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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21231

FusionGeneSummary for MBP_GNB1

check button Fusion gene summary
Fusion gene informationFusion gene name: MBP_GNB1
Fusion gene ID: 21231
HgeneTgene
Gene symbol

MBP

GNB1

Gene ID

5553

2782

Gene nameproteoglycan 2, pro eosinophil major basic proteinG protein subunit beta 1
SynonymsBMPG|MBP|MBP1|proMBPMRD42
Cytomap

11q12.1

1p36.33

Type of geneprotein-codingprotein-coding
Descriptionbone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1beta subunit, signal-transducing proteins GS/GIguanine nucleotide binding protein (G protein), beta polypeptide 1testicular tissue protein Li 72transducin beta chain 1
Modification date2018051920180522
UniProtAcc

P02686

P62873

Ensembl transtripts involved in fusion geneENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
ENST00000378609, 
ENST00000472614, 
Fusion gene scores* DoF score13 X 13 X 3=50717 X 20 X 9=3060
# samples 1526
** MAII scorelog2(15/507*10)=-1.75702324650746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(26/3060*10)=-3.55694812455156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBP [Title/Abstract] AND GNB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG315176MBPchr18

74725205

+GNB1chr1

1718782

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000382582ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000382582ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000355994ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000355994ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000397875ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000397875ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000397866ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000397866ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000397865ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000397865ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000527041ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000527041ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000359645ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000359645ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000528160ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000528160ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000397869ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000397869ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000354542ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000354542ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000526111ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000526111ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000580402ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000580402ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000579129ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000579129ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000578193ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000578193ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000397863ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000397863ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000397860ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000397860ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-
intron-3CDSENST00000487778ENST00000378609MBPchr18

74725205

+GNB1chr1

1718782

-
intron-intronENST00000487778ENST00000472614MBPchr18

74725205

+GNB1chr1

1718782

-

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FusionProtFeatures for MBP_GNB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBP

P02686

GNB1

P62873

Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MBP_GNB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MBP_GNB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MBP_GNB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MBP_GNB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMBPC0036341Schizophrenia4PSYGENET
HgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
HgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneMBPC0011303Demyelinating Diseases1CTD_human
HgeneMBPC0027873Neuromyelitis Optica1CTD_human
TgeneGNB1C0003469Anxiety Disorders1CTD_human
TgeneGNB1C0011581Depressive disorder1CTD_human