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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21275

FusionGeneSummary for MCF2L_ATP11A

check button Fusion gene summary
Fusion gene informationFusion gene name: MCF2L_ATP11A
Fusion gene ID: 21275
HgeneTgene
Gene symbol

MCF2L

ATP11A

Gene ID

23263

23250

Gene nameMCF.2 cell line derived transforming sequence likeATPase phospholipid transporting 11A
SynonymsARHGEF14|DBS|OSTATPIH|ATPIS
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide exchange factor DBSDBL's big sisterMCF2 transforming sequence-like proteinprobable phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11Aphospholipid-translocating ATPasepotential phospholipid-transporting ATPase IH
Modification date2018051920180523
UniProtAcc

O15068

P98196

Ensembl transtripts involved in fusion geneENST00000375608, ENST00000442652, 
ENST00000375604, ENST00000397030, 
ENST00000535094, ENST00000421756, 
ENST00000375601, ENST00000397036, 
ENST00000434480, ENST00000423482, 
ENST00000375597, ENST00000397024, 
ENST00000480321, ENST00000397021, 
ENST00000283558, ENST00000375630, 
ENST00000487903, ENST00000375645, 
ENST00000419448, 
Fusion gene scores* DoF score7 X 6 X 6=25211 X 10 X 4=440
# samples 613
** MAII scorelog2(6/252*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/440*10)=-1.7589919004962
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MCF2L [Title/Abstract] AND ATP11A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-KF-A41W-01AMCF2Lchr13

113556685

+ATP11Achr13

113478658

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375608ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000375608ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000375608ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000375608ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
5CDS-intronENST00000375608ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000442652ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000442652ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000442652ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000442652ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
5CDS-intronENST00000442652ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375604ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375604ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375604ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375604ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000375604ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397030ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397030ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397030ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397030ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000397030ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000535094ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000535094ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000535094ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000535094ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000535094ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000421756ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000421756ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000421756ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000421756ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000421756ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375601ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375601ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375601ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375601ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000375601ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000397036ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000397036ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000397036ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
In-frameENST00000397036ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
5CDS-intronENST00000397036ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000434480ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000434480ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000434480ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000434480ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000434480ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000423482ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000423482ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000423482ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000423482ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000423482ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375597ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375597ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375597ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000375597ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000375597ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397024ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397024ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397024ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397024ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000397024ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000480321ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000480321ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000480321ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000480321ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000480321ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397021ENST00000283558MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397021ENST00000375630MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397021ENST00000487903MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-3CDSENST00000397021ENST00000375645MCF2Lchr13

113556685

+ATP11Achr13

113478658

+
intron-intronENST00000397021ENST00000419448MCF2Lchr13

113556685

+ATP11Achr13

113478658

+

Top

FusionProtFeatures for MCF2L_ATP11A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MCF2L

O15068

ATP11A

P98196

Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). May be involved in the uptake offarnesyltransferase inhibitor drugs, such as lonafarnib.{ECO:0000269|PubMed:15860663, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+8291024_10292631135Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+8291051_10682631135Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+8291094_11342631135Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829319_3492631135Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829373_8812631135Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829903_9142631135Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829935_9642631135Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829987_10002631135Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+8301024_10292632857Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+8301051_10682632857Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+8301094_11342632857Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830319_3492632857Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830373_8812632857Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830903_9142632857Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830935_9642632857Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830987_10002632857Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+8301024_10292632878Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+8301051_10682632878Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+8301094_11342632878Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830319_3492632878Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830373_8812632878Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830903_9142632878Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830935_9642632878Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830987_10002632878Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+8291001_10232631135TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+8291030_10502631135TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+8291069_10932631135TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829297_3182631135TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829350_3722631135TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829882_9022631135TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829915_9342631135TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829965_9862631135TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+8301001_10232632857TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+8301030_10502632857TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+8301069_10932632857TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830297_3182632857TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830350_3722632857TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830882_9022632857TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830915_9342632857TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830965_9862632857TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+8301001_10232632878TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+8301030_10502632878TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+8301069_10932632878TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830297_3182632878TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830350_3722632878TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830882_9022632878TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830915_9342632878TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830965_9862632878TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375597+127503_529-53985Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375608+230503_529561138Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000397030+128503_529-131097Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000421756+128503_529-1191068Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000423482+130503_529-651124Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000434480+129503_529-871114Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000442652+129503_529561138Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000535094+130503_529-531126Coiled coilOntology_term=ECO:0000255
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375597+1271055_1116-53985DomainSH3
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375597+12752_224-53985DomainCRAL-TRIO
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375597+127631_811-53985DomainDH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375597+127829_945-53985DomainPH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375608+2301055_1116561138DomainSH3
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375608+23052_224561138DomainCRAL-TRIO
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375608+230631_811561138DomainDH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375608+230829_945561138DomainPH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000397030+1281055_1116-131097DomainSH3
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000397030+12852_224-131097DomainCRAL-TRIO
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000397030+128631_811-131097DomainDH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000397030+128829_945-131097DomainPH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000421756+1281055_1116-1191068DomainSH3
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000421756+12852_224-1191068DomainCRAL-TRIO
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000421756+128631_811-1191068DomainDH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000421756+128829_945-1191068DomainPH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000423482+1301055_1116-651124DomainSH3
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000423482+13052_224-651124DomainCRAL-TRIO
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000423482+130631_811-651124DomainDH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000423482+130829_945-651124DomainPH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000434480+1291055_1116-871114DomainSH3
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000434480+12952_224-871114DomainCRAL-TRIO
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000434480+129631_811-871114DomainDH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000434480+129829_945-871114DomainPH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000442652+1291055_1116561138DomainSH3
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000442652+12952_224561138DomainCRAL-TRIO
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000442652+129631_811561138DomainDH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000442652+129829_945561138DomainPH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000535094+1301055_1116-531126DomainSH3
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000535094+13052_224-531126DomainCRAL-TRIO
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000535094+130631_811-531126DomainDH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000535094+130829_945-531126DomainPH
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375597+127351_456-53985RepeatNote=Spectrin
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000375608+230351_456561138RepeatNote=Spectrin
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000397030+128351_456-131097RepeatNote=Spectrin
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000421756+128351_456-1191068RepeatNote=Spectrin
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000423482+130351_456-651124RepeatNote=Spectrin
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000434480+129351_456-871114RepeatNote=Spectrin
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000442652+129351_456561138RepeatNote=Spectrin
HgeneMCF2Lchr13:113556685chr13:113478658ENST00000535094+130351_456-531126RepeatNote=Spectrin
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+829111_2962631135Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+8291_612631135Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+82983_882631135Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+830111_2962632857Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+8301_612632857Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+83083_882632857Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+830111_2962632878Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+8301_612632878Topological domainCytoplasmic
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+83083_882632878Topological domainExtracellular
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+82962_822631135TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000283558+82989_1102631135TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+83062_822632857TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000375645+83089_1102632857TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+83062_822632878TransmembraneHelical
TgeneATP11Achr13:113556685chr13:113478658ENST00000487903+83089_1102632878TransmembraneHelical


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FusionGeneSequence for MCF2L_ATP11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MCF2L_ATP11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MCF2LRAC1, CDC42, RHOA, YAE1D1, RABAC1, AIMP2, GNB1, TRIM25ATP11ATMEM30A, NPDC1, PICK1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MCF2L_ATP11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MCF2L_ATP11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATP11AC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET