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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21116

FusionGeneSummary for MAST2_CLDN14

check button Fusion gene summary
Fusion gene informationFusion gene name: MAST2_CLDN14
Fusion gene ID: 21116
HgeneTgene
Gene symbol

MAST2

CLDN14

Gene ID

23139

23562

Gene namemicrotubule associated serine/threonine kinase 2claudin 14
SynonymsMAST205|MTSSKDFNB29
Cytomap

1p34.1

21q22.13

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated serine/threonine-protein kinase 2microtubule associated testis specific serine/threonine protein kinaseclaudin-14
Modification date2018052320180411
UniProtAcc

Q6P0Q8

O95500

Ensembl transtripts involved in fusion geneENST00000372009, ENST00000361297, 
ENST00000477968, 
ENST00000399136, 
ENST00000342108, ENST00000399139, 
ENST00000399137, ENST00000399135, 
ENST00000478313, 
Fusion gene scores* DoF score16 X 9 X 12=17284 X 2 X 3=24
# samples 184
** MAII scorelog2(18/1728*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAST2 [Title/Abstract] AND CLDN14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-13-0801-01AMAST2chr1

46295253

+CLDN14chr21

37834074

-
TCGALDOVTCGA-13-0801-01AMAST2chr1

46295253

+CLDN14chr21

37882798

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000372009ENST00000399136MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-5UTRENST00000372009ENST00000342108MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-5UTRENST00000372009ENST00000399139MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-5UTRENST00000372009ENST00000399137MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-5UTRENST00000372009ENST00000399135MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-intronENST00000372009ENST00000478313MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-5UTRENST00000361297ENST00000399136MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-5UTRENST00000361297ENST00000342108MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-5UTRENST00000361297ENST00000399139MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-5UTRENST00000361297ENST00000399137MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-5UTRENST00000361297ENST00000399135MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-intronENST00000361297ENST00000478313MAST2chr1

46295253

+CLDN14chr21

37834074

-
intron-5UTRENST00000477968ENST00000399136MAST2chr1

46295253

+CLDN14chr21

37834074

-
intron-5UTRENST00000477968ENST00000342108MAST2chr1

46295253

+CLDN14chr21

37834074

-
intron-5UTRENST00000477968ENST00000399139MAST2chr1

46295253

+CLDN14chr21

37834074

-
intron-5UTRENST00000477968ENST00000399137MAST2chr1

46295253

+CLDN14chr21

37834074

-
intron-5UTRENST00000477968ENST00000399135MAST2chr1

46295253

+CLDN14chr21

37834074

-
intron-intronENST00000477968ENST00000478313MAST2chr1

46295253

+CLDN14chr21

37834074

-
5CDS-5UTRENST00000372009ENST00000399136MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-5UTRENST00000372009ENST00000342108MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-intronENST00000372009ENST00000399139MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-intronENST00000372009ENST00000399137MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-intronENST00000372009ENST00000399135MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-intronENST00000372009ENST00000478313MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-5UTRENST00000361297ENST00000399136MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-5UTRENST00000361297ENST00000342108MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-intronENST00000361297ENST00000399139MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-intronENST00000361297ENST00000399137MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-intronENST00000361297ENST00000399135MAST2chr1

46295253

+CLDN14chr21

37882798

-
5CDS-intronENST00000361297ENST00000478313MAST2chr1

46295253

+CLDN14chr21

37882798

-
intron-5UTRENST00000477968ENST00000399136MAST2chr1

46295253

+CLDN14chr21

37882798

-
intron-5UTRENST00000477968ENST00000342108MAST2chr1

46295253

+CLDN14chr21

37882798

-
intron-intronENST00000477968ENST00000399139MAST2chr1

46295253

+CLDN14chr21

37882798

-
intron-intronENST00000477968ENST00000399137MAST2chr1

46295253

+CLDN14chr21

37882798

-
intron-intronENST00000477968ENST00000399135MAST2chr1

46295253

+CLDN14chr21

37882798

-
intron-intronENST00000477968ENST00000478313MAST2chr1

46295253

+CLDN14chr21

37882798

-

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FusionProtFeatures for MAST2_CLDN14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAST2

Q6P0Q8

CLDN14

O95500

Appears to link the dystrophin/utrophin network withmicrotubule filaments via the syntrophins. Phosphorylation of DMDor UTRN may modulate their affinities for associated proteins.Functions in a multi-protein complex in spermatid maturation.Regulates lipopolysaccharide-induced IL-12 synthesis inmacrophages by forming a complex with TRAF6, resulting in theinhibition of TRAF6 NF-kappa-B activation (By similarity).{ECO:0000250}. Plays a major role in tight junction-specificobliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAST2_CLDN14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAST2_CLDN14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAST2CDHR2, GCN1L1, TRAF6, TRAF2, SNTB2, SH3GL2, TK1, SMN1, STK36, RASSF1, LATS1, APP, HSP90AA1, YWHAE, SUMO2, YWHAB, FBXW11, BTRC, SRPK2, GAN, EGFRCLDN14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAST2_CLDN14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAST2_CLDN14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCLDN14C3279660DEAFNESS, AUTOSOMAL RECESSIVE 292UNIPROT
TgeneCLDN14C0011053Deafness1CTD_human;HPO
TgeneCLDN14C0022650Kidney Calculi1CTD_human