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Fusion gene ID: 21110 |
FusionGeneSummary for MAST1_ASIC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAST1_ASIC2 | Fusion gene ID: 21110 | Hgene | Tgene | Gene symbol | MAST1 | ASIC2 | Gene ID | 23332 | 40 |
| Gene name | cytoplasmic linker associated protein 1 | acid sensing ion channel subunit 2 | |
| Synonyms | MAST1 | ACCN|ACCN1|ASIC2a|BNC1|BNaC1|MDEG|hBNaC1 | |
| Cytomap | 2q14.2-q14.3 | 17q11.2-q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CLIP-associating protein 1multiple asters 1multiple asters homolog 1protein Orbit homolog 1 | acid-sensing ion channel 2acid sensing (proton gated) ion channel 2amiloride-sensitive cation channel 1, neuronalbrain sodium channel 1mammalian degenerin homologneuronal amiloride-sensitive cation channel 1 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9Y2H9 | Q16515 | |
| Ensembl transtripts involved in fusion gene | ENST00000251472, ENST00000591495, | ENST00000225823, ENST00000359872, ENST00000448983, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 10 X 9 X 5=450 |
| # samples | 2 | 12 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(12/450*10)=-1.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAST1 [Title/Abstract] AND ASIC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAST1 | GO:0051294 | establishment of spindle orientation | 21822276 |
| Hgene | MAST1 | GO:0051301 | cell division | 21822276 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA113340 | MAST1 | chr19 | 12951320 | + | ASIC2 | chr17 | 31582128 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000251472 | ENST00000225823 | MAST1 | chr19 | 12951320 | + | ASIC2 | chr17 | 31582128 | - |
| 5CDS-intron | ENST00000251472 | ENST00000359872 | MAST1 | chr19 | 12951320 | + | ASIC2 | chr17 | 31582128 | - |
| 5CDS-intron | ENST00000251472 | ENST00000448983 | MAST1 | chr19 | 12951320 | + | ASIC2 | chr17 | 31582128 | - |
| 5CDS-intron | ENST00000591495 | ENST00000225823 | MAST1 | chr19 | 12951320 | + | ASIC2 | chr17 | 31582128 | - |
| 5CDS-intron | ENST00000591495 | ENST00000359872 | MAST1 | chr19 | 12951320 | + | ASIC2 | chr17 | 31582128 | - |
| 5CDS-intron | ENST00000591495 | ENST00000448983 | MAST1 | chr19 | 12951320 | + | ASIC2 | chr17 | 31582128 | - |
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FusionProtFeatures for MAST1_ASIC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAST1 | ASIC2 |
| Appears to link the dystrophin/utrophin network withmicrotubule filaments via the syntrophins. Phosphorylation of DMDor UTRN may modulate their affinities for associated proteins (Bysimilarity). {ECO:0000250|UniProtKB:Q9R1L5}. | Cation channel with high affinity for sodium, which isgated by extracellular protons and inhibited by the diureticamiloride. Also permeable for Li(+) and K(+). Generates a biphasiccurrent with a fast inactivating and a slow sustained phase.Heteromeric channel assembly seems to modulate. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAST1_ASIC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAST1_ASIC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAST1_ASIC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | ASIC2 | Q16515 | DB00594 | Amiloride | Acid-sensing ion channel 2 {ECO:0000303|PubMed:10842183} | small molecule | approved |
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RelatedDiseases for MAST1_ASIC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ASIC2 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | ASIC2 | C0021368 | Inflammation | 1 | CTD_human |
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