	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 21237

FusionGeneSummary for MBP_RGS2

Fusion gene summary

Fusion gene information	Fusion gene name: MBP_RGS2
	Fusion gene ID: 21237
		Hgene	Tgene
	Gene symbol	MBP	RGS2
	Gene ID	5553	5997
	Gene name	proteoglycan 2, pro eosinophil major basic protein	regulator of G protein signaling 2
	Synonyms	BMPG\|MBP\|MBP1\|proMBP	G0S8
	Cytomap	11q12.1	1q31.2
	Type of gene	protein-coding	protein-coding
	Description	bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	regulator of G-protein signaling 2G0 to G1 switch regulatory 8, 24kDG0/G1 switch regulatory protein 8cell growth-inhibiting gene 31 proteincell growth-inhibiting protein 31regulator of G-protein signaling 2, 24kDa
	Modification date	20180519	20180522
	UniProtAcc	P02686	P41220
	Ensembl transtripts involved in fusion gene	ENST00000382582, ENST00000355994, ENST00000397875, ENST00000397866, ENST00000397865, ENST00000527041, ENST00000359645, ENST00000528160, ENST00000397869, ENST00000354542, ENST00000526111, ENST00000580402, ENST00000579129, ENST00000578193, ENST00000397863, ENST00000397860, ENST00000487778,	ENST00000483295, ENST00000235382,
Fusion gene scores	* DoF score	13 X 13 X 3=507	2 X 2 X 1=4
	# samples	15	2
	** MAII score	log2(15/507*10)=-1.75702324650746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: MBP [Title/Abstract] AND RGS2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CD558589	MBP	chr18	74724750	-	RGS2	chr1	192780233	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000382582	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000382582	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000355994	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000355994	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397875	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397875	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397866	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397866	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397865	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397865	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000527041	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000527041	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000359645	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000359645	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000528160	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000528160	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397869	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397869	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000354542	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000354542	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000526111	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000526111	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000580402	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000580402	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000579129	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000579129	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000578193	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000578193	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397863	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397863	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397860	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000397860	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000487778	ENST00000483295	MBP	chr18	74724750	-	RGS2	chr1	192780233	+
intron-intron	ENST00000487778	ENST00000235382	MBP	chr18	74724750	-	RGS2	chr1	192780233	+

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FusionProtFeatures for MBP_RGS2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MBP P02686	RGS2 P41220
	Regulates G protein-coupled receptor signaling cascades.Inhibits signal transduction by increasing the GTPase activity ofG protein alpha subunits, thereby driving them into their inactiveGDP-bound form (PubMed:11063746, PubMed:19478087). It is involvedin the negative regulation of the angiotensin-activated signalingpathway (PubMed:28784619). Plays a role in the regulation of bloodpressure in response to signaling via G protein-coupled receptorsand GNAQ. Plays a role in regulating the constriction andrelaxation of vascular smooth muscle (By similarity). Binds EIF2B5and blocks its activity, thereby inhibiting the translation ofmRNA into protein (PubMed:19736320).{ECO:0000250\|UniProtKB:O08849, ECO:0000269\|PubMed:11063746,ECO:0000269\|PubMed:11278586, ECO:0000269\|PubMed:17901199,ECO:0000269\|PubMed:19736320, ECO:0000269\|PubMed:28784619,ECO:0000305\|PubMed:7643615}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for MBP_RGS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MBP_RGS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MBP_RGS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MBP_RGS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MBP	C0036341	Schizophrenia	4	PSYGENET
Hgene	MBP	C0014072	Experimental Autoimmune Encephalomyelitis	3	CTD_human
Hgene	MBP	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Hgene	MBP	C0011303	Demyelinating Diseases	1	CTD_human
Hgene	MBP	C0027873	Neuromyelitis Optica	1	CTD_human
Tgene	RGS2	C0036341	Schizophrenia	2	PSYGENET
Tgene	RGS2	C0020538	Hypertensive disease	1	CTD_human
Tgene	RGS2	C0023467	Leukemia, Myelocytic, Acute	1	CTD_human
Tgene	RGS2	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	RGS2	C0030569	Secondary Parkinson Disease	1	CTD_human
Tgene	RGS2	C0038356	Stomach Neoplasms	1	CTD_human
Tgene	RGS2	C1458155	Mammary Neoplasms	1	CTD_human

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Fusion gene ID: 21237

FusionGeneSummary for MBP_RGS2

FusionProtFeatures for MBP_RGS2

FusionGeneSequence for MBP_RGS2

FusionGenePPI for MBP_RGS2

RelatedDrugs for MBP_RGS2

RelatedDiseases for MBP_RGS2