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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21224

FusionGeneSummary for MBOAT7_MBOAT7

check button Fusion gene summary
Fusion gene informationFusion gene name: MBOAT7_MBOAT7
Fusion gene ID: 21224
HgeneTgene
Gene symbol

MBOAT7

MBOAT7

Gene ID

79143

79143

Gene namemembrane bound O-acyltransferase domain containing 7membrane bound O-acyltransferase domain containing 7
SynonymsBB1|LENG4|LPIAT|LPLAT|LRC4|MBOA7|MRT57|OACT7|hMBOA-7BB1|LENG4|LPIAT|LPLAT|LRC4|MBOA7|MRT57|OACT7|hMBOA-7
Cytomap

19q13.42

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionlysophospholipid acyltransferase 71-acylglycerophosphatidylinositol O-acyltransferaseLPLAT 7bladder and breast carcinoma-overexpressed gene 1 proteinh-mboa-7leukocyte receptor cluster (LRC) member 4lyso-PI acyltransferaselysophosphatidylinositol aclysophospholipid acyltransferase 71-acylglycerophosphatidylinositol O-acyltransferaseLPLAT 7bladder and breast carcinoma-overexpressed gene 1 proteinh-mboa-7leukocyte receptor cluster (LRC) member 4lyso-PI acyltransferaselysophosphatidylinositol ac
Modification date2018051920180519
UniProtAcc

Q96N66

Q96N66

Ensembl transtripts involved in fusion geneENST00000431666, ENST00000338624, 
ENST00000245615, ENST00000391754, 
ENST00000474910, 		ENST00000431666, 
ENST00000338624, ENST00000245615, 
ENST00000391754, ENST00000474910, 
Fusion gene scores* DoF score3 X 2 X 3=185 X 5 X 3=75
# samples 36
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBOAT7 [Title/Abstract] AND MBOAT7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF919648MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000431666ENST00000431666MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000431666ENST00000338624MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000431666ENST00000245615MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000431666ENST00000391754MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-5UTRENST00000431666ENST00000474910MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000338624ENST00000431666MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000338624ENST00000338624MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000338624ENST00000245615MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000338624ENST00000391754MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-5UTRENST00000338624ENST00000474910MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000245615ENST00000431666MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000245615ENST00000338624MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000245615ENST00000245615MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000245615ENST00000391754MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-5UTRENST00000245615ENST00000474910MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000391754ENST00000431666MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000391754ENST00000338624MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000391754ENST00000245615MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000391754ENST00000391754MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-5UTRENST00000391754ENST00000474910MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000474910ENST00000431666MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000474910ENST00000338624MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000474910ENST00000245615MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-intronENST00000474910ENST00000391754MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-
intron-5UTRENST00000474910ENST00000474910MBOAT7chr19

54688505

+MBOAT7chr19

54691069

-

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FusionProtFeatures for MBOAT7_MBOAT7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBOAT7

Q96N66

MBOAT7

Q96N66


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MBOAT7_MBOAT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MBOAT7_MBOAT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MBOAT7_MBOAT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MBOAT7_MBOAT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMBOAT7C0023891Liver Cirrhosis, Alcoholic1CTD_human
TgeneMBOAT7C0023891Liver Cirrhosis, Alcoholic1CTD_human