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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21276

FusionGeneSummary for MCF2L_F10

check button Fusion gene summary
Fusion gene informationFusion gene name: MCF2L_F10
Fusion gene ID: 21276
HgeneTgene
Gene symbol

MCF2L

F10

Gene ID

23263

83541

Gene nameMCF.2 cell line derived transforming sequence likefamily with sequence similarity 110 member A
SynonymsARHGEF14|DBS|OSTC20orf55|F10|bA371L19.3
Cytomap

13q34

20p13

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide exchange factor DBSDBL's big sisterMCF2 transforming sequence-like proteinprotein FAM110A
Modification date2018051920180519
UniProtAcc

O15068

P00742

Ensembl transtripts involved in fusion geneENST00000375608, ENST00000442652, 
ENST00000375604, ENST00000397030, 
ENST00000535094, ENST00000421756, 
ENST00000375601, ENST00000397036, 
ENST00000434480, ENST00000423482, 
ENST00000375597, ENST00000397024, 
ENST00000480321, ENST00000397021, 
ENST00000409306, ENST00000375551, 
ENST00000375559, ENST00000483537, 
Fusion gene scores* DoF score7 X 6 X 6=2525 X 4 X 4=80
# samples 64
** MAII scorelog2(6/252*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MCF2L [Title/Abstract] AND F10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-56-A4ZK-01AMCF2Lchr13

113720484

+F10chr13

113803230

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375608ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375608ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375608ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000375608ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000442652ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000442652ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000442652ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000442652ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000375604ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375604ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375604ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000375604ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000397030ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000397030ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000397030ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000397030ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000535094ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000535094ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000535094ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000535094ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000421756ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000421756ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000421756ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000421756ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000375601ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375601ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375601ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000375601ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397036ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397036ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397036ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-intronENST00000397036ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000434480ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000434480ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000434480ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000434480ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000423482ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000423482ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000423482ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000423482ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
In-frameENST00000375597ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375597ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
Frame-shiftENST00000375597ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
5CDS-intronENST00000375597ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397024ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397024ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397024ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-intronENST00000397024ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000480321ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000480321ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000480321ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-intronENST00000480321ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397021ENST00000409306MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397021ENST00000375551MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-3CDSENST00000397021ENST00000375559MCF2Lchr13

113720484

+F10chr13

113803230

+
intron-intronENST00000397021ENST00000483537MCF2Lchr13

113720484

+F10chr13

113803230

+

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FusionProtFeatures for MCF2L_F10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCF2L

O15068

F10

P00742

Factor Xa is a vitamin K-dependent glycoprotein thatconverts prothrombin to thrombin in the presence of factor Va,calcium and phospholipid during blood clotting.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+82752_224291985DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+93052_2243231138DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+82852_2243261097DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+82852_2242971068DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+83052_2242911124DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+82952_2242991114DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+82952_2243231138DomainCRAL-TRIO
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+83052_2242931126DomainCRAL-TRIO
TgeneF10chr13:113720484chr13:113803230ENST00000375559+68476_485288489RegionNote=O-glycosylated at one site

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+827503_529291985Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+930503_5293231138Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+828503_5293261097Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+828503_5292971068Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+830503_5292911124Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+829503_5292991114Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+829503_5293231138Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+830503_5292931126Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+8271055_1116291985DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+827631_811291985DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+827829_945291985DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+9301055_11163231138DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+930631_8113231138DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+930829_9453231138DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+8281055_11163261097DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+828631_8113261097DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+828829_9453261097DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+8281055_11162971068DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+828631_8112971068DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+828829_9452971068DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+8301055_11162911124DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+830631_8112911124DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+830829_9452911124DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+8291055_11162991114DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+829631_8112991114DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+829829_9452991114DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+8291055_11163231138DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+829631_8113231138DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+829829_9453231138DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+8301055_11162931126DomainSH3
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+830631_8112931126DomainDH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+830829_9452931126DomainPH
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375597+827351_456291985RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000375608+930351_4563231138RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000397030+828351_4563261097RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000421756+828351_4562971068RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000423482+830351_4562911124RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000434480+829351_4562991114RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000442652+829351_4563231138RepeatNote=Spectrin
HgeneMCF2Lchr13:113720484chr13:113803230ENST00000535094+830351_4562931126RepeatNote=Spectrin
TgeneF10chr13:113720484chr13:113803230ENST00000375559+68125_165288489DomainEGF-like 2
TgeneF10chr13:113720484chr13:113803230ENST00000375559+68235_467288489DomainPeptidase S1
TgeneF10chr13:113720484chr13:113803230ENST00000375559+6841_85288489DomainGla
TgeneF10chr13:113720484chr13:113803230ENST00000375559+6886_122288489DomainEGF-like 1%3B calcium-binding
TgeneF10chr13:113720484chr13:113803230ENST00000375559+68183_203288489RegionNote=O-glycosylated at one site


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FusionGeneSequence for MCF2L_F10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MCF2L_F10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MCF2LRAC1, CDC42, RHOA, YAE1D1, RABAC1, AIMP2, GNB1, TRIM25F10PRKAB1, SERPINB8, F7, F5, F8, PLAT, PLG, TFPI


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MCF2L_F10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneF10P00742DB00036Coagulation factor VIIa Recombinant HumanCoagulation factor Xbiotechapproved
TgeneF10P00742DB01225EnoxaparinCoagulation factor Xsmall moleculeapproved
TgeneF10P00742DB06228RivaroxabanCoagulation factor Xsmall moleculeapproved
TgeneF10P00742DB06605ApixabanCoagulation factor Xsmall moleculeapproved
TgeneF10P00742DB13192Antihemophilic factor humanCoagulation factor Xbiotechapproved
TgeneF10P00742DB00025Antihemophilic factor, human recombinantCoagulation factor Xbiotechapproved|investigational
TgeneF10P00742DB00100Coagulation Factor IX (Recombinant)Coagulation factor Xbiotechapproved|investigational
TgeneF10P00742DB01109HeparinCoagulation factor Xsmall moleculeapproved|investigational
TgeneF10P00742DB09258BemiparinCoagulation factor Xsmall moleculeapproved|investigational
TgeneF10P00742DB13151Anti-inhibitor coagulant complexCoagulation factor Xbiotechapproved|investigational
TgeneF10P00742DB00170MenadioneCoagulation factor Xsmall moleculeapproved|nutraceutical

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RelatedDiseases for MCF2L_F10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneF10C0015519Factor X Deficiency12CTD_human;HPO;ORPHANET;UNIPROT
TgeneF10C0005779Blood Coagulation Disorders1CTD_human
TgeneF10C0040053Thrombosis1CTD_human