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Fusion gene ID: 21298 |
FusionGeneSummary for MCM3_CARS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MCM3_CARS | Fusion gene ID: 21298 | Hgene | Tgene | Gene symbol | MCM3 | CARS | Gene ID | 4172 | 833 |
| Gene name | minichromosome maintenance complex component 3 | cysteinyl-tRNA synthetase | |
| Synonyms | HCC5|P1-MCM3|P1.h|RLFB | CARS1|CYSRS|MGC:11246 | |
| Cytomap | 6p12.2 | 11p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA replication licensing factor MCM3DNA polymerase alpha holoenzyme-associated protein P1DNA replication factor MCM3MCM3 minichromosome maintenance deficient 3RLF subunit betacervical cancer proto-oncogene 5hRlf beta subunitminichromosome maintena | cysteine--tRNA ligase, cytoplasmiccysteine tRNA ligase 1, cytoplasmiccysteine translase | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P25205 | P49589 | |
| Ensembl transtripts involved in fusion gene | ENST00000229854, ENST00000596288, ENST00000419835, ENST00000476448, | ENST00000380525, ENST00000397111, ENST00000278224, ENST00000470221, ENST00000401769, ENST00000397114, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 8 X 8 X 6=384 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/384*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MCM3 [Title/Abstract] AND CARS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CARS | GO:0006423 | cysteinyl-tRNA aminoacylation | 10908348|17303165 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI117082 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000229854 | ENST00000380525 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000229854 | ENST00000397111 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000229854 | ENST00000278224 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000229854 | ENST00000470221 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000229854 | ENST00000401769 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000229854 | ENST00000397114 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000596288 | ENST00000380525 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000596288 | ENST00000397111 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000596288 | ENST00000278224 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000596288 | ENST00000470221 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000596288 | ENST00000401769 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000596288 | ENST00000397114 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000419835 | ENST00000380525 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000419835 | ENST00000397111 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000419835 | ENST00000278224 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000419835 | ENST00000470221 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000419835 | ENST00000401769 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000419835 | ENST00000397114 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000476448 | ENST00000380525 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000476448 | ENST00000397111 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-3CDS | ENST00000476448 | ENST00000278224 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000476448 | ENST00000470221 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000476448 | ENST00000401769 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
| intron-intron | ENST00000476448 | ENST00000397114 | MCM3 | chr6 | 52146874 | + | CARS | chr11 | 3047971 | - |
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FusionProtFeatures for MCM3_CARS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MCM3 | CARS |
| Acts as component of the MCM2-7 complex (MCM complex)which is the putative replicative helicase essential for 'once percell cycle' DNA replication initiation and elongation ineukaryotic cells. The active ATPase sites in the MCM2-7 ring areformed through the interaction surfaces of two neighboringsubunits such that a critical structure of a conserved argininefinger motif is provided in trans relative to the ATP-binding siteof the Walker A box of the adjacent subunit. The six ATPase activesites, however, are likely to contribute differentially to thecomplex helicase activity. Required for DNA replication and cellproliferation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MCM3_CARS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MCM3_CARS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MCM3_CARS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MCM3_CARS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CARS | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
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