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Fusion gene ID: 21245 |
FusionGeneSummary for MBTD1_THRA |
Fusion gene summary |
Fusion gene information | Fusion gene name: MBTD1_THRA | Fusion gene ID: 21245 | Hgene | Tgene | Gene symbol | MBTD1 | THRA | Gene ID | 54799 | 7067 |
Gene name | mbt domain containing 1 | thyroid hormone receptor alpha | |
Synonyms | SA49P01 | AR7|CHNG6|EAR7|ERB-T-1|ERBA|ERBA1|NR1A1|THRA1|THRA2|c-ERBA-1 | |
Cytomap | 17q21.33 | 17q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | MBT domain-containing protein 1 | thyroid hormone receptor alphaEAR-7ERBA-related 7V-erbA-related protein 7c-erbA-alphanuclear receptor subfamily 1 group A member 1thyroid hormone receptor alpha 1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homo | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q05BQ5 | P10827 | |
Ensembl transtripts involved in fusion gene | ENST00000586178, ENST00000415868, ENST00000376381, ENST00000593259, | ENST00000394121, ENST00000264637, ENST00000584985, ENST00000450525, ENST00000546243, | |
Fusion gene scores | * DoF score | 8 X 4 X 7=224 | 6 X 5 X 5=150 |
# samples | 9 | 8 | |
** MAII score | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MBTD1 [Title/Abstract] AND THRA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | THRA | GO:0006357 | regulation of transcription by RNA polymerase II | 18052923 |
Tgene | THRA | GO:0006366 | transcription by RNA polymerase II | 8710870|9653119 |
Tgene | THRA | GO:0009755 | hormone-mediated signaling pathway | 18052923 |
Tgene | THRA | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly | 8524305 |
Tgene | THRA | GO:0045892 | negative regulation of transcription, DNA-templated | 8710870 |
Tgene | THRA | GO:2000143 | negative regulation of DNA-templated transcription, initiation | 8524305 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | ESCA | TCGA-L5-A8NG-01A | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000586178 | ENST00000394121 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
5UTR-3CDS | ENST00000586178 | ENST00000264637 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
5UTR-3CDS | ENST00000586178 | ENST00000584985 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
5UTR-3CDS | ENST00000586178 | ENST00000450525 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
5UTR-3CDS | ENST00000586178 | ENST00000546243 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
intron-3CDS | ENST00000415868 | ENST00000394121 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
intron-3CDS | ENST00000415868 | ENST00000264637 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
intron-3CDS | ENST00000415868 | ENST00000584985 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
intron-3CDS | ENST00000415868 | ENST00000450525 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
intron-3CDS | ENST00000415868 | ENST00000546243 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
5UTR-3CDS | ENST00000376381 | ENST00000394121 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
5UTR-3CDS | ENST00000376381 | ENST00000264637 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
5UTR-3CDS | ENST00000376381 | ENST00000584985 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
5UTR-3CDS | ENST00000376381 | ENST00000450525 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
5UTR-3CDS | ENST00000376381 | ENST00000546243 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
intron-3CDS | ENST00000593259 | ENST00000394121 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
intron-3CDS | ENST00000593259 | ENST00000264637 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
intron-3CDS | ENST00000593259 | ENST00000584985 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
intron-3CDS | ENST00000593259 | ENST00000450525 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
intron-3CDS | ENST00000593259 | ENST00000546243 | MBTD1 | chr17 | 49336504 | - | THRA | chr17 | 38240088 | + |
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FusionProtFeatures for MBTD1_THRA |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MBTD1 | THRA |
Putative Polycomb group (PcG) protein. PcG proteinsmaintain the transcriptionally repressive state of genes, probablyvia a modification of chromatin, rendering it heritably changed inits expressibility (By similarity). Specifically binds tomonomethylated and dimethylated 'Lys-20' on histone H4.{ECO:0000250, ECO:0000269|PubMed:19841675}. | Isoform Alpha-1: Nuclear hormone receptor that can actas a repressor or activator of transcription. High affinityreceptor for thyroid hormones, including triiodothyronine andthyroxine. {ECO:0000269|PubMed:12699376,ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438,ECO:0000269|PubMed:19926848}. Isoform Alpha-2: Does not bind thyroid hormone andfunctions as a weak dominant negative inhibitor of thyroid hormoneaction. {ECO:0000269|PubMed:8910441}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MBTD1_THRA |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MBTD1_THRA |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MBTD1 | MORF4L1, MORF4L2, MRGBP, COPS6, PLAC1, PSME3, FOXR1, FOXR2, KAT5, HIST1H2BA, YEATS4, EPC1, TRRAP, EP400, BRD8, EPC2, DMAP1, ING3, RUVBL1, RUVBL2, VPS72, ACTB, MEAF6, ACTL6A, H2AFZ, HIST1H2BB, HIST1H4A, MYCL | THRA | NCOA6, TDG, CCND1, MEF2A, EP300, YWHAQ, ITGB3BP, POU2F1, DAP3, NR0B2, NRIP1, HR, AKAP13, MED12, MED16, MED6, MED24, CDK8, MED21, TRIM24, COPS2, TRIP11, RXRA, MED1, FUS, HDAC3, NCOR1, ZBTB3, SUV39H1, PARP1, NCOA1, NCOA2, NCOA3, TAF11, TAF7, GRIP1, NCOR2, EMD, PRKDC, SMC1A, LIG3, XRCC5, XRCC6, HSPA4, TBL1XR1, GPS2, TBL1X, CUL1, RGN, SEPP1, CDK7, MED25, ARID5A, GTF2B, C1D, THRA, CLIC1, FOXJ1, BUB3, PTGES3, RANBP9, AMOTL2, L3MBTL3, ENO1, MOV10, NXF1, UBE2I, CEP76, TRIM63, A2ML1, HAL, CST6, MTNR1B |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MBTD1_THRA |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | THRA | P10827 | DB00451 | Levothyroxine | Thyroid hormone receptor alpha | small molecule | approved |
Tgene | THRA | P10827 | DB00509 | Dextrothyroxine | Thyroid hormone receptor alpha | small molecule | approved|investigational |
Tgene | THRA | P10827 | DB01118 | Amiodarone | Thyroid hormone receptor alpha | small molecule | approved|investigational |
Tgene | THRA | P10827 | DB00279 | Liothyronine | Thyroid hormone receptor alpha | small molecule | approved|vet_approved |
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RelatedDiseases for MBTD1_THRA |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | THRA | C3280817 | HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 6 | 2 | UNIPROT |
Tgene | THRA | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | THRA | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |