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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21187

FusionGeneSummary for MBD5_GRM7

check button Fusion gene summary
Fusion gene informationFusion gene name: MBD5_GRM7
Fusion gene ID: 21187
HgeneTgene
Gene symbol

MBD5

GRM7

Gene ID

55777

2917

Gene namemethyl-CpG binding domain protein 5glutamate metabotropic receptor 7
SynonymsMRD1GLUR7|GPRC1G|MGLU7|MGLUR7|PPP1R87
Cytomap

2q23.1

3p26.1

Type of geneprotein-codingprotein-coding
Descriptionmethyl-CpG-binding domain protein 5methyl-CpG-binding protein MBD5metabotropic glutamate receptor 7glutamate receptor, metabotropic 7protein phosphatase 1, regulatory subunit 87
Modification date2018052320180523
UniProtAcc

Q9P267

Q14831

Ensembl transtripts involved in fusion geneENST00000407073, ENST00000478804, 
ENST00000404807, 
ENST00000357716, 
ENST00000486284, ENST00000389336, 
ENST00000402647, ENST00000403881, 
ENST00000458641, 
Fusion gene scores* DoF score6 X 4 X 4=969 X 7 X 7=441
# samples 79
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/441*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBD5 [Title/Abstract] AND GRM7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRM7

GO:0007196

adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway

9473604

TgeneGRM7

GO:0007268

chemical synaptic transmission

9473604


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-A6AN-01AMBD5chr2

148779253

+GRM7chr3

7188139

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000407073ENST00000357716MBD5chr2

148779253

+GRM7chr3

7188139

+
5UTR-3CDSENST00000407073ENST00000486284MBD5chr2

148779253

+GRM7chr3

7188139

+
5UTR-3CDSENST00000407073ENST00000389336MBD5chr2

148779253

+GRM7chr3

7188139

+
5UTR-3CDSENST00000407073ENST00000402647MBD5chr2

148779253

+GRM7chr3

7188139

+
5UTR-3CDSENST00000407073ENST00000403881MBD5chr2

148779253

+GRM7chr3

7188139

+
5UTR-intronENST00000407073ENST00000458641MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-3CDSENST00000478804ENST00000357716MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-3CDSENST00000478804ENST00000486284MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-3CDSENST00000478804ENST00000389336MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-3CDSENST00000478804ENST00000402647MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-3CDSENST00000478804ENST00000403881MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-intronENST00000478804ENST00000458641MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-3CDSENST00000404807ENST00000357716MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-3CDSENST00000404807ENST00000486284MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-3CDSENST00000404807ENST00000389336MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-3CDSENST00000404807ENST00000402647MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-3CDSENST00000404807ENST00000403881MBD5chr2

148779253

+GRM7chr3

7188139

+
intron-intronENST00000404807ENST00000458641MBD5chr2

148779253

+GRM7chr3

7188139

+

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FusionProtFeatures for MBD5_GRM7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBD5

Q9P267

GRM7

Q14831

Binds to heterochromatin. Does not interact with eithermethylated or unmethylated DNA (in vitro). G-protein coupled receptor for glutamate. Ligand bindingcauses a conformation change that triggers signaling via guaninenucleotide-binding proteins (G proteins) and modulates theactivity of down-stream effectors, such as adenylate cyclase.Signaling inhibits adenylate cyclase activity.{ECO:0000269|PubMed:9473604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MBD5_GRM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MBD5_GRM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MBD5APC, KIAA1549, UBE2T, EIF2S2, PMVK, HDGFRP2, UBE2E1, NME2P1, NAA15, ETF1, SNX3, HMGCS1, RHOA, UBA6, ASXL2, LZIC, BID, NAA50, HIST1H3AGRM7PICK1, PRKCA, GNAQ, GRIP1, SDCBP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MBD5_GRM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGRM7Q14831DB00142Glutamic AcidMetabotropic glutamate receptor 7small moleculeapproved|nutraceutical

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RelatedDiseases for MBD5_GRM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMBD5C0005586Bipolar Disorder1PSYGENET
TgeneGRM7C0011570Mental Depression5PSYGENET
TgeneGRM7C0011581Depressive disorder5PSYGENET
TgeneGRM7C0041696Unipolar Depression5PSYGENET
TgeneGRM7C1269683Major Depressive Disorder5PSYGENET
TgeneGRM7C0036341Schizophrenia4PSYGENET
TgeneGRM7C0005586Bipolar Disorder3PSYGENET
TgeneGRM7C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGRM7C0236969Substance-Related Disorders1CTD_human
TgeneGRM7C1263846Attention deficit hyperactivity disorder1CTD_human