	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 21089

FusionGeneSummary for MARK3_MARK3

Fusion gene summary

Fusion gene information	Fusion gene name: MARK3_MARK3
	Fusion gene ID: 21089
		Hgene	Tgene
	Gene symbol	MARK3	MARK3
	Gene ID	4140	4140
	Gene name	microtubule affinity regulating kinase 3	microtubule affinity regulating kinase 3
	Synonyms	CTAK1\|KP78\|PAR1A\|Par-1a	CTAK1\|KP78\|PAR1A\|Par-1a
	Cytomap	14q32.32-q32.33	14q32.32-q32.33
	Type of gene	protein-coding	protein-coding
	Description	MAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78	MAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78
	Modification date	20180523	20180523
	UniProtAcc	P27448	P27448
	Ensembl transtripts involved in fusion gene	ENST00000440884, ENST00000416682, ENST00000429436, ENST00000303622, ENST00000216288, ENST00000553942, ENST00000335102, ENST00000561071,	ENST00000440884, ENST00000416682, ENST00000429436, ENST00000303622, ENST00000216288, ENST00000553942, ENST00000335102, ENST00000561071,
Fusion gene scores	* DoF score	17 X 13 X 8=1768	8 X 10 X 6=480
	# samples	20	15
	** MAII score	log2(20/1768*10)=-3.14404636961671 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/480*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MARK3 [Title/Abstract] AND MARK3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MARK3	GO:0018105	peptidyl-serine phosphorylation	9543386
Hgene	MARK3	GO:0032092	positive regulation of protein binding	9543386
Hgene	MARK3	GO:0035331	negative regulation of hippo signaling	28087714
Hgene	MARK3	GO:0036289	peptidyl-serine autophosphorylation	9543386
Tgene	MARK3	GO:0018105	peptidyl-serine phosphorylation	9543386
Tgene	MARK3	GO:0032092	positive regulation of protein binding	9543386
Tgene	MARK3	GO:0035331	negative regulation of hippo signaling	28087714
Tgene	MARK3	GO:0036289	peptidyl-serine autophosphorylation	9543386

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF356202	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000440884	ENST00000440884	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000440884	ENST00000416682	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000440884	ENST00000429436	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000440884	ENST00000303622	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000440884	ENST00000216288	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000440884	ENST00000553942	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000440884	ENST00000335102	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
5CDS-3UTR	ENST00000440884	ENST00000561071	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000416682	ENST00000440884	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000416682	ENST00000416682	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000416682	ENST00000429436	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000416682	ENST00000303622	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000416682	ENST00000216288	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000416682	ENST00000553942	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000416682	ENST00000335102	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
5CDS-3UTR	ENST00000416682	ENST00000561071	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000429436	ENST00000440884	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000429436	ENST00000416682	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000429436	ENST00000429436	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000429436	ENST00000303622	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000429436	ENST00000216288	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000429436	ENST00000553942	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000429436	ENST00000335102	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
5CDS-3UTR	ENST00000429436	ENST00000561071	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000303622	ENST00000440884	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000303622	ENST00000416682	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000303622	ENST00000429436	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000303622	ENST00000303622	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000303622	ENST00000216288	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000303622	ENST00000553942	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000303622	ENST00000335102	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
5CDS-3UTR	ENST00000303622	ENST00000561071	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000216288	ENST00000440884	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000216288	ENST00000416682	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000216288	ENST00000429436	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000216288	ENST00000303622	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000216288	ENST00000216288	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000216288	ENST00000553942	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000216288	ENST00000335102	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
5CDS-3UTR	ENST00000216288	ENST00000561071	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000553942	ENST00000440884	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000553942	ENST00000416682	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000553942	ENST00000429436	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000553942	ENST00000303622	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000553942	ENST00000216288	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000553942	ENST00000553942	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000553942	ENST00000335102	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
5CDS-3UTR	ENST00000553942	ENST00000561071	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000335102	ENST00000440884	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000335102	ENST00000416682	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000335102	ENST00000429436	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000335102	ENST00000303622	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
Frame-shift	ENST00000335102	ENST00000216288	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000335102	ENST00000553942	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
In-frame	ENST00000335102	ENST00000335102	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
5CDS-3UTR	ENST00000335102	ENST00000561071	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
intron-3CDS	ENST00000561071	ENST00000440884	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
intron-3CDS	ENST00000561071	ENST00000416682	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
intron-3CDS	ENST00000561071	ENST00000429436	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
intron-3CDS	ENST00000561071	ENST00000303622	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
intron-3CDS	ENST00000561071	ENST00000216288	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
intron-3CDS	ENST00000561071	ENST00000553942	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
intron-3CDS	ENST00000561071	ENST00000335102	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+
intron-3UTR	ENST00000561071	ENST00000561071	MARK3	chr14	103941522	-	MARK3	chr14	103969381	+

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FusionProtFeatures for MARK3_MARK3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MARK3 P27448	MARK3 P27448

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for MARK3_MARK3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MARK3_MARK3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MARK3_MARK3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MARK3_MARK3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 21089

FusionGeneSummary for MARK3_MARK3

FusionProtFeatures for MARK3_MARK3

FusionGeneSequence for MARK3_MARK3

FusionGenePPI for MARK3_MARK3

RelatedDrugs for MARK3_MARK3

RelatedDiseases for MARK3_MARK3