FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 21080

FusionGeneSummary for MARK3_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: MARK3_BCAS3
Fusion gene ID: 21080
HgeneTgene
Gene symbol

MARK3

BCAS3

Gene ID

4140

54828

Gene namemicrotubule affinity regulating kinase 3BCAS3, microtubule associated cell migration factor
SynonymsCTAK1|KP78|PAR1A|Par-1aGAOB1|MAAB
Cytomap

14q32.32-q32.33

17q23.2

Type of geneprotein-codingprotein-coding
DescriptionMAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018052320180523
UniProtAcc

P27448

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000440884, ENST00000416682, 
ENST00000429436, ENST00000303622, 
ENST00000216288, ENST00000553942, 
ENST00000335102, ENST00000561071, 
ENST00000589222, ENST00000407086, 
ENST00000390652, ENST00000408905, 
ENST00000588462, ENST00000585744, 
ENST00000588874, ENST00000585812, 
Fusion gene scores* DoF score17 X 13 X 8=176826 X 15 X 15=5850
# samples 2041
** MAII scorelog2(20/1768*10)=-3.14404636961671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MARK3 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMARK3

GO:0018105

peptidyl-serine phosphorylation

9543386

HgeneMARK3

GO:0032092

positive regulation of protein binding

9543386

HgeneMARK3

GO:0035331

negative regulation of hippo signaling

28087714

HgeneMARK3

GO:0036289

peptidyl-serine autophosphorylation

9543386

TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1842-01AMARK3chr14

103852417

+BCAS3chr17

59445688

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000440884ENST00000589222MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000440884ENST00000407086MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000440884ENST00000390652MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000440884ENST00000408905MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000440884ENST00000588462MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000440884ENST00000585744MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000440884ENST00000588874MARK3chr14

103852417

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000440884ENST00000585812MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000416682ENST00000589222MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000416682ENST00000407086MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000416682ENST00000390652MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000416682ENST00000408905MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000416682ENST00000588462MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000416682ENST00000585744MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000416682ENST00000588874MARK3chr14

103852417

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000416682ENST00000585812MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000429436ENST00000589222MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000429436ENST00000407086MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000429436ENST00000390652MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000429436ENST00000408905MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000429436ENST00000588462MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000429436ENST00000585744MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000429436ENST00000588874MARK3chr14

103852417

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000429436ENST00000585812MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000303622ENST00000589222MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000303622ENST00000407086MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000303622ENST00000390652MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000303622ENST00000408905MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000303622ENST00000588462MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000303622ENST00000585744MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000303622ENST00000588874MARK3chr14

103852417

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000303622ENST00000585812MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000216288ENST00000589222MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000216288ENST00000407086MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000216288ENST00000390652MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000216288ENST00000408905MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000216288ENST00000588462MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000216288ENST00000585744MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000216288ENST00000588874MARK3chr14

103852417

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000216288ENST00000585812MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000553942ENST00000589222MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000553942ENST00000407086MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000553942ENST00000390652MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000553942ENST00000408905MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000553942ENST00000588462MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000553942ENST00000585744MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000553942ENST00000588874MARK3chr14

103852417

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000553942ENST00000585812MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000335102ENST00000589222MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000335102ENST00000407086MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000335102ENST00000390652MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000335102ENST00000408905MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000335102ENST00000588462MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000335102ENST00000585744MARK3chr14

103852417

+BCAS3chr17

59445688

+
Frame-shitENST00000335102ENST00000588874MARK3chr14

103852417

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000335102ENST00000585812MARK3chr14

103852417

+BCAS3chr17

59445688

+
intron-3CDSENST00000561071ENST00000589222MARK3chr14

103852417

+BCAS3chr17

59445688

+
intron-3CDSENST00000561071ENST00000407086MARK3chr14

103852417

+BCAS3chr17

59445688

+
intron-3CDSENST00000561071ENST00000390652MARK3chr14

103852417

+BCAS3chr17

59445688

+
intron-3CDSENST00000561071ENST00000408905MARK3chr14

103852417

+BCAS3chr17

59445688

+
intron-3CDSENST00000561071ENST00000588462MARK3chr14

103852417

+BCAS3chr17

59445688

+
intron-3CDSENST00000561071ENST00000585744MARK3chr14

103852417

+BCAS3chr17

59445688

+
intron-3CDSENST00000561071ENST00000588874MARK3chr14

103852417

+BCAS3chr17

59445688

+
intron-3UTRENST00000561071ENST00000585812MARK3chr14

103852417

+BCAS3chr17

59445688

+

Top

FusionProtFeatures for MARK3_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MARK3

P27448

BCAS3

Q9H6U6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MARK3_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MARK3_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MARK3SFN, YWHAB, YWHAG, YWHAQ, RASGRF1, ATP6V0C, CHGB, SAAL1, PMPCB, PNPLA2, VPS11, TCEA2, TTR, USP21, MARK2, HDAC7, HDAC4, HDAC5, TADA2A, TERF2, PRKAA1, YWHAZ, YWHAH, MITF, MAP2, YWHAE, CDC25C, KSR1, PKP2, PIM1, MARK3, ASB13, MAPT, CAPZA1, CAPZB, CNBP, DLG5, HNRNPDL, MTCL1, ALYREF, CASQ2, NTRK1, CEP192, TMEM17, CTBP2, PPP2CB, CPSF3, MEX3C, CDH1, COL4A3BP, NRROS, TMCC2, NUAK2, PCDHGB4, CDH19, MANSC1, TRIM25, HEY1BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MARK3_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MARK3_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource