contribute differentially to thecomplex helicase activity. Required for S-phase checkpointactivation upon UV-induced damage. {ECO:0000269|PubMed:15210935,ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:9305914}. Transcriptional repressor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MCM7_TSC22D4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MCM7_TSC22D4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MCM7ORC1, RB1, DBF4, CDC7, ORC3, RPA1, FHL2, ORC2, ORC5, RBM8A, MBIP, MCM7, NEK6, GIPC1, NELFCD, GSTK1, PELO, CNOT8, TRAF6, MYC, ATR, MCM8, MCM2, MCM4, MCM6, MCM3, MCM5, CDC6, CDC45, ATRIP, RBL2, RBL1, UBE3A, MNAT1, CCNH, CDK7, MCM10, RECQL5, IKBKG, HIST1H4A, SSRP1, SUV420H2, HIST3H3, CCL2, HIF1A, EPAS1, TCEB1, VHL, TERF1, TERF2, L3MBTL1, HDAC5, MMS22L, TONSL, PIDD1, RAD21, POLR2A, CCND1, ASF1A, FBXO25, INTS6, CUL3, CUL5, CDK2, COPS5, FBXO6, APP, SMC1A, SF3A1, LAMP2, DCTN2, RBBP4, SNRPA1, DDX5, C14orf166, DSTN, ACTR1A, FN1, VCAM1, ORC4, ORC6, ITGA4, SNTA1, HDAC6, BAG3, ASB8, HIPK4, MIB1, PARK2, HSP90AB1, HYOU1, CLUH, PRRC1, TRIM16, PRMT1, TOMM34, MCMBP, STAU1, CEP250, CEP57, HAUS2, PCNA, GOLGA2, KIFC3, NAB2, TRIM27, SP2, PNMA1, UBQLN1, TRIM54, CCDC102B, USHBP1, C8orf34, MIPOL1, AK8, NXF1, CUL7, OBSL1, CCDC8, SUZ12, RNF2, ILF2, GINS3, TIPIN, VPS29, VPS35, TIMELESS, CCDC88C, VPS26A, CEP290, GINS2, GINS4, HIST1H2BA, RASSF10, CCT4, MAPRE2, CAD, CCT3, IPO5, PSMD12, RANBP6, PSMD2, SF3B1, NTRK1, ASF1B, HIST1H3E, AHSA1, CRY1, CRY2, KCTD5, SENP3, RC3H1, HIST1H3A, GINS1, USP15, SPAG9, FANCA, CYLD, FANCD2, CEP68, FOXA1, TRIM25, G3BP1TSC22D4GORASP2, CCNK, PIN1, FRMD6, ENKD1, PSMA1, TEX11, CDK5R1, ZNF580, SAT1, MAD2L1, CCDC42, ZMYND10, PIH1D1, CDC23, FXR2, ABLIM1, NRBP1, LNX1, CKS2, CCDC33, NOC4L, SYT17, NIF3L1, UBLCP1, MTHFS, GNB2L1, KEAP1, AIFM1, PRNP, SACS, PCBP1, SMAD3, CLU, KPNA2, LBP, BZRAP1, AES, GOLGA2, LMO2, PPL, PRKAA1, PRKAA2, BLZF1, POLR1C, ZBTB24, MYLIP, APIP, CCDC146, KRT40, NRBP2, SMG8, STK39, P4HA1, TSC22D2, TSC22D1, TSC22D3, CRTAP, TCEB1, P3H1, IFT172, LRWD1, CUL1, RAP1GDS1, RHOA, PDPR, WNK3, WNK1, WNK2, P4HA2, CPVL, TTL, FBXW11, BTRC, TBL1XR1, TBL1X, MAD2L1BP, PRKD2, LHX4, FBXW7, SMARCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MCM7_TSC22D4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MCM7_TSC22D4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource