|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 21143 |
FusionGeneSummary for MAT2A_CNTN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAT2A_CNTN2 | Fusion gene ID: 21143 | Hgene | Tgene | Gene symbol | MAT2A | CNTN2 | Gene ID | 4144 | 6900 |
| Gene name | methionine adenosyltransferase 2A | contactin 2 | |
| Synonyms | MATA2|MATII|SAMS2 | AXT|FAME5|TAG-1|TAX|TAX1 | |
| Cytomap | 2p11.2 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | S-adenosylmethionine synthase isoform type-2MAT 2MAT-IIadoMet synthase 2adoMet synthetase 2methionine adenosyltransferase 2methionine adenosyltransferase II, alphatesticular tissue protein Li 121 | contactin-2axonal glycoprotein TAG-1axonin-1 cell adhesion moleculecontactin 2 (axonal)contactin 2 (transiently expressed)transient axonal glycoprotein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P31153 | Q02246 | |
| Ensembl transtripts involved in fusion gene | ENST00000306434, ENST00000409017, ENST00000490878, | ENST00000331830, | |
| Fusion gene scores | * DoF score | 5 X 5 X 1=25 | 4 X 4 X 4=64 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAT2A [Title/Abstract] AND CNTN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAT2A | GO:0006556 | S-adenosylmethionine biosynthetic process | 10644686|25075345 |
| Hgene | MAT2A | GO:0034214 | protein hexamerization | 25075345 |
| Hgene | MAT2A | GO:0051291 | protein heterooligomerization | 25075345 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP362529 | MAT2A | chr2 | 85770157 | + | CNTN2 | chr1 | 205036226 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000306434 | ENST00000331830 | MAT2A | chr2 | 85770157 | + | CNTN2 | chr1 | 205036226 | + |
| Frame-shift | ENST00000409017 | ENST00000331830 | MAT2A | chr2 | 85770157 | + | CNTN2 | chr1 | 205036226 | + |
| intron-3CDS | ENST00000490878 | ENST00000331830 | MAT2A | chr2 | 85770157 | + | CNTN2 | chr1 | 205036226 | + |
Top |
FusionProtFeatures for MAT2A_CNTN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAT2A | CNTN2 |
| Catalyzes the formation of S-adenosylmethionine frommethionine and ATP. The reaction comprises two steps that are bothcatalyzed by the same enzyme: formation of S-adenosylmethionine(AdoMet) and triphosphate, and subsequent hydrolysis of thetriphosphate. {ECO:0000269|PubMed:10644686,ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}. | In conjunction with another transmembrane protein,CNTNAP2, contributes to the organization of axonal domains atnodes of Ranvier by maintaining voltage-gated potassium channelsat the juxtaparanodal region. May be involved in cell adhesion.{ECO:0000269|PubMed:23518707}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MAT2A_CNTN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MAT2A_CNTN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAT2A | MAT2B, HGS, ELAVL1, CUL3, COPS5, GRK5, MAT1A, RPS3A, CSTB, RPS3, RPLP0P6, SMURF1, VCPKMT, FBXO6, CAPNS1, DFFA, EEF2, MTHFD1, TUBA1A, UGDH, FUS, MAT2A, TMEM213, ABCB7, ACSS2, ASNS, XPO1, NMD3, SDHB, TUBB, NTRK1, HIST1H3E, SLC33A1, UBE2I, BCL2, MCM2, CYLD, DLD, DNM1L, HSD17B10, SDHA, SOD1, TRIM25, URI1 | CNTN2 | CNTNAP2, NRCAM, L1CAM, CNTN1, NCAN, EGFR, IKBKG |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MAT2A_CNTN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MAT2A | P31153 | DB00118 | Ademetionine | S-adenosylmethionine synthase isoform type-2 | small molecule | approved|investigational|nutraceutical |
Top |
RelatedDiseases for MAT2A_CNTN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|