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Fusion gene ID: 2123 |
FusionGeneSummary for APBB1IP_DNAJC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APBB1IP_DNAJC1 | Fusion gene ID: 2123 | Hgene | Tgene | Gene symbol | APBB1IP | DNAJC1 | Gene ID | 54518 | 64215 |
| Gene name | amyloid beta precursor protein binding family B member 1 interacting protein | DnaJ heat shock protein family (Hsp40) member C1 | |
| Synonyms | INAG1|PREL1|RARP1|RIAM | DNAJL1|ERdj1|HTJ1|MTJ1 | |
| Cytomap | 10p12.1 | 10p12.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | amyloid beta A4 precursor protein-binding family B member 1-interacting proteinAPBB1-interacting protein 1PREL-1RARP-1Rap1-GTP-interacting adaptor moleculeRap1-interacting adaptor moleculeproline rich EVH1 ligand 1proline-rich protein 73rap1-GTP-i | dnaJ homolog subfamily C member 1DnaJ (Hsp40) homolog, subfamily C, member 1DnaJ-like proteindnaJ protein homolog MTJ1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q7Z5R6 | Q96KC8 | |
| Ensembl transtripts involved in fusion gene | ENST00000376236, ENST00000356785, ENST00000493857, | ENST00000376980, ENST00000376946, ENST00000483085, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 4 X 4=80 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: APBB1IP [Title/Abstract] AND DNAJC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DNAJC1 | GO:0050708 | regulation of protein secretion | 14668352 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A196-01A | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000376236 | ENST00000376980 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - |
| In-frame | ENST00000376236 | ENST00000376946 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - |
| 5CDS-intron | ENST00000376236 | ENST00000483085 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - |
| intron-3CDS | ENST00000356785 | ENST00000376980 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - |
| intron-3CDS | ENST00000356785 | ENST00000376946 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - |
| intron-intron | ENST00000356785 | ENST00000483085 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - |
| intron-3CDS | ENST00000493857 | ENST00000376980 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - |
| intron-3CDS | ENST00000493857 | ENST00000376946 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - |
| intron-intron | ENST00000493857 | ENST00000483085 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - |
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FusionProtFeatures for APBB1IP_DNAJC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APBB1IP | DNAJC1 |
| Appears to function in the signal transduction from Rasactivation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287,ECO:0000269|PubMed:15469846}. | May modulate protein synthesis. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APBB1IP | chr10:26830621 | chr10:22218070 | ENST00000376236 | + | 11 | 15 | 129_148 | 385 | 667 | Compositional bias | Note=Pro-rich |
| Hgene | APBB1IP | chr10:26830621 | chr10:22218070 | ENST00000376236 | + | 11 | 15 | 152_155 | 385 | 667 | Compositional bias | Note=Poly-Glu |
| Hgene | APBB1IP | chr10:26830621 | chr10:22218070 | ENST00000376236 | + | 11 | 15 | 176_263 | 385 | 667 | Domain | Ras-associating |
| Tgene | >DNAJC1 | chr10:26830621 | chr10:22218070 | ENST00000376980 | - | 0 | 12 | 325_379 | 74 | 555 | Domain | SANT 1 |
| Tgene | >DNAJC1 | chr10:26830621 | chr10:22218070 | ENST00000376980 | - | 0 | 12 | 492_547 | 74 | 555 | Domain | SANT 2 |
| Tgene | >DNAJC1 | chr10:26830621 | chr10:22218070 | ENST00000376980 | - | 0 | 12 | 175_554 | 74 | 555 | Topological domain | Cytoplasmic |
| Tgene | >DNAJC1 | chr10:26830621 | chr10:22218070 | ENST00000376980 | - | 0 | 12 | 154_174 | 74 | 555 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >APBB1IP | chr10:26830621 | chr10:22218070 | ENST00000376236 | + | 11 | 15 | 503_640 | 385 | 667 | Compositional bias | Note=Pro-rich |
| Hgene | >APBB1IP | chr10:26830621 | chr10:22218070 | ENST00000376236 | + | 11 | 15 | 310_419 | 385 | 667 | Domain | PH |
| Tgene | DNAJC1 | chr10:26830621 | chr10:22218070 | ENST00000376980 | - | 0 | 12 | 65_129 | 74 | 555 | Domain | J |
| Tgene | DNAJC1 | chr10:26830621 | chr10:22218070 | ENST00000376980 | - | 0 | 12 | 48_153 | 74 | 555 | Topological domain | Lumenal |
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FusionGeneSequence for APBB1IP_DNAJC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_APBB1IP_ENST00000376236_chr10_26830621_+_DNAJC1_ENST00000376980_chr10_22218070_-_866aa MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFNYSVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESL QNQHHSASLQASIFSGAASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVV KVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNP QNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFE NVNIYYGTQHKMKYKAPTDYCFVLKDASSADIRKAYRKLSLTLHPDKNKDENAETQFRQLVAIYEVLKDDERRQRYDDILINGLPDWRQP VFYYRRVRKMSNAELALLLFIILTVGHYAVVWSIYLEKQLDELLSRKKREKKKKTGSKSVDVSKLGASEKNERLLMKPQWHDLLPCKLGI WFCLTLKALPHLIQDAGQFYAKYKETRLKEKEDALTRTELETLQKQKKVKKPKPEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDWLENR NRTQKKQAPEWTEEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATTLPDD MITQREDAEGVAAEEEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQ >In-frame_APBB1IP_ENST00000376236_chr10_26830621_+_DNAJC1_ENST00000376946_chr10_22218070_-_421aa MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFNYSVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESL QNQHHSASLQASIFSGAASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVV KVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNP QNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_APBB1IP_ENST00000376236_chr10_26830621_+_DNAJC1_ENST00000376980_chr10_22218070_-_2598nt ATGGGTGAGTCAAGTGAAGACATAGACCAAATGTTCAGCACTTTGCTGGGAGAGATGGATCTTCTGACTCAGAGTTTAGGAGTTGACACT CTCCCTCCTCCTGACCCTAATCCACCCAGAGCTGAATTTAACTACAGTGTGGGGTTTAAAGATTTAAATGAGTCCTTAAATGCACTGGAA GACCAAGATTTAGATGCTCTCATGGCAGATCTGGTAGCAGACATAAGTGAGGCTGAGCAGAGGACAATCCAGGCACAGAAAGAGTCCTTG CAGAATCAACATCATTCAGCATCTCTACAAGCATCAATTTTCAGTGGTGCAGCCTCTCTTGGTTATGGAACAAATGTTGCTGCCACTGGT ATCAGCCAATATGAGGATGACTTACCACCTCCACCAGCCGATCCTGTGTTAGACCTTCCACTGCCACCACCACCTCCTGAACCTCTCTCT CAGGAAGAGGAAGAAGCCCAAGCCAAGGCTGATAAAATTAAGCTGGCGCTGGAAAAACTGAAGGAGGCCAAGGTTAAGAAGCTCGTCGTC AAGGTGCACATGAATGATAACAGCACAAAGTCACTGATGGTGGATGAGCGGCAGCTGGCCCGAGATGTTCTGGACAACCTTTTCGAGAAA ACTCATTGTGACTGCAATGTAGACTGGTGTCTTTATGAAATCTACCCGGAACTACAAATTGAGAGGTTTTTTGAAGACCATGAAAATGTT GTTGAAGTCTTATCAGACTGGACAAGAGACACAGAAAATAAAATACTATTTTTGGAGAAAGAGGAGAAATATGCTGTATTTAAAAACCCC CAGAATTTCTACTTGGATAACAGAGGAAAAAAAGAAAGCAAGGAAACTAATGAGAAAATGAATGCTAAGAACAAGGAATCCTTACTTGAG GAAAGTTTCTGTGGAACATCTATCATTGTACCAGAACTGGAAGGAGCTCTTTATTTGAAAGAAGATGGAAAGAAATCCTGGAAAAGGCGC TATTTTCTTTTACGGGCTTCTGGAATTTATTATGTACCCAAAGGAAAGACTAAGACATCTCGAGATCTGGCGTGTTTTATACAGTTTGAA AATGTCAACATTTACTATGGGACTCAGCATAAAATGAAATATAAAGCGCCCACTGACTATTGCTTTGTTTTAAAGGATGCATCATCTGCA GACATCAGAAAAGCATATCGTAAGCTTTCACTAACTTTACATCCAGACAAGAATAAAGATGAAAATGCAGAAACTCAGTTTAGACAATTG GTGGCCATTTATGAAGTTTTAAAGGATGATGAACGAAGGCAGAGGTATGATGATATTCTGATCAATGGACTTCCAGATTGGCGACAGCCT GTATTCTACTACAGGCGGGTGAGAAAAATGAGCAATGCTGAGCTGGCATTACTCTTGTTCATTATTCTCACAGTGGGTCATTATGCTGTG GTTTGGTCAATCTACCTGGAAAAACAACTGGATGAACTACTAAGTAGAAAAAAGAGAGAAAAGAAAAAAAAGACTGGCAGCAAGAGTGTG GATGTATCAAAACTCGGTGCTTCAGAAAAAAATGAAAGATTGCTGATGAAACCACAGTGGCATGATTTGCTTCCATGCAAACTGGGGATT TGGTTTTGCCTTACACTAAAAGCATTACCTCACCTCATCCAGGATGCTGGGCAGTTTTATGCTAAATATAAAGAAACAAGATTGAAGGAA AAGGAAGATGCACTGACTAGAACTGAACTTGAAACACTTCAAAAACAGAAGAAAGTTAAAAAACCAAAACCTGAATTTCCTGTATACACA CCTTTAGAAACTACATATATTCAGTCTTATGATCATGGAACTTCCATAGAAGAAATTGAGGAACAAATGGATGATTGGTTGGAAAACAGG AACCGAACACAGAAAAAACAGGCACCTGAATGGACAGAAGAGGACCTCAGCCAACTGACAAGAAGTATGGTTAAGTTCCCAGGAGGGACT CCAGGTCGATGGGAAAAGATTGCCCACGAATTGGGTCGATCTGTGACAGATGTGACAACCAAAGCCAAGCAACTGAAGGATTCAGTGACC TGCTCCCCAGGAATGGTTAGACTCTCCGAACTCAAATCGACAGTTCAGAATTCCAGGCCCATCAAAACGGCCACCACCTTGCCCGATGAC ATGATCACCCAGCGAGAGGACGCAGAGGGGGTGGCAGCGGAGGAGGAGCAGGAGGGAGACTCCGGTGAGCAGGAGACCGGGGCCACTGAT GCCCGGCCTCGGAGGCGGAAGCCAGCCAGGCTGCTGGAGGCTACAGCGAAGCCGGAGCCAGAGGAGAAGTCCAGAGCCAAGCGGCAGAAG GACTTTGACATAGCAGAACAAAACGAGTCCAGCGACGAGGAGAGCCTGAGAAAAGAGAGAGCTCGGTCTGCAGAGGAGCCGTGGACTCAA AATCAACAGAAACTTCTGGAACTGGCGTTGCAGCAGTACCCAAGGGGATCCTCTGACCGCTGGGACAAAATAGCCAGATGTGTCCCGTCC >In-frame_APBB1IP_ENST00000376236_chr10_26830621_+_DNAJC1_ENST00000376946_chr10_22218070_-_1263nt ATGGGTGAGTCAAGTGAAGACATAGACCAAATGTTCAGCACTTTGCTGGGAGAGATGGATCTTCTGACTCAGAGTTTAGGAGTTGACACT CTCCCTCCTCCTGACCCTAATCCACCCAGAGCTGAATTTAACTACAGTGTGGGGTTTAAAGATTTAAATGAGTCCTTAAATGCACTGGAA GACCAAGATTTAGATGCTCTCATGGCAGATCTGGTAGCAGACATAAGTGAGGCTGAGCAGAGGACAATCCAGGCACAGAAAGAGTCCTTG CAGAATCAACATCATTCAGCATCTCTACAAGCATCAATTTTCAGTGGTGCAGCCTCTCTTGGTTATGGAACAAATGTTGCTGCCACTGGT ATCAGCCAATATGAGGATGACTTACCACCTCCACCAGCCGATCCTGTGTTAGACCTTCCACTGCCACCACCACCTCCTGAACCTCTCTCT CAGGAAGAGGAAGAAGCCCAAGCCAAGGCTGATAAAATTAAGCTGGCGCTGGAAAAACTGAAGGAGGCCAAGGTTAAGAAGCTCGTCGTC AAGGTGCACATGAATGATAACAGCACAAAGTCACTGATGGTGGATGAGCGGCAGCTGGCCCGAGATGTTCTGGACAACCTTTTCGAGAAA ACTCATTGTGACTGCAATGTAGACTGGTGTCTTTATGAAATCTACCCGGAACTACAAATTGAGAGGTTTTTTGAAGACCATGAAAATGTT GTTGAAGTCTTATCAGACTGGACAAGAGACACAGAAAATAAAATACTATTTTTGGAGAAAGAGGAGAAATATGCTGTATTTAAAAACCCC CAGAATTTCTACTTGGATAACAGAGGAAAAAAAGAAAGCAAGGAAACTAATGAGAAAATGAATGCTAAGAACAAGGAATCCTTACTTGAG GAAAGTTTCTGTGGAACATCTATCATTGTACCAGAACTGGAAGGAGCTCTTTATTTGAAAGAAGATGGAAAGAAATCCTGGAAAAGGCGC TATTTTCTTTTACGGGCTTCTGGAATTTATTATGTACCCAAAGGAAAGACTAAGACATCTCGAGATCTGGCGTGTTTTATACAGTTTGAA AATGTCAACATTTACTATGGGACTCAGCATAAAATGAAATATAAAGCGCCCACTGACTATTGCTTTGTTTTAAAGGATGCATCATCTGCA GACATCAGAAAAGCATATCGTAAGCTTTCACTAACTTTACATCCAGACAAGAATAAAGATGAAAATGCAGAAACTCAGTTTAGACAAGTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_APBB1IP_ENST00000376236_chr10_26830621_+_DNAJC1_ENST00000376980_chr10_22218070_-_3203nt AGTCCAGCCCTGCACCGCGTCCCCTGAGGGCGGGCTGCAGGCGGCCGGGAAGCCTTGCACAACCGGCCCAAAAGAGGAAGCCCAGAAAGT GCTGAAGTAAACACTTTGGGAGACCGTTGCAACATAAAGCGGCCTCTCAGTCTTTGGTGGAACCATCACTAGGCCCCAATCCCTTAGTCC CTCTTGCGTCGAGGCTGCAAAATGGTTCCATTCGCCAGGAGACGCTCCTGAGAGAAGGGCGCGCGCGGCACAGGGGCCTTCCTTGCACCT CGGAGCAAAGCAGCTCGGATAGCGCCACACGTCTGCGCGCTGCGTGGGAAGGGCAGGGCTGACAGCACTTCCTCCCCGGGGCAGCGACCT GGAGCCCGGGTGCGGCAGTCTGCACCGCGCGTCGCTTTCCCGGCCGGAGTCTCGCCGCCTTCCCGCGCCCCGCAGCGCCCCGCAGAGCAG TCGAGATGGGTGAGTCAAGTGAAGACATAGACCAAATGTTCAGCACTTTGCTGGGAGAGATGGATCTTCTGACTCAGAGTTTAGGAGTTG ACACTCTCCCTCCTCCTGACCCTAATCCACCCAGAGCTGAATTTAACTACAGTGTGGGGTTTAAAGATTTAAATGAGTCCTTAAATGCAC TGGAAGACCAAGATTTAGATGCTCTCATGGCAGATCTGGTAGCAGACATAAGTGAGGCTGAGCAGAGGACAATCCAGGCACAGAAAGAGT CCTTGCAGAATCAACATCATTCAGCATCTCTACAAGCATCAATTTTCAGTGGTGCAGCCTCTCTTGGTTATGGAACAAATGTTGCTGCCA CTGGTATCAGCCAATATGAGGATGACTTACCACCTCCACCAGCCGATCCTGTGTTAGACCTTCCACTGCCACCACCACCTCCTGAACCTC TCTCTCAGGAAGAGGAAGAAGCCCAAGCCAAGGCTGATAAAATTAAGCTGGCGCTGGAAAAACTGAAGGAGGCCAAGGTTAAGAAGCTCG TCGTCAAGGTGCACATGAATGATAACAGCACAAAGTCACTGATGGTGGATGAGCGGCAGCTGGCCCGAGATGTTCTGGACAACCTTTTCG AGAAAACTCATTGTGACTGCAATGTAGACTGGTGTCTTTATGAAATCTACCCGGAACTACAAATTGAGAGGTTTTTTGAAGACCATGAAA ATGTTGTTGAAGTCTTATCAGACTGGACAAGAGACACAGAAAATAAAATACTATTTTTGGAGAAAGAGGAGAAATATGCTGTATTTAAAA ACCCCCAGAATTTCTACTTGGATAACAGAGGAAAAAAAGAAAGCAAGGAAACTAATGAGAAAATGAATGCTAAGAACAAGGAATCCTTAC TTGAGGAAAGTTTCTGTGGAACATCTATCATTGTACCAGAACTGGAAGGAGCTCTTTATTTGAAAGAAGATGGAAAGAAATCCTGGAAAA GGCGCTATTTTCTTTTACGGGCTTCTGGAATTTATTATGTACCCAAAGGAAAGACTAAGACATCTCGAGATCTGGCGTGTTTTATACAGT TTGAAAATGTCAACATTTACTATGGGACTCAGCATAAAATGAAATATAAAGCGCCCACTGACTATTGCTTTGTTTTAAAGGATGCATCAT CTGCAGACATCAGAAAAGCATATCGTAAGCTTTCACTAACTTTACATCCAGACAAGAATAAAGATGAAAATGCAGAAACTCAGTTTAGAC AATTGGTGGCCATTTATGAAGTTTTAAAGGATGATGAACGAAGGCAGAGGTATGATGATATTCTGATCAATGGACTTCCAGATTGGCGAC AGCCTGTATTCTACTACAGGCGGGTGAGAAAAATGAGCAATGCTGAGCTGGCATTACTCTTGTTCATTATTCTCACAGTGGGTCATTATG CTGTGGTTTGGTCAATCTACCTGGAAAAACAACTGGATGAACTACTAAGTAGAAAAAAGAGAGAAAAGAAAAAAAAGACTGGCAGCAAGA GTGTGGATGTATCAAAACTCGGTGCTTCAGAAAAAAATGAAAGATTGCTGATGAAACCACAGTGGCATGATTTGCTTCCATGCAAACTGG GGATTTGGTTTTGCCTTACACTAAAAGCATTACCTCACCTCATCCAGGATGCTGGGCAGTTTTATGCTAAATATAAAGAAACAAGATTGA AGGAAAAGGAAGATGCACTGACTAGAACTGAACTTGAAACACTTCAAAAACAGAAGAAAGTTAAAAAACCAAAACCTGAATTTCCTGTAT ACACACCTTTAGAAACTACATATATTCAGTCTTATGATCATGGAACTTCCATAGAAGAAATTGAGGAACAAATGGATGATTGGTTGGAAA ACAGGAACCGAACACAGAAAAAACAGGCACCTGAATGGACAGAAGAGGACCTCAGCCAACTGACAAGAAGTATGGTTAAGTTCCCAGGAG GGACTCCAGGTCGATGGGAAAAGATTGCCCACGAATTGGGTCGATCTGTGACAGATGTGACAACCAAAGCCAAGCAACTGAAGGATTCAG TGACCTGCTCCCCAGGAATGGTTAGACTCTCCGAACTCAAATCGACAGTTCAGAATTCCAGGCCCATCAAAACGGCCACCACCTTGCCCG ATGACATGATCACCCAGCGAGAGGACGCAGAGGGGGTGGCAGCGGAGGAGGAGCAGGAGGGAGACTCCGGTGAGCAGGAGACCGGGGCCA CTGATGCCCGGCCTCGGAGGCGGAAGCCAGCCAGGCTGCTGGAGGCTACAGCGAAGCCGGAGCCAGAGGAGAAGTCCAGAGCCAAGCGGC AGAAGGACTTTGACATAGCAGAACAAAACGAGTCCAGCGACGAGGAGAGCCTGAGAAAAGAGAGAGCTCGGTCTGCAGAGGAGCCGTGGA CTCAAAATCAACAGAAACTTCTGGAACTGGCGTTGCAGCAGTACCCAAGGGGATCCTCTGACCGCTGGGACAAAATAGCCAGATGTGTCC CGTCCAAGAGCAAGGAAGACTGTATCGCTAGGTACAAGTTGCTGGTTGAACTGGTCCAAAAGAAAAAACAAGCTAAAAGCTGAATATTCT GGGAGATGATGTTCACCTTCATTTTCCAAAATGAATATCTTAAAAATCTTATGCAGAAATTTGCATTTTGTACCTCAATATTTCTACGTC >In-frame_APBB1IP_ENST00000376236_chr10_26830621_+_DNAJC1_ENST00000376946_chr10_22218070_-_2066nt AGTCCAGCCCTGCACCGCGTCCCCTGAGGGCGGGCTGCAGGCGGCCGGGAAGCCTTGCACAACCGGCCCAAAAGAGGAAGCCCAGAAAGT GCTGAAGTAAACACTTTGGGAGACCGTTGCAACATAAAGCGGCCTCTCAGTCTTTGGTGGAACCATCACTAGGCCCCAATCCCTTAGTCC CTCTTGCGTCGAGGCTGCAAAATGGTTCCATTCGCCAGGAGACGCTCCTGAGAGAAGGGCGCGCGCGGCACAGGGGCCTTCCTTGCACCT CGGAGCAAAGCAGCTCGGATAGCGCCACACGTCTGCGCGCTGCGTGGGAAGGGCAGGGCTGACAGCACTTCCTCCCCGGGGCAGCGACCT GGAGCCCGGGTGCGGCAGTCTGCACCGCGCGTCGCTTTCCCGGCCGGAGTCTCGCCGCCTTCCCGCGCCCCGCAGCGCCCCGCAGAGCAG TCGAGATGGGTGAGTCAAGTGAAGACATAGACCAAATGTTCAGCACTTTGCTGGGAGAGATGGATCTTCTGACTCAGAGTTTAGGAGTTG ACACTCTCCCTCCTCCTGACCCTAATCCACCCAGAGCTGAATTTAACTACAGTGTGGGGTTTAAAGATTTAAATGAGTCCTTAAATGCAC TGGAAGACCAAGATTTAGATGCTCTCATGGCAGATCTGGTAGCAGACATAAGTGAGGCTGAGCAGAGGACAATCCAGGCACAGAAAGAGT CCTTGCAGAATCAACATCATTCAGCATCTCTACAAGCATCAATTTTCAGTGGTGCAGCCTCTCTTGGTTATGGAACAAATGTTGCTGCCA CTGGTATCAGCCAATATGAGGATGACTTACCACCTCCACCAGCCGATCCTGTGTTAGACCTTCCACTGCCACCACCACCTCCTGAACCTC TCTCTCAGGAAGAGGAAGAAGCCCAAGCCAAGGCTGATAAAATTAAGCTGGCGCTGGAAAAACTGAAGGAGGCCAAGGTTAAGAAGCTCG TCGTCAAGGTGCACATGAATGATAACAGCACAAAGTCACTGATGGTGGATGAGCGGCAGCTGGCCCGAGATGTTCTGGACAACCTTTTCG AGAAAACTCATTGTGACTGCAATGTAGACTGGTGTCTTTATGAAATCTACCCGGAACTACAAATTGAGAGGTTTTTTGAAGACCATGAAA ATGTTGTTGAAGTCTTATCAGACTGGACAAGAGACACAGAAAATAAAATACTATTTTTGGAGAAAGAGGAGAAATATGCTGTATTTAAAA ACCCCCAGAATTTCTACTTGGATAACAGAGGAAAAAAAGAAAGCAAGGAAACTAATGAGAAAATGAATGCTAAGAACAAGGAATCCTTAC TTGAGGAAAGTTTCTGTGGAACATCTATCATTGTACCAGAACTGGAAGGAGCTCTTTATTTGAAAGAAGATGGAAAGAAATCCTGGAAAA GGCGCTATTTTCTTTTACGGGCTTCTGGAATTTATTATGTACCCAAAGGAAAGACTAAGACATCTCGAGATCTGGCGTGTTTTATACAGT TTGAAAATGTCAACATTTACTATGGGACTCAGCATAAAATGAAATATAAAGCGCCCACTGACTATTGCTTTGTTTTAAAGGATGCATCAT CTGCAGACATCAGAAAAGCATATCGTAAGCTTTCACTAACTTTACATCCAGACAAGAATAAAGATGAAAATGCAGAAACTCAGTTTAGAC AAGTATGATGATATTCTGATCAATGGACTTCCAGATTGGCGACAGCCTGTATTCTACTACAGGCGGGTGAGAAAAATGAGCAATGCTGAG CTGGCATTACTCTTGTTCATTATTCTCACAGTGGGTCATTATGCTGTGGTTTGGTCAATCTACCTGGAAAAACAACTGGTAAGTGTTAGT AATAAATCAAATGAACTAGCCTCCTTAATTTTATATGGAATTTTGGACATTTATTTTTCAACTGATGAAAATTTCTGTTTCTCTCTGTAT |
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FusionGenePPI for APBB1IP_DNAJC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| APBB1IP | PACSIN1, PACSIN2, PACSIN3, PRPF40A, GAS7, NDN, ZDHHC17, PLEKHH1, ANXA13, SNW1 | DNAJC1 | ABHD16A, SERPINA3, LMNA, CLEC12A, MRPS27, HLA-C, FAM189A2, FAM63B, EVA1C, HSPA8, HSPA9, TCTN2, TCTN3, TMEM216, HSPA5, CLEC2D, RMND1, CDH5, SCGB2A2, VAV1, CORO1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for APBB1IP_DNAJC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for APBB1IP_DNAJC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | APBB1IP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | DNAJC1 | C0025202 | melanoma | 1 | CTD_human |
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