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Fusion gene ID: 21136 |
FusionGeneSummary for MAST4_MRPS27 |
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Fusion gene information | Fusion gene name: MAST4_MRPS27 | Fusion gene ID: 21136 | Hgene | Tgene | Gene symbol | MAST4 | MRPS27 | Gene ID | 375449 | 23107 |
Gene name | microtubule associated serine/threonine kinase family member 4 | mitochondrial ribosomal protein S27 | |
Synonyms | - | MRP-S27|S27mt | |
Cytomap | 5q12.3 | 5q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | microtubule-associated serine/threonine-protein kinase 4 | 28S ribosomal protein S27, mitochondrialmitochondrial 28S ribosomal protein S27mitochondrial small ribosomal subunit protein mS27 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O15021 | Q92552 | |
Ensembl transtripts involved in fusion gene | ENST00000404260, ENST00000403625, ENST00000406374, ENST00000406039, ENST00000478569, ENST00000490016, ENST00000403666, ENST00000405643, ENST00000261569, ENST00000407621, | ENST00000261413, ENST00000457646, ENST00000513900, ENST00000515404, ENST00000522562, ENST00000522095, | |
Fusion gene scores | * DoF score | 10 X 9 X 7=630 | 3 X 3 X 2=18 |
# samples | 10 | 4 | |
** MAII score | log2(10/630*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MAST4 [Title/Abstract] AND MRPS27 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-49-4514-01A | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shit | ENST00000404260 | ENST00000261413 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000404260 | ENST00000457646 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000404260 | ENST00000513900 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000404260 | ENST00000515404 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000404260 | ENST00000522562 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000404260 | ENST00000522095 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000403625 | ENST00000261413 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000403625 | ENST00000457646 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000403625 | ENST00000513900 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000403625 | ENST00000515404 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000403625 | ENST00000522562 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000403625 | ENST00000522095 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000406374 | ENST00000261413 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000406374 | ENST00000457646 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000406374 | ENST00000513900 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000406374 | ENST00000515404 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000406374 | ENST00000522562 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000406374 | ENST00000522095 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000406039 | ENST00000261413 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000406039 | ENST00000457646 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000406039 | ENST00000513900 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000406039 | ENST00000515404 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000406039 | ENST00000522562 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000406039 | ENST00000522095 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000478569 | ENST00000261413 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000478569 | ENST00000457646 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000478569 | ENST00000513900 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000478569 | ENST00000515404 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000478569 | ENST00000522562 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000478569 | ENST00000522095 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000490016 | ENST00000261413 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000490016 | ENST00000457646 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000490016 | ENST00000513900 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000490016 | ENST00000515404 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000490016 | ENST00000522562 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000490016 | ENST00000522095 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000403666 | ENST00000261413 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000403666 | ENST00000457646 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000403666 | ENST00000513900 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000403666 | ENST00000515404 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000403666 | ENST00000522562 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000403666 | ENST00000522095 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000405643 | ENST00000261413 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000405643 | ENST00000457646 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000405643 | ENST00000513900 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000405643 | ENST00000515404 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000405643 | ENST00000522562 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000405643 | ENST00000522095 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000261569 | ENST00000261413 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000261569 | ENST00000457646 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
Frame-shit | ENST00000261569 | ENST00000513900 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000261569 | ENST00000515404 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000261569 | ENST00000522562 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
5CDS-intron | ENST00000261569 | ENST00000522095 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000407621 | ENST00000261413 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000407621 | ENST00000457646 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-3CDS | ENST00000407621 | ENST00000513900 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000407621 | ENST00000515404 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000407621 | ENST00000522562 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
intron-intron | ENST00000407621 | ENST00000522095 | MAST4 | chr5 | 66396420 | + | MRPS27 | chr5 | 71516975 | - |
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FusionProtFeatures for MAST4_MRPS27 |
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Hgene | Tgene |
MAST4 | MRPS27 |
RNA-binding component of the mitochondrial smallribosomal subunit (mt-SSU) that plays a role in mitochondrialprotein synthesis (PubMed:22841715). Stimulates mitochondrial mRNAtranslation of subunit components of the mitochondrial electrontransport chain (PubMed:22841715). Binds to the mitochondrial 12SrRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved alsoin positive regulation of cell proliferation and tumor cell growth(PubMed:28714366). {ECO:0000269|PubMed:22841715,ECO:0000269|PubMed:28714366}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAST4_MRPS27 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAST4_MRPS27 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAST4 | SMAD1 | MRPS27 | HNRNPA1, KHDRBS2, CDK9, ICT1, HDGF, ELAVL1, CUL3, CUL1, COPS5, CAND1, GRK5, MRPS23, DAP3, ILF3, SMURF1, ESR2, C1QBP, YWHAQ, MRPL3, MRPL12, TARDBP, PARK2, RIOK2, GRSF1, AURKB, HAUS2, CEP76, TP53, NECAB2, MOV10, NXF1, BTRC, FBXW11, NOL12, RPL13, TRA2A, RPL6, RPS8, DNAJC1, LRRC15, TRMT10B, ZNF707, LUC7L, MRPS31, MRPS5, MRPS22, MRPS28, NTRK1, CENPA, HNRNPU, RPL10, TSNAX, THOC5, PHF8, THOC2, MYH7B, FBXO31, FERMT3, ZSCAN26, ERBB3, ZNF746, C8orf82, NOA1, MRPS34, MRPS9, MRPS33, MRPS7, MRPS11, MRPS26, PTCD3, MRPS35, MRPS24, MRPS21, STRBP, MRPS15, MRPS10, MRPS14, MRPS18C, MRPS2, MRPS25, MRPS16, MRPS18B, METTL17, AURKAIP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAST4_MRPS27 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAST4_MRPS27 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |